Fluoride and organic weak acids as modulators of microbial physiologyRobert E Marquis
Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642 8672, USA
FEMS Microbiol Rev 26:493-510. 2003
..Hopefully, this review will stimulate interest in the antimicrobial effects of fluoride or other weak acids and lead to more effective use of the agents for disease control and other applications...
Alkali production associated with malolactic fermentation by oral streptococci and protection against acid, oxidative, or starvation damageJiangyun Sheng
Department of Microbiology and Immunology, Center for Oral Biology, University of Rochester Medical Center, NY 14642 8672, USA
Can J Microbiol 56:539-47. 2010
..Malolactic fermentation is clearly a major process for alkali generation by oral streptococci and for protection against environmental stresses...
- Mutation of the NADH oxidase gene (nox) reveals an overlap of the oxygen- and acid-mediated stress responses in Streptococcus mutans
Adam M Derr
Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
Appl Environ Microbiol 78:1215-27. 2012
..Appl. Environ. Microbiol. 70:929-936, 2004). The heightened ability of the nox strain to survive acidic and oxidative environmental stress suggests a multifaceted response system that is partially dependent on oxygen metabolites...
- Malolactic fermentation by Streptococcus mutans
Jiangyun Sheng
Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
FEMS Microbiol Lett 272:196-201. 2007
..The net conclusion is that malate has the potential to be effective for alkalinization of dental plaque, although the fermentation is sensitive to fluoride and triclosan, which are commonly added to oral care products...
- Enhanced acid resistance of oral streptococci at lethal pH values associated with acid-tolerant catabolism and with ATP synthase activity
Jiangyun Sheng
Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642-8672, USA
FEMS Microbiol Lett 262:93-8. 2006
..Protection against acid killing involving catabolism and synthase activity is likely to be important for plaque cariogenicity...
- Protocols to study the physiology of oral biofilms
JOSE A LEMOS
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
Methods Mol Biol 666:87-102. 2010
..In this chapter, we use oral streptococci as examples for studying the physiology of oral biofilms...
Targets for hydrogen-peroxide-induced damage to suspension and biofilm cells of Streptococcus mutansJeremiah D Baldeck
Department of Microbiology and Immunology and Center for Oral Biology, Box 672, University of Rochester Medical Center, Rochester, NY 14642 8672, USA
Can J Microbiol 54:868-75. 2008
..mutans. A major target for bactericidal damage was protein synthesis, thus rendering cells incapable of repairing or replacing oxidatively damaged proteins...
- Triclosan inhibition of membrane enzymes and glycolysis of Streptococcus mutans in suspensions and biofilms
Tuan-Nghia Phan
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642-8672, USA
Can J Microbiol 52:977-83. 2006
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- Antimicrobial actions of benzimidazoles against the oral anaerobes Fusobacterium nucleatum and Prevotella intermedia
Jiangyun Sheng
Department of Microbiology and Immunology and Center for Oral Biology, The University of Rochester Medical Center, Rochester, NY 14642-8672, USA
Arch Oral Biol 51:1015-23. 2006
..Thus, catabolic pathways are potential targets for use of benzimidazoles against bacteria involved in gingivitis...
- Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface
Kiran S Ambatipudi
Departments of Pharmacology and Physiology, Rochester Proteomics Center, University of Rochester Medical Center, Rochester, New York 14642, United States
J Proteome Res 9:6605-14. 2010
..Thus, our data demonstrate that the host salivary protein CSP-1 binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface...
- Co-operative inhibition by fluoride and zinc of glucosyl transferase production and polysaccharide synthesis by mutans streptococci in suspension cultures and biofilms
Hyun Koo
Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642-8672, USA
FEMS Microbiol Lett 254:134-40. 2006
..As insoluble glucans are important for virulence of mutans streptococci, the inhibitory actions of fluoride and zinc could significantly affect cariogenicity...
- Applied and ecological aspects of oxidative-stress damage to bacterial spores and to oral microbes
Robert E Marquis
University of Rochester School of Medicine and Dentistry in Rochester, New York, NY 14642 8672, USA
Sci Prog 87:153-77. 2004
..The other example considered is related to oral microbiology and infectious disease in which oxidative stress may arise from the metabolism of the oral microbiota or may come from outside through use of oral care products...
- Repressed respiration of oral streptococci grown in biofilms
Phuong T M Nguyen
Department of Microbiology and Immunology, Box 672, University of Rochester Medical Center, Rochester, NY 14642-8672, USA
Curr Microbiol 44:262-6. 2002
..sanguis and S. gordonii to produce H2O2 also were markedly repressed by biofilm growth, and presumably this repression would affect the ecology of dental plaque by reducing oxidative stresses under crowded conditions...
