Tracy L McGaha

Summary

Publications

  1. doi Amino acid catabolism: a pivotal regulator of innate and adaptive immunity
    Tracy L McGaha
    Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Immunol Rev 249:135-57. 2012
  2. doi Heterologous protein incites abnormal plasma cell accumulation and autoimmunity in MRL-MpJ mice
    Tracy L McGaha
    Department of Medicine, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA
    Autoimmunity 45:279-89. 2012
  3. doi Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen
    Tracy L McGaha
    Department of Medicine, Immunotherapy Center, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA
    Blood 117:5403-12. 2011
  4. pmc Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses
    Lei Huang
    Cancer Immunology, Inflammation and Tolerance Program, Cancer Center, Augusta, GA 30912
    J Immunol 191:3509-13. 2013
  5. pmc Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
    Buvana Ravishankar
    Department of Medicine, and Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 109:3909-14. 2012
  6. pmc Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells
    Lei Huang
    Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Immunol 188:4913-20. 2012
  7. doi GCN2-Dependent Metabolic Stress Is Essential for Endotoxemic Cytokine Induction and Pathology
    Haiyun Liu
    Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA
    Mol Cell Biol 34:428-38. 2014
  8. ncbi FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice
    Tracy L McGaha
    Department of Medicine, Section of Nephrology and Kidney Transplantation, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 180:5670-9. 2008
  9. pmc O death where is thy sting? Immunologic tolerance to apoptotic self
    Buvana Ravishankar
    Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Georgia Regents University, Building CN4143, 1120 15th Street, Augusta, GA, 30904, USA
    Cell Mol Life Sci 70:3571-89. 2013
  10. doi A human monoclonal antibody against the collagen type IV α3NC1 domain is a non-invasive optical biomarker for glomerular diseases
    Kapil Chaudhary
    Cancer Immunology, Inflammation, and Tolerance Program, Cancer Center, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Kidney Int 84:403-8. 2013

Collaborators

Detail Information

Publications10

  1. doi Amino acid catabolism: a pivotal regulator of innate and adaptive immunity
    Tracy L McGaha
    Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Immunol Rev 249:135-57. 2012
    ..In this review, we summarize recent developments and highlight novel concepts and key outstanding questions in this active research field...
  2. doi Heterologous protein incites abnormal plasma cell accumulation and autoimmunity in MRL-MpJ mice
    Tracy L McGaha
    Department of Medicine, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA
    Autoimmunity 45:279-89. 2012
    ..This model may provide an important tool to further investigate the mechanisms whereby environmental stimuli trigger autoimmune reactivity in susceptible hosts...
  3. doi Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen
    Tracy L McGaha
    Department of Medicine, Immunotherapy Center, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA
    Blood 117:5403-12. 2011
    ..These findings support the hypothesis that MZMs are central in the clearance of apoptotic cells to minimize the immunogenicity of autoantigens...
  4. pmc Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses
    Lei Huang
    Cancer Immunology, Inflammation and Tolerance Program, Cancer Center, Augusta, GA 30912
    J Immunol 191:3509-13. 2013
    ..Thus, previously unrecognized functional diversity among physiologic innate immune cells regarding DNA sensing via STING is pivotal in driving immune responses to DNA. ..
  5. pmc Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
    Buvana Ravishankar
    Department of Medicine, and Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 109:3909-14. 2012
    ..Thus, IDO limits innate and adaptive immunity to apoptotic self-antigens and IDO-mediated regulation inhibits inflammatory pathology caused by systemic autoimmune disease...
  6. pmc Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells
    Lei Huang
    Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Immunol 188:4913-20. 2012
    ..Thus, DNPs lacking TLR9 ligands may be safe and effective reagents to protect healthy tissues from immune-mediated destruction in clinical hyperimmune syndromes...
  7. doi GCN2-Dependent Metabolic Stress Is Essential for Endotoxemic Cytokine Induction and Pathology
    Haiyun Liu
    Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA
    Mol Cell Biol 34:428-38. 2014
    ..Thus, the data show that amino acid depletion stress signals (via GCN2) synergize with proinflammatory signals to potently increase innate immune responsiveness. ..
  8. ncbi FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice
    Tracy L McGaha
    Department of Medicine, Section of Nephrology and Kidney Transplantation, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 180:5670-9. 2008
    ..Additionally, the data indicates FcgammaRIIB function has a significant impact on APC activity, suggesting a prominent role in dendritic cell activity in response to interaction with particulate autoantigens...
  9. pmc O death where is thy sting? Immunologic tolerance to apoptotic self
    Buvana Ravishankar
    Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Georgia Regents University, Building CN4143, 1120 15th Street, Augusta, GA, 30904, USA
    Cell Mol Life Sci 70:3571-89. 2013
    ..This challenges the paradigm that apoptotic cells are inherently immunosuppressive, suggesting that apoptotic cell tolerance is a "context-dependent" event. ..
  10. doi A human monoclonal antibody against the collagen type IV α3NC1 domain is a non-invasive optical biomarker for glomerular diseases
    Kapil Chaudhary
    Cancer Immunology, Inflammation, and Tolerance Program, Cancer Center, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Kidney Int 84:403-8. 2013
    ..Thus, NC1 domain exposure may represent an in situ biomarker for assessment of kidney injury. Our study suggests that F1.1 and similar antibodies may represent a new class of non-invasive renal imaging reagents...