Interventions to prevent sexually transmitted infections, including HIV infectionJeanne M Marrazzo
Department of Medicine, Division of Allergy and Infectious Diseases, University of Seattle, WA 98104, USA
Clin Infect Dis 53:S64-78. 2011
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- Extravaginal reservoirs of vaginal bacteria as risk factors for incident bacterial vaginosis
Jeanne M Marrazzo
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, WA, USA
J Infect Dis 205:1580-8. 2012
..to diverse anaerobes. Although antibiotics relieve symptoms and temporarily eradicate BV-associated bacteria (BVAB), BV usually recurs. We investigated the role of extravaginal BVAB reservoirs in recurrence...
- Bacterial vaginosis: identifying research gaps proceedings of a workshop sponsored by DHHS/NIH/NIAID
Jeanne M Marrazzo
University of Washington, Seattle, WA, USA
Sex Transm Dis 37:732-44. 2010
..In this report, we offer suggestions and recommendations that we hope will facilitate conduct of consistent approaches to collaborative efforts towards advancing our understanding of the vaginal microbiota and its impact on human health...
- A behavioural intervention to reduce persistence of bacterial vaginosis among women who report sex with women: results of a randomised trial
Jeanne M Marrazzo
Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
Sex Transm Infect 87:399-405. 2011
..Risks include sexual behaviours that transmit vaginal fluid. The authors measured efficacy of a behavioural intervention to reduce sexual transfer of vaginal fluid between female sex partners in reducing BV persistence...
- Interpreting the epidemiology and natural history of bacterial vaginosis: are we still confused?
Jeanne M Marrazzo
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98104, United States
Anaerobe 17:186-90. 2011
..This review provides background on BV, and discusses the epidemiologic and microbiologic data to support a role for acquisition of BVAB and how this process might differ among subsets of women...
- Risks for acquisition of bacterial vaginosis among women who report sex with women: a cohort study
Jeanne M Marrazzo
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e11139. 2010
..Bacterial vaginosis (BV) is common in women who have sex with women. While cross-sectional data support a role for sexual transmission, risks for incident BV have not been prospectively studied in this group...
- Relationship of specific vaginal bacteria and bacterial vaginosis treatment failure in women who have sex with women
Jeanne M Marrazzo
University of Washington and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Ann Intern Med 149:20-8. 2008
..Bacterial vaginosis frequently persists after treatment. The role of newly defined bacterial vaginosis-associated bacteria (BVAB), which have a specificity for this condition of 97% or greater, has not been assessed...
- Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis
Sujatha Srinivasan
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 5:e10197. 2010
..This study used PCR to assess the variability in concentrations of key vaginal bacteria in healthy women and the immediate response to antibiotic treatment in women with bacterial vaginosis (BV)...
- Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR
David N Fredricks
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Clin Microbiol 47:721-6. 2009
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Risk factors for cervicitis among women with bacterial vaginosisJeanne M Marrazzo
Department of Medicine, University of Washington, Seattle 98104, and Department of Pediatrics, Children s Hospital of Pittsburgh, PA, USA
J Infect Dis 193:617-24. 2006
..Cervicitis commonly occurs in women with bacterial vaginosis (BV), often without concomitant chlamydial or gonococcal infection. The risk factors for cervicitis have not been described...
- Effect of sexual activity on vaginal colonization with hydrogen peroxide-producing lactobacilli and Gardnerella vaginalis
Caroline Mitchell
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
Sex Transm Dis 38:1137-44. 2011
..Bacterial vaginosis is associated with sexual activity, but mechanisms for this association are unclear...
- Prevalence and risks for bacterial vaginosis in women who have sex with women
Jeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, USA
Sex Transm Dis 37:335-9. 2010
..Bacterial vaginosis (BV) is a common cause of vaginitis and, for unknown reasons, is common in lesbian and bisexual women. We defined risks for prevalent BV in lesbian and bisexual women with attention to detailed sexual risk history...
Acceptability of urine-based screening for Chlamydia trachomatis in asymptomatic young men: a systematic reviewJeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, Washington, USA
Sex Transm Dis 35:S28-33. 2008
..Interventions to enhance uptake of testing in asymptomatic men should be developed and selected with underlying C. trachomatis population prevalence in mind...
- Distribution of genital Lactobacillus strains shared by female sex partners
Jeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, Washington, USA
J Infect Dis 199:680-3. 2009
..04) and increased bacterial vaginosis risk (odds ratio, 4.2; 95% confidence interval, 1.4-13.4). Of 31 couples monogamous for >3 months, rep-PCR fingerprints were identical in both members in 23 (77%)...
- Women's satisfaction with an intravaginal Lactobacillus capsule for the treatment of bacterial vaginosis
Jeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, Washington, USA
J Womens Health (Larchmt) 15:1053-60. 2006
..To assess women's satisfaction with a vaginal capsule containing human-derived, H(2)O(2)-producing Lactobacillus crispatus at completion of a randomized, placebo-controlled study for treatment of bacterial vaginosis (BV)...
- Diversity of human vaginal bacterial communities and associations with clinically defined bacterial vaginosis
Brian B Oakley
Program in Infectious Diseases, D3 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109 1024, USA
Appl Environ Microbiol 74:4898-909. 2008
..The human vagina hosts many bacteria that are only distantly related to known species, and subjects with BV harbor particularly taxon-rich and diverse bacterial communities...
- Impact of patient characteristics on performance of nucleic acid amplification tests and DNA probe for detection of Chlamydia trachomatis in women with genital infections
Jeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, WA, USA
J Clin Microbiol 43:577-84. 2005
..These findings support expanded use of NAAT for screening and diagnosis of C. trachomatis in diverse clinical populations of women...
- Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria
Sujatha Srinivasan
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 7:e37818. 2012
..We investigated the associations between the presence of individual bacterial species and clinical diagnostic characteristics of BV...
- Characterization of vaginal flora and bacterial vaginosis in women who have sex with women
Jeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Infect Dis 185:1307-13. 2002
..These data support the hypothesis that sexual exchange of vaginal secretions is a possible mechanism for acquisition of BV...
- Targeted PCR for detection of vaginal bacteria associated with bacterial vaginosis
David N Fredricks
Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North, D3 100, Box 19024, Seattle, WA 98109 1024, USA
J Clin Microbiol 45:3270-6. 2007
..PCR detection of one or more fastidious bacterial species is a more reliable indicator of BV than detection of bacteria, such as Gardnerella vaginalis, previously linked to BV, highlighting the potential of PCR for the diagnosis of BV...
- Chlamydia trachomatis infection among women reporting sexual activity with women screened in Family Planning Clinics in the Pacific Northwest, 1997 to 2005
Devika Singh
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle WA 98104, USA
Am J Public Health 101:1284-90. 2011
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- Molecular identification of bacteria associated with bacterial vaginosis
David N Fredricks
Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
N Engl J Med 353:1899-911. 2005
..The cause of bacterial vaginosis remains poorly understood despite numerous studies based on cultures. Bacteria in microbial communities can be identified without cultivation by characterizing their ribosomal DNA (rDNA) sequences...
- Population-based outreach for Chlamydia screening in men: results from a randomized trial
Delia Scholes
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
Sex Transm Dis 34:837-9. 2007
..To evaluate the feasibility and efficacy of population-based outreach strategies to improve genital Chlamydia trachomatis (CT) screening in men...
- Sexual practices, risk perception and knowledge of sexually transmitted disease risk among lesbian and bisexual women
Jeanne M Marrazzo
Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA
Perspect Sex Reprod Health 37:6-12. 2005
..However, few data on sexual practices or perceived STD risk among lesbians are available to guide development of interventions aimed at reducing the risk...
- Reproductive health history of lesbians: implications for care
Jeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, Washngton, USA
Am J Obstet Gynecol 190:1298-304. 2004
..We report lifetime pregnancy-related outcomes and hormonal contraception for 392 women who reported sexual activity with another woman in the preceding year...
- Chlamydial infections among female adolescents screened in juvenile detention centers in Washington State, 1998-2002
Kathryn H Lofy
Washington State Department of Health, Washington, USA
Sex Transm Dis 33:63-7. 2006
..87, 95% CI = 1.45-2.40). CONCLUSIONS: Efforts are needed to promote chlamydia screening programs in juvenile detention centers because these sites have access to high-risk sexually active female adolescents...
- Mucopurulent cervicitis: no longer ignored, but still misunderstood
Jeanne M Marrazzo
Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98104, USA
Infect Dis Clin North Am 19:333-49, viii. 2005
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- Chlamydia trachomatis infection in asymptomatic men
D Scott LaMontagne
Center for Health Training, Seattle, Washington 98144, USA
Am J Prev Med 24:36-42. 2003
..Established C. trachomatis screening programs for women have demonstrated the benefit of routine screening in reducing prevalence over time, but the yield and benefit of screening asymptomatic men are unclear...
- Management of women with cervicitis
Jeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Clin Infect Dis 44:S102-10. 2007
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- Acceptability of urine-based screening for Chlamydia trachomatis to asymptomatic young men and their providers
Jeanne M Marrazzo
Department of Medicine, Division of Infectious Diseases, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
Sex Transm Dis 34:147-53. 2007
..The objective of this study was to describe acceptability of urine chlamydia testing among asymptomatic men and providers' attitudes toward testing...
- Selective testing criteria for gonorrhea among young women screened for Chlamydial infection: contribution of race and geographic prevalence
Lisa E Manhart
Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
J Infect Dis 196:731-7. 2007
..Selective screening criteria have been widely implemented for genital Chlamydia trachomatis (CT) infections but have rarely been developed for Neisseria gonorrhoeae (GC) infection...
- Evolving issues in understanding and treating bacterial vaginosis
Jeanne M Marrazzo
University of Washington, Department of Medicine, Harborview Medical Center, Division of Allergy and Infectious Diseases, 325 Ninth Avenue, Mailbox 359931, Seattle, WA 98104, USA
Expert Rev Anti Infect Ther 2:913-22. 2004
..For these reasons, innovative approaches to therapy are urgently required...
- Superficial hepatic capsular lesions in a systemically ill young woman
Lindy S Klaff
Department of Medicine, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
Sex Transm Dis 34:139-40. 2007
- Prevalence and risk factors for infection with herpes simplex virus type-1 and -2 among lesbians
Jeanne M Marrazzo
Department of Medicine, University of Washington, Seattle, Washington, USA
Sex Transm Dis 30:890-5. 2003
..Sexual transmission of bacterial and viral sexually transmitted disease has been reported between women. No data are available on seroprevalence of herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) among lesbians...
- The clinical and economic consequences of screening young men for genital chlamydial infection
Rachel H S Ginocchio
Department of Health Services, Maternal and Child Health, University of Washington, Seattle, Washington 98104, USA
Sex Transm Dis 30:99-106. 2003
..CONCLUSION: At a chlamydia prevalence of 5%, LE-LCR is the most efficient use of resources. If LCR cost decreases or chlamydia prevalence increases, the LCR strategy is favored...
- Predicting chlamydial and gonococcal cervical infection: implications for management of cervicitis
Jeanne M Marrazzo
Department of Medicine, University of Washington School of Medicine, Seattle, USA
Obstet Gynecol 100:579-84. 2002
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- Barriers to infectious disease care among lesbians
Jeanne M Marrazzo
University of Washington, Seattle, Washington, USA
Emerg Infect Dis 10:1974-8. 2004
..Education of lesbians and their care providers should counter assumptions that sex between women confers no risk for transmission of sexually transmitted infections, and lesbians should receive Pap smears according to current guidelines...
- Sexual tourism: implications for travelers and the destination culture
Jeanne M Marrazzo
Division of Allergy and Infectious Diseases, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
Infect Dis Clin North Am 19:103-20. 2005
..Most of the relevant diagnostic tests are relatively affordable, and patient-centered risk-reduction counseling, once mastered, can be brief and easily integrated into the overall conversation about protecting oneself during travel...
