Research Topics

Yulia A Medvedeva



  1. Medvedeva Y, Fridman M, Oparina N, Malko D, Ermakova E, Kulakovskiy I, et al. Intergenic, gene terminal, and intragenic CpG islands in the human genome. BMC Genomics. 2010;11:48 pubmed publisher
    ..In exons, overlapping with these islands, the synonymous substitution rate of CpG containing codons is decreased. This suggests that these CpG islands are involved in transcription initiation, possibly of some non-coding RNAs. ..
  2. Lioznova A, Khamis A, Artemov A, Besedina E, Ramensky V, Bajic V, et al. CpG traffic lights are markers of regulatory regions in human genome. BMC Genomics. 2019;20:102 pubmed publisher
    ..g. in clinic where measuring DNA methylation is easier compared to directly measuring gene expression due to more stable nature of DNA. ..
  3. Medvedeva Y, Lennartsson A, Ehsani R, Kulakovskiy I, Vorontsov I, Panahandeh P, et al. EpiFactors: a comprehensive database of human epigenetic factors and complexes. Database (Oxford). 2015;2015:bav067 pubmed publisher
    ..EpiFactors also contains information on 69 protein complexes that are involved in epigenetic regulation. The resource is practical for a wide range of users, including biologists, pharmacologists and clinicians. ..
  4. Pilsner J, Shershebnev A, Medvedeva Y, Suvorov A, Wu H, Goltsov A, et al. Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults. Reprod Toxicol. 2018;78:40-49 pubmed publisher
    ..Findings from our limited sample size suggest that peripubertal environmental exposures are associated with sperm DNA methylation in young adults. ..
  5. Medvedeva Y, Shershebnev A. Experimental Design and Bioinformatic Analysis of DNA Methylation Data. Methods Mol Biol. 2018;1766:175-194 pubmed publisher
  6. Panchin A, Makeev V, Medvedeva Y. Preservation of methylated CpG dinucleotides in human CpG islands. Biol Direct. 2016;11:11 pubmed publisher
    ..Our findings are consistent with strong negative selection preserving methylated CpGs within CGIs including intergenic ones. ..
  7. Suvorov A, Shershebnev A, Wu H, Medvedeva Y, Sergeyev O, Pilsner J. Perinatal exposure to low dose 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) alters sperm DNA methylation in adult rats. Reprod Toxicol. 2018;75:136-143 pubmed publisher
    ..Two DMRs overlapped between the two time-points. This is the first study to demonstrate that environmentally-relevant perinatal exposure to PBDE results in long-lasting changes in sperm DNA methylation. ..