Paul E Marik

Summary

Publications

  1. doi request reprint Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine PEM, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 37:2642-7. 2009
  2. ncbi request reprint Techniques for assessment of intravascular volume in critically ill patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Intensive Care Med 24:329-37. 2009
  3. doi request reprint Prolonged and profound therapeutic hypothermia for the treatment of "brain death" after a suicidal intoxication. Challenging conventional wisdoms
    Paul E Marik
    EVMS Internal Medicine, Norfolk, VA 2350, USA
    Am J Emerg Med 28:258.e1-4. 2010
  4. ncbi request reprint The use of bioreactance and carotid Doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Sentara Norfolk General Hospital, Norfolk, VA 23507, USA
    Chest 143:364-70. 2013
  5. doi request reprint Changes in end-tidal carbon dioxide and volumetric carbon dioxide as predictors of volume responsiveness in hemodynamically unstable patients
    Alisha Young
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Cardiothorac Vasc Anesth 27:681-4. 2013
  6. ncbi request reprint Enteral nutrition in the critically ill: myths and misconceptions
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA
    Crit Care Med 42:962-9. 2014
  7. doi request reprint Norepinephrine or dopamine for septic shock: systematic review of randomized clinical trials
    Tajender S Vasu
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 27:172-8. 2012
  8. doi request reprint Association between time of admission to the ICU and mortality: a systematic review and metaanalysis
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Chest 138:68-75. 2010
  9. doi request reprint Early goal-directed therapy: on terminal life support?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Am J Emerg Med 28:243-5. 2010
  10. ncbi request reprint Stress hyperlactatemia modifies the relationship between stress hyperglycemia and outcome: a retrospective observational study
    Kirsi Maija Kaukonen
    1Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia 2Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan 3Intensive Care Unit, Geelong Hospital, Barwon Health, Geelong, Australia 4Intensive Care Unit, Austin Health, Heidelberg, Australia 5Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA
    Crit Care Med 42:1379-85. 2014

Detail Information

Publications58

  1. doi request reprint Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine PEM, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 37:2642-7. 2009
    ..Dynamic changes in systolic pressure, pulse pressure, and stroke volume in patients undergoing mechanical ventilation have emerged as useful techniques to assess volume responsiveness...
  2. ncbi request reprint Techniques for assessment of intravascular volume in critically ill patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Intensive Care Med 24:329-37. 2009
    ..This paper reviews the evolution and accuracy of methods for assessing fluid responsiveness in critically ill patients...
  3. doi request reprint Prolonged and profound therapeutic hypothermia for the treatment of "brain death" after a suicidal intoxication. Challenging conventional wisdoms
    Paul E Marik
    EVMS Internal Medicine, Norfolk, VA 2350, USA
    Am J Emerg Med 28:258.e1-4. 2010
    ..Inappropriately labeling such patients as "brain dead" will result in the failure to institute therapeutic hypothermia and other advanced neuroprotective interventions in patients who could be salvaged with a good neurologic outcome...
  4. ncbi request reprint The use of bioreactance and carotid Doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Sentara Norfolk General Hospital, Norfolk, VA 23507, USA
    Chest 143:364-70. 2013
    ..A secondary end point was to evaluate the change in carotid Doppler fl ow following the PLR maneuver...
  5. doi request reprint Changes in end-tidal carbon dioxide and volumetric carbon dioxide as predictors of volume responsiveness in hemodynamically unstable patients
    Alisha Young
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Cardiothorac Vasc Anesth 27:681-4. 2013
    ..The purpose of this study was to determine whether changes in PETCO2 and exhaled CO2 (VCO2) can predict fluid responsiveness after a preload challenge...
  6. ncbi request reprint Enteral nutrition in the critically ill: myths and misconceptions
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA
    Crit Care Med 42:962-9. 2014
    ..Optimal provision of calories and protein has been demonstrated to reduce morbidity, mortally, and length of ICU and hospital stay. Yet, a large proportion of ICU patients receive inadequate nutrition...
  7. doi request reprint Norepinephrine or dopamine for septic shock: systematic review of randomized clinical trials
    Tajender S Vasu
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 27:172-8. 2012
    ..According to current guidelines either dopamine or norepinephrine may be considered as the first-line agent for the management of refractory hypotension of septic shock...
  8. doi request reprint Association between time of admission to the ICU and mortality: a systematic review and metaanalysis
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Chest 138:68-75. 2010
    ..A change in the ICU staffing structure frequently occurs at nighttime and on weekends (off-hours). We postulated that patients who are admitted to an ICU during off hours may be at an increased risk of death...
  9. doi request reprint Early goal-directed therapy: on terminal life support?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Am J Emerg Med 28:243-5. 2010
    ..Although the concept of early resuscitation is a scientifically sound concept, we believe that the major elements of the sepsis bundle are fatally flawed...
  10. ncbi request reprint Stress hyperlactatemia modifies the relationship between stress hyperglycemia and outcome: a retrospective observational study
    Kirsi Maija Kaukonen
    1Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia 2Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan 3Intensive Care Unit, Geelong Hospital, Barwon Health, Geelong, Australia 4Intensive Care Unit, Austin Health, Heidelberg, Australia 5Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA
    Crit Care Med 42:1379-85. 2014
    ..To study the effect of stress hyperlactatemia on the association between stress hyperglycemia and mortality...
  11. ncbi request reprint Goal directed fluid therapy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Curr Pharm Des 18:6215-24. 2012
    ..This review focuses on methods to assess fluid responsiveness and the application of these methods for goal directed fluid therapy in critically ill and peri-operative patients...
  12. doi request reprint Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  13. doi request reprint Immunonutrition in high-risk surgical patients: a systematic review and analysis of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    JPEN J Parenter Enteral Nutr 34:378-86. 2010
    ..The goal of this meta-analysis was to determine the impact of IMDs on the clinical outcomes of high-risk patients undergoing elective surgery...
  14. doi request reprint Is the band count useful in the diagnosis of infection? An accuracy study in critically ill patients
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 25:353-7. 2010
    ..However, the literature regarding the diagnostic accuracy of an elevated band count for the diagnosis of infection is limited...
  15. ncbi request reprint Inferior vena cava variation compared to pulse contour analysis as predictors of fluid responsiveness: a prospective cohort study
    Enrique Machare-Delgado
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 26:116-24. 2011
    ..Accurately predicting fluid responsiveness (FRes) allows for optimization of cardiac performance while avoiding fluid overload and prolonged mechanical ventilation...
  16. ncbi request reprint Requirement of perioperative stress doses of corticosteroids: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Ste 650, Philadelphia, PA 19107, USA
    Arch Surg 143:1222-6. 2008
    ..Patients receiving therapeutic dosages of corticosteroids frequently require surgery; these patients are almost universally treated with stress doses of corticosteroids during the perioperative period...
  17. doi request reprint Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Suite 650, Philadelphia, PA 19107, USA
    Chest 134:172-8. 2008
    ..Central venous pressure (CVP) is used almost universally to guide fluid therapy in hospitalized patients. Both historical and recent data suggest that this approach may be flawed...
  18. doi request reprint Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 41:1774-81. 2013
    ..Despite a previous meta-analysis that concluded that central venous pressure should not be used to make clinical decisions regarding fluid management, central venous pressure continues to be recommended for this purpose...
  19. ncbi request reprint Characteristics of patients with the "malignant obesity hypoventilation syndrome" admitted to an ICU
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Intensive Care Med 28:124-30. 2013
    ..We have coined the term the malignant obesity hypoventilation syndrome (MOHS) to describe this entity...
  20. doi request reprint Hypertensive emergencies: an update
    Paul E Marik
    Department of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Curr Opin Crit Care 17:569-80. 2011
    ..However, only patients with true hypertensive emergencies require the immediate and controlled reduction of blood pressure with an intravenous antihypertensive agent...
  21. ncbi request reprint Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:2667-74. 2008
    ..However, the hematocrit that should be maintained in any particular patient because the risks of further transfusion of RBC outweigh the benefits remains unclear...
  22. doi request reprint Natriuretic peptides in acute pulmonary embolism: a systematic review
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Intensive Care Med 34:2147-56. 2008
    ..Patients with pulmonary embolism (PE) have a high risk of death, and it is important to recognize factors associated with higher mortality. Recently, several biomarkers have been studied for risk stratification in patients with PE...
  23. doi request reprint The role of head computer tomographic scans on the management of MICU patients with neurological dysfunction
    Daniel Salerno
    Division of Pulmonary and Critical Care Medicine, Christiana Health Care System, Newark, Delaware 19805, USA
    J Intensive Care Med 24:372-5. 2009
    ..This study suggests that clinicians should have a low threshold for ordering a CT scan in MICU patients with acute neurological dysfunction...
  24. doi request reprint Pulmonary aspiration syndromes
    Paul E Marik
    Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23507, USA
    Curr Opin Pulm Med 17:148-54. 2011
    ..These syndromes are often misdiagnosed and their management is frequently suboptimal. This paper reviews the clinical features and management of the most common aspiration syndromes...
  25. doi request reprint Glucocorticoid treatment in acute lung injury and acute respiratory distress syndrome
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Clin 27:589-607. 2011
    ..The authors recommend prolonged methylprednisolone at 1 mg/kg/d initially in early ARDS, increasing to 2 mg/kg/d after 7 to 9 days of no improvement...
  26. doi request reprint Critical illness-related corticosteroid insufficiency
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Chest 135:181-93. 2009
    ..The paper reviews cortisol physiology, CIRCI, and the role of corticosteroid therapy in critically ill patients...
  27. doi request reprint Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 38:2222-8. 2010
    ..Stress ulcer prophylaxis may, however, increase the risk of hospital-acquired pneumonia and Clostridia difficile infection...
  28. ncbi request reprint Aspiration syndromes: aspiration pneumonia and pneumonitis
    Paul E Marik
    Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Hosp Pract (1995) 38:35-42. 2010
    ..Treatment of aspiration pneumonitis is essentially supportive; however, corticosteroids and other immunomodulating agents may have a role in these patients...
  29. doi request reprint Immunonutrition in critically ill patients: a systematic review and analysis of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Intensive Care Med 34:1980-90. 2008
    ..The role of immuno-modulating diets (IMDs) in critically ill patients is controversial...
  30. ncbi request reprint Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Cardiol 32:365-72. 2009
    ..The clinical benefit of dietary fish oil supplementation in preventing cardiovascular events in both high and low risk patients is unclear...
  31. ncbi request reprint Should age limit admission to the intensive care unit?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 24:63-6. 2007
    ..This suggests that age alone should not be used in making intensive care unit triage decisions...
  32. ncbi request reprint Mechanisms and clinical consequences of critical illness associated adrenal insufficiency
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 13:363-9. 2007
    ..The review summarizes our current understanding of the causes and consequences of adrenal insufficiency in critically ill patients...
  33. doi request reprint Narrative review: the management of acute decompensated heart failure
    Paul E Marik
    Department of Medicine, Eastern Virginia Medial School, Norfolk, VA 23507, USA
    J Intensive Care Med 27:343-53. 2012
    ..The goal of this review is to provide evidence-based recommendations for the diagnosis and management of ADHF...
  34. doi request reprint The risk of catheter-related bloodstream infection with femoral venous catheters as compared to subclavian and internal jugular venous catheters: a systematic review of the literature and meta-analysis
    Paul E Marik
    Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 40:2479-85. 2012
    ..However, the risk of catheter-related bloodstream infections from femoral as compared to subclavian and internal jugular venous catheterization has not been systematically reviewed...
  35. pmc Glucocorticoids in sepsis: dissecting facts from fiction
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, 825 Fairfax Ave, Suite 410, Norfolk, VA 23507, USA
    Crit Care 15:158. 2011
    ..Severe sepsis is, however, associated with complex alterations of the HPA axis, which may result in decreased production of cortisol as well as glucocorticoid tissue resistance...
  36. doi request reprint Do dietary supplements have beneficial health effects in industrialized nations: what is the evidence?
    Paul E Marik
    Department of Medicine and the Nutrition Study Group, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    JPEN J Parenter Enteral Nutr 36:159-68. 2012
    ..Dietary supplements are regularly used by at least half of the American population, yet the health benefits of these agents are unclear...
  37. doi request reprint Inhaled nitric oxide as salvage therapy in massive pulmonary embolism: a case series
    Douglas T Summerfield
    Eastern Virginia Medical School, Norfolk, VA, USA
    Respir Care 57:444-8. 2012
    ..We describe 4 cases in which INO was used as a temporizing agent to decrease right ventricular after-load following massive near-fatal pulmonary embolism. All 4 patients survived to hospital discharge...
  38. ncbi request reprint Noninvasive hemodynamic monitoring in the intensive care unit
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Crit Care Clin 23:383-400. 2007
    ..In addition this article reviews some of the surrogate markers that can be used to assess adequacy of cardiac output...
  39. ncbi request reprint Noninvasive positive-pressure ventilation in patients with malignancy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Hosp Palliat Care 24:417-21. 2007
    ..In rare instances, NIPPV may have a role in treating patients with advanced cancer who have intractable dyspnea; however, NIPPV should not be used for the sole purpose of prolonging life in patients with terminal respiratory failure...
  40. ncbi request reprint Management of patients with metastatic malignancy in the intensive care unit
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 23:479-82. 2006
    ..Intensivists, who are charged with making the best use of limited resources, should ultimately be the individuals who determine the appropriateness of admitting such patients to the intensive care unit...
  41. ncbi request reprint The definition of septic shock: implications for treatment
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Resusc 9:101-3. 2007
    ....
  42. doi request reprint Acute lung injury following blood transfusion: expanding the definition
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:3080-4. 2008
    ..The objectives of this review are to summarize current knowledge of TRALI with an emphasis on issues pertinent to the intensivist and to define the newly recognized "Delayed TRALI syndrome."..
  43. ncbi request reprint The hazards of blood transfusion
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Br J Hosp Med (Lond) 70:12-5. 2009
    ..This article reviews the major complications associated with blood transfusion...
  44. doi request reprint What is the best way to feed patients with pancreatitis?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 15:131-8. 2009
    ..Recent data, however, suggest that this approach may be associated with increased morbidity and mortality. This paper reviews evolving concepts in the nutritional management of patients with acute pancreatitis...
  45. ncbi request reprint A 64-year-old male with fever and persistent lung infiltrate
    Tajender S Vasu
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia PA 19107, USA
    Respir Care 54:1263-5. 2009
    ..He had substantial clinical and radiological improvement after the discontinuation of decitabine and a course of corticosteroids...
  46. doi request reprint Thrombolytic therapy in a patient with suspected pulmonary embolism despite a negative computed tomography pulmonary angiogram
    Urvashi Vaid
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Respir Care 56:336-8. 2011
    ..Autopsy confirmed the diagnosis of multiple pulmonary emboli and unexpectedly discovered a patent foramen ovale that explained paradoxical embolism to the brain...
  47. ncbi request reprint The effect of APRV ventilation on ICP and cerebral hemodynamics
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Respiratory Services, Eastern Virginia Medical School, 825 Fairfax Ave, Suite 410, Norfolk, VA 23507, USA
    Neurocrit Care 17:219-23. 2012
    ..APRV is associated with a higher mean airway pressure than conventional ventilation and has therefore not been evaluated in patients with acute neurological injuries...
  48. pmc Delirium in the ICU: an overview
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care, Eastern Virginia Medical School, Norfolk, VA, USA
    Ann Intensive Care 2:49. 2012
    ..Second-generation antipsychotics have emerged as an alternative for the treatment of delirium, and they may have a better safety profile. Dexmedetomidine may prove to be a valuable adjunctive agent for patients with delirium in the ICU...
  49. doi request reprint Therapeutic effect of conivaptan bolus dosing in hyponatremic neurosurgical patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Pharmacotherapy 33:51-5. 2013
    ..To determine the natremic response of a single 20-mg bolus dose of conivaptan, an arginine vasopressin antagonist, in hyponatremic neurosurgical patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH)...
  50. doi request reprint Neonatal incubators: a toxic sound environment for the preterm infant?*
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine and Division of Medical and Experimental Ultrasound, Eastern Virginia Medical School, Norfolk, VA, USA
    Pediatr Crit Care Med 13:685-9. 2012
    ..Knowledge of the contribution of each component and source is important to develop effective strategies to reduce noise within the incubator...
  51. doi request reprint The immune response to surgery and trauma: Implications for treatment
    Paul E Marik
    Divisions of General Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    J Trauma Acute Care Surg 73:801-8. 2012
    ..Recent data, however, suggests that his paradigm may not be correct...
  52. pmc The diagnosis of adrenal insufficiency in the critically ill patient: does it really matter?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Walnut Street, Philadelphia, Pennsylvania 19107, USA
    Crit Care 10:176. 2006
    ..In those patients in whom the diagnosis of adrenal insufficiency may be important, this diagnosis may best be made based on the free cortisol level or the total cortisol level stratified by serum albumin...
  53. doi request reprint Multidisciplinary family meetings in the ICU facilitate end-of-life decision making
    Enrique Machare Delgado
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA
    Am J Hosp Palliat Care 26:295-302. 2009
    ..The aim of this study was to assess the feasibility of establishing a multi-disciplinary family meeting (MDFM) program and the impact of such a program on the end-of-life decision making in the setting of an ICU...
  54. ncbi request reprint Management of the critically ill geriatric patient
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 34:S176-82. 2006
    ..To review the effect of an aging society on the utilization of critical care services and the physiology of aging as it applies to critical illness and prognosis and management issues in the intensive care unit (ICU)...
  55. doi request reprint Venous thromboembolism in pregnancy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, EVMS Internal Medicine, Eastern Virginia Medical School, HH Suite 410, 825 Fairfax Avenue, Norfolk VA 23507, USA
    Clin Chest Med 31:731-40. 2010
    ..The indications for antepartum anticoagulant prophylaxis are somewhat controversial. This article reviews the management of VTE during pregnancy and in the postpartum period...
  56. doi request reprint The efficacy and dosage effect of corticosteroids for the prevention of atrial fibrillation after cardiac surgery: a systematic review
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Crit Care 24:458-63. 2009
    ..Corticosteroids down-regulate activation of the proinflammatory response (including C-reactive protein) after cardiopulmonary bypass and have been suggested to reduce the risk of postoperative AF...
  57. doi request reprint The DRESS syndrome: the great clinical mimicker
    Peter Fleming
    Department of Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Pharmacotherapy 31:332. 2011
    ..Furthermore, considering the potential severe effects associated with phenytoin, the risks and benefits should be carefully evaluated before using this agent for seizure prophylaxis...
  58. doi request reprint Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Chest 137:544-51. 2010
    ..The goal of this systematic review was to determine the benefits and risks of tight glycemic control in ICU patients and to explain the differences in outcomes among reported trials...