Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumoniaI Martin-Loeches
Critical Care Center, ParcTaulí Hospital Sabadell, CibeRes, ParcTauli s n, 08208, Sabadell, Spain
Intensive Care Med 39:693-702. 2013
..To determine whether macrolide-based treatment is associated with mortality in critically ill H1N1 patients with primary viral pneumonia...
- Effectiveness of an inspiratory pressure-limited approach to mechanical ventilation in septic patients
Ignacio Martin-Loeches
Critical Care Centre, Corporación Sanitaria Universitaria Parc Tauli, Sabadell University Hospital, Universidad Autonoma de Barcelona, CIBER Enfermedades Respiratorias, Sabadell, Spain
Eur Respir J 41:157-64. 2013
..84, 95% CI 0.72-0.99; p=0.038). ALI in sepsis was associated with higher mortality, especially when an inspiratory pressure-limited mechanical ventilation approach was not implemented...
- Intubated patients developing tracheobronchitis or pneumonia have distinctive complement system gene expression signatures in the pre-infection period: a pilot study
I Martin-Loeches
Critical Care Centre, Corporació Sanitaria Parc Taulí Hospital de Sabadell CIBERES, Sabadell, Spain
Med Intensiva 36:257-63. 2012
..It remains unknown why some intubated patients remain infection-free while others develop tracheobronchitis (VAT) or pneumonia (VAP)...
Pandemic and post-pandemic influenza A (H1N1) infection in critically ill patientsIgnacio Martin-Loeches
Critical Care Center, Parc Taulí Hospital Sabadell, CibeRes, Sabadell, Spain
Crit Care 15:R286. 2011
..There is a vast amount of information published regarding the impact of 2009 pandemic Influenza A (pH1N1) virus infection. However, a comparison of risk factors and outcome during the 2010-2011 post-pandemic period has not been described...
- Community-acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A(H1N1) virus
Ignacio Martin-Loeches
Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, CibeRes, Mallafre Guasch 4, 43007 Tarragona, Spain
Chest 139:555-62. 2011
..Little is known about the impact of community-acquired respiratory coinfection in patients with pandemic 2009 influenza A(H1N1) virus infection...
- Severe pandemic (H1N1)v influenza A infection: report on the first deaths in Spain
Ignacio Martin-Loeches
Critical Care Department, Joan XXIII University Hospital, Spain
Respirology 16:78-85. 2011
..The impact of pandemic influenza A (H1N1)v infection is still unknown but it is associated with a high case-fatality rate...
- Acute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection
Ignacio Martin-Loeches
Critical Care Department, Joan XXIII University Hospital CIBER Enfermedades Respiratorias, URV, and IISPV, Mallafre i Guasch, ES 43007 Tarragona, Spain
Crit Care 15:R66. 2011
..Little information exists about the impact of acute kidney injury (AKI) in critically ill patients with the pandemic 2009 influenza A (H1N1) virus infection...
- Host adaptive immunity deficiency in severe pandemic influenza
Jesus F Bermejo-Martin
Infection and Immunity Unit, Hospital Clínico Universitario IECSCYL, Avda, Ramon y Cajal 3, 47005 Valladolid, Spain
Crit Care 14:R167. 2010
..Pandemic A/H1N1/2009 influenza causes severe lower respiratory complications in rare cases. The association between host immune responses and clinical outcome in severe cases is unknown...
- Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
Jesus F Bermejo-Martin
National Centre of Influenza, Hospital Clinico Universitario de Valladolid, Valladolid, Spain
Crit Care 13:R201. 2009
..We utilize here systemic cytokine and antibody levels in evaluating differences in early immune response in both mild and severe patients infected with nvH1N1...
- Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza
Raquel Almansa
Infection and Immunity Medical Investigation Unit IMI, Hospital Clínico Universitario IECSCYL, Avda Ramón, y Cajal 3, 47005 Valladolid, Spain
BMC Infect Dis 11:232. 2011
..The objective of the present study was to evaluate the relationship between host cytokine responses and viral levels in pandemic influenza critically ill patients...
- Impact of obesity in patients infected with 2009 influenza A(H1N1)
Emili Diaz
Critical Care Department, Hospital Universitario Joan XXIII CIBER Enfermedades Respiratorias, URV, and IISPV, Carrer Dr, Mallafre Guasch 4, 43007 Tarragona, Spain
Chest 139:382-6. 2011
..However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality...
- Mortality and regional oxygen saturation index in septic shock patients: a pilot study
Alejandro Rodriguez
Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias, Tarragona, Spain
J Trauma 70:1145-52. 2011
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- Corticosteroid therapy in patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza
Emili Diaz
Critical Care Department, Hospital Sant Joan Despí Moisès Broggi, Jacint Verdaguer, 90, 08970 Sant Joan Despí, Barcelona, CibeRes, IISPV, Spain
J Infect 64:311-8. 2012
..The objective of this study was to assess the effect on survival of corticosteroid therapy in patients with pandemic (H1N1) 2009 influenza...
- Bacteremia is an independent risk factor for mortality in nosocomial pneumonia: a prospective and observational multicenter study
Monica Magret
Critical Care Department, Vall d Hebron University Hospital, CibeRes, VHIR, Universitat Autonoma de Barcelona, Vall d Hebron St, Barcelona 08035, Spain
Crit Care 15:R62. 2011
..The purpose of the study is to compare risk factors, pathogens and outcomes between bacteremic nosocomial pneumonia (B-NP) and nonbacteremic nosocomial pneumonia (NB-NP) episodes...
- Evolution over a 15-year period of clinical characteristics and outcomes of critically ill patients with community-acquired bacteremia
Jordi Valles
Critical Care Center, Parc Taulí Hospital Sabadell, UAB, CIBER Enfermedades Respiratorias, Sabadell, Spain
Crit Care Med 41:76-83. 2013
..We aimed to analyze the changes in the prevalence, characteristics, and outcome of critically ill patients with community-acquired bacteremia over the past 15 yrs...
- Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection
I Martin-Loeches
Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias CIBERES, Tarragona, Spain
Intensive Care Med 37:272-83. 2011
..Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial...
- Variants at the promoter of the interleukin-6 gene are associated with severity and outcome of pneumococcal community-acquired pneumonia
Ignacio Martin-Loeches
Critical Care Centre, Corporació Sanitaria Parc Tauli University Hospital Sabadell, Sabadell, Spain
Intensive Care Med 38:256-62. 2012
..We studied the genetic variability at IL6 in patients with community-acquired pneumonia (CAP) and pneumococcal CAP (P-CAP)...
- Mortality in ICU patients with bacterial community-acquired pneumonia: when antibiotics are not enough
Alejandro Rodriguez
Critical Care Department, Pere Virgili Health Institut and CIBER Enfermedades Respiratorias, Joan XXIII University Hospital, Tarragona, Spain
Intensive Care Med 35:430-8. 2009
..It remains uncertain why immunocompetent patients with bacterial community-acquired pneumonia (CAP) die, in spite of adequate antibiotics...
- Ventilator-associated pneumonia in trauma patients is associated with lower mortality: results from EU-VAP study
M Magret
Critical Care Department, Sant Joan University Hospital, Reus, Spain
J Trauma 69:849-54. 2010
..Differences in trauma patients developing ventilator-associated pneumonia (VAP) are described regarding etiology and risk factors associated. We aim to describe the differences in outcomes in trauma and nontrauma patients with VAP...
- Potentially resistant microorganisms in intubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors
Ignacio Martin-Loeches
Critical Care Centre, Coporació Sanitaria Parc Tauli, Sabadell, Spain
Intensive Care Med 39:672-81. 2013
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