Donald W Marion

Summary

Publications

  1. doi request reprint Current and future role of therapeutic hypothermia
    Donald Marion
    The Children s Neurobiological Solutions Foundation, Santa Barbara, California, USA
    J Neurotrauma 26:455-67. 2009
  2. ncbi request reprint Evidenced-based guidelines for traumatic brain injuries
    Donald W Marion
    Fusion Medical Education, LLC, Wakefield, MA, USA
    Prog Neurol Surg 19:171-96. 2006
  3. ncbi request reprint Controlled normothermia in neurologic intensive care
    Donald W Marion
    Department of Neurological Surgery, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA
    Crit Care Med 32:S43-5. 2004
  4. ncbi request reprint Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients
    Hulya Bayir
    Safar Center for Resuscitation Research, and Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 21:1-8. 2004
  5. ncbi request reprint The effects of admission alcohol level on cerebral blood flow and outcomes after severe traumatic brain injury
    Sheila Alexander
    Acute and Tertiary Care, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania 15261, USA
    J Neurotrauma 21:575-83. 2004
  6. ncbi request reprint Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Exp Neurol 190:192-203. 2004
  7. ncbi request reprint Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury
    Amy K Wagner
    Safar Center for Resuscitation Research, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 33:407-13. 2005
  8. ncbi request reprint Early Glasgow Outcome Scale scores predict long-term functional outcome in patients with severe traumatic brain injury
    Joseph T King
    Section of Neurosurgery, VA Connecticut Healthcare System 112, West Haven, Connecticut 06516, USA
    J Neurotrauma 22:947-54. 2005
  9. ncbi request reprint Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats
    Xiaopeng Zhang
    Department of Critical Care Medicine, The Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennyslvania 15260, USA
    J Cereb Blood Flow Metab 26:915-26. 2006
  10. ncbi request reprint Does hyperventilation cause secondary brain injury?
    Donald W Marion
    Crit Care Med 34:1284-5. 2006

Collaborators

  • Robert S Clark
  • A K Wagner
  • Patrick Kochanek
  • Ross Zafonte
  • ANTHONY KLINE
  • Steven T DeKosky
  • Edward D Hall
  • HARVEY contact LEVIN
  • K D Statler
  • Kenneth Strauss
  • John Whyte
  • Sheila A Alexander
  • Melissa Lee McCarthy
  • G L Clifton
  • A Marmarou
  • Xiaopeng Zhang
  • Milos D Ikonomovic
  • Marie E Rose
  • Stephen R Wisniewski
  • Steven H Graham
  • Mary E Kerr
  • John R Ciallella
  • C Edward Dixon
  • Joseph T King
  • Larry W Jenkins
  • Hulya Bayir
  • Ava M Puccio
  • Joanne K Schiding
  • Alan M Palmer
  • Ellen J MacKenzie
  • John Melick
  • Michele B Huerbin
  • Raj K Narayan
  • Barbara B Weber
  • Yaming Chen
  • Sean Alber
  • Paula D Nathaniel
  • Simon C Watkins
  • Patricia M Carlier
  • Kunihiro Uryu
  • John Q Trojanowski
  • Virginia M Y Lee
  • Keri L Janesko
  • Eric E Abrahamson
  • Howard Ferimer
  • Marilyn F Kraus
  • Xiecheng Ma
  • Kim Yookyung
  • M Ilyas Kamboh
  • Hong Q Yan
  • Noel Mohberg
  • A Byron Young
  • Peter Quinn
  • Sean M Grady
  • Michael D Walker
  • Claudia S Robertson
  • Emmy Miller
  • Jack Jallo
  • Lorraine Yurkewicz
  • David A Hovda
  • Michael B Bracken
  • Sung C Choi
  • William C Schwab
  • Nancy Temkin
  • W Dalton Dietrich
  • Lawrence R Wechsler
  • William M Coplin
  • Lawrence H Pitts
  • Robert G Grossman
  • William Heetderks
  • Michael Weinrich
  • Anat Biegon
  • J Paul Muizelaar
  • John F Ditunno
  • Charles F Contant
  • Andrew I Maas
  • Jeannine Majde
  • Graham Teasdale
  • M Ross Bullock
  • Carol Forrester-Staz
  • Charles Wade
  • William R Paljug
  • Jamshid Ghajar
  • Gad Riesenfeld
  • Tracy K McIntosh
  • Lawrence F Marshall
  • Alex Baethmann
  • Gary S Gruen
  • Ronald Tuma
  • Yetta I Wilbur

Detail Information

Publications30

  1. doi request reprint Current and future role of therapeutic hypothermia
    Donald Marion
    The Children s Neurobiological Solutions Foundation, Santa Barbara, California, USA
    J Neurotrauma 26:455-67. 2009
    ..For many of the other indications, such as stroke and spinal cord injury, trials are ongoing, but the data are insufficient to recommend routine use of hypothermia at this time...
  2. ncbi request reprint Evidenced-based guidelines for traumatic brain injuries
    Donald W Marion
    Fusion Medical Education, LLC, Wakefield, MA, USA
    Prog Neurol Surg 19:171-96. 2006
    ..In this chapter the conclusions of those guidelines is reviewed. In addition, the studies that demonstrate improved outcomes as a result of implementation of the guidelines are summarized...
  3. ncbi request reprint Controlled normothermia in neurologic intensive care
    Donald W Marion
    Department of Neurological Surgery, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA
    Crit Care Med 32:S43-5. 2004
    ..Further study is needed to establish if such better control of temperature will lead to improved outcomes...
  4. ncbi request reprint Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients
    Hulya Bayir
    Safar Center for Resuscitation Research, and Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 21:1-8. 2004
    ..These results established that gender is an important consideration in clinical trial design, particularly in the case of antioxidant strategies...
  5. ncbi request reprint The effects of admission alcohol level on cerebral blood flow and outcomes after severe traumatic brain injury
    Sheila Alexander
    Acute and Tertiary Care, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania 15261, USA
    J Neurotrauma 21:575-83. 2004
    ..The data indicated that serum ETOH levels > 100 mg/dL at the time of admission after a TBI were associated with a decrease in global CBF. Elevated serum ETOH level at time of injury did not, however, impact outcomes...
  6. ncbi request reprint Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Exp Neurol 190:192-203. 2004
    ....
  7. ncbi request reprint Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury
    Amy K Wagner
    Safar Center for Resuscitation Research, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 33:407-13. 2005
    ..The purpose of this study was to evaluate associations between gender and cerebrospinal fluid glutamate and lactate/pyruvate production and the role of hypothermia with gender in attenuating these markers...
  8. ncbi request reprint Early Glasgow Outcome Scale scores predict long-term functional outcome in patients with severe traumatic brain injury
    Joseph T King
    Section of Neurosurgery, VA Connecticut Healthcare System 112, West Haven, Connecticut 06516, USA
    J Neurotrauma 22:947-54. 2005
    ..The 3-month GOS is a powerful independent predictor of long-term outcome for patients with severe TBI. Prolonged hypotension, DAI, and the presence of fixed and dilated pupils were also independent predictors of poor outcome...
  9. ncbi request reprint Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats
    Xiaopeng Zhang
    Department of Critical Care Medicine, The Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennyslvania 15260, USA
    J Cereb Blood Flow Metab 26:915-26. 2006
    ..These data show increased phosphorylation of PKB, PKB substrates, and related proteins after both experimental and clinical TBI, suggesting either activation of the PKB signaling pathway or reduced phosphatase activity in both species...
  10. ncbi request reprint Does hyperventilation cause secondary brain injury?
    Donald W Marion
    Crit Care Med 34:1284-5. 2006
  11. ncbi request reprint Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans
    Xiaopeng Zhang
    Department of Critical Care Medicine, The Safar Center for Resuscitation Research, University of Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 23:1583-90. 2006
    ..Thus, caspase-7 may play a role in the glial and inflammatory responses, and possibly neuronal death, after TBI in humans...
  12. ncbi request reprint Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 106:538-47. 2007
    ..The purpose of this study was to determine associations between factors that affect DAT expression and cerebrospinal fluid (CSF) DA and metabolite levels after severe TBI...
  13. ncbi request reprint Relationship between apoE4 allele and excitatory amino acid levels after traumatic brain injury
    Mary E Kerr
    University of Pittsburgh, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA, USA
    Crit Care Med 31:2371-9. 2003
    ....
  14. ncbi request reprint Acute etomidate treatment reduces cognitive deficits and histopathology in rats with traumatic brain injury
    C Edward Dixon
    Department of Neurological Surgery and Safar Center for Resuscitation Research, University of Pittsburgh, PA 15260, USA
    Crit Care Med 31:2222-7. 2003
    ..To test the hypothesis that etomidate treatment improves functional, cognitive, and histologic outcome after experimental traumatic brain injury...
  15. ncbi request reprint Hypothermia on admission in patients with severe brain injury
    Guy L Clifton
    Vivian L Smith Center for Neurologic Research, Department of Neurosurgery, University of Texas Houston Medical School, 77030, USA
    J Neurotrauma 19:293-301. 2002
    ..It is unclear whether the improved outcome when hypothermia is maintained is a beneficial effect of very early hypothermia induction or an adverse effect of permitting the patients to rewarm passively...
  16. ncbi request reprint Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact
    Anthony E Kline
    The Brain Trauma Research Center, Department of Neurosurgery, University of Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 19:415-25. 2002
    ..These data reveal that CCI produces working memory deficits in rats that are similar to those observed following FP, and that the delayed and chronic bromocriptine treatment regimen conferred cognitive and neural protection after TBI...
  17. ncbi request reprint Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats
    Anthony E Kline
    Department of Neurological Surgery and Brain Trauma Research Center, University of Pittsburgh, 3434 Fifth Avenue, Suite 201, Pittsburgh, PA 15260, USA
    Brain Res 937:22-31. 2002
    ..Rather, IL-10 administration suppressed the beneficial effects produced by hypothermia alone after TBI. The mechanism(s) for the negative effects of IL-10 combined with hypothermia after TBI remain to be determined...
  18. pmc Clinical trials in head injury
    Raj K Narayan
    Department of Neurosurgery, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    J Neurotrauma 19:503-57. 2002
    ..This paper is an attempt to summarize the key points made at the workshop. It is hoped that these lessons will enhance the planning and design of future efforts in this important field of research...
  19. ncbi request reprint Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury
    Marie E Rose
    Department of Neurology, 526 South BST, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 935:40-6. 2002
    ..These results suggest that neither increased release of EAAs due to Na+ channel-mediated depolarization nor failure of glutamate reuptake due to glucose deprivation can explain the majority of the increase in EAA(I) following TBI...
  20. ncbi request reprint Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury
    Marie E Rose
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 943:15-22. 2002
    ..These results suggest that neither increased release of EAAs due to Na+ channel-mediated depolarization nor failure of glutamate reuptake due to glucose deprivation can explain the majority of the increase in EAA(I) following TBI...
  21. ncbi request reprint Increasing blood pressure causes a decrease in intracranial pressure in patients with brain injury
    Donald W Marion
    Crit Care Med 30:1671-2. 2002
  22. ncbi request reprint Absence of a diastolic velocity notch does not indicate hyperemia in traumatic brain injured patients without elevated cerebral blood flow velocity
    Barbara B Weber
    University of Pittsburgh School of Nursing, Pennsylvania, USA
    J Neurosurg Anesthesiol 14:279-86. 2002
    ..7% and 57.9% respectively. The results showed that relative hyperemia was present without an elevation in blood flow velocities, and that the lack of a diastolic notch did not detect the presence of hyperemia in the TBI patient...
  23. ncbi request reprint Moderate hypothermia in severe head injuries: the present and the future
    Donald W Marion
    Brain Trauma Research Center and Center for Injury Research and Control, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Crit Care 8:111-4. 2002
    ..Future investigations are aimed at further identifying the physiologic mechanisms responsible for secondary brain injury and ways in which other novel combination therapies may be expected to improve outcomes...
  24. ncbi request reprint Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury
    Donald W Marion
    Brain Trauma Research Center, Department of Neurological Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Suite B400, Pittsburgh, PA 15213, USA
    Crit Care Med 30:2619-25. 2002
    ..To determine the potential adverse effects of brief periods of hyperventilation commonly used for acute neurologic deterioration...
  25. ncbi request reprint Changes in expression of amyloid precursor protein and interleukin-1beta after experimental traumatic brain injury in rats
    John R Ciallella
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 19:1555-67. 2002
    ..Our results demonstrate that both APP and IL-1beta are rapidly elevated after injury. Because of the rapidity in the IL-1beta peak increase, it may serve a role in regulation of APP expression after TBI...
  26. ncbi request reprint Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats
    Kimberly D Statler
    Safar Center for Resuscitation Research, 3434 Fifth Avenue, Suite 201, Pittsburgh, PA 15260, USA
    Crit Care Med 31:1134-9. 2003
    ..To determine whether transient, moderate hypothermia is beneficial after traumatic brain injury in fentanyl-anesthetized rats...
  27. ncbi request reprint Physical medicine and rehabilitation consultation: relationships with acute functional outcome, length of stay, and discharge planning after traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA
    Am J Phys Med Rehabil 82:526-36. 2003
    ..The purpose of this study was to delineate relationships between physical medicine and rehabilitation consultation in this population and acute functional outcome, length of stay, and discharge planning...
  28. ncbi request reprint Using the SF-36 for characterizing outcome after multiple trauma involving head injury
    Ellen J MacKenzie
    Center for Injury Research and Policy, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Trauma 52:527-34. 2002
    ....