Executive dysfunction following traumatic brain injury: neural substrates and treatment strategiesBrenna C McDonald
Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA
NeuroRehabilitation 17:333-44. 2002
..This review summarizes the nature of executive deficits following TBI, their neuroanatomical substrates, selected assessment and treatment strategies, and recent research findings and trends...
Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: altered working memory and BOLD responseThomas W McAllister
Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
Int J Psychophysiol 82:107-14. 2011
..On guanfacine the MTBI group showed increased activation within a WM task-specific region of interest. Findings are consistent with the hypothesis that alterations in WM after MTBI may be improved with the alpha-2 agonist guanfacine...
- Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury
Thomas W McAllister
Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 05756, USA
J Neurotrauma 29:1111-8. 2012
..Polymorphisms in BDNF influence cognitive performance shortly after mTBI. The results raise the possibility that a functional polymorphism other than rs6265 may contribute to memory function after mTBI...
- Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: a pilot study
Julie A Dumas
Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
Menopause 17:852-9. 2010
....
Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury: altered working memory and BOLD responseThomas W McAllister
Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH, USA
J Neuropsychiatry Clin Neurosci 23:277-86. 2011
..On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine...
- Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments
Thomas W McAllister
Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Curr Psychiatry Rep 6:364-71. 2004
..Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described...
- Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics
Thomas W McAllister
Section of Neuropsychiatry, Neuropsychology Program, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Neurotrauma 23:1450-67. 2006
..We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI...
- Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study
Thomas W McAllister
Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Brain Inj 22:705-14. 2008
....
- Nicotinic versus muscarinic blockade alters verbal working memory-related brain activity in older women
Julie A Dumas
Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vermont College of Medicine, Burlington, VT 05401, USA
Am J Geriatr Psychiatry 16:272-82. 2008
..This approach simulates the effects of age- or disease-related neuroreceptor or neuronal loss by temporarily blocking pre- and postsynaptic muscarinic and nicotinic cholinergic receptors...
- Cognitive function in breast cancer patients prior to adjuvant treatment
Tim A Ahles
Department of Psychiatry and Center for Psycho Oncology, The Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center Lebanon, Lebanon, NH, USA
Breast Cancer Res Treat 110:143-52. 2008
..To compare the neuropsychological functioning of breast cancer patients with invasive cancer and noninvasive cancer prior to adjuvant treatment...
- FLAIR lesion volume in multiple sclerosis: relation to processing speed and verbal memory
John J Randolph
Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
J Int Neuropsychol Soc 11:205-9. 2005
..These findings, considered in the context of prior work, suggest that FLAIR TLV is a useful predictor of commonly impaired cognitive functions in MS, and shows promise as a functionally relevant biomarker for disease status...
- Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives
Andrew J Saykin
Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
Semin Clin Neuropsychiatry 8:201-16. 2003
..Large-scale prospective studies are needed to help isolate the pathophysiological mechanisms underlying the cognitive deficits associated with chemotherapy...
- Recent developments in the application of the nonverbal learning disabilities model
Brenna C McDonald
Neuropsychology Program, Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Curr Psychiatry Rep 4:323-30. 2002
....
- Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury
Thomas W McAllister
Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756
Am J Psychiatry 162:1749-51. 2005
..The authors tested the hypothesis that the dopamine D2 receptor T allele (formerly described as the A1 allele) would be associated with poorer performance on memory and attention tasks following mild traumatic brain injury...
- Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy
Robert J Ferguson
Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
J Clin Oncol 25:3866-70. 2007
..Late cognitive effects after chemotherapy can have a deleterious impact on survivor quality of life and functional health; however, the etiology of chemotherapy-related cognitive dysfunction remains unknown...
- Cognitive-behavioral management of chemotherapy-related cognitive change
Robert J Ferguson
Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
Psychooncology 16:772-7. 2007
..Given these results, the treatment appears to be a feasible and practical cognitive-behavioral program that warrants continued evaluation among cancer survivors who experience persistent cognitive dysfunction...
