Francisco Marin

Summary

Publications

  1. ncbi request reprint Update on ischemic heart disease and critical care cardiology
    Francisco Marin
    Servicio de Cardiologia, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain Electronic address
    Rev Esp Cardiol (Engl Ed) 67:120-6. 2014
  2. ncbi request reprint New perspectives in antiplatelet therapy
    A Tello-Montoliu
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Ctra Madrid Cartagena Murcia, 30120, Spain
    Curr Med Chem 19:406-27. 2012
  3. ncbi request reprint Pharmacogenetics in cardiovascular antithrombotic therapy
    Francisco Marin
    Cardiology Department, Hospital General Universitario, c Pintor Baeza s n, Alicante, Spain
    Curr Med Chem Cardiovasc Hematol Agents 3:357-64. 2005
  4. ncbi request reprint The pharmacogenetics of antiplatelet drugs
    Francisco Marin
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Madrid Cartagen s n El Palmar, Murcia, 30008 Spain
    Curr Opin Investig Drugs 8:213-8. 2007
  5. ncbi request reprint [The implantable cardioverter-defibrillator and hypertrophic cardiomyopathy. Experience at three centers]
    Francisco Marin
    Servicio de Cardiologia, Hospital General de Alicante, Pintor Baeza s n, 03002 Alicante, Spain
    Rev Esp Cardiol 59:537-44. 2006
  6. ncbi request reprint Statins and postoperative risk of atrial fibrillation following coronary artery bypass grafting
    Francisco Marin
    Department of Cardiology, Hospital General University of Alicante, Alicante, Spain
    Am J Cardiol 97:55-60. 2006
  7. pmc Plasma von Willebrand factor, soluble thrombomodulin, and fibrin D-dimer concentrations in acute onset non-rheumatic atrial fibrillation
    F Marin
    Department of Cardiology, General Hospital of Alicante, Pintor Baeza s n, Alicante 03002, Spain
    Heart 90:1162-6. 2004
  8. ncbi request reprint The HAS-BLED score has better prediction accuracy for major bleeding than CHADS2 or CHA2DS2-VASc scores in anticoagulated patients with atrial fibrillation
    Vanessa Roldan
    Hematology and Medical Oncology Unit, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    J Am Coll Cardiol 62:2199-204. 2013
  9. ncbi request reprint Role of factor XIII Val34Leu polymorphism in patients <45 years of age with acute myocardial infarction
    Vanessa Roldan
    Hematology Unit, Hospital de San Vicente, Alicante, Spain
    Am J Cardiol 91:1242-5. 2003
  10. ncbi request reprint Should we recommend oral anticoagulation therapy in patients with atrial fibrillation undergoing coronary artery stenting with a high HAS-BLED bleeding risk score?
    Juan M Ruiz-Nodar
    Department of Cardiology, Hospital General Universitario de Alicante, Alicante, Spain
    Circ Cardiovasc Interv 5:459-66. 2012

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Update on ischemic heart disease and critical care cardiology
    Francisco Marin
    Servicio de Cardiologia, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain Electronic address
    Rev Esp Cardiol (Engl Ed) 67:120-6. 2014
    ..This article summarizes the main developments reported in 2013 on ischemic heart disease, together with the most important innovations in the management of acute cardiac patients...
  2. ncbi request reprint New perspectives in antiplatelet therapy
    A Tello-Montoliu
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Ctra Madrid Cartagena Murcia, 30120, Spain
    Curr Med Chem 19:406-27. 2012
    ..This review summarizes the mechanisms of action and current clinical evaluation of these novel antiplatelet agents...
  3. ncbi request reprint Pharmacogenetics in cardiovascular antithrombotic therapy
    Francisco Marin
    Cardiology Department, Hospital General Universitario, c Pintor Baeza s n, Alicante, Spain
    Curr Med Chem Cardiovasc Hematol Agents 3:357-64. 2005
    ..The present review article explores the genetic influence on antithrombotic drug efficacy, analysing the modulating role of different polymorphisms on individuals' response to drugs commonly used in current day practice...
  4. ncbi request reprint The pharmacogenetics of antiplatelet drugs
    Francisco Marin
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Madrid Cartagen s n El Palmar, Murcia, 30008 Spain
    Curr Opin Investig Drugs 8:213-8. 2007
    ..This review explores the genetic influences on antiplatelet drug efficacy by analyzing the modulating role of different genetic polymorphisms on individual responses to antiplatelet therapy...
  5. ncbi request reprint [The implantable cardioverter-defibrillator and hypertrophic cardiomyopathy. Experience at three centers]
    Francisco Marin
    Servicio de Cardiologia, Hospital General de Alicante, Pintor Baeza s n, 03002 Alicante, Spain
    Rev Esp Cardiol 59:537-44. 2006
    ..Our aims were to describe the characteristics of HCM patients who received ICDs at three hospitals in Spain, and to study indications for device implantation and the results of follow-up in device users...
  6. ncbi request reprint Statins and postoperative risk of atrial fibrillation following coronary artery bypass grafting
    Francisco Marin
    Department of Cardiology, Hospital General University of Alicante, Alicante, Spain
    Am J Cardiol 97:55-60. 2006
    ..Statin use may be protective against AF after coronary artery bypass grafting, possibly due to alterations in the extracellular matrix and remodeling after coronary artery bypass grafting...
  7. pmc Plasma von Willebrand factor, soluble thrombomodulin, and fibrin D-dimer concentrations in acute onset non-rheumatic atrial fibrillation
    F Marin
    Department of Cardiology, General Hospital of Alicante, Pintor Baeza s n, Alicante 03002, Spain
    Heart 90:1162-6. 2004
    ....
  8. ncbi request reprint The HAS-BLED score has better prediction accuracy for major bleeding than CHADS2 or CHA2DS2-VASc scores in anticoagulated patients with atrial fibrillation
    Vanessa Roldan
    Hematology and Medical Oncology Unit, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    J Am Coll Cardiol 62:2199-204. 2013
    ....
  9. ncbi request reprint Role of factor XIII Val34Leu polymorphism in patients <45 years of age with acute myocardial infarction
    Vanessa Roldan
    Hematology Unit, Hospital de San Vicente, Alicante, Spain
    Am J Cardiol 91:1242-5. 2003
  10. ncbi request reprint Should we recommend oral anticoagulation therapy in patients with atrial fibrillation undergoing coronary artery stenting with a high HAS-BLED bleeding risk score?
    Juan M Ruiz-Nodar
    Department of Cardiology, Hospital General Universitario de Alicante, Alicante, Spain
    Circ Cardiovasc Interv 5:459-66. 2012
    ..Despite the guidelines, this approach has never been tested in a cohort of patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation...
  11. doi request reprint An evaluation of the CHADS₂ stroke risk score in patients with atrial fibrillation who undergo percutaneous coronary revascularization
    Juan M Ruiz-Nodar
    Department of Cardiology, Hospital General Universitario de Alicante, Alicante, Spain
    Chest 139:1402-9. 2011
    ..We evaluated whether the CHADS(2) score was adequate for TE risk stratification while assessing cardiac risk in patients with AF revascularized with coronary artery stents...
  12. ncbi request reprint [Effect of maximum dose of atorvastatin on inflammation, thrombogenesis and fibrinolysis in high-risk patients with ischemic heart disease]
    Antonio Tello
    Servicio de Cardiologia, Hospital General Universitario de Alicante, Alicante, Spain
    Rev Esp Cardiol 58:934-40. 2005
    ....
  13. doi request reprint Usefulness of β-trace protein and cystatin C for the prediction of mortality in non ST segment elevation acute coronary syndromes
    Sergio Manzano-Fernández
    Division of Cardiology, University Hospital Virgen de la Arrixaca, Murcia, Spain
    Am J Cardiol 110:1240-8. 2012
    ..In conclusion, BTP and CysC levels were associated with all-cause death risk and modestly improved prognostic discrimination beyond the GRACE risk score in patients with non-ST segment elevation acute coronary syndromes...
  14. ncbi request reprint Oral anticoagulation improves the prognosis of octogenarian patients with atrial fibrillation undergoing percutaneous coronary intervention and stenting
    Luis Caballero
    Cardiology Unit, Hospital Universitario Virgen de la Arrixaca, University of Murcia, Ctra Madrid Cartagena s n Ctra Madrid Cartagena s n, Murcia 30120, Spain
    Age Ageing 42:70-5. 2013
    ..Dual antiplatelet therapy is recommended in these patients, requiring a period of triple therapy with dual antiplatelet agent plus oral anticoagulation (OAC). Concerns remain regarding the appropriateness of OAC in octogenarians...
  15. doi request reprint Renal impairment in a "real-life" cohort of anticoagulated patients with atrial fibrillation (implications for thromboembolism and bleeding)
    Vanessa Roldan
    Hematology and Medical Oncology Unit, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    Am J Cardiol 111:1159-64. 2013
    ..Importantly, normal or mild renal dysfunction at baseline did not exclude the subsequent development of severe renal dysfunction during the follow-up period...
  16. ncbi request reprint Plasma levels of von Willebrand factor are increased in patients with hypertrophic cardiomyopathy
    Francisco Cambronero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, and Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain
    Thromb Res 126:e46-50. 2010
    ..We hypothesised that vWf could be raised in patients with HCM and be related to different variables associated with severity of HCM...
  17. doi request reprint Atherosclerosis and thromboembolic risk in atrial fibrillation: focus on peripheral vascular disease
    Eva Jover
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Ann Med 45:274-90. 2013
    ..The aim of this present review article is to provide an overview of the association between atherosclerosis (with particular focus on PVD) and AF as well as its complications...
  18. ncbi request reprint Relation of interleukin-6 levels and prothrombin fragment 1+2 to a point-based score for stroke risk in atrial fibrillation
    Vanessa Roldan
    Hematology Unit, Hospital San Vicente, Alicante, Spain
    Am J Cardiol 95:881-2. 2005
    ..Interleukin-6 levels, but not prothrombin fragment 1 + 2, correlates with a point-based score for stroke risk in atrial fibrillation, even after oral anticogulation...
  19. doi request reprint Predictive value of the CHA2DS2-VASc score in atrial fibrillation patients at high risk for stroke despite oral anticoagulation
    Eva Jover
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Ctra Madrid Cartagena s n, El Palmar, Murcia, Spain
    Rev Esp Cardiol (Engl Ed) 65:627-33. 2012
    ....
  20. ncbi request reprint Synergistic association between hypercholesterolemia and the C46T factor XII polymorphism for developing premature myocardial infarction
    Vanessa Roldan
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    Thromb Haemost 94:1294-9. 2005
    ..This effect could be associated with an increased pro-inflammatory state, as the 46T allele associates with high levels of CRP...
  21. doi request reprint The prognostic role of the adiponectin levels in atrial fibrillation
    Diana Hernandez-Romero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia 30008, Spain
    Eur J Clin Invest 43:168-73. 2013
    ..The aim is to evaluate whether plasma adiponectin can be predictive of cardiovascular risk in anticoagulated patients with AF...
  22. ncbi request reprint Predictive value of the HAS-BLED and ATRIA bleeding scores for the risk of serious bleeding in a "real-world" population with atrial fibrillation receiving anticoagulant therapy
    Vanessa Roldan
    Hematology and Medical Oncology Unit, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    Chest 143:179-84. 2013
    ..We assessed the predictive value of the ATRIA bleeding score in a large cohort of patients with AF receiving anticoagulant therapy, compared with the well-validated HAS-BLED score...
  23. ncbi request reprint Growth differentiation factor-15, a novel biomarker related with disease severity in patients with hypertrophic cardiomyopathy
    Silvia Montoro-García
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, University of Murcia, Spain
    Eur J Intern Med 23:169-74. 2012
    ..We hypothesized that GDF-15 could be related to disease severity and functional status in patients with hypertrophic cardiomyopathy (HCM)...
  24. ncbi request reprint Relation of the HAS-BLED bleeding risk score to major bleeding, cardiovascular events, and mortality in anticoagulated patients with atrial fibrillation
    Pilar Gallego
    Hematology and Medical Oncology Unit, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    Circ Arrhythm Electrophysiol 5:312-8. 2012
    ..We tested the usefulness of the HAS-BLED score for predicting both major bleeding and cardiovascular events in a cohort of anticoagulated patients with AF...
  25. doi request reprint Plasma von Willebrand factor levels are an independent risk factor for adverse events including mortality and major bleeding in anticoagulated atrial fibrillation patients
    Vanessa Roldan
    Hematology and Medical Oncology Unit, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    J Am Coll Cardiol 57:2496-504. 2011
    ..The purpose of this study was to evaluate the prognostic value of plasma von Willebrand factor (vWF) levels and fibrin d-dimer in a large cohort of anticoagulated permanent atrial fibrillation (AF) patients...
  26. doi request reprint CALU A29809G polymorphism in coronary atherothrombosis: Implications for coronary calcification and prognosis
    Diana Hernandez-Romero
    Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Ann Med 42:439-46. 2010
    ..We recently described that CALU polymorphism A29809G was related to acenocoumarol requirements, and we wanted to evaluate its role in arterial calcification and prognosis...
  27. doi request reprint Ankle brachial index as an independent predictor of mortality in anticoagulated atrial fibrillation
    Pilar Gallego
    Hematology and Medical Oncology Unit, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    Eur J Clin Invest 42:1302-8. 2012
    ..We hypothesised that the ABI would predict mortality and adverse events in anticoagulated chronic nonvalvular AF patients...
  28. doi request reprint Factor VII -323 decanucleotide D/I polymorphism in atrial fibrillation: implications for the prothrombotic state and stroke risk
    Vanessa Roldan
    Centro de Hemodonación, Universidad de Murcia, Murcia, Spain
    Ann Med 40:553-9. 2008
    ..Other functional polymorphisms were also tested...
  29. ncbi request reprint A pharmacogenetic effect of factor XIII valine 34 leucine polymorphism on fibrinolytic therapy for acute myocardial infarction
    Francisco Marin
    Cardiology Department, Hospital General Universitario, Alicante, Spain
    J Am Coll Cardiol 45:25-9. 2005
    ..The aim of this study was to evaluate the pharmacogenetic role of the factor XIII (FXIII) valine 34 leucine (Val34Leu) polymorphism in the fibrinolytic therapy of acute myocardial infarction (MI)...
  30. ncbi request reprint Beta-trace protein and cystatin c as predictors of major bleeding in non-ST-segment elevation acute coronary syndrome
    Angel López-Cuenca
    Division of Cardiology, University Hospital Virgen de la Arrixaca, Murcia, Spain
    Circ J 77:2088-96. 2013
    ..We assessed the ability of both to predict major bleeding (MB) in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), compared to other renal function parameters and clinical risk scores...
  31. ncbi request reprint The prognostic value of biomarkers after a premature myocardial infarction
    Javier Pineda
    Department of Cardiology, Hospital General Universitario Alicante, Alicante, Spain
    Int J Cardiol 143:249-54. 2010
    ..We hypothesised that abnormalities of these biological systems would contribute to outcome of coronary artery disease presenting at a young age...
  32. doi request reprint β-Trace protein: from GFR marker to cardiovascular risk predictor
    Esteban Orenes-Piñero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain
    Clin J Am Soc Nephrol 8:873-81. 2013
    ....
  33. doi request reprint Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy
    Vanessa Roldan
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    Am Heart J 156:85-91. 2008
    ....
  34. ncbi request reprint Preoperative statin therapy and troponin T predict early complications of coronary artery surgery
    Domingo A Pascual
    Department of Cardiology, Hospital Universitario Arrixaca, Murcia, Spain
    Ann Thorac Surg 81:78-83. 2006
    ..We sought to examine the association between preoperative statin therapy, systemic inflammation, and myocardial ischemia with the occurrence of early cardiac complications after coronary artery bypass grafting surgery...
  35. doi request reprint Influence of CYP2C19 polymorphisms in platelet reactivity and prognosis in an unselected population of non ST elevation acute coronary syndrome
    Antonio Tello-Montoliu
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
    Rev Esp Cardiol (Engl Ed) 65:219-26. 2012
    ....
  36. doi request reprint Serum levels of high-sensitivity troponin T: a novel marker for cardiac remodeling in hypertrophic cardiomyopathy
    Victoria Moreno
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    J Card Fail 16:950-6. 2010
    ..Therefore we hypothesized that increased hs-TnT levels are related to different variables associated with myocardial remodeling, such as the presence of fibrosis assessed with cardiac magnetic resonance imaging (MRI)...
  37. ncbi request reprint Gadolinium-enhanced cardiovascular magnetic resonance and exercise capacity in hypertrophic cardiomyopathy
    Antonio Romero-Puche
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Rev Esp Cardiol 61:853-60. 2008
    ..Our objective was to study the relationship between the degree of myocardial fibrosis observed by cardiac magnetic resonance and exercise capacity...
  38. doi request reprint Gadolinium-enhanced cardiovascular magnetic resonance and exercise capacity in hypertrophic cardiomyopathy
    Antonio Romero-Puche
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Rev Esp Cardiol (Engl Ed) 61:853-60. 2008
    ..Our objective was to study the relationship between the degree of myocardial fibrosis observed by cardiac magnetic resonance and exercise capacity...
  39. pmc High-sensitivity troponin T and copeptin in non-ST acute coronary syndromes: implications for prognosis and role of hsTnT and copeptin in non-STEACS
    Diana Hernandez-Romero
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, 30120 Murcia, Spain
    ScientificWorldJournal 2012:578616. 2012
    ..Abnormalities of serum hsTnT and copeptin levels in non-STEACS and negative TnT, could have prognostic implications...
  40. ncbi request reprint Anticoagulant and antiplatelet therapy use in 426 patients with atrial fibrillation undergoing percutaneous coronary intervention and stent implantation implications for bleeding risk and prognosis
    Juan M Ruiz-Nodar
    Department of Cardiology, Hospital General Universitario de Alicante, Alicante, Spain
    J Am Coll Cardiol 51:818-25. 2008
    ..This study was designed to review outcomes in relation to antithrombotic therapy management strategies for patients with atrial fibrillation (AF) who undergo percutaneous coronary intervention (PCI) with stenting...
  41. doi request reprint Variables associated with contrast-enhanced cardiovascular magnetic resonance in hypertrophic cardiomyopathy: clinical implications
    Eduardo Payá
    Department of Cardiology, Hospital General Universitario, Alicante, Spain
    J Card Fail 14:414-9. 2008
    ..The aim of the present study was to describe the clinical characteristics and the presence of risk factors for sudden death in a series of patients from 2 referral centers for HCM in relation to late gadolinium enhancement in CMR...
  42. ncbi request reprint Are there ethnic differences in the circadian variation in onset of acute myocardial infarction? A comparison of 3 ethnic groups in Birmingham, UK and Alicante, Spain
    Francisca López
    Coronary Care Unit, Hospital General Universitario, Alicante, Spain
    Int J Cardiol 100:151-4. 2005
    ..Further studies are required to determine the pathophysiological mechanism(s) underlying these differences...
  43. ncbi request reprint Short alleles of P-selectin glycoprotein ligand-1 protect against premature myocardial infarction
    Vanessa Roldan
    Hematology Unit, Hospital de San Vicente, Alicante, Spain
    Am Heart J 148:602-5. 2004
    ..We sought to evaluate the role of this polymorphism in premature myocardial infarction because genetic risk factors have more relevance in the development of disease in young patients...
  44. doi request reprint Comparative determination and monitoring of biomarkers of necrosis and myocardial remodeling between radiofrequency ablation and cryoablation
    Diana Hernandez-Romero
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain
    Pacing Clin Electrophysiol 36:31-6. 2013
    ..There is scarce information on biomarkers' behavior after cryoablation. Our aim was to study biomarkers of necrosis, inflammation, and interstitial remodeling after two different approaches: RF versus cryoablation...
  45. doi request reprint Mild kidney disease as a risk factor for major bleeding in patients with atrial fibrillation undergoing percutaneous coronary stenting
    Sergio Manzano-Fernández
    Sergio Manzano Fernández, MD, PhD, Cardiology Department, University Hospital Virgen de la Arrixaca, C Madrid Cartagena s n CP 30120, Murcia, Spain, Tel 34 968399445, Fax 34 968369662, E mail
    Thromb Haemost 107:51-8. 2012
    ..Future studies should assess the potential role of incorporating mild KD into the bleeding risk scales to improve the stratification of these patients...
  46. ncbi request reprint Factor XIII Val34Leu polymorphism modulates the prothrombotic and inflammatory state associated with atrial fibrillation
    Francisco Marin
    Cardiology Service, Hospital General Universitario, c Pintor Baeza s n, 03010 Alicante, Spain
    J Mol Cell Cardiol 37:699-704. 2004
    ....
  47. doi request reprint Efficacy and safety of drug-eluting stent use in patients with atrial fibrillation
    Juan M Ruiz-Nodar
    Department of Cardiology, Hospital General Universitario de Alicante, Alicante, Spain
    Eur Heart J 30:932-9. 2009
    ..The aim of this study was to evaluate the safety and efficacy of the use of DES vs. bare-metal stents (BMS) in a cohort of patients with AF...
  48. ncbi request reprint Plasma angiogenin levels in acute coronary syndromes: implications for prognosis
    Antonio Tello-Montoliu
    Cardiology Department, Hospital General Universitario, Alicante, Spain
    Eur Heart J 28:3006-11. 2007
    ..We hypothesized abnormalities of angiogenin levels in acute coronary syndrome (ACS), with prognostic implications for predicting adverse events...
  49. doi request reprint Influence of electrical cardioversion on inflammation and indexes of structural remodeling, in persistent atrial fibrillation
    Vicente Climent
    Department of Cardiology General Hospital of Alicante, Alicante, Spain
    Int J Cardiol 132:227-32. 2009
    ....
  50. ncbi request reprint Implications of pharmacogenetics for oral anticoagulants metabolism
    Virginia Pérez-Andreu
    Department of Hematology and Oncology, Hospital Morales Meseguer, Murcia, Spain
    Curr Drug Metab 10:632-42. 2009
    ..There is a considerable controversy about the clinical use of genotyping before starting the anticoagulant therapy so, further randomized, prospective and large trials are required to recommend the use of pharmacogenetic testing...
  51. ncbi request reprint Genetic polymorphisms and atrial fibrillation: Insights into the prothrombotic state and thromboembolic risk
    Angel López-Cuenca
    Department of Cardiology, Hospital Universitario Virgen Arrixaca, Murcia, Spain
    Ann Med 42:562-75. 2010
    ..In this article, we provide an overview of the limited data about the possible influence of genetic polymorphisms on thromboembolic risk in AF, as well as the genetic influences on anticoagulant drug responsiveness...
  52. doi request reprint Hypertrophic cardiomyopathy. A study of the troponin-T gene in 127 spanish families
    Juan R Gimeno
    Servicio de Cardiologia, Hospital Virgen de la Arrixaca, El Palmar, Murcia, Spain
    Rev Esp Cardiol (Engl Ed) 62:1473-7. 2009
    ..In conclusion, troponin-T mutations were responsible for 3% of the hypertrophic cardiomyopathy cases in our study population. The Phe87Leu mutation was associated with only mild hypertrophy but with a high risk of sudden death. ..
  53. ncbi request reprint Exercise eco-Doppler in hypertrophic cardiomyopathy patients. Determinant factors of exercise intolerance
    Gonzalo de la Morena
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain Electronic address
    Rev Esp Cardiol (Engl Ed) 66:98-103. 2013
    ..We aimed to test the performance of treadmill exercise Doppler echocardiography in the prediction of functional limitations in these patients...
  54. ncbi request reprint Interleukin-6 and high-sensitivity C-reactive protein for the prediction of outcomes in non-ST-segment elevation acute coronary syndromes
    Angel López-Cuenca
    Departamento de Cardiologia, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
    Rev Esp Cardiol (Engl Ed) 66:185-92. 2013
    ....
  55. doi request reprint High-sensitivity troponin T as a biomarker for the development of atrial fibrillation after cardiac surgery
    Diana Hernandez-Romero
    Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain
    Eur J Cardiothorac Surg 45:733-8. 2014
    ..We investigated whether hsTnT and NT-proBNP levels could be used as valuable biomarkers for AF occurrence after cardiac surgery...
  56. doi request reprint Identification and confirmation of haptoglobin as a potential serum biomarker in hypertrophic cardiomyopathy using proteomic approaches
    Esteban Orenes-Piñero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain
    Ann Med 45:341-7. 2013
    ..Aiming at identifying biomarkers for hypertrophic cardiomyopathy (HCM), the serum proteome was explored through a two-dimensional gel-based proteomic approach (2D-DIGE) coupled with mass spectrometry and database interrogation...
  57. ncbi request reprint Does smoking status influence the effect of physical exercise on fibrinolytic function in healthy volunteers?
    Antonio Tello-Montoliu
    Cardiology Department, Hospital General Universitario, Alicante, Spain
    J Thromb Thrombolysis 21:163-6. 2006
    ..The aim of the present study was to assess the fibrinolytic system after strenuous exercise in healthy people and explored the influence of smoking habit...
  58. ncbi request reprint Correlation of plasma von Willebrand factor levels, an index of endothelial damage/dysfunction, with two point-based stroke risk stratification scores in atrial fibrillation
    Vanessa Roldan
    Hematology Unit, Hospital San Vicente, Alicante, Spain
    Thromb Res 116:321-5. 2005
    ..Further prospective studies are needed to assess the prognostic role of prothrombotic indices in AF in relation to stroke and thromboembolic events, and their role in complementing clinical risk stratification schemas...
  59. ncbi request reprint Common carotid artery intima-media thickness and intracranial pulsatility index in non-ST-elevation acute coronary syndromes
    Antonio Tello-Montoliu
    Cardiology Department, Hospital General Universitario, Alicante, Spain
    Cerebrovasc Dis 24:338-42. 2007
    ..The relation to the prognosis after an acute event was also assessed...
  60. ncbi request reprint [Plasma concentration of big endothelin-1 and its relation with plasma NT-proBNP and ventricular function in heart failure patients]
    Miguel Rivera
    Servicio de Cardiologia, Centro de investigación Hospital La Fe, Valencia, Spain
    Rev Esp Cardiol 58:278-84. 2005
    ..The purpose of this study was to investigate the relationship between plasma levels of big ET-1 and NT-proBNP, and between the former and ventricular function...
  61. ncbi request reprint Pre and post-operative treatments for prevention of atrial fibrillation after cardiac surgery
    Esteban Orenes-Piñero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Mini Rev Med Chem 12:1419-31. 2012
    ..The aim of this review is to analyse and determine the efficiency of existing therapies in the reduction of post-operative AF development...
  62. doi request reprint Small-size circulating microparticles in acute coronary syndromes: relevance to fibrinolytic status, reparative markers and outcomes
    Silvia Montoro-García
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH, UK
    Atherosclerosis 227:313-22. 2013
    ..5 μm polystyrene beads, denoted as small-size microparticles (sMP), their relation to markers of cardiovascular repair and their impact on prognosis in patients with acute coronary syndromes (ACS)...
  63. ncbi request reprint Prognostic value of mean platelet volume in patients with non-ST-elevation acute coronary syndrome
    Angel A López-Cuenca
    Cardiology Department, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Angiology 63:241-4. 2012
    ..In conclusion, patients with nSTEACS present with larger platelets than healthy controls, however this parameter did not show an independent prognostic significance at 6-month follow-up...
  64. doi request reprint Impact of polymorphisms in the renin-angiotensin-aldosterone system on hypertrophic cardiomyopathy
    Esteban Orenes-Piñero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    J Renin Angiotensin Aldosterone Syst 12:521-30. 2011
    ..The main objective of this review is to provide an overview of the role of different polymorphisms identified in the RAAS, in patients with HCM...
  65. doi request reprint Prevalence and prognostic influence of peripheral arterial disease in patients >or=40 years old admitted into hospital following an acute coronary event
    V Bertomeu
    Hospital Universitario de San Juan, Alicante, Spain
    Eur J Vasc Endovasc Surg 36:189-96. 2008
    ..We aimed to study the prevalence of PAD in patients with an acute coronary syndrome (ACS) and to evaluate its influence in hospital clinical outcomes...
  66. ncbi request reprint [Myocardial fibrosis in hypertrophic cardiomyopathy]
    Eduardo Payá
    Servicio de Cardiologia, Hospital General Universitario, Alicante, Espana
    Rev Esp Cardiol 58:585-6. 2005
  67. doi request reprint [Should we add antiplatelet therapy to oral anticoagulation in patients with atrial fibrillation and vascular disease? Review of available evidence]
    Jose Manuel Andreu
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Murcia, Espana
    Arch Cardiol Mex 82:248-51. 2012
    ..Current recommendation is to add antiplatelet drug to oral anticoagulation in patients with atrial fibrillation (AF) and vascular disease. However, it is debatable to join both antithrombotic drugs in stable vascular disease...
  68. doi request reprint Biomarkers of pathophysiology in hypertrophic cardiomyopathy: implications for clinical management and prognosis
    Francisco Cambronero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Eur Heart J 30:139-51. 2009
    ..Several pathophysiological models are presented and discussed, including studies that have investigated these biomarkers for diagnostic and prognostic reasons, in relation to disease progression and/or mortality...
  69. ncbi request reprint An insight of novel pharmacological therapies in hypertrophic cardiomyopathy
    Esteban Orenes-Piñero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Ctra Madrid Cartagena, El Palmar, Murcia, Spain
    Med Chem 7:275-85. 2011
    ..In this review, we analyse potential beneficial effects of specific experimental pharmacological agents on decreasing myocardial hypertrophy, regression of fibrosis or improving myocardial metabolic efficiency...
  70. ncbi request reprint Growth hormone therapy and the heart
    Vicente E Climent
    Department of Cardiology, General Hospital of Alicante, Alicante, Spain
    Am J Cardiol 97:1097-102. 2006
    ..However, these patients exhibited improved exercise capacity, especially those with childhood-onset GH deficiency...
  71. ncbi request reprint A common polymorphism in the annexin V Kozak sequence (-1C>T) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients
    Rocio Gonzalez-Conejero
    Hematology and Neurology Services, Hospital General Universitario, 30003 Murcia, Spain
    Blood 100:2081-6. 2002
    ..006; odds ratio, 0.51; 95% confidence interval, 0.30-0.85)...
  72. ncbi request reprint Hypertrophic cardiomyopathy. A study of the troponin-T gene in 127 Spanish families
    Juan R Gimeno
    Servicio de Cardiologia, Hospital Virgen de la Arrixaca, El Palmar, Murcia, Espana
    Rev Esp Cardiol 62:1473-7. 2009
    ..In conclusion, troponin-T mutations were responsible for 3% of the hypertrophic cardiomyopathy cases in our study population. The Phe87Leu mutation was associated with only mild hypertrophy but with a high risk of sudden death...
  73. doi request reprint Pharmacogenetics in cardiovascular antithrombotic therapy
    Francisco Marin
    Department of Cardiology, Hospital Universitario Virgen de Arrixaca, Murcia, Spain
    J Am Coll Cardiol 54:1041-57. 2009
    ..The present paper reviews the modulating role of different polymorphisms on individuals' responses to antithrombotic drugs commonly used in clinical practice...
  74. ncbi request reprint Pharmacologic therapy in growth hormone disorders and the heart
    Vicente Climent
    Department of Cardiology, General Hospital of Alicante, Spain
    Curr Med Chem 14:1399-407. 2007
    ..The aim of the present review is to provide an update overview describing the role of GH on acromegaly, adult GH deficiency and heart failure, as well as the influence of GH-based therapy on heart structure and function...
  75. ncbi request reprint Effects of pretreatment with intravenous flecainide on efficacy of external cardioversion of persistent atrial fibrillation
    Vicente E Climent
    Department of Cardiology, General Hospital of Alicante, Hospital Clinico Universitario of Valencia, Spain
    Pacing Clin Electrophysiol 27:368-72. 2004
    ..Pretreatment with intravenous flecainide before electrical cardioversion is not useful in reducing technical failure of cardioversion, however, flecainide does not diminish the effectiveness of electrical cardioversion...
  76. ncbi request reprint [Hemolytic anemia secondary to paravalvular regurgitation]
    Vanessa Roldan
    Unidad de Hematologia, Hospital de San Vicente, Alicante, Spain
    Rev Esp Cardiol 55:987. 2002
  77. ncbi request reprint [NT-proBNP levels and hypertension. Their importance in the diagnosis of heart failure]
    Miguel Rivera
    Servicio de Cardiologia, Centro de investigación Hospital La Fe, Valencia, Spain
    Rev Esp Cardiol 57:396-402. 2004
    ..N-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in the diagnosis of heart failure. We compared NT-proBNP levels in patients with and without a diagnosis of arterial hypertension...
  78. ncbi request reprint Fractional shortening-velocity ratio for assessment of aortic stenosis severity in patients with systolic dysfunction
    Vicente E Climent
    Department of Cardiology, General Hospital of Alicante, Maestro Alonso, 109, 03010 Alicante, Spain
    Int J Cardiol 92:229-34. 2003
    ..The objective of this study was to assess the utility of a described echocardiographic index: the fractional shortening-velocity ratio (FSVR=FS/4Vmax2) in those patients with left ventricular systolic dysfunction...
  79. ncbi request reprint Usefulness of an abnormal ankle-brachial index for detecting multivessel coronary disease in patients with acute coronary syndrome
    Daniel Núñez
    Servicio de Cardiologia, Hospital Universitario de San Juan, San Juan de Alicante, Alicante, Spain
    Rev Esp Cardiol 63:54-9. 2010
    ..The aim of this study was to assess the usefulness of an abnormal ABI for identifying multivessel coronary artery disease in patients with acute coronary syndrome (ACS)...
  80. ncbi request reprint Interactions between clopidogrel and proton pump inhibitors: a review of evidence
    C Muñoz-Esparza
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Ctra Madrid Cartagena s n, El Palmar Murcia 30120, Spain
    Curr Med Chem 18:2386-400. 2011
    ..In this article, we will review the current status and controversies in relation to a possible interaction between clopidogrel and PPIs...
  81. ncbi request reprint Enzyme replacement therapy in Fabry disease: influence on cardiac manifestations
    L Caballero
    Department of Cardiology, Hospital Universitario Virgen de la Arrixaca of Murcia, Spain
    Curr Med Chem 17:1679-89. 2010
    ....