Joshua J McElwee

Summary

Publications

  1. ncbi Ageing: Microarraying mortality
    David Gems
    Nature 424:259-61. 2003
  2. ncbi Evolutionary conservation of regulated longevity assurance mechanisms
    Joshua J McElwee
    Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 8:R132. 2007
  3. ncbi DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO
    Eugene Schuster
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
    Mol Syst Biol 6:399. 2010
  4. ncbi Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans
    Joshua J McElwee
    Department of Biology, University College London, UK
    Mech Ageing Dev 127:458-72. 2006
  5. ncbi Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472]
    Joshua J McElwee
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Mech Ageing Dev 127:922-36. 2006
  6. ncbi Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
    Joshua J McElwee
    Department of Biology, University College London, WC1E 6BT, United Kingdom
    J Biol Chem 279:44533-43. 2004
  7. ncbi Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor
    Dhaval S Patel
    Department of Biology, University College London, London, United Kingdom
    Genetics 178:931-46. 2008
  8. ncbi Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    Ryan Doonan
    Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 22:3236-41. 2008
  9. ncbi Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
    Camilla Burnett
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Nature 477:482-5. 2011
  10. ncbi Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?
    David Gems
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Mech Ageing Dev 126:381-7. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Ageing: Microarraying mortality
    David Gems
    Nature 424:259-61. 2003
  2. ncbi Evolutionary conservation of regulated longevity assurance mechanisms
    Joshua J McElwee
    Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 8:R132. 2007
    ..To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS...
  3. ncbi DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO
    Eugene Schuster
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
    Mol Syst Biol 6:399. 2010
    ..This study demonstrates the efficacy of DamID for chromatin profiling in C. elegans...
  4. ncbi Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans
    Joshua J McElwee
    Department of Biology, University College London, UK
    Mech Ageing Dev 127:458-72. 2006
    ..We postulate that this fuels increased somatic maintenance activity, as suggested by the disposable soma theory...
  5. ncbi Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472]
    Joshua J McElwee
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Mech Ageing Dev 127:922-36. 2006
    ..We postulate that this fuels increased somatic maintenance activity, as suggested by the disposable soma theory...
  6. ncbi Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
    Joshua J McElwee
    Department of Biology, University College London, WC1E 6BT, United Kingdom
    J Biol Chem 279:44533-43. 2004
    ..By contrast, the daf-16-associated element was enriched in genes down-regulated in dauers and daf-2 mutants. Thus, particular promoter elements appear longevity-associated or aging associated...
  7. ncbi Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor
    Dhaval S Patel
    Department of Biology, University College London, London, United Kingdom
    Genetics 178:931-46. 2008
    ..These studies consolidate and extend our understanding of the complex genetics of daf-2 and its underlying molecular biology...
  8. ncbi Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    Ryan Doonan
    Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 22:3236-41. 2008
    ..However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O(2)(-) is not a major determinant of aging in C. elegans...
  9. ncbi Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
    Camilla Burnett
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Nature 477:482-5. 2011
    ..Our findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila...
  10. ncbi Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?
    David Gems
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Mech Ageing Dev 126:381-7. 2005
    ..Given the emphasis in this theory on investment in cellular waste disposal, and on protein conservation, we have dubbed it the green theory...
  11. ncbi Addressing the age-old question of old age
    Joshua J McElwee
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Genome Biol 5:337. 2004