Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult ratsR Sujatha
School of Life Sciences, Pondicherry University, India
Asian J Androl 3:135-8. 2001
..The levels of DNA, RNA and protein were also decreased in lindane-treated rats. CONCLUSION: Lindane induces oxidative stress and decreases antioxidant enzymes in adult male rats...
- Effect of lindane on antioxidant enzymes in epididymis and epididymal sperm of adult rats
K C Chitra
School of Life Sciences, Pondicherry University, India
Asian J Androl 3:205-8. 2001
..CONCLUSION: Lindane decreases the levels of antioxidant enzymes in the epididymis and epididymal sperm of adult rats thereby inducing oxidative stress...
- Effect of methoxychlor on antioxidant system of goat epididymal sperm in vitro
B Gangadharan
School of Life Sciences, Pondicherry University, India
Asian J Androl 3:285-8. 2001
..Co-incubation of sperm with methoxychlor and vitamin C, a natural antioxidant, reversed the effect of methoxychlor...
- The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antioxidant system in mitochondrial and microsomal fractions of rat testis
C Latchoumycandane
School of Life Sciences, Pondicherry University, 605 014, Pondicherry, India
Toxicology 171:127-35. 2002
..In conclusion the adverse effect of TCDD on male reproduction could be due to induction of oxidative stress...
- The effect of methoxychlor on the epididymal antioxidant system of adult rats
C Latchoumycandane
School of Life Sciences, Pondicherry University, 605 014, India
Reprod Toxicol 16:161-72. 2002
..In conclusion the adverse effect of methoxychlor on the male reproduction could be due to induction of oxidative stress...
- Bisphenol A induces reactive oxygen species generation in the liver of male rats
V Bindhumol
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Toxicology 188:117-24. 2003
..The results indicated that bisphenol A induces oxidative stress in the liver of rats by decreasing the antioxidant enzymes. Co-administration of vitamin C reversed the effects of bisphenol A-induced oxidative stress in the liver of rats...
- Induction of oxidative stress by bisphenol A in the epididymal sperm of rats
K C Chitra
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Toxicology 185:119-27. 2003
..In conclusion, the adverse effect of bisphenol A on male reproduction may be due to induction of oxidative stress in sperm...
- Effect of nonylphenol on the antioxidant system in epididymal sperm of rats
K C Chitra
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Arch Toxicol 76:545-51. 2002
..The results suggest that graded doses of nonylphenol elicit depletion of antioxidant defence system in sperm, indicating nonylphenol-induced oxidative stress in the epididymal sperm of rats...
Effect of restraint stress on 2,3,7,8 tetrachloro dibenzo-p-dioxin induced testicular and epididymal toxicity in ratsS Dhanabalan
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India
Hum Exp Toxicol 30:567-78. 2011
..Thus, restraint stress potentiates the adverse effects of TCDD on male reproductive organs...
- Effect of methoxychlor on the antioxidant system in mitochondrial and microsome-rich fractions of rat testis
C Latchoumycandane
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Toxicology 176:67-75. 2002
..In conclusion, the adverse effect of methoxychlor on male reproduction could be due to the induction of oxidative stress in testis...
- Vitamin E prevents nonylphenol-induced oxidative stress in testis of rats
K C Chitra
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Indian J Exp Biol 42:220-3. 2004
....
- Piperine activates testicular apoptosis in adult rats
Shereen Cynthia D'Cruz
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
J Biochem Mol Toxicol 22:382-8. 2008
..These observations indicate that piperine induces oxidative stress and thereby triggers apoptosis in the testis, contributing to hampered reproductive functions...
- Effect of experimental varicocele on structure and function of epididymis in adolescent rats: a histological and biochemical study
K C Chitra
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Asian J Androl 5:203-8. 2003
..Co-administration with vitamin C had a protective effect against the bisphenol A-induced toxicity in epididymal sperm and epididymis...
- Effects of vitamin E on reactive oxygen species-mediated 2,3,7,8-tetrachlorodi-benzo-p-dioxin toxicity in rat testis
C Latchoumycandane
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
J Appl Toxicol 22:345-51. 2002
..The results suggested that administration of TCDD induces oxidative stress in testis, and vitamin E could impart a protective effect against TCDD-induced oxidative stress...
- Effect of piperine on the epididymis of adult male rats
P P Mathur
School of Life Sciences, Pondicherry University, Pondicherry 605014, India
Asian J Androl 7:363-8. 2005
..CONCLUSION: Piperine caused a decrease in the activity of antioxidant enzymes and sialic acid levels in the epididymis and thereby increased reactive oxygen species levels that could damage the epididymal environment and sperm function...
- Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: an in vivo study
S Vaithinathan
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605014, India
Arch Toxicol 82:833-9. 2008
..The present study demonstrates transient effect of methoxychlor at LOAEL on testicular steroidogenesis and the possible role of hydrogen peroxide in mediating these effects...
- Effects of corticosterone and 2,3,7,8-tetrachloro- dibenzo-p-dioxin on epididymal antioxidant system in adult rats
S Dhanabalan
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
J Biochem Mol Toxicol 24:242-9. 2010
..Stress, characterized by increased glucocorticoid levels and activity, may enhance TCDD-induced epididymal toxicity...
- Induction of oxidative stress in the rat testis after short-term exposure to the organochlorine pesticide methoxychlor
C Latchoumycandane
School of Life Sciences, Pondicherry University, India
Arch Toxicol 76:692-8. 2002
..In conclusion, the adverse effect of methoxychlor on the male reproduction could be due to induction of oxidative stress in testis...
- 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) induces oxidative stress in the epididymis and epididymal sperm of adult rats
C Latchoumycandane
School of Life Sciences, Pondicherry University, 605 014, Pondicherry, India
Arch Toxicol 77:280-4. 2003
..Thus, the adverse effects of TCDD on the epididymal sperm were due to direct effect of TCDD on epididymis...
- Short-term exposure to nonylphenol induces pancreatic oxidative stress and alters liver glucose metabolism in adult female rats
R Jubendradass
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
J Biochem Mol Toxicol 25:77-83. 2011
..Western blot analysis revealed a significant decrease in the levels of GLUT-2. These results show that nonylphenol causes oxidative stress in pancreas and impairs liver glucose homeostasis...
- Methoxychlor induces apoptosis via mitochondria- and FasL-mediated pathways in adult rat testis
S Vaithinathan
Department of Biochemistry and Molecular Biology, Pondicherry University, India
Chem Biol Interact 185:110-8. 2010
..The study demonstrates induction of testicular apoptosis in adult rats following exposure to a single dose of methoxychlor...
- Methoxychlor-induced alteration in the levels of HSP70 and clusterin is accompanied with oxidative stress in adult rat testis
S Vaithinathan
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India
J Biochem Mol Toxicol 23:29-35. 2009
..The present data demonstrate methoxychlor-elicited increase in the levels of inducible HSP72 and sCLU, which could be a part of protective mechanism mounted to reduce cellular oxidative damage...
- Low dose of 2,3,7,8 tetrachlorodibenzo-p-dioxin induces testicular oxidative stress in adult rats under the influence of corticosterone
S Dhanabalan
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India
Exp Toxicol Pathol 61:415-23. 2009
..It is concluded that stress may enhance the effects of TCDD on the testis...
- Lindane induces testicular apoptosis in adult Wistar rats through the involvement of Fas-FasL and mitochondria-dependent pathways
B Saradha
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Toxicology 255:131-9. 2009
..Early activation of NF-kappaB in contrast to late increase in Fas expression suggests a pro-apoptotic role of NF-kappaB in testicular response to lindane...
- Lindane alters the levels of HSP70 and clusterin in adult rat testis
B Saradha
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Toxicology 243:116-23. 2008
..These findings indicate a transitory state of stress induced by lindane in rat testis accompanied by an alteration in the levels of stress proteins, which could be a part of protective mechanism mounted to reduce cellular damage...
- Antioxidative effect of fullerenol on goat epididymal spermatozoa
M Arul Murugan
School of Life Sciences, Pondicherry University, Pondicherry-605 014, India
Asian J Androl 4:149-52. 2002
..CONCLUSION: Fullerenol reduces iron-induced oxidative stress in epididymal sperm of goat by increasing the activities of antioxidant enzymes and decreasing lipid peroxidation...
- Single exposure to low dose of lindane causes transient decrease in testicular steroidogenesis in adult male Wistar rats
B Saradha
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Toxicology 244:190-7. 2008
..These findings demonstrate transient inhibitory effects of lindane on testicular steroidogenesis and the possible role of H2O2 in mediating these effects...
- Adjudin-mediated germ cell depletion alters the anti-oxidant status of adult rat testis
Oli Sarkar
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India
Mol Reprod Dev 76:31-7. 2009
..However, transient elevation in reactive oxygen species levels did not affect androgen transport...
- Long-term exposure to nonylphenol affects insulin signaling in the liver of adult male rats
R Jubendradass
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India
Hum Exp Toxicol 31:868-76. 2012
..These results suggest that NP downregulates insulin signaling in liver, which could be due to ROS production and oxidative damage...
- Nonylphenol induces apoptosis via mitochondria- and Fas-L-mediated pathways in the liver of adult male rat
R Jubendradass
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Regul Toxicol Pharmacol 62:405-11. 2012
..It is concluded that NP induces apoptosis in liver involving both mitochondria-dependent and Fas-Fas-l pathways and thereby, leading to hepatic damage in rats...
- Protein profiles in various epididymal segments of normal and castrated rats
P P Mathur
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Asian J Androl 2:57-64. 2000
..Epididymal proteins are known to play an important role in the maturation of spermatozoa. We ought to determine if there are regional differences in androgen-dependent epididymal proteins...
