Lyle McKinnon

Summary

Publications

  1. pmc Does antiretroviral therapy initiation increase sexual risk taking in Kenyan female sex workers? A retrospective case-control study
    Elysha Mawji
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    BMJ Open 2:e000565. 2012
  2. pmc HIV-1 clade D is associated with increased rates of CD4 decline in a Kenyan cohort
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Toronto, Canada
    PLoS ONE 7:e49797. 2012
  3. doi request reprint HIV-specific CD8+ T-cell proliferation is prospectively associated with delayed disease progression
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Immunol Cell Biol 90:346-51. 2012
  4. ncbi request reprint HIV vaccine efficacy trials: A brief history, and options for going forward
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Canada
    AIDS Rev 12:209-17. 2010
  5. ncbi request reprint HIV-specific T cells: strategies for fighting a moving target
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Room 6356, Medical Sciences Building, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Curr HIV Res 8:587-95. 2010
  6. pmc Effect of baseline HIV disease parameters on CD4+ T cell recovery after antiretroviral therapy initiation in Kenyan women
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Toronto, Canada
    PLoS ONE 5:e11434. 2010
  7. pmc Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24
    Lyle R McKinnon
    Departments of Medical Microbiology1 and Immunolgy, 5 University of Manitoba, Winnipeg, Canada
    J Virol 83:12636-42. 2009
  8. pmc Epitope mapping of HIV-specific CD8+ T cells in a cohort dominated by clade A1 infection
    Lyle R McKinnon
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    PLoS ONE 4:e6965. 2009
  9. pmc CD26/dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected female sex workers
    Elijah M Songok
    Centre for Virus Research, Mbagathi Road Kenya Medical Research Institute, Nairobi, Kenya
    Virol J 7:343. 2010
  10. pmc Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T cell responses in the cervix
    Duncan Chege
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e13077. 2010

Collaborators

  • Rachel E Horton
  • Ma Luo
  • Nico Nagelkerke
  • Richard T Lester
  • Duncan Chege
  • Souradet Y Shaw
  • Tae Joon Yi
  • Rupert Kaul
  • Elysha Mawji
  • Charles Wachihi
  • Joshua Kimani
  • Elijah M Songok
  • Christina A Semeniuk
  • Brett Shannon
  • Jessica Prodger
  • T Blake Ball
  • Francis Plummer
  • LAWRENCE GELMON
  • Paul Thottingal
  • Walter Jaoko
  • Elizabeth Ngugi
  • Anthony Kariri
  • Martin K Rono
  • Blake T Ball
  • Solomon Mpoke
  • Bernard Osero
  • Frank A Plummer
  • Winnie Apidi
  • Adrienne F A Meyers
  • Elizabeth J Matey
  • Xiaojuan Mao
  • Terry B Ball
  • Francis A Plummer
  • Michael Gubbins
  • Harold O Peters

Detail Information

Publications13

  1. pmc Does antiretroviral therapy initiation increase sexual risk taking in Kenyan female sex workers? A retrospective case-control study
    Elysha Mawji
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    BMJ Open 2:e000565. 2012
    ..Although antiretroviral therapy (ART) prolongs life and reduces infectiousness, in some contexts, it has been associated with increased sexual risk taking...
  2. pmc HIV-1 clade D is associated with increased rates of CD4 decline in a Kenyan cohort
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Toronto, Canada
    PLoS ONE 7:e49797. 2012
    ..The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles...
  3. doi request reprint HIV-specific CD8+ T-cell proliferation is prospectively associated with delayed disease progression
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Immunol Cell Biol 90:346-51. 2012
    ..112). Age and baseline viral load were not predictive of progression. HIV-specific CD8(+) T-cell proliferation was a correlate of protective immunity in this prospective study; such responses may be important for HIV vaccine protection...
  4. ncbi request reprint HIV vaccine efficacy trials: A brief history, and options for going forward
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Canada
    AIDS Rev 12:209-17. 2010
    ..In this review, we describe the development of three HIV vaccine efficacy trials to date, and highlight some of the possible avenues available for the field of biomedical HIV prevention to proceed...
  5. ncbi request reprint HIV-specific T cells: strategies for fighting a moving target
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Room 6356, Medical Sciences Building, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Curr HIV Res 8:587-95. 2010
    ..Though some cues can be found from observational studies, more in depth analyses of past and ongoing HIV vaccine trials will be needed to know if and how HIV genetic diversity can be overcome by vaccine-induced T cells...
  6. pmc Effect of baseline HIV disease parameters on CD4+ T cell recovery after antiretroviral therapy initiation in Kenyan women
    Lyle R McKinnon
    Department of Medicine, University of Toronto, Toronto, Canada
    PLoS ONE 5:e11434. 2010
    ..However, the rate and extent of CD4+ T cell recovery varies widely. We assessed the impact of several factors on immune reconstitution in a large Kenyan cohort...
  7. pmc Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24
    Lyle R McKinnon
    Departments of Medical Microbiology1 and Immunolgy, 5 University of Manitoba, Winnipeg, Canada
    J Virol 83:12636-42. 2009
    ..HLA-B*57 evolution also differed between clades in the KF11 and IW9 epitopes. A better understanding of clade-specific evolution is important for the development of HIV vaccines in regions with multiple clades...
  8. pmc Epitope mapping of HIV-specific CD8+ T cells in a cohort dominated by clade A1 infection
    Lyle R McKinnon
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    PLoS ONE 4:e6965. 2009
    ..Population differences in CD8+ T cell epitope specificity will need to be understood if vaccines are to be effective in multiple geographic regions...
  9. pmc CD26/dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected female sex workers
    Elijah M Songok
    Centre for Virus Research, Mbagathi Road Kenya Medical Research Institute, Nairobi, Kenya
    Virol J 7:343. 2010
    ....
  10. pmc Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T cell responses in the cervix
    Duncan Chege
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e13077. 2010
    ..Nonetheless, this platform may have a potential role in measuring mitogen-induced immune responses in the genital tract...
  11. pmc Multiple T-cell epitopes overlap positively-selected residues in the p1 spacer protein of HIV-1 gag
    Christina A Semeniuk
    Department of Medical Microbiology, University of Manitoba, National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    AIDS 23:771-7. 2009
    ..Identifying and characterizing CD8+ epitopes that are under host immune selection in this region will help in designing effective vaccines for HIV-1...
  12. doi request reprint Cervical HIV-specific IgA in a population of commercial sex workers correlates with repeated exposure but not resistance to HIV
    Rachel E Horton
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    AIDS Res Hum Retroviruses 25:83-92. 2009
    ..They also indicate that resistance to HIV is a complex condition related to more factors than exposure. Further studies of correlates of immune protection in these individuals would be beneficial to the field...
  13. doi request reprint Genital immunology and HIV susceptibility in young women
    Tae Joon Yi
    Departments of Medicine and Immunology, University of Toronto, Toronto, ON, Canada
    Am J Reprod Immunol 69:74-9. 2013
    ..These important biological reasons for enhanced HIV susceptibility in young women highlight the need for targeted HIV prevention within this vulnerable population...