Patrick D McClanahan

Summary

Publications

  1. Trojanowski N, Nelson M, Flavell S, Fang Yen C, Raizen D. Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States. J Neurosci. 2015;35:14571-84 pubmed publisher
    ..Together these results indicate that, as in mammals, quiescence is subserved by different mechanisms during distinct sleep-like states in C. elegans. ..
  2. Fang Yen C, Alkema M, Samuel A. Illuminating neural circuits and behaviour in Caenorhabditis elegans with optogenetics. Philos Trans R Soc Lond B Biol Sci. 2015;370:20140212 pubmed publisher
    ..Here, we show how optogenetics applied to this transparent roundworm has contributed to our understanding of neural circuits. ..
  3. Trojanowski N, Fang Yen C. Simultaneous Optogenetic Stimulation of Individual Pharyngeal Neurons and Monitoring of Feeding Behavior in Intact C. elegans. Methods Mol Biol. 2015;1327:105-19 pubmed publisher
  4. Churgin M, Fang Yen C. An Imaging System for C. elegans Behavior. Methods Mol Biol. 2015;1327:199-207 pubmed publisher
    ..elegans neurobiology and development benefit from automated imaging of worm behavior. Here we describe procedures for building a flexible and inexpensive imaging system using standard optical and mechanical components. ..
  5. Fouad A, Pu S, Teng S, Mark J, Fu M, Zhang K, et al. Quantitative Assessment of Fat Levels in Caenorhabditis elegans Using Dark Field Microscopy. G3 (Bethesda). 2017;7:1811-1818 pubmed publisher
    ..Using our method, we track fat storage with high temporal resolution in developing larvae, and show that fat storage in the intestine increases in at least one burst during development. ..
  6. Churgin M, McCloskey R, Peters E, Fang Yen C. Antagonistic Serotonergic and Octopaminergic Neural Circuits Mediate Food-Dependent Locomotory Behavior in Caenorhabditis elegans. J Neurosci. 2017;37:7811-7823 pubmed publisher
    ..Understanding the molecular pathways through which biogenic amines function in model organisms may improve our understanding of dysfunctions of appetite and behavior found in mammals, including humans. ..
  7. McClanahan P, Xu J, Fang Yen C. Comparing Caenorhabditis elegans gentle and harsh touch response behavior using a multiplexed hydraulic microfluidic device. Integr Biol (Camb). 2017;9:800-809 pubmed publisher
    ..Differences in gentle and harsh touch response characteristics may reflect the different innervation of the respective mechanosensory cells. Our assay will facilitate studies of mechanosensation, sensory adaptation, and nociception. ..
  8. McCloskey R, Fouad A, Churgin M, Fang Yen C. Food responsiveness regulates episodic behavioral states in Caenorhabditis elegans. J Neurophysiol. 2017;117:1911-1934 pubmed publisher
    ..We show that decisions to engage in these behaviors are controlled by the nervous system through insulin-like signaling and the perception of food. ..