Rui Medeiros

Summary

Publications

  1. ncbi request reprint Platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma: glutathione S-transferase genetic polymorphisms as predictive biomarkers of disease outcome
    Rui Medeiros
    Unit of Molecular Oncology, Laboratórios Piso 4, Instituto Português de Oncologia Porto, R Dr Ant Bernardino Almeida, 4200 072 Porto, Portugal
    Int J Clin Oncol 8:156-61. 2003
  2. ncbi request reprint Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms
    Rui Medeiros
    Molecular Oncology Unit, Instituto Portugues de Oncologia, Porto, Portugal
    Prostate 58:414-20. 2004
  3. ncbi request reprint Steroid hormone genotypes ARStuI and ER325 are linked to the progression of human prostate cancer
    Rui Medeiros
    Molecular Oncology Unit, Instituto Portugues de Oncologia, 4200 072, Porto, Portugal
    Cancer Genet Cytogenet 141:91-6. 2003
  4. ncbi request reprint TP53 and P21 polymorphisms: response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer
    Alexandra M Santos
    Molecular Oncology Unit, Portuguese Institute of Oncology Oporto, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Biochem Biophys Res Commun 340:256-62. 2006
  5. doi request reprint The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration
    Avelino Fraga
    Urology Department, Sto António Hospital, Porto Hospital Centre, Porto, Portugal ICBAS, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal Electronic address
    Eur J Cancer 50:359-65. 2014
  6. doi request reprint IL-1RN VNTR polymorphism as a susceptibility marker for nasopharyngeal carcinoma in Portugal
    Hugo Sousa
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Porto, Portugal
    Arch Oral Biol 58:1040-6. 2013
  7. ncbi request reprint The influence of chemokine receptor CCR2 genotypes in the route to cervical carcinogenesis
    Ana Coelho
    Molecular Oncology Virology, Instituto Portugues de Oncologia, Porto, Portugal
    Gynecol Obstet Invest 64:208-12. 2007
  8. ncbi request reprint Linkage of TP53 codon 72 pro/pro genotype as predictive factor for nasopharyngeal carcinoma development
    Hugo Sousa
    Molecular Oncology Unit, Portuguese Institute of Oncology Oporto, Porto, Portugal
    Eur J Cancer Prev 15:362-6. 2006
  9. ncbi request reprint Linking TP53 codon 72 and P21 nt590 genotypes to the development of cervical and ovarian cancer
    Alexandra M Santos
    Molecular Oncology Unit, Portuguese Institute of Oncology Oporto, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Eur J Cancer 42:958-63. 2006
  10. ncbi request reprint The influence of HER2 genotypes as molecular markers in ovarian cancer outcome
    Daniela Pinto
    Pathology and Molecular Oncology Unit, Portuguese Institute of Oncology, Porto, Portugal
    Biochem Biophys Res Commun 335:1173-8. 2005

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma: glutathione S-transferase genetic polymorphisms as predictive biomarkers of disease outcome
    Rui Medeiros
    Unit of Molecular Oncology, Laboratórios Piso 4, Instituto Português de Oncologia Porto, R Dr Ant Bernardino Almeida, 4200 072 Porto, Portugal
    Int J Clin Oncol 8:156-61. 2003
    ..A significant percentage of normal individuals exhibit genetic polymorphism with a homozygous deletion (null genotype) of the genes, leading to absence of the enzyme...
  2. ncbi request reprint Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms
    Rui Medeiros
    Molecular Oncology Unit, Instituto Portugues de Oncologia, Porto, Portugal
    Prostate 58:414-20. 2004
    ..Glutathione S-transferase (GST) metabolic enzymes may be involved in the development of human cancer. Genetic polymorphisms have been reported in GSTM1, GSTM3, and GSTT1 with functional alterations and influencing cancer risk...
  3. ncbi request reprint Steroid hormone genotypes ARStuI and ER325 are linked to the progression of human prostate cancer
    Rui Medeiros
    Molecular Oncology Unit, Instituto Portugues de Oncologia, 4200 072, Porto, Portugal
    Cancer Genet Cytogenet 141:91-6. 2003
    ..Our results support the hypothesis that genetic factors related to steroid hormone receptors may influence the behavior of human prostate cancer...
  4. ncbi request reprint TP53 and P21 polymorphisms: response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer
    Alexandra M Santos
    Molecular Oncology Unit, Portuguese Institute of Oncology Oporto, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Biochem Biophys Res Commun 340:256-62. 2006
    ..020). This study suggests that the characterisation of a genetic profile can contribute to the definition of a better chemotherapy treatment...
  5. doi request reprint The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration
    Avelino Fraga
    Urology Department, Sto António Hospital, Porto Hospital Centre, Porto, Portugal ICBAS, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal Electronic address
    Eur J Cancer 50:359-65. 2014
    ..Molecular profiles using hypoxia markers may help predict clinically relevant prostate cancer and response to ADT. ..
  6. doi request reprint IL-1RN VNTR polymorphism as a susceptibility marker for nasopharyngeal carcinoma in Portugal
    Hugo Sousa
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Porto, Portugal
    Arch Oral Biol 58:1040-6. 2013
    ....
  7. ncbi request reprint The influence of chemokine receptor CCR2 genotypes in the route to cervical carcinogenesis
    Ana Coelho
    Molecular Oncology Virology, Instituto Portugues de Oncologia, Porto, Portugal
    Gynecol Obstet Invest 64:208-12. 2007
    ..013; OR = 2.21; 95%CI: 1.17-4.15), suggesting that CCR2-64I polymorphism might contribute to the establishment of HSIL, through the disruption of the naturally fragile immune response directed towards human papillomavirus infection...
  8. ncbi request reprint Linkage of TP53 codon 72 pro/pro genotype as predictive factor for nasopharyngeal carcinoma development
    Hugo Sousa
    Molecular Oncology Unit, Portuguese Institute of Oncology Oporto, Porto, Portugal
    Eur J Cancer Prev 15:362-6. 2006
    ....
  9. ncbi request reprint Linking TP53 codon 72 and P21 nt590 genotypes to the development of cervical and ovarian cancer
    Alexandra M Santos
    Molecular Oncology Unit, Portuguese Institute of Oncology Oporto, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Eur J Cancer 42:958-63. 2006
    ..No association was found between these polymorphisms and cervical cancer. Our results suggest that the TP53 codon 72 genotypes may be considered as a molecular marker, contributing to a genetic profile for ovarian cancer in women...
  10. ncbi request reprint The influence of HER2 genotypes as molecular markers in ovarian cancer outcome
    Daniela Pinto
    Pathology and Molecular Oncology Unit, Portuguese Institute of Oncology, Porto, Portugal
    Biochem Biophys Res Commun 335:1173-8. 2005
    ..We hypothesize that HER2 genotypes can be predictive biomarkers in ovarian cancer, contributing to a genetic individual profile of great interest in clinical oncology...
  11. ncbi request reprint Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease
    Ricardo Ribeiro
    Molecular Oncology Unit, Instituto Portugues de Oncologia, Porto, Portugal
    Prostate 59:268-74. 2004
    ..Leptin has been consistently associated with angiogenesis and tumoral growth. A G/A single nucleotide polymorphism (SNP) at the -2548 site in leptin gene (LEP) is associated with overexpression of leptin (A-allele)...
  12. pmc Improvement of a predictive model of castration-resistant prostate cancer: functional genetic variants in TGFβ1 signaling pathway modulation
    Ana L Teixeira
    Molecular Oncology Group, Portuguese Institute of Oncology Porto, Porto, Portugal
    PLoS ONE 8:e72419. 2013
    ..Furthermore, according to our results, we hypothesize the potential benefits of the association of genetic information in predictive models of CR development. ..
  13. ncbi request reprint A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer
    Ricardo Ribeiro
    Molecular Oncology CI, Portuguese Institute of Oncology, Porto, Portugal
    Eur J Cancer 42:1188-93. 2006
    ..023). Results suggest the existence of genetic susceptibility for lung cancer in carriers of this LEP functional polymorphism. Further studies are warranted to extend knowledge of leptin involvement in lung cancer...
  14. doi request reprint The role of p73 G4C14-to-A4T14 polymorphism in the susceptibility to cervical cancer
    Rogéria Craveiro
    Radiotherapy, Gynecology, and Oncology Departments, Instituto Portugues de Oncologia, Porto, Portugal
    DNA Cell Biol 31:224-9. 2012
    ....
  15. ncbi request reprint Angiotensin I-converting enzyme gene insertion/deletion polymorphism and endometrial human cancer in normotensive and hypertensive women
    Margarida Freitas-Silva
    Departamento de Medicina, Servico de Medicina A, Hospital de São João 3 PISO, 4200 403, Porto, Portugal
    Cancer Genet Cytogenet 155:42-6. 2004
    ..The definition of a pharmacogenomic profile of human neoplasia may help to identify targets for the development of therapeutic or chemoprevention strategies...
  16. ncbi request reprint Influence of DNA repair RAD51 gene variants in overall survival of non-small cell lung cancer patients treated with first line chemotherapy
    Augusto Nogueira
    Molecular Oncology Unit, Portuguese Institute of Oncology, Instituto Portugues de Oncologia, Laboratórios Piso 4, R Dr Ant Bernardino Almeida, 4200 072, Porto, Portugal
    Cancer Chemother Pharmacol 66:501-6. 2010
    ..We conducted this study in order to investigate the effect of the RAD51 G135C polymorphism in treatment response to combined platinum taxanes/gemcitabine first line chemotherapy in NSCLC patients...
  17. ncbi request reprint Linkage of angiotensin I-converting enzyme gene insertion/deletion polymorphism to the progression of human prostate cancer
    Rui Medeiros
    Molecular Oncology Unit, Instituto Portugues de Oncologia, 4200 072, Porto, Portugal
    J Pathol 202:330-5. 2004
    ..001, OR = 10.87, 95% CI = 4.06-29.13) were significantly associated with advanced disease. The results of this study support the hypothesis that genetic factors related to ACE may influence the behaviour of human prostate cancer...
  18. ncbi request reprint Cervical cancer and CYP2E1 polymorphisms: implications for molecular epidemiology
    Paula M Ferreira
    Oncologia Molecular Laboratórios, Instituto Português de Oncologia Porto, Piso 4, Rua Dr Antonio Bernardino de Almeida, 4200 072, Porto, Portugal
    Eur J Clin Pharmacol 62:15-21. 2006
    ..The aim of this study was to evaluate the role of CYP2E1 polymorphisms in the susceptibility to cervical cancer in a Portuguese population...
  19. ncbi request reprint Linkage between polymorphisms in the prostate specific antigen ARE1 gene region, prostate cancer risk, and circulating tumor cells
    Rui Medeiros
    Molecular Oncology Unit, Instituto Portugues de Oncologia, Porto, Portugal
    Prostate 53:88-94. 2002
    ..The prostate specific antigen (PSA) gene has a polymorphic androgen response element (ARE) sequence with two alleles, A and G. PSA A-allele carriers have higher serum PSA levels in healthy men (HM)...
  20. ncbi request reprint Higher circulating expression levels of miR-221 associated with poor overall survival in renal cell carcinoma patients
    Ana L Teixeira
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Rua Dr Antonio Bernardino de Almeida, 4200 072, Porto, Portugal
    Tumour Biol 35:4057-66. 2014
    ..800 vs model 2, 0.961). Our results, which identified the plasma miR-221/222 at variable levels during RCC development, suggest that these miRNAs may have a potential as noninvasive biomarkers of RCC development...
  21. ncbi request reprint Ovarian cancer and genetic susceptibility: association of A61G polymorphism in the EGF gene
    Ana Paula Araújo
    Molecular Oncology Group, Portuguese Institute of Oncology, Porto Centre, Edifício Laboratórios PISO 4, Rua Dr Ant Bernardino Almeida, 4200 072 Porto, Portugal
    Exp Biol Med (Maywood) 234:241-5. 2009
    ..035). We hypothesize that this polymorphism confers protection for ovarian cancer development...
  22. ncbi request reprint The CYP3A4 *1B polymorphism and prostate cancer susceptibility in a Portuguese population
    Ana Nogal
    Molecular Oncology Department, Portuguese Institute of Oncology, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Cancer Genet Cytogenet 177:149-52. 2007
    ..Our results suggest that the CYP3A4*1B polymorphism is not associated with prostate cancer risk within the Portuguese population...
  23. doi request reprint Quantification of free circulating tumor DNA as a diagnostic marker for breast cancer
    Raquel Catarino
    Molecular Oncology Group and Virology Laboratory, Portuguese Institute of Oncology, Porto, Portugal
    DNA Cell Biol 27:415-21. 2008
    ..To determine whether the amounts of circulating DNA could discriminate between breast cancer patients and healthy individuals by using real-time PCR quantification methodology...
  24. pmc Association between EGF +61A/G polymorphism and gastric cancer in Caucasians
    Ana Paula Araújo
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Porto, Portugal
    World J Gastroenterol 17:488-92. 2011
    ..To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study...
  25. ncbi request reprint -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia
    Carina Pereira
    Servico de Gastrenterologia, Instituto Português de Oncologia do Porto FG EPE, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    World J Gastroenterol 12:5473-8. 2006
    ..To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma...
  26. ncbi request reprint Association of the A870G cyclin D1 gene polymorphism with genetic susceptibility to nasopharyngeal carcinoma
    Raquel J Catarino
    Molecular Oncology Unit, Instituto Portugues de Oncologia, Porto, Laboratorios, Piso 4, Unit of Molecular Oncology, R Dr Ant Bernardino Almeida, 4200 072 Porto, Portugal
    Head Neck 28:603-8. 2006
    ..Nasopharyngeal cancer (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Cyclin D1 (CCND1) is a key regulator of the cell cycle, and its altered activity is associated with the development of cancer...
  27. ncbi request reprint Glutathione S-transferase genotype GSTM1 as a predictor of elevated angiogenic phenotype in patients with early onset breast cancer
    Rui Medeiros
    Molecular Oncology Unit Department of Pathology, Instituto Portugues de Oncologia, Porto, Portugal
    Angiogenesis 7:53-8. 2004
    ..Further studies on the enzymatic components of the glutathione biosynthetic pathway in other cancers could define a pharmacogenomic profile of human neoplasia and help identify targets for the development of therapeutic strategies...
  28. pmc Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue
    Ricardo Ribeiro
    Molecular Oncology Group, Portuguese Institute of Oncology, ED, Laboratórios Piso 4, Rua Dr, António Bernardino de Almeida 4200 072, Porto, Portugal
    BMC Med 10:108. 2012
    ..This study aimed to determine the genome-wide expression of genes in PP adipose tissue in obesity/overweight (OB/OW) and prostate cancer patients...
  29. doi request reprint The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
    Inês Hilário Silva
    Molecular Oncology Unit, Portuguese Institute of Oncology, Porto, Portugal
    Gene 512:247-50. 2013
    ..Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C>T polymorphism in treatment response in cervical cancer...
  30. doi request reprint COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention
    Carina Pereira
    Portuguese Institute of Oncology, Porto, Portugal
    Eur J Gastroenterol Hepatol 22:607-13. 2010
    ..Therefore, we sought to understand the role of three COX-2 polymorphisms (-1195A>G, -765G>C, and 8473T>C) in colorectal cancer (CRC) onset...
  31. ncbi request reprint The role of vitamin D receptor gene polymorphisms in the susceptibility to prostate cancer of a southern European population
    Rui Medeiros
    Molecular Oncology Unit and Department of Urology, Laboratórios Piso 4, Instituto Portugues de Oncologia, R Dr Ant Bernardino Almeida 4200 072 Porto, Portugal
    J Hum Genet 47:413-8. 2002
    ....
  32. ncbi request reprint Overall survival in women with breast cancer: the influence of pepsinogen C gene polymorphism
    Ana L Pinto-Correia
    Molecular Oncology Group, Portuguese Institute of Oncology, Porto, Portugal
    DNA Cell Biol 27:333-6. 2008
    ..We hypothesize that PGC polymorphism can be a predictive biomarker in breast cancer, contributing to an individual profile of great interest in clinical oncology...
  33. ncbi request reprint Haemochromatosis gene (HFE) mutations in viral-associated neoplasia: Linkage to cervical cancer
    Carla S Cardoso
    Institute for Molecular and Cell Biology IBMC, Iron Genes and Immune System IRIS, Porto, Portugal
    Biochem Biophys Res Commun 341:232-8. 2006
    ..0012). These results indicate that HFE could be considered a candidate modifier gene of viral-related neoplasia such as cervical carcinoma possibly by a dual role on iron metabolism and immunological system...
  34. ncbi request reprint TP53 codon 72 polymorphism and risk for cervical cancer in Portugal
    Alexandra M Santos
    Molecular Oncology Unit, Portuguese Institute of Oncology Porto, Laboratórios 4 Piso, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Cancer Genet Cytogenet 159:143-7. 2005
    ..05). Our results indicate that there is no association between the presence of the Arg allele in codon 72 of TP53 polymorphism and risk of cervical cancer in our population...
  35. ncbi request reprint Increased risk of cervical cancer associated with cyclin D1 gene A870G polymorphism
    Raquel Catarino
    Molecular Oncology Unit, Portuguese Institute of Oncology, Rua Dr António Bernardino de Almedia, Porto 4200 072, Portugal
    Cancer Genet Cytogenet 160:49-54. 2005
    ....
  36. ncbi request reprint Tumour necrosis factor alpha 308 G/A is a risk marker for the progression from high-grade lesions to invasive cervical cancer
    Hugo Sousa
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Rua Dr Antonio Bernardino Almeida, 4200 072, Porto, Portugal
    Tumour Biol 35:2561-4. 2014
    ..Considering previous data and this study, this polymorphism confirms to be a significant marker in our population. ..
  37. pmc Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients
    Raquel Catarino
    Molecular Oncology Group Investigation Center, Portuguese Institute of Oncology, Porto, Portugal
    PLoS ONE 7:e38559. 2012
    ..The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease...
  38. doi request reprint DNA repair system and prostate cancer progression: the role of NBS1 polymorphism (rs1805794)
    Joana Silva
    Molecular Oncology GRP and Virology, Portuguese Institute of Oncology, Porto, Portugal
    DNA Cell Biol 31:1182-6. 2012
    ..894, respectively). Our results suggest for the first time that rs1805794 GG genotype appears to be associated with a higher risk for advanced prostate cancer, thus, suggesting a possible new role for NBS1 in prostate cancer progression...
  39. doi request reprint Influence of functional genetic polymorphism (-590C/T) in non-small cell lung cancer (NSCLC) development: the paradoxal role of IL-4
    Mónica Gomes
    Molecular Oncology Group CI, Portuguese Institute of Oncology, Porto, Portugal
    Gene 504:111-5. 2012
    ..024, OR=0.221: 95% CI=0.053-0.928). We present for the first time that increased expression of IL-4 associated with the TT genotype may contribute to immune surveillance during NSCLC development...
  40. ncbi request reprint A slow acetylator genotype associated with an increased risk of advanced cervical cancer
    Sandra Costa
    Unit of Molecular Oncology, Portuguese Institute of Oncology, Laboratórios Piso 4, Rua Dr Bernardino de Almeida, 4200 072 Porto, Portugal
    J Cancer Res Clin Oncol 128:678-82. 2002
    ..This case-control study was designed to evaluate the association between NAT2 polymorphism and genetic susceptibility to cervical cancer...
  41. ncbi request reprint G-308A TNF-alpha polymorphism is associated with an increased risk of invasive cervical cancer
    Isabel Duarte
    Molecular Oncology Laboratory, Portuguese Institute of Oncology, Porto, Portugal
    Biochem Biophys Res Commun 334:588-92. 2005
    ..006; OR=1.88; 95% CI [1.20-2.94]). In conclusion, our study suggests that the presence of the high producer allele -308A in the TNF-alpha gene appears to be associated with an increased risk for the development of ICC...
  42. ncbi request reprint Endothelial nitric oxide synthase gene polymorphisms and the shedding of circulating tumour cells in the blood of prostate cancer patients
    Rui Medeiros
    Molecular Oncology Unit, Laboratórios Piso 4, Instituto Portugues de Oncologia, Porto, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Cancer Lett 189:85-90. 2003
    ..We hypothesize that genotypes with the a allele of the ecNOS4a/b polymorphism may facilitate the survival of CTCs in the blood of cancer patients...
  43. doi request reprint Genetic risk markers for nasopharyngeal carcinoma in Portugal: tumor necrosis factor alpha  -308G >A polymorphism
    Hugo Sousa
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Porto, Portugal
    DNA Cell Biol 30:99-103. 2011
    ....
  44. ncbi request reprint Influence of survivin (BIRC5) and caspase-9 (CASP9) functional polymorphisms in renal cell carcinoma development: a study in a southern European population
    Inés Marqués
    Grupo de Oncologia Molecular CI, Edifício Laboratórios, Instituto Português de Oncologia do Porto Francisco Gentil, EPE, 4º piso, Rua Dr Antonio Bernardino de Almeida, 4200 072, Porto, Portugal
    Mol Biol Rep 40:4819-26. 2013
    ..This genetic profile may help to define higher risk groups that would benefit from individualized chemoprevention strategies and therapies...
  45. doi request reprint IL-1RN VNTR polymorphism and genetic susceptibility to cervical cancer in Portugal
    Hugo Sousa
    Grupo de Oncologia Molecular CI, Laboratórios 4 Piso, Instituto Português de Oncologia do Porto FG, EPE, Rua Dr Antonio Bernardino Almeida, 4200 072, Porto, Portugal
    Mol Biol Rep 39:10837-42. 2012
    ..028). Our results indicated that IL-1RN A2 allele is associated with an increased susceptibility to cervical cancer development, probably by increasing predisposition to shorter immune responses...
  46. doi request reprint Molecular study of the PCA3 gene: genotypic analysis of PCA3 polymorphism -845G>A and metastatic prostate cancer
    Silvia Fontenete
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Porto, Portugal
    Genet Test Mol Biomarkers 16:418-22. 2012
    ..This case-control study sought to analyze the frequency of the polymorphism PCA3 -845 G>A in participants without prostate cancer and patients with metastatic prostate cancer...
  47. ncbi request reprint EGF genetic polymorphism is associated with clinical features but not malignant phenotype in neurofibromatosis type 1 patients
    Ricardo Ribeiro
    Molecular Oncology CI, Portuguese Institute of Oncology, Edifício Laboratórios PISO 4, R Dr Ant Bernardino Almeida, 4200 072, Porto, Portugal
    J Neurooncol 81:225-9. 2007
    ..Further studies in larger samples should confirm the absence of risk for having higher severity grade or malignant phenotype in NF1 patients...
  48. doi request reprint Role of the MDM2 SNP309 polymorphism in the initiation and early age of onset of nasopharyngeal carcinoma
    Hugo Sousa
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Porto, Portugal
    Mol Carcinog 50:73-9. 2011
    ..2 vs. 61.9) and early clinical stages (55.3 vs. 65.3). Our study suggests that MDM2 SNP309 can be considered a risk marker for the development of NPC mainly in early ages probably as an initiation marker for potential cancer development...
  49. ncbi request reprint Protective role of the polymorphism CCR2-64I in the progression from squamous intraepithelial lesions to invasive cervical carcinoma
    Ana Coelho
    Molecular Oncology Unit and Gynaecology, Instituto Portugues de Oncologia, Laboratórios Piso 4, R Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Gynecol Oncol 96:760-4. 2005
    ..The aim of this study was to explore the association of the CCR2-64I polymorphism with the risk of developing invasive cervical cancer (ICC) from squamous intraepithelial lesions (SILs)...
  50. doi request reprint Influence of TGFB1+869T>C functional polymorphism in non-small cell lung cancer (NSCLC) risk
    Ana L Teixeira
    Molecular Oncology GRP CI, Portuguese Institute of Oncology, Porto Centre, Edifício Laboratórios, 4º piso, Rua Dr Antonio Bernardino de Almeida, 4200 072, Porto, Portugal
    J Cancer Res Clin Oncol 137:435-9. 2011
    ....
  51. doi request reprint DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients
    Augusto Nogueira
    Portuguese Institute of Oncology, Molecular Oncology Group CI, Edifícios Laboratórios Piso 4, Rua Dr Ant Bernardino Almeida, 4200 072 Porto, Portugal
    Pharmacogenomics 14:689-700. 2013
    ..We conducted this review to show the possible influence of the RAD51 genetic variants in damage repair capacity and treatment response in non-small-cell lung carcinoma patients...
  52. doi request reprint Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma
    Ricardo Ribeiro
    Molecular Oncology Group CI, Portuguese Institute of Oncology, Rua Dr Antonio Bernardino Almeida, Porto, Portugal
    Exp Biol Med (Maywood) 237:1155-62. 2012
    ..Present findings indicate that PP adipose tissue is a reservoir of progenitor cells with the potential to migrate towards prostate tumors, although its clinical significance merits further evaluation...
  53. ncbi request reprint [Characterization of the clinical evolution of nasopharyngeal carcinoma in Portuguese population]
    Eduardo Breda
    Departamento de Otorrinolarongologia, Instituto Portugues de Oncologia, Porto, Portugal
    Acta Otorrinolaringol Esp 58:191-7. 2007
    ..Characterization of the clinical evolution of nasopharyngeal cancer (NPC) patients in a Portuguese population during 31 years of follow-up...
  54. ncbi request reprint Analysis of estrogen receptor polymorphism in codon 325 by PCR-SSCP in breast cancer: association with lymph node metastasis
    André Vasconcelos
    Oncologia Molecular Serv de Anat Patológica, Centro Regional Norte, Instituto Portugues de Oncologia Francisco Gentil, Porto, Portugal
    Breast J 8:226-9. 2002
    ..038). Our data suggest that there is a relationship between the ER325 polymorphism and susceptibility to breast cancer (OR = 2.3; 1.10 < OR < 5.1) and that it can also be related with the metastasization process...
  55. pmc Genetic Variability in Key Genes in Prostaglandin E2 Pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and Their Involvement in Colorectal Cancer Development
    Carina Pereira
    Molecular Oncology Group, Investigation Centre, Portuguese Institute of Oncology, Porto, Portugal Abel Salazar Institute of Biomedical Sciences, University of Porto, Porto, Portugal Research Department, Portuguese League Against Cancer, Porto, Portugal
    PLoS ONE 9:e92000. 2014
    ....
  56. ncbi request reprint The -1195G allele increases the transcriptional activity of cyclooxygenase-2 gene (COX-2) in colon cancer cell lines
    Carina Pereira
    Molecular Oncology Group, Investigation Centre, Portuguese Institute of Oncology, Porto, Portugal Abel Salazar Institute of Biomedical Sciences, University of Porto, Porto, Portugal
    Mol Carcinog 53:E92-5. 2014
    ..001). The -1195G allele appeared to enhance COX-2 transcription, providing a molecular basis underlying the increased susceptibility for CRC and potentially a new mechanism for COX-2 overexpression...
  57. ncbi request reprint Characterization of human papillomavirus genotypes and HPV-16 physical status in cervical neoplasias of women from northern Portugal
    Joana Ribeiro
    Virology Service, Portuguese Institute of Oncology, Porto, Portugal Molecular Oncology Group, Portuguese Institute of Oncology, Porto, Portugal Faculty of Medicine, University of Porto, Porto, Portugal Research Department, Portuguese League Against Cancer Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Porto, Portugal
    Int J Gynaecol Obstet 125:107-10. 2014
    ..To determine human papillomavirus (HPV) genotypes and the physical status of HPV-16 DNA among women from northern Portugal with cervical lesions...
  58. doi request reprint Genetic variants in AR and SHBG and resistance to hormonal castration in prostate cancer
    Cátia Monteiro
    Molecular Oncology Group CI, Portuguese Institute of Oncology, Edifício Laboratórios PISO 4, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Med Oncol 30:490. 2013
    ..Our results suggest that the SHBG +5790 G>A polymorphism may be a useful marker to include in the pharmacogenomic profile of prostate cancer resistant to hormonal castration...
  59. ncbi request reprint Renal cell carcinoma development and miRNAs: a possible link to the EGFR pathway
    Francisca Dias
    Molecular Oncology Group, Portuguese Institute of Oncology, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Pharmacogenomics 14:1793-803. 2013
    ..In this review we highlight some potential miRNAs that could be involved in the modulation of the EGF receptor pathway and consequently in RCC development. ..
  60. ncbi request reprint CXCL12-3' A polymorphism and lung cancer metastases protection: new perspectives in immunotherapy?
    Ana Coelho
    Molecular Oncology Unit and Radiotherapy Department, Portuguese Institute of Oncology, R Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Cancer Immunol Immunother 55:639-43. 2006
  61. doi request reprint FcgammaRIIa polymorphism and clinical response to rituximab in non-Hodgkin lymphoma patients
    Márcia Paiva
    Unit of Molecular Oncology, Laboratórios Piso 4, Instituto Portugues de Oncologia, R Dr Ant Bernardino Almeida, 4200 072 Porto, Portugal
    Cancer Genet Cytogenet 183:35-40. 2008
    ....
  62. doi request reprint CXCL12 chemokine genotypes as predictive biomarkers of ovarian cancer outcome
    Ana Coelho
    Instituto Portugues de Oncologia de Francisco Gentil, Laboratórios Piso 4, 4200 072 Porto, Portugal
    Mol Med Report 2:103-6. 2009
    ..CXCL12-3'A may therefore serve as an important predictive biomarker for the determination of outcome in ovarian cancer...
  63. doi request reprint Characterization of cytomegalovirus and epstein-barr virus infection in cervical lesions in Portugal
    Joana Marinho-Dias
    Virology Service, Portuguese Institute of Oncology of Porto, Porto, Portugal
    J Med Virol 85:1409-13. 2013
    ..28; P=0.035). The study reveals a low prevalence for both viruses; nevertheless, these results are important for knowledge on the shedding of EBV and CMV in cervical samples...
  64. doi request reprint Is Chlamydia trachomatis related to human papillomavirus infection in young women of southern European population? A self-sampling study
    Jani Silva
    Molecular Oncology GRP, Portuguese Institute of Oncology, Porto, Portugal
    Arch Gynecol Obstet 288:627-33. 2013
    ..Chlamydia trachomatis (CT) infection seems to synergize with HPV in CC multistage process. The aim of this study was to assess the correlation of HPV and CT infection in young student women...
  65. pmc Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro
    Ricardo Ribeiro
    Molecular Oncology Group CI, Portuguese Institute of Oncology, Porto, Portugal
    J Exp Clin Cancer Res 31:32. 2012
    ..Thus, this study aimed to determine if periprostatic adipose tissue is linked with aggressive tumor biology in prostate cancer...
  66. doi request reprint Epidermal growth factor genetic variation associated with advanced cervical cancer in younger women
    Ana Paula Araújo
    Molecular Oncology Group, Department of Medical Oncology, Portuguese Institute of Oncology Porto, Portugal
    Am J Clin Oncol 35:247-50. 2012
    ..The EGF gene presents a polymorphism at position 61 (A/G), associated with higher EGF production. We examined the association between this polymorphism and cervical cancer through a case-control study...
  67. ncbi request reprint Immunoinflammatory mechanisms in lung cancer development: is leptin a mediator?
    Ricardo Ribeiro
    Molecular Oncology CI, Portuguese Institute of Oncology, Porto, Portugal
    J Thorac Oncol 2:105-8. 2007
    ..We explored the complex and intricate interaction of leptin with immune cells to propose a pathway of inflammation-associated lung cancer development...
  68. ncbi request reprint TP73 alterations in cervical carcinoma
    Rogéria Craveiro
    Department of Radiotherapy, Instituto Portugues de Oncologia, Porto, Rua Dr Ant Bernardino Almeida, 4200 072 Porto, Portugal
    Cancer Genet Cytogenet 150:116-21. 2004
    ..041). These results suggest that TP73 genetic alterations may contribute to the genesis and/or progression of cervical carcinoma in an HPV-infected transformation zone under prolonged exposure to events related to pregnancy...
  69. doi request reprint Role of the RAD51 G172T polymorphism in the clinical outcome of cervical cancer patients under concomitant chemoradiotherapy
    Augusto Nogueira
    Molecular Oncology GRP and Virology CI, Portuguese Institute of Oncology, Rua Dr Ant Bernardino Almeida, Porto, Portugal
    Gene 504:279-83. 2012
    ..This is the first study evaluating the role of the RAD51 G172T genetic variants in cancer prognosis and clinical outcome of cervical cancer patients...
  70. doi request reprint Schistosoma haematobium: identification of new estrogenic molecules with estradiol antagonistic activity and ability to inactivate estrogen receptor in mammalian cells
    Monica Catarina Botelho
    CIBP Centre for Parasite Immunology and Biology, INSA, Porto, Portugal
    Exp Parasitol 126:526-35. 2010
    ..The identification of these molecules opens new ways for the development of alternative drugs to treat schistosomiasis...
  71. ncbi request reprint Molecular epidemiology characterization of the urinary excretion of polyomavirus in healthy individuals from Portugal--a Southern European population
    Carla Rodrigues
    Virology and Molecular Oncology Laboratory, Portuguese Institute of Oncology, Porto, Portugal
    J Med Virol 79:1194-8. 2007
    ..Further studies are needed to evaluate the prevalence of polyomaviruses in healthy individuals, in order to understand the biological behaviour of these viruses...
  72. doi request reprint Localization of candidate genes in a region of high frequency of microvariant alleles for prostate cancer susceptibility: the chromosome region Yp11.2 genetic variation
    Raquel Carvalho
    Molecular Oncology Group, Portuguese Institute of Oncology, Porto, Portugal
    DNA Cell Biol 29:3-7. 2010
    ..STR allele studies may add further information from the definition of a genetic profile of PCa resistance or susceptibility. As TSPY is located at region Yp11.2, this gene could play an essential role in PCa development...
  73. doi request reprint Overweight and obese patients do not seem to adequately recognize their own risk for colorectal cancer
    Fernanda Leite-Pereira
    CINTESIS Biostatistics and Medical Informatics, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4200, Porto, Portugal
    J Cancer Educ 26:767-73. 2011
    ..Practice implications: health education programs concerning obesity must include colorectal cancer as a potential outcome for overweight patients...
  74. doi request reprint IL-4 and TNF-α polymorphisms are associated with risk of multiple superficial tumors or carcinoma in situ development
    Luis Lima
    Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, University of Porto, Porto, Portugal luis14lima gmail com
    Urol Int 87:457-63. 2011
    ....
  75. pmc Oncogenic HPV Types Infection in Adolescents and University Women from North Portugal: From Self-Sampling to Cancer Prevention
    Jani Silva
    Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Road Dr António Bernardino Almeida, 4200 072 Porto, Portugal
    J Oncol 2011:953469. 2011
    ..Moreover, these results demonstrate that HPV detection performed in self-collected samples may be important to appraise better preventive strategies and to monitorize the influence of vaccination programmes within different populations...
  76. doi request reprint Knowledge differences between male and female university students about human papillomavirus (HPV) and cervical cancer: Implications for health strategies and vaccination
    Rui Medeiros
    Molecular Oncology GRP, Instituto Português de Oncologia Porto, Portugal
    Vaccine 29:153-60. 2010
    ..001) and in "relation between HPV and CC" (p<0.001) were found. Therefore, these differences may help to develop effective strategies that lead to decline CC incidence and mortality...
  77. ncbi request reprint [Tumor hypoxia: the role of HIF]
    Avelino Fraga
    Instituto Português Oncologia, Oncologia Molecular, Porto, Portugal
    Actas Urol Esp 33:941-51. 2009
    ..The purpose of this study was to review the significance of hypoxia in carcinogenesis and tumor progression by reviewing the current knowledge on the subject and the mechanisms of action and activation of HIF-1a...
  78. ncbi request reprint Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population
    Sandra Costa
    ICVS, Life and Health Sciences Research Institute, Health Science School, Minho University, Braga, Portugal
    Prostate 64:246-52. 2005
    ..The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens, including those found in well-cooked meat and cigarette smoke...
  79. pmc Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer
    Sandra Costa
    Life and Health Sciences Research Institute, School of Health Science, University of Minho, Braga, 4710 057, Portugal
    BMC Cancer 8:32. 2008
    ..The purpose of this study was to evaluate the role of Arg72Pro and PIN3 Ins16bp polymorphisms in TP53 gene as genetic susceptibility and predictive markers to breast cancer...
  80. ncbi request reprint Gastric cancer in a Caucasian population: role of pepsinogen C genetic variants
    Ana L Pinto-Correia
    Portuguese Institute of Oncology of Porto, Portugal
    World J Gastroenterol 12:5033-6. 2006
    ..To study the role of an insertion/deletion polymorphism in the pepsinogen C (PGC) gene, an effective marker for terminal differentiation of the stomach mucosa, in the susceptibility to the development of gastric lesions...
  81. ncbi request reprint Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
    Sandra Costa
    ICVS, Life and Health Sciences Research Institute, Health Science School, Minho University, Braga, Portugal
    Cancer Lett 246:324-30. 2007
    ..61-7.15; P=0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer...
  82. ncbi request reprint Is the p53 codon 72 polymorphism a key biomarker for cervical cancer development? A meta-analysis review within European populations
    Hugo Sousa
    Molecular Oncology Group and Virology Department, Portuguese Institute of Oncology of Porto, Portugal
    Int J Mol Med 20:731-41. 2007
    ..However, in countries with low incidence rates of cervical cancer, this polymorphism might represent a significant genetic marker...
  83. doi request reprint Genetic polymorphism in EGF is associated with prostate cancer aggressiveness and progression-free interval in androgen blockade-treated patients
    Ana L Teixeira
    Molecular Oncology Group CI, Portuguese Institute of Oncology, Porto Centre
    Clin Cancer Res 14:3367-71. 2008
    ..Our purpose was to investigate the potential prognostic and predictive role of EGF functional genetic variant +61 G>A in prostate cancer patients submitted to androgen blockade therapy (ABT)...
  84. pmc Epstein-Barr virus is associated with gastric carcinoma: the question is what is the significance?
    Hugo Sousa
    Molecular Oncology Group and Molecular Virology Laboratory, Portuguese Institute of Oncology of Porto, Porto 4200 072, Portugal
    World J Gastroenterol 14:4347-51. 2008
    ..It is unclear whether EBV is involved in GC development or is a consequence of gastric inflammation secondary to immunosuppressive treatments...
  85. ncbi request reprint DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population
    Sandra Costa
    ICVS, Life and Health Sciences Research Institute, Health Science School, Minho University, Braga, 4710 057, Portugal
    Breast Cancer Res Treat 103:209-17. 2007
    ....
  86. ncbi request reprint Genetic polymorphisms of the epidermal growth factor and related receptor in non-small cell lung cancer--a review of the literature
    Antonio Araujo
    Department of Medical Oncology, Portuguese Institute of Oncology, Porto Centre, Rua Dr Antonio Bernardino de Almeida, 4200 Porto, Portugal
    Oncologist 12:201-10. 2007
    ..Herein, we review the literature on EGF and EGFR functions and activities, particularly the current role of their functional polymorphisms as related to NSCLC...
  87. ncbi request reprint XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms and their outcome in tumor aggressiveness and survival of Portuguese breast cancer patients
    Sandra Costa
    Breast Cancer Res Treat 109:183-5. 2008