Helen McNeill

Summary

Publications

  1. pmc Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development
    Antoine Reginensi
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS Genet 9:e1003380. 2013
  2. ncbi request reprint When pathways collide: collaboration and connivance among signalling proteins in development
    Helen McNeill
    Department of Molecular Genetics, Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Nat Rev Mol Cell Biol 11:404-13. 2010
  3. doi request reprint The Hippo pathway regulates Wnt/beta-catenin signaling
    Xaralabos Varelas
    Center for Systems Biology, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Dev Cell 18:579-91. 2010
  4. pmc Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity
    Sakura Saburi
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Development 139:1806-20. 2012
  5. doi request reprint Regulation of long-range planar cell polarity by Fat-Dachsous signaling
    Praveer Sharma
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Development 140:3869-81. 2013
  6. doi request reprint The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Dev Cell 16:411-20. 2009
  7. doi request reprint Herding Hippos: regulating growth in flies and man
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Canada
    Curr Opin Cell Biol 21:837-43. 2009
  8. pmc Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
  9. pmc Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation
    Avais M Daulat
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada
    Mol Cell Biol 32:173-85. 2012
  10. doi request reprint Apical junctions and growth control in Drosophila
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Canada
    Biochim Biophys Acta 1788:755-60. 2009

Collaborators

Detail Information

Publications19

  1. pmc Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development
    Antoine Reginensi
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS Genet 9:e1003380. 2013
    ..We propose that Yap responds to Cdc42-dependent signals in nephron progenitor cells to activate a genetic program required to shape the functioning nephron...
  2. ncbi request reprint When pathways collide: collaboration and connivance among signalling proteins in development
    Helen McNeill
    Department of Molecular Genetics, Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Nat Rev Mol Cell Biol 11:404-13. 2010
    ..However, as illustrated by the Wnt and Hippo pathways, there is increasing evidence that components are often shared between multiple pathways and other components talk to each other through multiple mechanisms...
  3. doi request reprint The Hippo pathway regulates Wnt/beta-catenin signaling
    Xaralabos Varelas
    Center for Systems Biology, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Dev Cell 18:579-91. 2010
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control...
  4. pmc Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity
    Sakura Saburi
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Development 139:1806-20. 2012
    ..These studies highlight the wide range and complexity of Fat activities and suggest that a Fat-Atrophin interaction is a conserved element of planar polarity signaling...
  5. doi request reprint Regulation of long-range planar cell polarity by Fat-Dachsous signaling
    Praveer Sharma
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Development 140:3869-81. 2013
    ....
  6. doi request reprint The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Dev Cell 16:411-20. 2009
    ..These data lead to a new model whereby Expanded functions downstream of Warts, in concert with 14-3-3 proteins to sequester Yorkie in the cytoplasm, inhibiting growth activity of the Hippo pathway...
  7. doi request reprint Herding Hippos: regulating growth in flies and man
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Canada
    Curr Opin Cell Biol 21:837-43. 2009
    ..We will explore the differences between the Hippo pathway in invertebrates and mammals, and focus on recent advances in understanding how this conserved pathway is regulated...
  8. pmc Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
    ..We propose that Ds regulates Dco-dependent phosphorylation of Fat and Fat-associated proteins to control Fat signaling in growth and PCP...
  9. pmc Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation
    Avais M Daulat
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada
    Mol Cell Biol 32:173-85. 2012
    ..Our results provide a link between Mink and the Vangl-Prickle complex and highlight the importance of Prickle phosphorylation and endosomal trafficking for its function during Wnt-PCP signaling...
  10. doi request reprint Apical junctions and growth control in Drosophila
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Canada
    Biochim Biophys Acta 1788:755-60. 2009
    ..We will explore in this review the links between growth and apical junction proteins in the regulation of growth control in Drosophila...
  11. doi request reprint Fat and Dachsous cadherins
    Praveer Sharma
    Samuel Lunenfeld Research Institute, Toronto, Canada
    Prog Mol Biol Transl Sci 116:215-35. 2013
    ..There is one Ds protein in Drosophila and two in vertebrates, Dachsous1-2. In this chapter, we discuss the roles of Fat and Ds family members, focusing on Drosophila and mouse development...
  12. doi request reprint Planar cell polarity and the kidney
    Helen McNeill
    Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    J Am Soc Nephrol 20:2104-11. 2009
    ..In this review, I first cover the current knowledge of PCP signaling in invertebrate and vertebrate models and then explore how loss of PCP might underlie some forms of cystic kidney disease...
  13. doi request reprint In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle
    Vladimir E Belozerov
    Department of Biology, York University, Toronto, Canada
    Mol Cell Biol 34:474-84. 2014
    ..Biochemical analyses of Rack1 in aging and stressed muscle suggest a model whereby p38 MAPK signaling causes a redistribution of Rack1 between a ribosome-bound pool and a putative translational repressor complex. ..
  14. pmc Planar cell polarity: keeping hairs straight is not so simple
    Helen McNeill
    Samuel Lunenfeld Research Institute, Department of Molecular Genetics, University of Toronto, Toronto, Canada
    Cold Spring Harb Perspect Biol 2:a003376. 2010
    ..This review will first briefly review data from the Drosophila field, where PCP was first identified and genetically characterized, and then explore how vertebrate tissues become polarized during development...
  15. doi request reprint The skinny on Fat: an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Department of Molecular Genetics, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada
    Curr Opin Cell Biol 21:717-23. 2009
    ....
  16. doi request reprint Organizer formation in Hydra is disrupted by thalidomide treatment
    Maria Brooun
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 884, Toronto, Ontario, Canada M5G1X5
    Dev Biol 378:51-63. 2013
    ..Finally, we find that interstitial cells, multipotent cells which give rise to nemoatocytes, neural, digestive and germline cells, are partially responsible for the inhibitory effect of thalidomide...
  17. pmc LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye
    Nancy Amin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 106:8941-6. 2009
    ..These data suggest that in complex tissues, LKB1 acts on an array of targets to regulate cell polarity...
  18. doi request reprint Visualization of PCP defects in the eye and wing of Drosophila melanogaster
    Natalia Arbouzova
    Samuel Lunenfeld Research Institute, University of Toronto, Ontario M5G 1X5, Toronto, Canada
    Methods Mol Biol 469:127-40. 2008
    ..These methods include confocal immunofluorescent analysis of larval or pupal tissues, stained with antibodies specific to PCP components or cytoskeleton markers, and light microscopy of the adult eye and wing...
  19. doi request reprint Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
    Sakura Saburi
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto M5G 1X5, Canada
    Nat Genet 40:1010-5. 2008
    ..In addition, Fat4 represses Fjx1 expression, indicating that Fat signaling is conserved. Together, these data suggest that Fat4 regulates vertebrate PCP and that loss of PCP signaling may underlie some cystic diseases in humans...