Caloric restriction and aging: controversial issuesEdward J Masoro
Department of Physiology, University of Texas Health Science at San Antonio, TX, USA
J Gerontol A Biol Sci Med Sci 61:14-9. 2006
..These differences in mortality responses to food restriction provide a potentially powerful tool for uncovering basic mechanisms underlying its life-prolonging action. A hypothesis is presented for use in the search for these mechanisms...
- Caloric restriction and aging: an update
E J Masoro
Department of Physiology, University of Texas Health Science Center at San Antonio, 78284 7756, TX, USA
Exp Gerontol 35:299-305. 2000
..The evolution of the antiaging action of CR is also considered. Based on this consideration, a scenario unifying the above mechanisms is presented...
- Subfield history: caloric restriction, slowing aging, and extending life
Edward J Masoro
Department of Physiology at the University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Sci Aging Knowledge Environ 2003:RE2. 2003
..Caloric restriction has resulted in a consistent robust increase in the maximal length of life in mammalian species. This article reviews significant advances over the long history of research on calorie restriction and longevity...
- A forum for commentaries on recent publications. FIRKO mouse report: important new model--but questionable interpretation
Edward J Masoro
Department of Physiology, University of Texas Health Science Center, San Antonio, USA
J Gerontol A Biol Sci Med Sci 58:B871-2. 2003
- Overview of caloric restriction and ageing
Edward J Masoro
Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Mech Ageing Dev 126:913-22. 2005
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Caloric restriction-induced life extension of rats and mice: a critique of proposed mechanismsEdward J Masoro
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
Biochim Biophys Acta 1790:1040-8. 2009
..Based on currently available data, a provisional broad framework is presented depicting the complex of mechanisms that likely underlie the life-extending and other anti-aging actions of caloric restriction...
- The role of hormesis in life extension by dietary restriction
Edward J Masoro
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
Interdiscip Top Gerontol 35:1-17. 2007
..These findings suggest that hormesis plays a role in the life-extending and anti-aging actions of DR. The evidence for and against this possibility is considered, and it is concluded that hormesis does have an important role...
- Dietary restriction-induced life extension: a broadly based biological phenomenon
Edward J Masoro
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Biogerontology 7:153-5. 2006
..It is also concluded that given the currently available database, it is not possible to predict the quantitative effect of dietary restriction on the human life span...
- Role of sirtuin proteins in life extension by caloric restriction
Edward J Masoro
Department of Physiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio 78229 3900, USA
Mech Ageing Dev 125:591-4. 2004
..Further research is needed to firmly establish the role of sirtuin proteins in life extension by caloric restriction in mammals...
- Action of food restriction on age-related changes in adipocyte lipolysis
H A Bertrand
Department of Physiology, University of Texas Health Science Center at San Antonio
J Gerontol 42:666-73. 1987
..Phosphodiesterase activity is not influenced by diet, making it unlikely to be a postreceptor component lost with age...
- Senescent terminal weight loss in the male F344 rat
Bill J Black
Departments of Medicine, Pathology and Physiology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA
Am J Physiol Regul Integr Comp Physiol 284:R336-42. 2003
..The duration of the period of terminal weight loss was similar for the AL and DR groups. Apparently, restricting calories delays the occurrence but does not affect the duration of senescent terminal weight loss...
- Physiology of aging
E J Masoro
Aging Research and Education Center, Department of Physiology, University of Texas Health Science Center, San Antonio 78229-3900, USA
Int J Sport Nutr Exerc Metab 11:S218-22. 2001
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- Genetic mouse models of extended lifespan
Hanyu Liang
Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MSC 7762, San Antonio, TX 78229 3900, USA
Exp Gerontol 38:1353-64. 2003
..However, these mouse models are already providing new information about the mechanism underlying mammalian aging...
- Caloric intake versus temporal pattern of food intake
Edward J Masoro
Aging Clin Exp Res 16:423-4. 2004
- Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Edward J Calabrese
School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
Toxicol Appl Pharmacol 222:122-8. 2007
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