The cognitive cost of sleep lostJohn G McCoy
VA Boston Healthcare System, Research Service and Harvard Medical School, Department of Psychiatry, 940 Belmont St, Brockton, MA 02301 5596, USA
Neurobiol Learn Mem 96:564-82. 2011
..Thus, this review concludes with a description of recent neurobiological findings concerning the neuroplastic changes and putative brain mechanisms that may underlie the cognitive deficits produced by sleep disturbances...
One week of exposure to intermittent hypoxia impairs attentional set-shifting in ratsJohn G McCoy
VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
Behav Brain Res 210:123-6. 2010
..Instead, the deficit is likely to reflect impaired allocation of attentional resources of the working memory system...
- Spatial learning and memory deficits following exposure to 24 h of sleep fragmentation or intermittent hypoxia in a rat model of obstructive sleep apnea
Christopher P Ward
VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Brockton, MA 02301, USA
Brain Res 1294:128-37. 2009
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- Chronic ramelteon treatment in a mouse model of Alzheimer's disease
James Timothy McKenna
VA Boston Healthcare System Harvard Medical School, Brockton, MA 02301 5596, USA
Arch Ital Biol 150:5-14. 2012
..The ability of long term melatonin treatment to improve cognition and attenuate neuropathology in AD mice did not generalize to this dosage of ramelteon...
- Assessing sleepiness in the rat: a multiple sleep latencies test compared to polysomnographic measures of sleepiness
James T McKenna
Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
J Sleep Res 17:365-75. 2008
..The rMSLT provided a simple, objective, robust and direct measure of sleepiness that was as effective as conventional polysomnographic measures of sleepiness...
- Chronic sleep restriction impairs spatial memory in rats
John G McCoy
VA Boston Healthcare System, Research Service and Harvard Medical School, Department of Psychiatry, Brockton, Massachusetts, USA
Neuroreport 24:91-5. 2013
..Thus, CSR impaired spatial memory, but did not affect the rate of learning/acquisition in the water maze...
Experimental sleep fragmentation impairs attentional set-shifting in ratsJohn G McCoy
VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
Sleep 30:52-60. 2007
..To evaluate the effect of experimental sleep fragmentation (sleep interruption; SI) on complex learning in an intradimensional-extradimensional (ID/ED) set-shifting task in rats...
