Plasma levels of matrix metalloproteinases and their inhibitors in hypertension: a systematic review and meta-analysisChiara Marchesi
Department of Clinical Medicine, University of Insubria, Varese, Italy
J Hypertens 30:3-16. 2012
..The aim of this meta-analysis is to elucidate the behavior of plasma MMP and TIMP levels in hypertension and their relationship to cardiovascular remodeling...
Masked hypertension in type 2 diabetes mellitus. Relationship with left-ventricular structure and functionChiara Marchesi
Department of Clinical Medicine, University of Insubria, Varese, Italy
Am J Hypertens 20:1079-84. 2007
..To evaluate in type 2 diabetes mellitus the relationship between masked hypertension (MH) and left ventricular (LV) morpho-functional characteristics...
- Metabolic syndrome and morphofunctional characteristics of the left ventricle in clinically hypertensive nondiabetic subjects
Anna M Grandi
Department of Clinical Medicine, University of Insubria, Varese, Italy
Am J Hypertens 19:199-205. 2006
..The study was aimed to evaluate the impact of the metabolic syndrome on left ventricular (LV) structure and function in nondiabetic patients, never treated with antihypertensive or lipid-lowering drugs...
- Effects of dual blockade of Renin-Angiotensin system on concentric left ventricular hypertrophy in essential hypertension: a randomized, controlled pilot study
Anna M Grandi
Department of Clinical Medicine, University of Insubria, Varese, Italy
Am J Hypertens 21:231-7. 2008
....
- Family history of hypertension influences left ventricular diastolic function during chronic antihypertensive therapy
Anna M Grandi
Department of Clinical Medicine, University of Insubria, Varese, Italy
Am J Hypertens 20:410-5. 2007
..This study was aimed to evaluate whether genetic predisposition to hypertension can also influence left ventricular (LV) changes during antihypertensive treatment...
- Weight gain after acute deep venous thrombosis: a prospective observational study
Walter Ageno
Department of Internal Medicine, Ospedale di Circolo, University of Insubria, Viale Borri 57, 21100 Varese, Italy
Thromb Res 109:31-5. 2003
..Weight gain is strongly associated with an increase in metabolic and cardiovascular risk factors. The aim of this study was to assess weight changes occurring after an episode of acute deep venous thrombosis (DVT)...
- Angiotensin-converting enzyme inhibitors influence left ventricular mass and function independently of the antihypertensive effect
Anna Maria Grandi
Department of Clinical Medicine, University of Insubria, Varese, Italy
J Cardiovasc Pharmacol 48:207-11. 2006
..In conclusion, our clinical study shows that ACE inhibitors can induce LV hypertrophy regression and improvement of diastolic function also in the absence of any antihypertensive effect...
- OSA, metabolic syndrome and CPAP: effect on cardiac remodeling in subjects with abdominal obesity
Anna M Grandi
Department of Clinical Medicine, University of Insubria, Varese, Italy
Respir Med 106:145-52. 2012
..We evaluated whether obstructive sleep apnoea (OSA) and continuous positive airway pressure (CPAP) treatment influence left ventricular (LV) remodelling independently of abdominal obesity and metabolic syndrome (MetS)...
- Isolated office hypertension: a 3-year follow-up study
Anna M Grandi
Department of Clinical Medicine, University of Insubria, Varese, Italy
Blood Press 14:298-305. 2005
..In conclusion, IO hypertensive patients show a high rate of progression towards sustained hypertension. Basal LV hypertrophy and/or preclinical diastolic dysfunction were the only markers of a greater risk of becoming hypertensives...
- Body mass index is associated with the development of the post-thrombotic syndrome
Walter Ageno
Department of Internal Medicine, University of Insubria, Varese, Italy
Thromb Haemost 89:305-9. 2003
..918 and p = 0.775, respectively). BMI is significantly correlated with the development of PTS. Patients with DVT should be encouraged to avoid weight gain. Reducing patient weight might be an important strategy to prevent PTS...
- The initial phase of oral anticoagulation with warfarin in outpatients with deep venous thrombosis
Walter Ageno
Department of Internal Medicine, University of Insubria, Varese, Italy
Blood Coagul Fibrinolysis 14:11-4. 2003
..039). Patients younger than 60 years old had an odds ratio for an extended treatment of 4.92 (P = 0.0057). Algorithms with different loading doses of warfarin according to age should be proposed for outpatient treatment of DVT...
- Thrombosis prophylaxis in medical patients: a retrospective review of clinical practice patterns
Walter Ageno
Department of Internal Medicine, University of Insubria, Italy
Haematologica 87:746-50; discussion 250. 2002
..The risk of venous thromboembolism in medical patients is comparable to the risk in general surgical patients. Thromboprophylaxis is recommended for specific medical patients, but its use in clinical practice is unknown...
- Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis
Francesco Dentali
University of Insubria, Varese, Italy
Thromb Haemost 106:429-38. 2011
..9-16.6). In conclusion, our results suggest there is a low but quantifiable risk of thromboembolism in VKA-treated patients receiving PCCs for anticoagulation reversal. These findings should be confirmed in randomised, controlled trials...
- Selecting patients for home treatment of deep vein thrombosis: the problem of cancer
Walter Ageno
Department of Internal Medicine University of Insubria, Varese, Italy
Haematologica 87:286-91. 2002
..Cancer is frequently associated with venous thromboembolism and is often considered an exclusion criterion for outpatient treatment. We investigated the impact of cancer on the outpatient management of venous thrombosis...
Correlation of circulating CD133+ progenitor subclasses with a mild phenotype in Duchenne muscular dystrophy patientsChiara Marchesi
Stem Cell Laboratory, Department of Neurological Science, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Centro Dino Ferrari, University of Milan, Milan, Italy
PLoS ONE 3:e2218. 2008
..Here we assessed whether the levels of certain stem cells may predict the progression of Duchenne muscular dystrophy (DMD)...
- Role of the renin-angiotensin system in vascular inflammation
Chiara Marchesi
Lady Davis Institute for Medical Research and Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Trends Pharmacol Sci 29:367-74. 2008
..The present review addresses recent findings regarding the pathophysiology of vascular inflammation in hypertension, focusing specifically on the role of Ang II...
