Lack of association between polymorphisms in the prostaglandin F2α receptor and solute carrier organic anion transporter family 2A1 genes and intraocular pressure response to prostaglandin analogsCatherine A McCarty
Marshfield Clinic Research Foundation, Marshfield, USA
Ophthalmic Genet 33:74-6. 2012
..To evaluate the association between variants in the prostaglandin F(α) receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and intraocular pressure (IOP) response to prostaglandin analogs...
Alcohol, genetics and risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening TrialCatherine A McCarty
Essentia Institute of Rural Health, Duluth, MN 55805, USA
Breast Cancer Res Treat 133:785-92. 2012
..This information could be useful for primary care providers to personalize information about breast cancer risk reduction...
- A novel gene-environment interaction involved in endometriosis
Catherine A McCarty
Essentia Institute of Rural Health, Duluth 55805, USA
Int J Gynaecol Obstet 116:61-3. 2012
..To establish a well-defined cohort for genetic epidemiology studies of endometriosis and conduct a pilot study to confirm validity using existing data associated with endometriosis...
- Intraocular pressure response to medication in a clinical setting: the Marshfield Clinic Personalized Medicine Research Project
Catherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
J Glaucoma 17:372-7. 2008
..To estimate glaucoma and ocular hypertension prevalence and to describe temporal trends in prescribing patterns and intraocular pressure (IOP) response to topical medications used in glaucoma and ocular hypertension...
- Importance of multi-modal approaches to effectively identify cataract cases from electronic health records
Peggy L Peissig
Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
J Am Med Inform Assoc 19:225-34. 2012
..We describe the construction and validation of an EHR-based algorithm to identify subjects with age-related cataracts...
- Cataract research using electronic health records
Carol J Waudby
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
BMC Ophthalmol 11:32. 2011
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- A pilot study of gene/gene and gene/environment interactions in Alzheimer disease
Nader Ghebranious
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Clin Med Res 9:17-25. 2011
..The purpose of this pilot study was to explore gene/gene and gene/environment associations in AD and to obtain data for sample size estimates for larger, more definitive studies of AD...
- Dietary intake in the Personalized Medicine Research Project: a resource for studies of gene-diet interaction
Lacie Strobush
Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 N, Oak Ave MLR, Marshfield, WI 54449, USA
Nutr J 10:13. 2011
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- Use of an electronic medical record for the identification of research subjects with diabetes mellitus
Russell A Wilke
Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449, USA
Clin Med Res 5:1-7. 2007
..This algorithm yielded an estimated prevalence of 24.2% for diabetes mellitus in adult subjects aged > or =50 years...
- Use of an electronic medical record to characterize cases of intermediate statin-induced muscle toxicity
Ravi K Mareedu
Department of Internal Medicine, Marshfield Clinic, Marshfield, WI, USA
Prev Cardiol 12:88-94. 2009
..The lines reflecting these relationships cross at a CK level of approximately 1175 U/L, approximately half the threshold level needed to make a clinical diagnosis of "myopathy" (ie, CK >10-fold the upper limit of normal)...
- Intraocular pressure response to topical beta-blockers associated with an ADRB2 single-nucleotide polymorphism
Catherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 N Oak Ave, Marshfield, WI 54449, USA
Arch Ophthalmol 126:959-63. 2008
..To determine whether candidate pharmacodynamic (beta-adrenergic receptor) and pharmacokinetic (cytochrome P450 2D6) gene polymorphisms are associated with the intraocular pressure (IOP) response to topical beta-blockers...
- Apolipoprotein e4 genotype increases the risk of being diagnosed with posttraumatic fibromyalgia
Jonathan C Reeser
Office of Research Integrity and Protections, Marshfield Clinic Research Foundation, 1000 North Oak Ave, Marshfield, WI 54449, USA
PM R 3:193-7. 2011
..To determine whether the apolipoprotein E4 (Apo E4) allele may be a genetic risk factor for fibromyalgia syndrome (FMS)...
- Study newsletters, community and ethics advisory boards, and focus group discussions provide ongoing feedback for a large biobank
Catherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
Am J Med Genet A 155:737-41. 2011
..The multi-faceted approach to communication including newsletters, external advisory boards, and focus group discussions has been successful for the PMRP biobank and may be a model for others to consider...
- Community consultation and communication for a population-based DNA biobank: the Marshfield clinic personalized medicine research project
Catherine A McCarty
Marshfield Clinic Research Foundation, Center for Human Genetics, Marshfield, Wisconsin 54449, USA
Am J Med Genet A 146:3026-33. 2008
..Researchers need to balance the provision of information for potential subjects to make informed decisions about study participation, with respect for individuals' time to read and interpret study materials...
- Development of an optical character recognition pipeline for handwritten form fields from an electronic health record
Luke V Rasmussen
Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
J Am Med Inform Assoc 19:e90-5. 2012
..The few previous studies on automated extraction of data from these handwritten notes have focused on monolithic, custom-developed recognition systems or third-party systems that require proprietary forms...
- Biobanking and pharmacogenomics
Catherine A McCarty
Marshfield Clinic Research Foundation, Center for Human Genetics, Marshfield, WI 54449, USA
Pharmacogenomics 11:637-41. 2010
..Longitudinal data available in practice-based datasets will position investigators to characterize genetic factors with small but reproducible effects on drug outcome in the context of gene-environment interactions...
Construction of atorvastatin dose-response relationships using data from a large population-based DNA biobankPeggy Peissig
Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Basic Clin Pharmacol Toxicol 100:286-8. 2007
- Novel measures of cardiovascular health and its association with prevalence and progression of age-related macular degeneration: the CHARM Study
Catherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, MA, USA
BMC Ophthalmol 8:25. 2008
..To determine if novel measures of cardiovascular health are associated with prevalence or progression of age-related macular degeneration (AMD)...
- Clinical genetics provider real-time workflow study
Elizabeth McPherson
Department of Medical Genetic Services, Marshfield Clinic, Marshfield, Wisconsin 54449, USA
Genet Med 10:699-706. 2008
..Our work is the first documentation, in real time, of workflow in a general genetics department including data on patient care, research, and other activities for both clinical geneticists and genetic counselors...
- Sunlight exposure assessment: can we accurately assess vitamin D exposure from sunlight questionnaires?
Catherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Am J Clin Nutr 87:1097S-101S. 2008
..Research should be directed to develop more objective, nonintrusive, and economical measures of sunlight exposure to quantify personal vitamin D status...
- Calories from newspaper dessert recipes are associated with community obesity rates
Catherine A McCarty
Marshfield Clinic Research Foundation, Center for Human Genetics, 1000 N Oak Ave ML1, Marshfield, WI 54449, USA
WMJ 106:68-70. 2007
..The purpose of this study was to determine if the nutrient content of recipes available in newspapers is related to community obesity rates...
- Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project
Deanna S Cross
Center for Human Genetics, Marshfield Clinic Research Foundation, WI, USA
BMC Genet 11:51. 2010
..We compared these allele frequencies to those in dbSNP and other data sources stratified by race. Differences in allele frequencies between self reported race, region of origin, and sex were determined...
