Filomena Mattner

Summary

Publications

  1. ncbi request reprint Pharmacological evaluation of (S)-8-[123I]iodobretazenil: a radioligand for in vivo studies of central benzodiazepine receptors
    Andrew Katsifis
    Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology Organisation Menai NSW 2234, Sydney, Australia
    Nucl Med Biol 30:191-8. 2003
  2. doi request reprint Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography
    Christopher J R Fookes
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, PMB 1 Menai NSW 2234, Sydney, Australia
    J Med Chem 51:3700-12. 2008
  3. ncbi request reprint Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation
    Nicolas Arlicot
    INSERM, U930, Tours 37000, France
    Eur J Nucl Med Mol Imaging 35:2203-11. 2008
  4. ncbi request reprint Pharmacological evaluation of [123I]-CLINDE: a radioiodinated imidazopyridine-3-acetamide for the study of peripheral benzodiazepine binding sites (PBBS)
    Filomena Mattner
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, PMB 1 Menai, NSW 2234 Sydney, Australia
    Eur J Nucl Med Mol Imaging 35:779-89. 2008
  5. ncbi request reprint In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors
    Herve Boutin
    CEA, DSV, I2BM, SHFJ, Laboratoire d Imagerie Moleculaire Experimentale, Orsay, France
    Glia 55:1459-68. 2007
  6. ncbi request reprint Preparation and biologic evaluation of a novel radioiodinated benzylpiperazine, 123I-MEL037, for malignant melanoma
    Tien Q Pham
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Sydney, Australia
    J Nucl Med 48:1348-56. 2007
  7. ncbi request reprint Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma
    Tien Q Pham
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, PMB 1 Menai N S W 2234, Sydney, Australia
    J Med Chem 50:3561-72. 2007
  8. ncbi request reprint Influence of trishomocubanes on sigma receptor binding of N-(1-benzyl-piperidin-4-yl)-4-[123I]iodobenzamide in vivo in the rat brain
    Xiang Liu
    Department of Pharmacology The University of Sydney, NSW 2006 Australia
    Med Chem 1:31-8. 2005
  9. ncbi request reprint Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites
    Taryn P Homes
    Department of Chemistry, University of Wollongong, NSW 2500, Wollongong, Australia
    Bioorg Med Chem 14:3938-46. 2006
  10. ncbi request reprint Pharmacological evaluation of an [(123)I] labelled imidazopyridine-3-acetamide for the study of benzodiazepine receptors
    Filomena Mattner
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, PMB 1 Menai N S W 2234, Sydney, Australia
    Life Sci 79:287-94. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Pharmacological evaluation of (S)-8-[123I]iodobretazenil: a radioligand for in vivo studies of central benzodiazepine receptors
    Andrew Katsifis
    Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology Organisation Menai NSW 2234, Sydney, Australia
    Nucl Med Biol 30:191-8. 2003
    ..S)-8-[(123)I]Iodobretazenil potently and selectively labels BZR in vivo and deserves further investigation as a possible SPECT radiotracer...
  2. doi request reprint Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography
    Christopher J R Fookes
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, PMB 1 Menai NSW 2234, Sydney, Australia
    J Med Chem 51:3700-12. 2008
    ..Hence, [ (18)F] 12 appeared to be the best candidate for evaluation as an imaging agent for PBR expression in neurodegenerative disorders...
  3. ncbi request reprint Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation
    Nicolas Arlicot
    INSERM, U930, Tours 37000, France
    Eur J Nucl Med Mol Imaging 35:2203-11. 2008
    ..Their expression rises after microglial activation following brain injury. Accordingly, TSPO are potential targets to evaluate neuroinflammatory changes in a variety of CNS disorders...
  4. ncbi request reprint Pharmacological evaluation of [123I]-CLINDE: a radioiodinated imidazopyridine-3-acetamide for the study of peripheral benzodiazepine binding sites (PBBS)
    Filomena Mattner
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, PMB 1 Menai, NSW 2234 Sydney, Australia
    Eur J Nucl Med Mol Imaging 35:779-89. 2008
    ..The study aims to evaluate the iodinated imidazopyridine, N',N'-diethyl-6-Chloro-(4'-[(123)I]iodophenyl)imidazo[1,2-a]pyridine-3-acetamide ([(123)I]-CLINDE) as a tracer for the study of peripheral benzodiazepine binding sites (PBBS)...
  5. ncbi request reprint In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors
    Herve Boutin
    CEA, DSV, I2BM, SHFJ, Laboratoire d Imagerie Moleculaire Experimentale, Orsay, France
    Glia 55:1459-68. 2007
    ..Further studies of this new compound should be carried out to better define its capacity to overcome the limitations of [(11)C]PK11195 for PBR PET imaging...
  6. ncbi request reprint Preparation and biologic evaluation of a novel radioiodinated benzylpiperazine, 123I-MEL037, for malignant melanoma
    Tien Q Pham
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Sydney, Australia
    J Nucl Med 48:1348-56. 2007
    ..A novel molecule, 2-(2-(4-(4-(123)I-iodobenzyl)piperazin-1-yl)-2-oxoethyl)isoindoline-1,3-dione (MEL037), was synthesized, labeled with 123I, and evaluated for application in melanoma tumor scintigraphy and radiotherapy...
  7. ncbi request reprint Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma
    Tien Q Pham
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, PMB 1 Menai N S W 2234, Sydney, Australia
    J Med Chem 50:3561-72. 2007
    ....
  8. ncbi request reprint Influence of trishomocubanes on sigma receptor binding of N-(1-benzyl-piperidin-4-yl)-4-[123I]iodobenzamide in vivo in the rat brain
    Xiang Liu
    Department of Pharmacology The University of Sydney, NSW 2006 Australia
    Med Chem 1:31-8. 2005
    ..This demonstrates for the first time the ability of functionalised trishomocubanes to interact with sigma receptors in vivo...
  9. ncbi request reprint Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites
    Taryn P Homes
    Department of Chemistry, University of Wollongong, NSW 2500, Wollongong, Australia
    Bioorg Med Chem 14:3938-46. 2006
    ..This high affinity and selective radioligand may be useful for imaging neurodegeneration, inflammation and tumours using single photon emission computed tomography...
  10. ncbi request reprint Pharmacological evaluation of an [(123)I] labelled imidazopyridine-3-acetamide for the study of benzodiazepine receptors
    Filomena Mattner
    Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, PMB 1 Menai N S W 2234, Sydney, Australia
    Life Sci 79:287-94. 2006
    ..123)I]IZOL may deserve further development for imaging selectively peripheral benzodiazepine binding sites...
  11. ncbi request reprint Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1)
    Sylvie Mavel
    Universite Francois Rabelais, Faculte de Pharmacie, Lab de Biophysique Médicale et Pharmaceutique, INSERM U619, Tours, France
    Bioorg Med Chem 14:1599-607. 2006
    ..Their MDR-reversing capacity suggests that, in particular, the 4'-fluoroalkyloxy and 4'-iodo apigenin derivatives are potential new radiopharmaceuticals to visualize in vivo MRP1-mediated MDR phenomenon by PET or SPECT...
  12. ncbi request reprint Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder
    Katerina Zavitsanou
    Neuroscience Institute of Schizophrenia and Allied Disorders, University of Wollongong, NSW, Australia
    Neuropsychopharmacology 29:619-25. 2004
    ..The changes observed in schizophrenia may contribute to dysfunctional ACC neural circuits...
  13. ncbi request reprint Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter
    Mitchell Quinlivan
    Department of Pharmacology, University of Sydney, NSW 2006, Australia
    Nucl Med Biol 30:741-6. 2003
    ..In view of these results [(123)I]1 and [(123)I]2 do not appear to be suitable radioligands for in vivo studies of the SERT...
  14. ncbi request reprint Synthesis and in vivo evaluation of [11C]zolpidem, an imidazopyridine with agonist properties at central benzodiazepine receptors
    Filip Dumont
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Nucl Med Biol 30:435-9. 2003
    ..A PET brain imaging study in one baboon confirmed the results obtained in rats. Therefore, it can be concluded that [(11)C]zolpidem is not a suitable tracer for in vivo visualization of central benzodiazepine receptors...
  15. pmc PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy
    Stefanie Dedeurwaerdere
    Department of Translational Neuroscience, University of Antwerp, FGEN CDE T4, 20, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium
    EJNMMI Res 2:60. 2012
    ..abstract:..
  16. doi request reprint Central nervous system expression and PET imaging of the translocator protein in relapsing-remitting experimental autoimmune encephalomyelitis
    Filomena Mattner
    Life Sciences Division, Australian Nuclear Science and Technology Organisation, Lucas Heights, New South Wales, Australia
    J Nucl Med 54:291-8. 2013
    ....
  17. doi request reprint Evaluation of [¹²³I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation
    Filomena Mattner
    ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Rd, Lucas Heights, Sydney, NSW 2234, Australia
    Eur J Nucl Med Mol Imaging 38:1516-28. 2011
    ....