Mouna Maroun

Summary

Publications

  1. pmc The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear
    Irit Akirav
    Department of Psychology, The Brain and Behavior Research Center, University of Haifa, Haifa 31905, Israel
    Neural Plast 2007:30873. 2007
  2. pmc Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons
    Mouna Maroun
    Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Eur J Neurosci 38:2611-20. 2013
  3. pmc Enhanced extinction of aversive memories by high-frequency stimulation of the rat infralimbic cortex
    Mouna Maroun
    Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    PLoS ONE 7:e35853. 2012
  4. doi request reprint D-cycloserine into the BLA reverses the impairing effects of exposure to stress on the extinction of contextual fear, but not conditioned taste aversion
    Irit Akirav
    Department of Psychology, University of Haifa, Haifa 31905, Israel
    Learn Mem 16:682-6. 2009
  5. doi request reprint Stress and amygdala suppression of metaplasticity in the medial prefrontal cortex
    Gal Richter-Levin
    Department of Neurobiology and Ethology, Faculty of Sciences, University of Haifa, Haifa 31905, Israel
    Cereb Cortex 20:2433-41. 2010
  6. pmc Exposure to forced swim stress alters local circuit activity and plasticity in the dentate gyrus of the hippocampus
    Orli Yarom
    Department of Psychobiology, Faculty of Sciences, University of Haifa, Haifa 31905, Israel
    Neural Plast 2008:194097. 2008
  7. doi request reprint Olfactory learning-induced enhancement of the predisposition for LTP induction
    Yaniv Cohen
    Department of Biology, Faculty of Natural Sciences, University of Haifa, Haifa 31905, Israel
    Learn Mem 18:594-7. 2011
  8. pmc Memory of conditioned taste aversion is erased by inhibition of PI3K in the insular cortex
    Ilana Slouzkey
    Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Neuropsychopharmacology 38:1143-53. 2013
  9. doi request reprint Different effects of low frequency stimulation to infralimbic prefrontal cortex on extinction of aversive memories
    Kamilia Shehadi
    Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Hafia, Haifa 31905, Israel
    Brain Res 1490:111-6. 2013
  10. ncbi request reprint Extinction of conditioned taste aversion depends on functional protein synthesis but not on NMDA receptor activation in the ventromedial prefrontal cortex
    Irit Akirav
    Department of Neurobiology and Ethology, The Brain and Behavior Research Center, University of Haifa, Haifa 31905, Israel
    Learn Mem 13:254-8. 2006

Collaborators

Detail Information

Publications26

  1. pmc The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear
    Irit Akirav
    Department of Psychology, The Brain and Behavior Research Center, University of Haifa, Haifa 31905, Israel
    Neural Plast 2007:30873. 2007
    ..We further discuss a possible dysfunction in the medial prefrontal cortex-amygdala circuit following a stressful experience that may explain the impaired extinction caused by exposure to a stressor...
  2. pmc Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons
    Mouna Maroun
    Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Eur J Neurosci 38:2611-20. 2013
    ..These findings may have implications for elucidating the role of the amygdala in the pathophysiology of stress-related disorders...
  3. pmc Enhanced extinction of aversive memories by high-frequency stimulation of the rat infralimbic cortex
    Mouna Maroun
    Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    PLoS ONE 7:e35853. 2012
    ..These data indicate that HFS of the IL may be an effective method for reducing both learned fear and learned aversion...
  4. doi request reprint D-cycloserine into the BLA reverses the impairing effects of exposure to stress on the extinction of contextual fear, but not conditioned taste aversion
    Irit Akirav
    Department of Psychology, University of Haifa, Haifa 31905, Israel
    Learn Mem 16:682-6. 2009
    ..This may suggest that the dysfunctional extinction of fear and taste aversion following exposure to a stressful experience may be modulated by different mechanisms...
  5. doi request reprint Stress and amygdala suppression of metaplasticity in the medial prefrontal cortex
    Gal Richter-Levin
    Department of Neurobiology and Ethology, Faculty of Sciences, University of Haifa, Haifa 31905, Israel
    Cereb Cortex 20:2433-41. 2010
    ..Taken together, these findings demonstrate a new form of NMDA-dependent emotional metaplasticity in the ventral hippocampus-mPFC pathway...
  6. pmc Exposure to forced swim stress alters local circuit activity and plasticity in the dentate gyrus of the hippocampus
    Orli Yarom
    Department of Psychobiology, Faculty of Sciences, University of Haifa, Haifa 31905, Israel
    Neural Plast 2008:194097. 2008
    ..It is possible that these alterations underlie some of the behavioral consequences of the stress experience...
  7. doi request reprint Olfactory learning-induced enhancement of the predisposition for LTP induction
    Yaniv Cohen
    Department of Biology, Faculty of Natural Sciences, University of Haifa, Haifa 31905, Israel
    Learn Mem 18:594-7. 2011
    ..We report that OD learning was associated with enhancement in the predisposition to induce LTP. This learning-related effect may be affected by process generation of new granule cells located in the olfactory bulb...
  8. pmc Memory of conditioned taste aversion is erased by inhibition of PI3K in the insular cortex
    Ilana Slouzkey
    Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Neuropsychopharmacology 38:1143-53. 2013
    ..Our present data add new evidence to suggest that PI3K is engaged in consolidation of aversive memories, as its inhibition is associated with erasure of CTA memory...
  9. doi request reprint Different effects of low frequency stimulation to infralimbic prefrontal cortex on extinction of aversive memories
    Kamilia Shehadi
    Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Hafia, Haifa 31905, Israel
    Brain Res 1490:111-6. 2013
    ..These results suggest that localized electrical stimulation to the IL may be an effective method for manipulating learned fear and affecting the ability to extinguish aversive associations...
  10. ncbi request reprint Extinction of conditioned taste aversion depends on functional protein synthesis but not on NMDA receptor activation in the ventromedial prefrontal cortex
    Irit Akirav
    Department of Neurobiology and Ethology, The Brain and Behavior Research Center, University of Haifa, Haifa 31905, Israel
    Learn Mem 13:254-8. 2006
    ..Anisomycin microinfusion into vmPFC had no effect on CTA acquisition and by itself did not induce CTA. These findings show the necessary role functional protein synthesis is playing in the vmPFC during the learning of CTA extinction...
  11. ncbi request reprint β-endorphin degradation and the individual reactivity to traumatic stress
    Alexandra Kavushansky
    Department of Internal Medicine, Rambam Medical Center, Laboratory of Psychobiology, B Rappaport Faculty of Medicine and B Rappaport Research Institute, Technion, Haifa, Israel
    Eur Neuropsychopharmacol 23:1779-88. 2013
    ..Modulation of opioid degradation may thus present a potential novel target for interference with extreme anxiety. ..
  12. ncbi request reprint Enhancement of conditioned fear extinction by infusion of the GABA(A) agonist muscimol into the rat prefrontal cortex and amygdala
    Irit Akirav
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Eur J Neurosci 23:758-64. 2006
    ..The involvement of GABA(A) receptors in fear extinction in the prefrontal cortex and amygdala is of particular interest, because of the role of these areas in emotional processes, and the role of the GABA(A) receptors in anxiety states...
  13. doi request reprint Differential involvement of protein synthesis and actin rearrangement in the reacquisition of contextual fear conditioning
    Helen Motanis
    Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 31905, Israel
    Hippocampus 22:494-500. 2012
    ..The results suggest that the two processes of acquisition and reacquisition of fear are not identical and they engage different mechanisms...
  14. ncbi request reprint Arousal and stress effects on consolidation and reconsolidation of recognition memory
    Mouna Maroun
    Department of Neurobiology and Etiology, The Brain and Behavior Research Center, University of Haifa, Haifa, Israel
    Neuropsychopharmacology 33:394-405. 2008
    ....
  15. doi request reprint Medial prefrontal cortex: multiple roles in fear and extinction
    Mouna Maroun
    The Sagol Department of Neurobiology, University of Haifa, Haifa, Israel
    Neuroscientist 19:370-83. 2013
    ....
  16. doi request reprint Inhibition of the PI3 kinase cascade in corticolimbic circuit: temporal and differential effects on contextual fear and extinction
    Milly Kritman
    The Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Israel
    Int J Neuropsychopharmacol 16:825-33. 2013
    ....
  17. doi request reprint Differential involvement of dopamine D1 receptor and MEK signaling pathway in the ventromedial prefrontal cortex in consolidation and reconsolidation of recognition memory
    Mouna Maroun
    Department of Neurobiology and Ethology, University of Haifa, Haifa, Israel
    Learn Mem 16:243-7. 2009
    ..The MEK inhibitor impaired consolidation and reconsolidation, regardless of arousal. Thus, vmPFC D1 receptors and MEK show differential involvement in memory and arousal...
  18. doi request reprint Exposure to a novel context following contextual fear conditioning enhances the induction of hippocampal long-term potentiation
    Helen Motanis
    Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Eur J Neurosci 32:840-6. 2010
    ....
  19. ncbi request reprint Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning
    Noam Hikind
    Department of Neurobiology and Ethology, Faculty of Science and Science Education, University of Haifa, Mount Carmel, Haifa, Israel
    Neurobiol Learn Mem 90:217-22. 2008
    ..These results further strengthen the role of mPFC in consolidation of extinction while highlighting the role of the D1 receptors in this process...
  20. ncbi request reprint Stress reverses plasticity in the pathway projecting from the ventromedial prefrontal cortex to the basolateral amygdala
    Mouna Maroun
    The Brain and Behaviour Research Center, Department of Neurobiology and Ethology, Faculty of Science and Science Education, University of Haifa, Haifa 31905, Israel
    Eur J Neurosci 24:2917-22. 2006
    ..Following stressful experiences, LTP in the BLA is promoted to encode memory of fear...
  21. doi request reprint Oxytocinergic manipulations in corticolimbic circuit differentially affect fear acquisition and extinction
    Nisrine Lahoud
    Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Psychoneuroendocrinology 38:2184-95. 2013
    ....
  22. ncbi request reprint Ventromedial prefrontal cortex is obligatory for consolidation and reconsolidation of object recognition memory
    Irit Akirav
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Cereb Cortex 16:1759-65. 2006
    ..These results indicate that both protein synthesis and NMDA receptors are required for consolidation and reconsolidation of recognition memory in the vmPFC...
  23. doi request reprint Learning-induced bidirectional plasticity of intrinsic neuronal excitability reflects the valence of the outcome
    Helen Motanis
    Department of Neurobiology and Biology, Faculty of Sciences, University of Haifa, Haifa 31905, Israel
    Cereb Cortex 24:1075-87. 2014
    ..We suggest that positive and negative changes in BLA excitability contribute to the encoding of opposite odor-value behaviors. ..
  24. ncbi request reprint Exposure to acute stress blocks the induction of long-term potentiation of the amygdala-prefrontal cortex pathway in vivo
    Mouna Maroun
    The Brain and Behavior Center, Faculty of Science and Science Education, University of Haifa, Haifa, 31905, Israel
    J Neurosci 23:4406-9. 2003
    ....
  25. doi request reprint Stress modulation of reconsolidation
    Irit Akirav
    Department of Psychology, University of Haifa, Haifa 31905, Israel
    Psychopharmacology (Berl) 226:747-61. 2013
    ....
  26. doi request reprint Olfactory learning-induced long-lasting enhancement of descending and ascending synaptic transmission to the piriform cortex
    Yaniv Cohen
    Departments of Biology and Neurobiology, Faculty of Science and Science Education, University of Haifa, Haifa 31905, Israel
    J Neurosci 28:6664-9. 2008
    ..These data suggest that enhanced connectivity between the APC and its input sources is required for OD rule learning...