Mikhail Y Maslov

Summary

Publications

  1. doi request reprint Vascular Dilation, Tachycardia, and Increased Inotropy Occur Sequentially with Increasing Epinephrine Dose Rate, Plasma and Myocardial Concentrations, and cAMP
    Mikhail Y Maslov
    Tufts University School of Medicine, Department of Anesthesiology and Pain Medicine, Elizabeth s Medical Center, Boston, Massachusetts, 02135, USA Electronic address
    Heart Lung Circ 24:912-8. 2015
  2. pmc Myocardial drug distribution generated from local epicardial application: potential impact of cardiac capillary perfusion in a swine model using epinephrine
    Mikhail Y Maslov
    Department of Anesthesiology and Pain Medicine, Steward St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA Electronic address
    J Control Release 194:257-65. 2014
  3. pmc High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: an example with epicardial inotropic drug delivery
    Mikhail Y Maslov
    Tufts University School of Medicine, Department of Anesthesiology and Pain Medicine, Steward St Elizabeth s Medical Center, Boston, MA 02135, USA Electronic address
    J Control Release 171:201-7. 2013
  4. doi request reprint Inhaled Nitric Oxide Augments Left Ventricular Assist Device Capacity by Ameliorating Secondary Right Ventricular Failure
    Mark A Lovich
    From the Department of Anesthesiology, Pain Medicine, and Critical Care, Department of Surgery, Steward St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts GeNO LLC, Cocoa, Florida and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts
    ASAIO J 61:379-85. 2015
  5. doi request reprint Drug infusion system manifold dead-volume impacts the delivery response time to changes in infused medication doses in vitro and also in vivo in anesthetized swine
    Mark A Lovich
    From the Department of Anesthesiology, Critical Care and Pain Medicine, Steward St Elizabeth s Medical Center Harvard Medical School, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Steward St Elizabeth s Medical Center and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts
    Anesth Analg 117:1313-8. 2013
  6. doi request reprint Computer control of drug delivery by continuous intravenous infusion: bridging the gap between intended and actual drug delivery
    Michael J Parker
    From the Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts M J P Department of Anesthesiology and Pain Medicine, Steward St Elizabeth s Medical Center, Boston, Massachusetts M A L, A E W, M G W, M Y M Division of Pulmonology, Department of Medicine, Steward St Elizabeth s Medical Center, Boston, Massachusetts H T and Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts A C T, R A P
    Anesthesiology 122:647-58. 2015
  7. doi request reprint Infusion system carrier flow perturbations and dead-volume: large effects on drug delivery in vitro and hemodynamic responses in a swine model
    Mark A Lovich
    From the Department of Anesthesiology, Pain Medicine and Critical Care, Steward St Elizabeth s Medical Center, Boston, Massachusetts and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts
    Anesth Analg 120:1255-63. 2015
  8. pmc Use of pressure-volume conductance catheters in real-time cardiovascular experimentation
    Abraham E Wei
    Department of Anesthesiology and Pain Medicine, Steward St Elizabeth s Medical Center Tufts University School of Medicine, Boston, MA, 02135, USA
    Heart Lung Circ 23:1059-69. 2014
  9. pmc Local epicardial inotropic drug delivery allows targeted pharmacologic intervention with preservation of myocardial loading conditions
    Mark A Lovich
    Department of Anesthesiology and Pain Medicine, St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Pharm Sci 100:4993-5006. 2011
  10. doi request reprint Generation of purified nitric oxide from liquid N2O4 for the treatment of pulmonary hypertension in hypoxemic swine
    Mark A Lovich
    Department of Anesthesiology, Pain Medicine, and Critical Care, Steward St Elizabeth s Medical Center, Boston, MA, United States Electronic address
    Nitric Oxide 37:66-72. 2014

Collaborators

Detail Information

Publications10

  1. doi request reprint Vascular Dilation, Tachycardia, and Increased Inotropy Occur Sequentially with Increasing Epinephrine Dose Rate, Plasma and Myocardial Concentrations, and cAMP
    Mikhail Y Maslov
    Tufts University School of Medicine, Department of Anesthesiology and Pain Medicine, Elizabeth s Medical Center, Boston, Massachusetts, 02135, USA Electronic address
    Heart Lung Circ 24:912-8. 2015
    ..We hypothesised that surrogate measurements, such as heart rate and vascular tone, may indicate if the plasma and tissue concentrations of epinephrine and cAMP are in a range sufficient to increase myocardial contractility...
  2. pmc Myocardial drug distribution generated from local epicardial application: potential impact of cardiac capillary perfusion in a swine model using epinephrine
    Mikhail Y Maslov
    Department of Anesthesiology and Pain Medicine, Steward St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA Electronic address
    J Control Release 194:257-65. 2014
    ....
  3. pmc High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: an example with epicardial inotropic drug delivery
    Mikhail Y Maslov
    Tufts University School of Medicine, Department of Anesthesiology and Pain Medicine, Steward St Elizabeth s Medical Center, Boston, MA 02135, USA Electronic address
    J Control Release 171:201-7. 2013
    ..Local epicardial inotropic delivery illustrates then a paradigm of how target tissues differentially handle and utilize drug compared to systemic infusion...
  4. doi request reprint Inhaled Nitric Oxide Augments Left Ventricular Assist Device Capacity by Ameliorating Secondary Right Ventricular Failure
    Mark A Lovich
    From the Department of Anesthesiology, Pain Medicine, and Critical Care, Department of Surgery, Steward St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts GeNO LLC, Cocoa, Florida and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts
    ASAIO J 61:379-85. 2015
    ..Inhaled NO may thus have broad utility for the management of biventricular disease managed by LVAD implantation through the effects of NO on LV and RV wall dynamics. ..
  5. doi request reprint Drug infusion system manifold dead-volume impacts the delivery response time to changes in infused medication doses in vitro and also in vivo in anesthetized swine
    Mark A Lovich
    From the Department of Anesthesiology, Critical Care and Pain Medicine, Steward St Elizabeth s Medical Center Harvard Medical School, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Steward St Elizabeth s Medical Center and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts
    Anesth Analg 117:1313-8. 2013
    ..We hypothesized that the time course of physiological responses to drug infusion in vivo reflects the impact of dead-volume on drug delivery...
  6. doi request reprint Computer control of drug delivery by continuous intravenous infusion: bridging the gap between intended and actual drug delivery
    Michael J Parker
    From the Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts M J P Department of Anesthesiology and Pain Medicine, Steward St Elizabeth s Medical Center, Boston, Massachusetts M A L, A E W, M G W, M Y M Division of Pulmonology, Department of Medicine, Steward St Elizabeth s Medical Center, Boston, Massachusetts H T and Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts A C T, R A P
    Anesthesiology 122:647-58. 2015
    ..This study evaluated computer algorithms for reducing temporal lags via coordinated control of drug and carrier flows...
  7. doi request reprint Infusion system carrier flow perturbations and dead-volume: large effects on drug delivery in vitro and hemodynamic responses in a swine model
    Mark A Lovich
    From the Department of Anesthesiology, Pain Medicine and Critical Care, Steward St Elizabeth s Medical Center, Boston, Massachusetts and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts
    Anesth Analg 120:1255-63. 2015
    ..In this study, we tested whether clinically relevant alterations in carrier flow generate perturbations in drug delivery and pharmacodynamic effect, and how these might be magnified when V is large...
  8. pmc Use of pressure-volume conductance catheters in real-time cardiovascular experimentation
    Abraham E Wei
    Department of Anesthesiology and Pain Medicine, Steward St Elizabeth s Medical Center Tufts University School of Medicine, Boston, MA, 02135, USA
    Heart Lung Circ 23:1059-69. 2014
    ..Use of these catheters as a continuous monitor, however, is fraught with complexities and limitations...
  9. pmc Local epicardial inotropic drug delivery allows targeted pharmacologic intervention with preservation of myocardial loading conditions
    Mark A Lovich
    Department of Anesthesiology and Pain Medicine, St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Pharm Sci 100:4993-5006. 2011
    ..These studies demonstrate a pharmacologic paradigm that may improve heart function without interference from effects on the vasculature, alterations in heart loading, and may ultimately improve the health of heart failure patients...
  10. doi request reprint Generation of purified nitric oxide from liquid N2O4 for the treatment of pulmonary hypertension in hypoxemic swine
    Mark A Lovich
    Department of Anesthesiology, Pain Medicine, and Critical Care, Steward St Elizabeth s Medical Center, Boston, MA, United States Electronic address
    Nitric Oxide 37:66-72. 2014
    ....