E R Martin

Summary

Publications

  1. pmc SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
    E R Martin
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, 27710, USA duke edu
    Am J Hum Genet 67:383-94. 2000
  2. ncbi request reprint An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder
    A E Ashley-Koch
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Ann Hum Genet 70:281-92. 2006
  3. pmc Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism
    D Q Ma
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 77:377-88. 2005
  4. ncbi request reprint Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease
    P I Lin
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 67:64-8. 2006
  5. ncbi request reprint Apolipoprotein E controls the risk and age at onset of Parkinson disease
    Y J Li
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 62:2005-9. 2004
  6. ncbi request reprint Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
    E R Martin
    Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2245-50. 2001
  7. ncbi request reprint Lack of association between UBQLN1 and Alzheimer disease
    M A Slifer
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 141:208-13. 2006
  8. ncbi request reprint Life after the screen: making sense of many P-values
    S Schmidt
    Center for Human Genetics, Duke University Medical Center, Box 3468, Durham, North Carolina 27710, USA
    Genet Epidemiol 21:S546-51. 2001
  9. pmc A test for linkage and association in general pedigrees: the pedigree disequilibrium test
    E R Martin
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 67:146-54. 2000
  10. ncbi request reprint Analysis of association at single nucleotide polymorphisms in the APOE region
    E R Martin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 63:7-12. 2000

Collaborators

Detail Information

Publications20

  1. pmc SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
    E R Martin
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, 27710, USA duke edu
    Am J Hum Genet 67:383-94. 2000
    ....
  2. ncbi request reprint An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder
    A E Ashley-Koch
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Ann Hum Genet 70:281-92. 2006
    ..However, the consistency of results across analyses suggests that we have defined a useful framework for evaluating gene-gene interactions...
  3. pmc Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism
    D Q Ma
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 77:377-88. 2005
    ..These results support the hypothesis that GABA receptor subunit genes are involved in autism, most likely via complex gene-gene interactions...
  4. ncbi request reprint Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease
    P I Lin
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 67:64-8. 2006
    ..A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD...
  5. ncbi request reprint Apolipoprotein E controls the risk and age at onset of Parkinson disease
    Y J Li
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 62:2005-9. 2004
    ..Most previous studies seeking to establish such a link used case-control datasets and results have been inconsistent...
  6. ncbi request reprint Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
    E R Martin
    Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2245-50. 2001
    ..001) was detected between 4 of the 5 SNPs (SNPs 3, 9i, 9ii, and 11). CONCLUSIONS: This integrated approach of genetic linkage and positional association analyses implicates tau as a susceptibility gene for idiopathic PD...
  7. ncbi request reprint Lack of association between UBQLN1 and Alzheimer disease
    M A Slifer
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 141:208-13. 2006
    ..Our results suggest that UBQLN1 variants do not increase risk for AD in these data...
  8. ncbi request reprint Life after the screen: making sense of many P-values
    S Schmidt
    Center for Human Genetics, Duke University Medical Center, Box 3468, Durham, North Carolina 27710, USA
    Genet Epidemiol 21:S546-51. 2001
    ..Genet Epidemiol, in press]. It appears that this approach is helpful for visualizing priority regions for follow-up analysis and reducing the number of false-positive linkage signals...
  9. pmc A test for linkage and association in general pedigrees: the pedigree disequilibrium test
    E R Martin
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 67:146-54. 2000
    ..Thus, the PDT provides a general test of linkage disequilibrium that can be widely applied to different data structures...
  10. ncbi request reprint Analysis of association at single nucleotide polymorphisms in the APOE region
    E R Martin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 63:7-12. 2000
    ..Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE...
  11. ncbi request reprint Analysis of the RELN gene as a genetic risk factor for autism
    D A Skaar
    Department of Medicine, Center for Human Genetics, IGSP, Duke University Medical Center, Durham, NC, USA
    Mol Psychiatry 10:563-71. 2005
    ..The most significant association identified from this combined data set was for the 5'-UTR repeat (PDT P-value=0.002). These analyses show the potential of RELN as an important contributor to genetic risk in autism...
  12. ncbi request reprint A novel method to identify gene-gene effects in nuclear families: the MDR-PDT
    E R Martin
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, DUMC 3445, Durham, NC 27710, USA
    Genet Epidemiol 30:111-23. 2006
    ..These results show the utility of the MDR-PDT for understanding the genetics of complex diseases...
  13. ncbi request reprint Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease
    J M van der Walt
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 60:1189-91. 2003
    ..The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals)...
  14. ncbi request reprint Analysis of linkage disequilibrium in gamma-aminobutyric acid receptor subunit genes in autistic disorder
    E R Martin
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet 96:43-8. 2000
    ..This finding lends support for previous reports implicating the involvement of genes in this region with AD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:43-48, 2000..
  15. pmc Power calculations for likelihood ratio tests for offspring genotype risks, maternal effects, and parent-of-origin (POO) effects in the presence of missing parental genotypes when unaffected siblings are available
    E Rampersaud
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genet Epidemiol 31:18-30. 2007
    ....
  16. ncbi request reprint No association between the APOE gene and autism
    K L Raiford
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 125:57-60. 2004
    ....
  17. ncbi request reprint Genotype-based association test for general pedigrees: the genotype-PDT
    E R Martin
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genet Epidemiol 25:203-13. 2003
    ....
  18. ncbi request reprint Linkage and association analysis of chromosome 19q13 in multiple sclerosis
    M A Pericak-Vance
    Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Neurogenetics 3:195-201. 2001
    ..While consistent, this effect appears to be modest with a maximum lambda(s) = 1.47, probably representing no more than 10% of the overall genetic effect in MS...
  19. ncbi request reprint A Monte Carlo procedure for two-stage tests with correlated data
    E R Martin
    Section of Medical Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Genet Epidemiol 18:48-62. 2000
    ..We also discuss the use of a two-stage procedure when doing a genome scan for the data presented in the Genetic Analysis Workshop 9 study...
  20. ncbi request reprint Articular hypermobility is a protective factor for hand osteoarthritis
    V B Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 50:2178-83. 2004
    ..Very few studies have evaluated the association of articular hypermobility and radiographic osteoarthritis (OA) in humans. We assessed hypermobility and its relationship to radiographic hand OA in a family-based study...