Management of treatment-refractory panic disorderS J Mathew
Columbia University, College of Physicians and Surgeons, Department of Clinical Psychobiology, New York State Psychiatric Institute, Unit 84, 1051 Riverside Drive, New York, NY 10032, USA
Psychopharmacol Bull 35:97-110. 2001
..The role of CBT in the medication refractory patient has been explored, with preliminary suggestions of efficacy...
- Differentiating depressed adolescent 24 h cortisol secretion in light of their adult clinical outcome
Sanjay J Mathew
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, USA
Neuropsychopharmacology 28:1336-43. 2003
..Dysregulation of the HPA axis, combined with dysfunction of sleep-onset mechanisms previously reported in this same cohort, might serve as premorbid biological substrates that predict suicide attempts during follow-up...
- Neurobiological mechanisms of social anxiety disorder
S J Mathew
New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Am J Psychiatry 158:1558-67. 2001
..The authors critically surveyed several preclinical and clinical neurobiological models of social anxiety disorder...
- Neuroendocrine predictors of response to intravenous clomipramine therapy for refractory obsessive-compulsive disorder
S J Mathew
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Depress Anxiety 14:199-208. 2001
..The limitations of IV CMI as a specific probe of serotonin function are discussed...
- Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing
Sanjay J Mathew
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Stress 5:185-93. 2002
..Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation...
A pilot study of the effects of chronic paroxetine administration on hippocampal N-acetylaspartate in generalized anxiety disorderS J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Psychopharmacol 24:1175-81. 2010
..This pilot study failed to support an association between a hippocampal neuronal marker and anxiolytic response to paroxetine, and suggests further investigation of potential trait-like hippocampal abnormalities in GAD...
- Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand
Jeremy D Coplan
Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
CNS Spectr 10:530-6. 2005
..Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident...
- Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations
Jeremy D Coplan
State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Ann N Y Acad Sci 1071:525-33. 2006
..However, absolute cortisol change was greater in early versus late VFD. Timing of the VFD stressor differentially affects maternal neuroendocrine response, with potential implications for the offspring's developmental trajectory...
- A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors
Sanjay J Mathew
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Biol Psychiatry 54:727-35. 2003
..Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing...
- Molecular targets in the treatment of anxiety
Justine M Kent
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Biol Psychiatry 52:1008-30. 2002
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- Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disorders
Adriana Feder
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, USA
Biol Psychiatry 56:198-204. 2004
..These findings suggest subtle alterations in HPA axis function in prepubertal children with anxiety disorders...
- Neurobiology of anxiety disorders and implications for treatment
Amir Garakani
Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 73:941-9. 2006
..Combining these medication approaches with psychotherapies that promote extinction, such as cognitive behavioral therapy (CBT), may offer patients with anxiety disorders a rapid and robust treatment with good durability of effect...
- Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics
Sanjay J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place Box 1217, New York, NY 10029
Am J Med Genet C Semin Med Genet 148:89-98. 2008
..Each of these active areas of research holds promise for expanding and improving evidence-based treatment options for individuals suffering with clinical anxiety...
