J R Mascola

Summary

Publications

  1. pmc Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    J R Mascola
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Virol 73:4009-18. 1999
  2. pmc Antibodies with specificity to native gp120 and neutralization activity against primary human immunodeficiency virus type 1 isolates elicited by immunization with oligomeric gp160
    T C Vancott
    Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Virol 71:4319-30. 1997
  3. pmc Potent and synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12
    J R Mascola
    Walter Reed Army Institute of Research and Department of Infectious Diseases, Naval Medical Research Institute, Rockville, Maryland 20850, USA
    J Virol 71:7198-206. 1997
  4. ncbi request reprint Correlation between humoral responses to human immunodeficiency virus type 1 envelope and disease progression in early-stage infection
    L D Loomis-Price
    H M Jackson Foundation, Walter Reed Army Institute of Research, Rockville, MD, USA
    J Infect Dis 178:1306-16. 1998
  5. pmc Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to T cells
    S S Frankel
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, USA
    J Virol 72:9788-94. 1998
  6. ncbi request reprint HIV-1 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with oligomeric gp160
    T C Vancott
    Henry M Jackson Foundation, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Immunol 160:2000-12. 1998
  7. pmc Cross-subtype neutralizing antibodies induced in baboons by a subtype E gp120 immunogen based on an R5 primary human immunodeficiency virus type 1 envelope
    T C Vancott
    Henry M Jackson Foundation, Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    J Virol 73:4640-50. 1999
  8. pmc Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolates of diverse subtypes
    N L Michael
    Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    J Clin Microbiol 37:2557-63. 1999
  9. ncbi request reprint Selective increases in HIV-specific neutralizing antibody and partial reconstitution of cellular immune responses during prolonged, successful drug therapy of HIV infection
    J H Kim
    Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 17:1021-34. 2001

Detail Information

Publications9

  1. pmc Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    J R Mascola
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Virol 73:4009-18. 1999
    ..These data indicate a general correlation between in vitro neutralization and protection and suggest that a vaccine that elicits neutralizing antibody should have a protective effect against HIV-1 infection or disease...
  2. pmc Antibodies with specificity to native gp120 and neutralization activity against primary human immunodeficiency virus type 1 isolates elicited by immunization with oligomeric gp160
    T C Vancott
    Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Virol 71:4319-30. 1997
    ..These studies demonstrate the capacity of a soluble HIV-1 envelope glycoprotein vaccine to elicit an antibody response capable of neutralizing primary HIV-1 isolates...
  3. pmc Potent and synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12
    J R Mascola
    Walter Reed Army Institute of Research and Department of Infectious Diseases, Naval Medical Research Institute, Rockville, Maryland 20850, USA
    J Virol 71:7198-206. 1997
    ..Passive immunotherapy for treatment or prophylaxis of HIV-1 should consider mixtures of potent neutralizing antibody reagents to expand the magnitude and breadth of virus neutralization...
  4. ncbi request reprint Correlation between humoral responses to human immunodeficiency virus type 1 envelope and disease progression in early-stage infection
    L D Loomis-Price
    H M Jackson Foundation, Walter Reed Army Institute of Research, Rockville, MD, USA
    J Infect Dis 178:1306-16. 1998
    ..While antibody-dependent cellular cytotoxicity against gp120 did not strongly differentiate the groups, slow progressors showed a broader neutralization pattern against 5 primary virus isolates...
  5. pmc Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to T cells
    S S Frankel
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, USA
    J Virol 72:9788-94. 1998
    ..These data suggest that neutralizing antibodies could interrupt the initial events associated with mucosal transmission and regional spread of HIV-1...
  6. ncbi request reprint HIV-1 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with oligomeric gp160
    T C Vancott
    Henry M Jackson Foundation, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Immunol 160:2000-12. 1998
    ..These data demonstrate the feasibility of inducing both systemic and mucosal HIV-1-neutralizing Ab by intranasal immunization with an oligomeric gp160 protein...
  7. pmc Cross-subtype neutralizing antibodies induced in baboons by a subtype E gp120 immunogen based on an R5 primary human immunodeficiency virus type 1 envelope
    T C Vancott
    Henry M Jackson Foundation, Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    J Virol 73:4640-50. 1999
    ..These data demonstrate that strain and/or phenotypic differences of HIV-1 subunit gp120 immunogens can substantially alter antibody binding specificities and subsequent HIV-1 neutralizing capacity...
  8. pmc Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolates of diverse subtypes
    N L Michael
    Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    J Clin Microbiol 37:2557-63. 1999
    ....
  9. ncbi request reprint Selective increases in HIV-specific neutralizing antibody and partial reconstitution of cellular immune responses during prolonged, successful drug therapy of HIV infection
    J H Kim
    Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 17:1021-34. 2001
    ..In the setting of stable anti-HIV Ab levels, the development of increased NAb in certain individuals suggests that control of the virus by HAART may assist in immune control of HIV...