F Matrisciano

Summary

Publications

  1. ncbi request reprint Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review
    Francesco Matrisciano
    Psychiatry and Behavioral Science, Northwestern University, Feinberg School of Medicine, 303E Chicago Ave, Chicago, IL 60611
    Curr Neuropharmacol 14:41-7. 2016
  2. pmc Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice
    Francesco Matrisciano
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropharmacology 68:184-94. 2013
  3. pmc Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice
    Francesco Matrisciano
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 37:929-38. 2012
  4. pmc Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain
    Francesco Matrisciano
    Department of Psychiatry, College of Medicine, University of Illinois Chicago, Chicago, Illinois, USA
    Mol Pharmacol 80:174-82. 2011
  5. doi request reprint Enhanced expression of the neuronal K+/Cl- cotransporter, KCC2, in spontaneously depressed Flinders Sensitive Line rats
    F Matrisciano
    Department of Physiology and Pharmacology, Sant Andrea Hospital, University of Rome Sapienza, Rome, Italy
    Brain Res 1325:112-20. 2010
  6. doi request reprint Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats
    F Matrisciano
    Department of Physiology and Pharmacology, University of Rome Sapienza, Piazzale Aldo Moro, 5, 00185 Rome, Italy
    Neuropharmacology 55:525-31. 2008
  7. ncbi request reprint Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis
    F Matrisciano
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Neuropharmacology 54:428-37. 2008
  8. ncbi request reprint Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands
    F Matrisciano
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 93:1345-52. 2005
  9. ncbi request reprint Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis
    S Scaccianoce
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Ple A Moro 5, Italy
    Neuropharmacology 44:555-61. 2003
  10. doi request reprint Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: mGlu2 receptors are resistant to homologous desensitization
    L Iacovelli
    Department of Physiology and Pharmacology, University of Rome Sapienza, Rome, Italy
    Mol Pharmacol 75:991-1003. 2009

Detail Information

Publications14

  1. ncbi request reprint Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review
    Francesco Matrisciano
    Psychiatry and Behavioral Science, Northwestern University, Feinberg School of Medicine, 303E Chicago Ave, Chicago, IL 60611
    Curr Neuropharmacol 14:41-7. 2016
    ..We will then focus on key proteins of chromatin remodeling machinery as potential target for new pharmacological treatment through the activation of metabotropic glutamate receptors. ..
  2. pmc Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice
    Francesco Matrisciano
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropharmacology 68:184-94. 2013
    ..Thus, PRS mice may be a valid model for the investigation of new drugs for schizophrenia treatment targeting DNA methylation. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'...
  3. pmc Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice
    Francesco Matrisciano
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 37:929-38. 2012
    ..Our data show for the first time that PRS induces a schizophrenia-like phenotype in mice, and suggest that epigenetic changes in mGlu2 and mGlu3 receptors lie at the core of the pathological programming induced by early-life stress...
  4. pmc Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain
    Francesco Matrisciano
    Department of Psychiatry, College of Medicine, University of Illinois Chicago, Chicago, Illinois, USA
    Mol Pharmacol 80:174-82. 2011
    ..These findings show that pharmacological activation of mGlu2/3 receptors has a strong impact on the epigenetic regulation of genes that have been linked to the pathophysiology of schizophrenia...
  5. doi request reprint Enhanced expression of the neuronal K+/Cl- cotransporter, KCC2, in spontaneously depressed Flinders Sensitive Line rats
    F Matrisciano
    Department of Physiology and Pharmacology, Sant Andrea Hospital, University of Rome Sapienza, Rome, Italy
    Brain Res 1325:112-20. 2010
    ..These data raise the interesting possibility that a spontaneous depressive state in animals is associated with an amplified GABAergic transmission in the CNS resulting from an enhanced expression of KCC2...
  6. doi request reprint Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats
    F Matrisciano
    Department of Physiology and Pharmacology, University of Rome Sapienza, Piazzale Aldo Moro, 5, 00185 Rome, Italy
    Neuropharmacology 55:525-31. 2008
    ..These data support the view that mGlu2/3 receptors might be involved in the pathophysiology of depressive disorders, and that pharmacological activation of these receptors may shorten the latency of antidepressant medication...
  7. ncbi request reprint Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis
    F Matrisciano
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Neuropharmacology 54:428-37. 2008
    ..These data support the hypothesis that a combination between classical antidepressants and mGlu2/3 receptor agonists may be helpful in the experimental treatment of depression...
  8. ncbi request reprint Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands
    F Matrisciano
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 93:1345-52. 2005
    ....
  9. ncbi request reprint Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis
    S Scaccianoce
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Ple A Moro 5, Italy
    Neuropharmacology 44:555-61. 2003
    ..The action of LY341495 was prevented by the combined application of the mGlu2/3 receptor agonist, LY379268. We conclude that group-II mGlu receptors tonically regulate the HPA axis by controlling CRH secretion at hypothalamic level...
  10. doi request reprint Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: mGlu2 receptors are resistant to homologous desensitization
    L Iacovelli
    Department of Physiology and Pharmacology, University of Rome Sapienza, Rome, Italy
    Mol Pharmacol 75:991-1003. 2009
    ..We predict the lack of tolerance when mixed mGlu2/3 receptor agonists or selective mGlu2 enhancers are used continually in patients...
  11. ncbi request reprint Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus
    F Matrisciano
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Neuropharmacology 42:1008-15. 2002
    ..Taken together, these results suggest that neuroadaptive changes in the expression and function of mGlu2/3 receptors occur in response to chronic antidepressants...
  12. doi request reprint Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs
    E Dong
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Transl Psychiatry 6:e711. 2016
    ..Furthermore, PRS mice may be invaluable for understanding the etiopathogenesis of SZ and BP disorder and for predicting treatment responses at early stages of the illness allowing for early detection and remedial intervention. ..
  13. pmc Epigenetic GABAergic targets in schizophrenia and bipolar disorder
    A Guidotti
    Department of Psychiatry, University of Illinois at Chicago, College of Medicine, Psychiatric Institute, 1601 Taylor, Chicago, IL 60612, USA
    Neuropharmacology 60:1007-16. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  14. ncbi request reprint Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the treatment of depression: a new strategy to shorten the latency of antidepressant medication?
    F Matrisciano
    Mol Psychiatry 12:704-6. 2007