ALEXANDER GEORG MARNEROS

Summary

Publications

  1. ncbi Endogenous endostatin inhibits choroidal neovascularization
    Alexander G Marneros
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA
    FASEB J 21:3809-18. 2007
  2. doi Classification of cutaneous intravascular breast cancer metastases based on immunolabeling for blood and lymph vessels
    Alexander G Marneros
    Department of Dermatology, Columbia Presbyterian Medical Center, New York, New York 10032, USA
    J Am Acad Dermatol 60:633-8. 2009
  3. doi Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions
    Alexander G Marneros
    Department of Dermatology, Columbia Presbyterian Medical Center, New York, NY, USA
    Blood 113:6338-41. 2009
  4. doi Tumor angiogenesis in melanoma
    Alexander G Marneros
    Cutaneous Biology Research Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Hematol Oncol Clin North Am 23:431-46, vii-viii. 2009
  5. pmc Lack of collagen XVIII/endostatin results in eye abnormalities
    Naomi Fukai
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 21:1535-44. 2002
  6. ncbi Age-dependent iris abnormalities in collagen XVIII/endostatin deficient mice with similarities to human pigment dispersion syndrome
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 44:2367-72. 2003
  7. pmc Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    EMBO J 23:89-99. 2004
  8. ncbi Physiological role of collagen XVIII and endostatin
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    FASEB J 19:716-28. 2005
  9. pmc Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 188 Longwood Ave, Boston, MA 02115, USA
    Am J Pathol 167:1451-9. 2005

Collaborators

Detail Information

Publications9

  1. ncbi Endogenous endostatin inhibits choroidal neovascularization
    Alexander G Marneros
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA
    FASEB J 21:3809-18. 2007
    ..Endostatin may have a regulatory role in the pathogenesis of CNV and could be used therapeutically to inhibit growth and leakage of CNV lesions...
  2. doi Classification of cutaneous intravascular breast cancer metastases based on immunolabeling for blood and lymph vessels
    Alexander G Marneros
    Department of Dermatology, Columbia Presbyterian Medical Center, New York, New York 10032, USA
    J Am Acad Dermatol 60:633-8. 2009
    ..It has not been demonstrated conclusively whether dermal blood vessels or whether dermal lymph vessels are principally involved in these clinically distinct forms of cutaneous breast cancer metastases...
  3. doi Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions
    Alexander G Marneros
    Department of Dermatology, Columbia Presbyterian Medical Center, New York, NY, USA
    Blood 113:6338-41. 2009
    ..This distinction is critical and may profoundly influence the clinical decision to continue pralatrexate treatment. Pralatrexate-induced skin erosions may indicate response to treatment...
  4. doi Tumor angiogenesis in melanoma
    Alexander G Marneros
    Cutaneous Biology Research Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Hematol Oncol Clin North Am 23:431-46, vii-viii. 2009
    ..However, a targeted treatment approach with antiangiogenic agents needs to be based on an in-depth understanding of the complex mechanisms involved in melanoma tumor angiogenesis...
  5. pmc Lack of collagen XVIII/endostatin results in eye abnormalities
    Naomi Fukai
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 21:1535-44. 2002
    ..The findings provide an explanation for high myopia, vitreoretinal degeneration and retinal detachment seen in patients with Knobloch syndrome caused by loss-of-function mutations in collagen XVIII...
  6. ncbi Age-dependent iris abnormalities in collagen XVIII/endostatin deficient mice with similarities to human pigment dispersion syndrome
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 44:2367-72. 2003
    ..In this study we investigated ocular structures in collagen XVIII/endostatin (Col18a1(-/-))-deficient mice to elucidate the role of this extracellular matrix component in the eye...
  7. pmc Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    EMBO J 23:89-99. 2004
    ..Consistent with such a role, the ultrastructural organization of collagen XVIII/endostatin in basement membranes, including Bruch's membrane, shows that it is part of basement membrane molecular networks...
  8. ncbi Physiological role of collagen XVIII and endostatin
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    FASEB J 19:716-28. 2005
    ..These recent findings demonstrate an important role for collagen XVIII/endostatin in cell-matrix interactions in certain tissues that may be compensated for in other tissues expressing this collagen...
  9. pmc Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 188 Longwood Ave, Boston, MA 02115, USA
    Am J Pathol 167:1451-9. 2005
    ..Thus, hypoxia-inducible factor-1alpha-independent expression of VEGF is essential for choroid development...

Research Grants4

  1. Molecular mechanisms of choroidal neovascularization and vascular homeostasis
    ALEXANDER GEORG MARNEROS; Fiscal Year: 2010
    ..These findings are likely to reveal novel molecular targets for the treatment of neovascular age-related macular degeneration. ..
  2. Molecular mechanisms of choroidal neovascularization and vascular homeostasis
    Alexander Marneros; Fiscal Year: 2008
    ..These findings are likely to reveal novel molecular targets for the treatment of neovascular age-related macular degeneration. ..
  3. Molecular mechanisms of choroidal neovascularization and vascular homeostasis
    Alexander Marneros; Fiscal Year: 2009
    ..These findings are likely to reveal novel molecular targets for the treatment of neovascular age-related macular degeneration. ..
  4. Molecular mechanisms of choroidal neovascularization and vascular homeostasis
    Alexander Marneros; Fiscal Year: 2008
    ..These findings are likely to reveal novel molecular targets for the treatment of neovascular age-related macular degeneration. ..