The depolymerization of sodium alginate by oxidative degradationShirui Mao
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China
Pharm Dev Technol 17:763-9. 2012
..In summary, this method is an effective and convenient approach for preparing low Mw oligosaccharides from sodium alginate and may be potentially useful for the drug delivery system design with alginate...
- Chitosan-based formulations for delivery of DNA and siRNA
Shirui Mao
School of Pharmacy, Shenyang Pharmaceutical University, 110016 Shenyang, China
Adv Drug Deliv Rev 62:12-27. 2010
..In summary, the transfection efficiency of chitosan-based delivery systems can be adjusted by changing formulation-related parameters...
- Bioadhesion and oral absorption of enoxaparin nanocomplexes
Wei Sun
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
Int J Pharm 386:275-81. 2010
..In conclusion, the oral bioavailability of enoxaparin can be enhanced by improving the bioadhesive properties of PEC via the chemical modification of chitosan employed...
Recent advances in polymeric microspheres for parenteral drug delivery--part 2Shirui Mao
Shenyang Pharmaceutical University, School of Pharmacy, China
Expert Opin Drug Deliv 9:1209-23. 2012
....
- Effect of novel stabilizers--cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals
Wei Sun
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China
Nanomedicine 8:460-7. 2012
..The electrostatic stabilization effect was found to be stronger than the steric one. Crystallinity of itraconazole was unchanged by the addition of cationic polymers, while drug physical stability remarkably improved...
- Nanonization of itraconazole by high pressure homogenization: stabilizer optimization and effect of particle size on oral absorption
Wei Sun
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China
J Pharm Sci 100:3365-73. 2011
..However, the AUC was not significantly affected by further reduction of the particle size within the nano-size range...
- Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and enoxaparin
Wei Sun
Shenyang Pharmaceutical University, Shenyang, China
Eur J Pharm Biopharm 69:417-25. 2008
..Oral absorption of the polyelectrolyte nanocomplexes will be studied in vivo...
- Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats
Dan Mei
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China
Eur J Pharm Biopharm 70:874-81. 2008
..Taking safety reason into account, chitosan 100 kDa is the most promising as an intranasal absorption enhancer...
- Amphiphilic polymeric micelles as the nanocarrier for peroral delivery of poorly soluble anticancer drugs
Ye Tian
Shenyang Pharmaceutical University, School of Pharmacy, Shenyang, China
Expert Opin Drug Deliv 9:687-700. 2012
..Furthermore, both the copolymer structure and drug loading methods should be controlled in order to get micelles with appropriate particle size for better absorption...
- Design and in vitro evaluation of a film-controlled dosage form self-converted from monolithic tablet in gastrointestinal environment
Tingting Zhang
School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, 110016 Shenyang, China
J Pharm Sci 99:4678-90. 2010
..The in vivo behavior of this hydrophilic matrix system will be investigated...
- Comparison of different absorption enhancers on the intranasal absorption of isosorbide dinitrate in rats
Lidong Na
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
Int J Pharm 397:59-66. 2010
..Taking both enhancing effect and safety into account, we suggest poloxamer 188 is the most promising as an intranasal absorption enhancer...
- Recent advances in polymeric microspheres for parenteral drug delivery--part 1
Shirui Mao
Shenyang Pharmaceutical University, School of Pharmacy, Shenyang, China
Expert Opin Drug Deliv 9:1161-76. 2012
..The limited availability of biodegradable polymers with a long history of regulatory approval and the challenges in gaining regulatory approval of a new polymer have hindered the development of microspheres for parenteral drug delivery...
Amphiphilic graft copolymer based on poly(styrene-co-maleic anhydride) with low molecular weight polyethylenimine for efficient gene deliveryXiaopin Duan
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China
Int J Nanomedicine 7:4961-72. 2012
..Fourier transform infrared spectrum, (1)H nuclear magnetic resonance, and gel permeation chromatography were used to characterize the graft copolymer...
- A novel permeation enhancer: N-succinyl chitosan on the intranasal absorption of isosorbide dinitrate in rats
Lidong Na
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, 32, Shenyang 110016, China
Eur J Pharm Sci 48:301-6. 2013
..Taking both absorption enhancing and safety reason into account, we suggest NSCS is a promising intranasal absorption enhancer...
- New strategies to improve the intranasal absorption of insulin
Xiaopin Duan
School of Pharmacy 32, Shenyang Pharmaceutical University, Wenhua Road 103, 110016 Shenyang, China
Drug Discov Today 15:416-27. 2010
..It seems that bioadhesive delivery systems or water-insoluble powders with absorption enhancers are the most promising methods for intranasal delivery of insulin...
- Characterization of chitosan and its derivatives using asymmetrical flow field-flow-fractionation: a comparison with traditional methods
Shirui Mao
School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, 110016 Shenyang, China
J Pharm Biomed Anal 45:736-41. 2007
..In contrast, the influence was marginal when the molecular weight of chitosan was less than 50 kDa. The AF4-MALS was found to be a suitable method for the characterization of pure chitosans and trimethyl chitosans...
