Mark F McCarty

Summary

Publications

  1. ncbi request reprint A role for cAMP-driven transactivation of EGFR in cancer aggressiveness - Therapeutic implications
    Mark F McCarty
    Catalytic Longevity, 7831 Rush Rose Drive, Apt 316, Carlsbad, CA 92009, United States Electronic address
    Med Hypotheses 83:142-7. 2014
  2. ncbi request reprint The molecular biology and pathophysiology of vascular calcification
    Mark F McCarty
    Catalytic Longevity, Carlsbad, CA
    Postgrad Med 126:54-64. 2014
  3. ncbi request reprint AMPK activation--protean potential for boosting healthspan
    Mark F McCarty
    Catalytic Longevity, 7831 Rush Rose Dr, Apt 316, Carlsbad, CA, 92009, USA
    Age (Dordr) 36:641-63. 2014
  4. ncbi request reprint Vaccination with heat-shocked mononuclear cells as a strategy for treating neurodegenerative disorders driven by microglial inflammation
    Mark F McCarty
    Catalytic Longevity, 7831 Rush Rose Drive, Apt 316, Carlsbad, California 92009, United States Electronic address
    Med Hypotheses 81:773-6. 2013
  5. doi request reprint Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues--a rationale for the versatile health protection associated with elevated plasma bilirubin
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States Electronic address
    Med Hypotheses 81:607-10. 2013
  6. doi request reprint Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States Electronic address
    Med Hypotheses 81:664-70. 2013
  7. doi request reprint Nutraceutical strategies for ameliorating the toxic effects of alcohol
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 80:456-62. 2013
  8. doi request reprint Dietary nitrate and reductive polyphenols may potentiate the vascular benefit and alleviate the ulcerative risk of low-dose aspirin
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 80:186-90. 2013
  9. doi request reprint Clinical potential of phycocyanobilin for induction of T regulatory cells in the management of inflammatory disorders
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 77:1031-3. 2011
  10. doi request reprint Zinc and multi-mineral supplementation should mitigate the pathogenic impact of cadmium exposure
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 79:642-8. 2012

Detail Information

Publications38

  1. ncbi request reprint A role for cAMP-driven transactivation of EGFR in cancer aggressiveness - Therapeutic implications
    Mark F McCarty
    Catalytic Longevity, 7831 Rush Rose Drive, Apt 316, Carlsbad, CA 92009, United States Electronic address
    Med Hypotheses 83:142-7. 2014
    ..This model also predicts that certain other hormones which activate adenylate cylase in various tissue may play a yet-unsuspected role in cancer induction and spread. ..
  2. ncbi request reprint The molecular biology and pathophysiology of vascular calcification
    Mark F McCarty
    Catalytic Longevity, Carlsbad, CA
    Postgrad Med 126:54-64. 2014
    ..Adequate but not excessive vitamin D status also appears to discourage VC. Etidronate, a structural analogue of pyrophosphate, has shown potential for blocking VC. ..
  3. ncbi request reprint AMPK activation--protean potential for boosting healthspan
    Mark F McCarty
    Catalytic Longevity, 7831 Rush Rose Dr, Apt 316, Carlsbad, CA, 92009, USA
    Age (Dordr) 36:641-63. 2014
    ..The activation of AMPK achievable with any of these measures may be potentiated by clinical doses of the drug salicylate, which can bind to AMPK and activate it allosterically. ..
  4. ncbi request reprint Vaccination with heat-shocked mononuclear cells as a strategy for treating neurodegenerative disorders driven by microglial inflammation
    Mark F McCarty
    Catalytic Longevity, 7831 Rush Rose Drive, Apt 316, Carlsbad, California 92009, United States Electronic address
    Med Hypotheses 81:773-6. 2013
    ..It would be appropriate to test the heat-shocked mononuclear cell vaccination strategy in animal models of neurodegeneration and major depression, and to evaluate this approach clinically if such studies yield encouraging results...
  5. doi request reprint Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues--a rationale for the versatile health protection associated with elevated plasma bilirubin
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States Electronic address
    Med Hypotheses 81:607-10. 2013
    ..Strategies for boosting bilirubin production within cells via HO-1 induction, or for mimicking bilirubin's antioxidant activity with cyanobacterial phycobilins, may have important potential for health promotion...
  6. doi request reprint Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States Electronic address
    Med Hypotheses 81:664-70. 2013
    ..Hence, oral sodium bicarbonate and intravenous DHA may have the potential to blunt the aggressiveness of certain cancers in which suboptimal intracellular ascorbate levels contribute to elevated HIF-1 activity...
  7. doi request reprint Nutraceutical strategies for ameliorating the toxic effects of alcohol
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 80:456-62. 2013
    ..Measures which boost or preserve ALDH-2 activity may also have important antioxidant potential, as this enzyme functions physiologically to protect cells from toxic aldehydes generated by oxidant stress...
  8. doi request reprint Dietary nitrate and reductive polyphenols may potentiate the vascular benefit and alleviate the ulcerative risk of low-dose aspirin
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 80:186-90. 2013
    ..Low-dose aspirin may be more unequivocally recommendable within the context of such a dietary strategy...
  9. doi request reprint Clinical potential of phycocyanobilin for induction of T regulatory cells in the management of inflammatory disorders
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 77:1031-3. 2011
    ....
  10. doi request reprint Zinc and multi-mineral supplementation should mitigate the pathogenic impact of cadmium exposure
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 79:642-8. 2012
    ..Hence, although Cd may prove to be a major risk factor for morbidity and mortality in humans, practical strategies for limiting its absorption and pathogenic impact are at hand...
  11. doi request reprint Metformin may antagonize Lin28 and/or Lin28B activity, thereby boosting let-7 levels and antagonizing cancer progression
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 78:262-9. 2012
    ..Multifocal strategies centering on metformin may have considerable potential for reversing cancer stemness and rendering advanced cancers more susceptible to long term control...
  12. doi request reprint Marinobufagenin and cyclic strain may activate endothelial NADPH oxidase, contributing to the adverse impact of salty diets on vascular and cerebral health
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 78:191-6. 2012
    ....
  13. doi request reprint Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention
    Mark F McCarty
    NutriGuard Research, Inc, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 78:45-57. 2012
    ..In aggregate, these considerations suggest that a comprehensive lifestyle strategy targeting cox-2 expression and bioactivity may have tremendous potential for cancer prevention...
  14. doi request reprint mTORC1 activity as a determinant of cancer risk--rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 77:642-8. 2011
    ....
  15. doi request reprint Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 77:550-6. 2011
    ..Finally, treatment with salsalate, an inhibitor of IkappaB kinase-beta, has potential for blunting the adverse impact of hepatic steatosis on oxidative stress and inflammation...
  16. ncbi request reprint AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1211-5. 2005
    ..More generally, metformin - or, preferably, better tolerated activators of AMPK - may have considerable potential for promoting vascular health in the large proportion of the adult population afflicted with insulin resistance syndrome...
  17. doi request reprint Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 75:141-7. 2010
    ....
  18. doi request reprint Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, 811 B Nahant Ct, San Diego, CA 92024, USA
    Med Hypotheses 75:276-81. 2010
    ..Appropriate rodent studies should pave the way for clinical trials with salsalate in patients at vascular risk...
  19. ncbi request reprint Low-insulin-response diets may decrease plasma C-reactive protein by influencing adipocyte function
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:385-7. 2005
    ..These considerations suggest that it may be possible to achieve worthwhile reductions in CRP by avoiding high-insulin-response starchy foods and by ingesting more soluble fiber, in foods or as a meal-time supplement...
  20. ncbi request reprint The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:394-8. 2005
    ..Thus, a taurine supplemented low-fat vegan diet may be recommended as a strategy for minimizing AGE-mediated complications in diabetics and in patients with renal failure...
  21. ncbi request reprint Does bitter melon contain an activator of AMP-activated kinase?
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:340-3. 2004
    ....
  22. ncbi request reprint Chronic activation of AMP-activated kinase as a strategy for slowing aging
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:334-9. 2004
    ....
  23. doi request reprint Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease
    Mark F McCarty
    NutriGuard Research, Encinitas CA 92024, USA
    Med Hypotheses 74:1055-8. 2010
    ....
  24. ncbi request reprint Manipulating tumor acidification as a cancer treatment strategy
    Mark F McCarty
    Oasis of Hope Hospital and Whitaker Wellness Institute
    Altern Med Rev 15:264-72. 2010
    ..A similar strategy, but without proton pump inhibition, could be employed to maximize extracellular tumor acidity, enabling tumor-selective release of cytotoxic drugs encased in pH-sensitive nanoparticles...
  25. ncbi request reprint Dietary saturate/unsaturate ratio as a determinant of adiposity
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 75:14-6. 2010
    ....
  26. ncbi request reprint Nutritional modulation of parathyroid hormone secretion may influence risk for left ventricular hypertrophy
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1015-21. 2005
    ..Whether these nutritional measures do indeed influence LVH risk could be examined in prospective studies targeting patients at high risk, such as hypertensives...
  27. ncbi request reprint Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 69:1367-70. 2007
    ..The impact of supplemental gamma-tocopherol on compromised endothelium-dependent vasodilation in various disorders merits examination...
  28. ncbi request reprint Chromium picolinate may favorably influence the vascular risk associated with smoking by combating cortisol-induced insulin resistance
    Mark F McCarty
    NutriGuard Research, 1054 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1220-4. 2005
    ..The impact of chromium picolinate on smoking- or nicotine-induced insulin resistance merits study...
  29. ncbi request reprint High mitochondrial redox potential may promote induction and activation of UCP2 in hepatocytes during hepatothermic therapy
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1216-9. 2005
    ..Under these conditions, high mitochondrial redox potential would be expected, and induction of UCP2's uncoupling activity would represent a homeostatically appropriate antioxidant response...
  30. ncbi request reprint Adjuvant strategies for prevention of glomerulosclerosis
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 67:1277-96. 2006
    ..Most of these measures may likewise reduce risk for left ventricular hypertrophy in hypertensives, inasmuch as the signaling mechanisms which mediate this disorder appear similar to those involved in glomerulosclerosis...
  31. ncbi request reprint Clinical potential of Spirulina as a source of phycocyanobilin
    Mark F McCarty
    NutriGuard Research, Encinitas, CA 92024, USA
    J Med Food 10:566-70. 2007
    ..Such a regimen should be evaluated in clinical syndromes characterized and in part mediated by NADPH oxidase overactivity in affected tissues...
  32. ncbi request reprint Nutraceutical resources for diabetes prevention--an update
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:151-8. 2005
    ..Nutraceuticals featuring meaningful doses of combinations of these agents would likely have substantial diabetes-preventive efficacy, and presumably could be marketed legally as aids to good glucose tolerance and insulin sensitivity...
  33. ncbi request reprint Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:399-407. 2005
    ..Phytanic acid, a branched-chain fatty acid found in omnivore diets, can also activate PPARdelta, and thus should be examined with respect to its impact on mitochondrial biogenesis and insulin sensitivity...
  34. ncbi request reprint Secondary hyperparathyroidism promotes the acute phase response -- a rationale for supplemental vitamin D in prevention of vascular events in the elderly
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:1022-6. 2005
    ....
  35. ncbi request reprint De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:388-93. 2005
    ..g., metformin), which can be expected to lessen tissue DAG synthesis...
  36. ncbi request reprint A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:419-25. 2004
    ..Moderate alcohol consumption, the well-tolerated drug pentoxifylline, and 5-lipoxygenase inhibitors--zileuton, boswellic acids, fish oil--may also have potential in this regard...
  37. ncbi request reprint cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in prevention/treatment of diabetes
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 66:323-8. 2006
    ....
  38. ncbi request reprint AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 63:328-33. 2004
    ..Although the impact of metformin on plasma IL-6 levels has not been reported, the possibility that AMPK activation could influence adipocyte secretion of this cytokine also merits scrutiny...