A novel mutation in the FGB: c.1105C>T turns the codon for amino acid Bβ Q339 into a stop codon causing hypofibrinogenemiaRita Marchi
Centro de Medicina Experimental, IVIC, Caracas, Bolivarian Republic of Venezuela
Blood Cells Mol Dis 50:177-81. 2013
..Electrospray ionization mass spectrometry (ESI MS) presented normal sialylation of the oligosaccharide chains, and liver function tests showed no evidence of liver dysfunction that might explain the functional abnormalities...
- Structure of fibrin network of two abnormal fibrinogens with mutations in the αC domain on the human dermal microvascular endothelial cells 1
Rita Marchi
Laboratorio Biología del Desarrollo de la Hemostasia, Centro de Medicina Experimental, Valencia, Bolivarian Republic of Venezuela
Blood Coagul Fibrinolysis 22:706-11. 2011
..The structure of normal and patient clots performed in the absence of cells resembled that observed far from the cell surface, concluding that Caracas V and Caracas I fibrin was modulated by the presence of endothelial cells...
A novel missense mutation in the FGB g. 3354 T>A (p. Y41N), fibrinogen Caracas VIIIRita Marchi
Centro de Medicina Experimental, Laboratorio Biología del Desarrollo de la Hemostasia, Instituto Venezolano de Investigaciones Cientificas, Caracas, República Bolivariana de Venezuela
Thromb Haemost 105:627-34. 2011
..These results demonstrate the significance of the amino terminal end of the β chain of fibrin in the polymerisation process and its consequences on the clot organisation on the surface of endothelial cells...
Preliminary study of the fibrin structure in hypertensive, dyslipidemic and type 2 diabetic patientsRita Marchi-Cappelletti
Instituto Venezolano de Investigaciones Cientificas, Centro de Medicina Experimental, Laboratorio de Fisiopatologia, Sección Biología del Desarrollo de la Hemostasia, Caracas, Venezuela
Invest Clin 51:315-24. 2010
..0015. Our results suggest that the fibrin structure was altered in DL and T2D patients, probably due to the increased cholesterol and glycation, respectively...
- [Effect of antiphospholipid antibodies on the formation and lysis of fibrin network in patients with recurrent miscarriage]
Rita Marchi
Centro de Medicina Experimental, Laboratorio Biología del Desarrollo de la Hemostasia, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Invest Clin 52:35-47. 2011
..The changes observed in the fibrin polymerization and lysis process of women with RM without APS and LA seem to be related to their higher fibrinogen levels, while the increased plasmin generation was related to the patients' morbidity...
- Invertebrate compounds acting on the hemostatic mechanism
C L Arocha-Pinango
Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Blood Coagul Fibrinolysis 10:43-68. 1999
..Some of these components have been well characterized, cloned and prepared in recombinant form, and seem to be very promising from the therapeutic point of view...
