Paolo Manzoni

Summary

Publications

  1. ncbi request reprint Clinical use of lactoferrin in preterm neonates: an update
    P Manzoni
    Neonatology and NICU Sant Anna Hospital, Torino, Italy
    Minerva Pediatr 62:101-4. 2010
  2. ncbi request reprint An association between anatomic site of Candida colonization and risk of invasive candidiasis exists also in preterm neonates in neonatal intensive care unit
    Paolo Manzoni
    Diagn Microbiol Infect Dis 56:459-60. 2006
  3. ncbi request reprint Risk factors for progression to invasive fungal infection in preterm neonates with fungal colonization
    Paolo Manzoni
    Neonatology and Hospital NICU, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10136 Torino, Italy
    Pediatrics 118:2359-64. 2006
  4. ncbi request reprint Use of Lactobacillus casei subspecies Rhamnosus GG and gastrointestinal colonization by Candida species in preterm neonates
    Paolo Manzoni
    Departments of Neonatology, Neonatal Intensive Care Unit, S Anna Hospital, Turin, Italy
    J Pediatr Gastroenterol Nutr 45:S190-4. 2007
  5. doi request reprint Routine use of fluconazole prophylaxis in a neonatal intensive care unit does not select natively fluconazole-resistant Candida subspecies
    Paolo Manzoni
    Neonatology and Hospital NICU, Azienda Ospedaliera Regina Margherita S Anna C Spezia 60, 10136 Torino, Italy
    Pediatr Infect Dis J 27:731-7. 2008
  6. doi request reprint Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital Torino, Italy Electronic address
    Early Hum Dev 90:S60-5. 2014
  7. pmc The use of ciprofloxacin and fluconazole in Italian neonatal intensive care units: a nationwide survey
    Chiara Pandolfini
    Laboratory for Mother and Child Health, Department of Public Health Mario Negri Pharmacological Research Institute, Milan, Italy
    BMC Pediatr 13:5. 2013
  8. doi request reprint Human milk feeding prevents retinopathy of prematurity (ROP) in preterm VLBW neonates
    Paolo Manzoni
    Neonatal Intensive Care Unit, S Anna Hospital, Torino, Italy
    Early Hum Dev 89:S64-8. 2013
  9. doi request reprint Prevention of nosocomial infections in neonatal intensive care units
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital, Turin, Italy
    Am J Perinatol 30:81-8. 2013
  10. doi request reprint Lutein and zeaxanthin supplementation in preterm very low-birth-weight neonates in neonatal intensive care units: a multicenter randomized controlled trial
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital, Torino, Italy
    Am J Perinatol 30:25-32. 2013

Detail Information

Publications50

  1. ncbi request reprint Clinical use of lactoferrin in preterm neonates: an update
    P Manzoni
    Neonatology and NICU Sant Anna Hospital, Torino, Italy
    Minerva Pediatr 62:101-4. 2010
    ..Future studies are warranted to better elucidate the extent of the prevention provided by Ictoferrin and to identify the most suitable dosages to be administered...
  2. ncbi request reprint An association between anatomic site of Candida colonization and risk of invasive candidiasis exists also in preterm neonates in neonatal intensive care unit
    Paolo Manzoni
    Diagn Microbiol Infect Dis 56:459-60. 2006
  3. ncbi request reprint Risk factors for progression to invasive fungal infection in preterm neonates with fungal colonization
    Paolo Manzoni
    Neonatology and Hospital NICU, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10136 Torino, Italy
    Pediatrics 118:2359-64. 2006
    ..We investigated such variables in a large number of colonized preterm neonates in an NICU...
  4. ncbi request reprint Use of Lactobacillus casei subspecies Rhamnosus GG and gastrointestinal colonization by Candida species in preterm neonates
    Paolo Manzoni
    Departments of Neonatology, Neonatal Intensive Care Unit, S Anna Hospital, Turin, Italy
    J Pediatr Gastroenterol Nutr 45:S190-4. 2007
    ....
  5. doi request reprint Routine use of fluconazole prophylaxis in a neonatal intensive care unit does not select natively fluconazole-resistant Candida subspecies
    Paolo Manzoni
    Neonatology and Hospital NICU, Azienda Ospedaliera Regina Margherita S Anna C Spezia 60, 10136 Torino, Italy
    Pediatr Infect Dis J 27:731-7. 2008
    ..With prolonged use, concerns exist for the emergence of acquired fungal resistance and of Candida subspecies that are natively fluconazole-resistant (NFR), mostly Candida glabrata and Candida krusei...
  6. doi request reprint Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital Torino, Italy Electronic address
    Early Hum Dev 90:S60-5. 2014
    ..Probiotics including lactobacillus rhamnosus GG (LGG) proved effective in preventing NEC in preterm infants in several RCTs...
  7. pmc The use of ciprofloxacin and fluconazole in Italian neonatal intensive care units: a nationwide survey
    Chiara Pandolfini
    Laboratory for Mother and Child Health, Department of Public Health Mario Negri Pharmacological Research Institute, Milan, Italy
    BMC Pediatr 13:5. 2013
    ..As part of a European initiative, a survey was set up to describe the use of two drugs in this area. The Italian national practices concerning neonatal sepsis, as well as calls for related guidance, are described...
  8. doi request reprint Human milk feeding prevents retinopathy of prematurity (ROP) in preterm VLBW neonates
    Paolo Manzoni
    Neonatal Intensive Care Unit, S Anna Hospital, Torino, Italy
    Early Hum Dev 89:S64-8. 2013
    ..Human, maternal milk is the best possible nutritional option for all premature infants, including those at high risk for severe complications of prematurity, such as ROP...
  9. doi request reprint Prevention of nosocomial infections in neonatal intensive care units
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital, Turin, Italy
    Am J Perinatol 30:81-8. 2013
    ..Additional measures may include the use of lactoferrin, fluconazole, and nystatin and specific measures to prevent ventilator associated pneumonia...
  10. doi request reprint Lutein and zeaxanthin supplementation in preterm very low-birth-weight neonates in neonatal intensive care units: a multicenter randomized controlled trial
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital, Torino, Italy
    Am J Perinatol 30:25-32. 2013
    ..The carotenoids, which are not found in formula milk, might play a key role in these actions...
  11. ncbi request reprint Echinocandins for the nursery: an update
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital, Azienda Ospedaliera Regina Margherita S Anna, C so Spezia 60 10126 Torino, Italy
    Curr Drug Metab 14:203-7. 2013
    ..Further studies properly designed for neonatal populations will better address long-term safety and echological issues related to Echinocandin use in neonates...
  12. doi request reprint High risk for RSV bronchiolitis in late preterms and selected infants affected by rare disorders: a dilemma of specific prevention
    P Manzoni
    Neonatology and NICU, S Anna Hospital, ASO OI Regina Margherita S Anna, Torino, Italy
    Early Hum Dev 88:S34-41. 2012
    ....
  13. doi request reprint Correct choices for correct treatments: key issues in the management of Candida infections in preterm neonates
    P Manzoni
    Neonatology and NICU, S Anna Hospital, Torino, Italy
    Early Hum Dev 88:S98-S100. 2012
    ..However, further studies are warranted to better establish kinetics and appropriate dosing of these agents in premature and term infants, as well as their ability to improve late outcomes of ICI...
  14. doi request reprint Liposomal amphotericin B does not induce nephrotoxicity or renal function impairment in premature neonates
    P Manzoni
    Neonatology and NICU, Sant Anna Hospital, Azienda Ospedaliera OIRM S Anna, Torino, Italy
    Early Hum Dev 88:S86-91. 2012
    ..Concerns exist on safety and tolerability of such drug in patients who are at risk for renal function impairment due to their prematurity...
  15. doi request reprint Neonatal cutaneous disseminated aspergillosis in a preterm extremely-low-birth-weight infant with favourable outcome at 3-year follow-up: a case report
    P Manzoni
    Neonatology and NICU, AO Regina Margherita S Anna S Anna Hospital, Torino, Italy
    Early Hum Dev 88:S65-8. 2012
    ..To our knowledge, this is one of the very few cases of survival, free from sequelae, for a preterm infant affected by neonatal cutaneous disseminated aspergillosis...
  16. doi request reprint Bovine lactoferrin prevents invasive fungal infections in very low birth weight infants: a randomized controlled trial
    Paolo Manzoni
    Department of Neonatology and NICU, S Anna Hospital, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10126 Torino, Italy
    Pediatrics 129:116-23. 2012
    ..Lactoferrin is a mammalian milk glycoprotein involved in innate immunity. Recent data show that bovine lactoferrin (bLF) prevents late-onset sepsis in preterm very low birth weight (VLBW) neonates...
  17. pmc Use of prophylactic fluconazole in a neonatal intensive care unit: efficacy is similar to that described in adult high-risk surgical patients
    Paolo Manzoni
    Crit Care 10:402. 2006
  18. doi request reprint Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial
    Paolo Manzoni
    Neonatology and Neonatal Intensive Care Unit, S Anna Hospital, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10126 Torino, Italy
    JAMA 302:1421-8. 2009
    ..In animal models, the probiotic Lactobacillus rhamnosus GG (LGG) enhances the activity of lactoferrin but has not been studied in human infants...
  19. doi request reprint Lactoferrin and prevention of late-onset sepsis in the pre-term neonates
    P Manzoni
    Neonatal Intensive Care Units of S Anna Hospital, Turin, Italy
    Early Hum Dev 86:59-61. 2010
    ..This article discusses the preliminary data from this study, along with the proposed mechanisms of action of bLF in pre-term infants...
  20. doi request reprint Role of echinocandins in the management of fungal infections in neonates
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital, Azienda Ospedaliera Regina Margherita, S Anna, Corso Spezia 60, Turin, Italy
    J Matern Fetal Neonatal Med 23:49-52. 2010
    ..Further studies properly designed for neonatal populations will better address long-term safety and ecological issues related to echinocandin use in neonates...
  21. doi request reprint Recent advances in prevention of sepsis in the premature neonates in NICU
    P Manzoni
    Neonatology and NICU, A O Regina Margherita S Anna S Anna Hospital, Torino, Italy
    Early Hum Dev 87:S31-3. 2011
    ....
  22. doi request reprint Antifungal prophylaxis in neonates
    Paolo Manzoni
    Neonatology and NICU, A O Regina Margherita S Anna S Anna Hospital, Torino, Italy
    Early Hum Dev 87:S59-60. 2011
    ..Alternative options needing further and more conclusive assessments include use of nystatin, bovine lactoferrin or probiotics...
  23. doi request reprint Routine Lactobacillus rhamnosus GG administration in VLBW infants: a retrospective, 6-year cohort study
    Paolo Manzoni
    Neonatology, S Anna Hospital, Torino, Italy
    Early Hum Dev 87:S35-8. 2011
    ..We report a 6-year, two-NICUs experience of routinary Lactobacillus rhamnosus GG (LGG) use in VLBW infants...
  24. doi request reprint Lactoferrin for prevention of neonatal infections
    Paolo Manzoni
    Neonatologia e TIN, A O Regina Margherita S Anna S Anna Hospital, Torino, Italy
    Curr Opin Infect Dis 24:177-82. 2011
    ..As treatment does not prevent severe long-term neurodevelopmental impairment and sequelae in septic premature neonates, the best strategy is to avoid infections rather than to treat them...
  25. doi request reprint The management of Candida infections in preterm neonates and the role of micafungin
    Paolo Manzoni
    Neonatology and NICU, S Anna Hospital, Torino, Italy
    J Matern Fetal Neonatal Med 24:24-7. 2011
    ..These studies should be properly designed for neonatal populations, and must better address long-term safety and the clinical outcomes related to echinocandin use in neonates...
  26. doi request reprint The use of fluconazole in neonatal intensive care units
    P Manzoni
    Neonatology and NICU, S Anna Hospital Azienda Ospedaliera Regina Margherita, S Anna, C so Spezia 60, 10126 Torino, Italy
    Arch Dis Child 94:983-7. 2009
    ..This article summarises current evidence on the use of fluconazole in preterm neonates and discusses the concerns surrounding its use in nurseries...
  27. ncbi request reprint Switch therapy in full-term neonates with presumed or proven bacterial infection
    P Manzoni
    Sant Anna Hospital, Turin, Italy
    J Chemother 21:68-73. 2009
    ....
  28. ncbi request reprint Hyperglycaemia as a possible marker of invasive fungal infection in preterm neonates
    Paolo Manzoni
    Neonatology Unit and Hospital NICU, Ospedale S Anna, Turin, Italy
    Acta Paediatr 95:486-93. 2006
    ..We evaluated whether glucose intolerance could represent a possible surrogate marker predictor of invasive fungal infection in preterm neonates...
  29. ncbi request reprint [G-CSF, neutropenia and candidiasis in VLBW patients]
    P Manzoni
    Divisione di Neonatologia e TIN Ospedaliera, Az Osp Regina Margherita, S Anna, Torino
    Pediatr Med Chir 27:92-7. 2005
    ..with eventual systemic fungal infection in ELBW patients are not clear. We tried to analyze these features in a retrospective study on a selected population of a large tertiary NICU...
  30. ncbi request reprint Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study
    P Manzoni
    Neonatology and Hospital Neonatal Intensive Care Unit, Azienda Ospedaliera Regina Margherita S Anna, Turin, Italy
    Clin Infect Dis 42:1735-42. 2006
    ..e., < 1500-g) neonates during their stay in a neonatal intensive care unit...
  31. ncbi request reprint Fungal and bacterial sepsis and threshold ROP in preterm very low birth weight neonates
    P Manzoni
    Neonatology and Hospital NICU, Azienda Ospedaliera OIRM Sant Anna, and Department of Paediatric Sciences, University of Torino, Italy
    J Perinatol 26:23-30. 2006
    ..To determine whether an association exists between either fungal or bacterial sepsis and retinopathy of prematurity (ROP)...
  32. ncbi request reprint Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study
    Paolo Manzoni
    Neonatology and Hospital NICU, Azienda Ospedaliera Regina Margherita S Anna, Turin, Italy
    Pediatrics 117:e22-32. 2006
    ..We have reviewed our 6-year series to assess the effectiveness and safety of this form of prophylaxis...
  33. ncbi request reprint Early-onset neutropenia is a risk factor for Candida colonization in very low-birth-weight neonates
    Paolo Manzoni
    Neonatology and Hospital NICU, Azienda Ospedaliera Regina Margherita S Anna 10136 Torino, Italy
    Diagn Microbiol Infect Dis 57:77-83. 2007
    ..Larger, prospective, adequately powered studies should verify whether increased CC related to neutropenia may translate into a similar increased occurrence of candidal sepsis in these settings...
  34. ncbi request reprint Type and number of sites colonized by fungi and risk of progression to invasive fungal infection in preterm neonates in neonatal intensive care unit
    Paolo Manzoni
    Azienda Ospedaliera OIRM Sant Anna Torino, Italy
    J Perinat Med 35:220-6. 2007
    ..Retrospective cohort study to assess if different patterns of Candida colonization determine different risks of progression to invasive fungal infection (IFI) in preterm neonates in NICU...
  35. ncbi request reprint Mode of delivery and threshold retinopathy of prematurity in pre-term ELBW neonates
    P Manzoni
    Neonatology and Hospital NICU, Azienda Ospedaliera OIRM SantAnna Hospital, Turin, Italy
    Acta Paediatr 96:221-6. 2007
    ..We tested the hypothesis that the mode of delivery may be associated with threshold ROP as defined by CRYO-ROP...
  36. ncbi request reprint A multicenter, randomized trial of prophylactic fluconazole in preterm neonates
    Paolo Manzoni
    Neonatology and Hospital Neonatal Intensive Care Unit, Sant Anna Hospital, Turin, Italy
    N Engl J Med 356:2483-95. 2007
    ..We performed a multicenter, randomized, double-blind, placebo-controlled trial of fluconazole for the prevention of fungal colonization and infection in very-low-birth-weight neonates...
  37. ncbi request reprint [Effectiveness of topical acetate tocopherol for the prevention and treatment of skin lesions in newborns: a 5 years experience in a 3rd level Italian Neonatal Intensive Care Unit]
    P Manzoni
    Divisione di Neonatologia e TIN Ospedaliera, Ospedale S Anna, Azienda Ospedale OIRM S Anna, Turin
    Minerva Pediatr 57:305-11. 2005
    ..Strategies for avoiding disruption of the skin barrier are thus highly needed in such patients...
  38. ncbi request reprint Neonatal fungal infections: the state of the art
    P Manzoni
    Neonatology and NICU, Sant Anna Hospital, Torino, Italy
    J Chemother 19:42-5. 2007
    ..As prevention is key in pediatrics, finally we can deliver this to this vulnerable population...
  39. doi request reprint Is thrombocytopenia suggestive of organism-specific response in neonatal sepsis?
    Paolo Manzoni
    Neonatology and Hospital Neonatal Intensive Care Unit, Sant Anna Hospital, University of Torino, Torino, Italy
    Pediatr Int 51:206-10. 2009
    ..It is controversial whether thrombocytopenia is suggestive of one (or more) causative agents of neonatal sepsis: a low platelet count has been related in turn to Gram-positive, Gram-negative or fungal sepsis...
  40. doi request reprint New possibilities of prevention of infection in the newborn
    Alessandro Borghesi
    Neonatology, Neonatal Pathology and NICU, Foundation IRCCS Policlinico San Matteo, Pavia, Italy
    J Matern Fetal Neonatal Med 24:28-30. 2011
    ..This review will focus on these new strategies and on their role in clinical practice in order to further reduce the incidence of infection in NICU...
  41. doi request reprint Viral outbreaks in neonatal intensive care units: what we do not know
    Elisa Civardi
    Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Am J Infect Control 41:854-6. 2013
    ..This analysis reviews the medical literature in an effort to establish the incidence, types of pathogens, and clinical features of noncongenital neonatal viral infections...
  42. doi request reprint Monolateral suppurative parotitis in a neonate and review of literature
    Lidia Decembrino
    Neonatology and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Int J Pediatr Otorhinolaryngol 76:930-3. 2012
    ..Antimicrobials and adequate hydration are an essential part of treatment. Surgical intervention is reserved for organized abscesses and for infections not responding to medical management...
  43. doi request reprint Global perfusion assessment and tissue oxygen saturation in preterm infants: where are we?
    Rosa Maria Cerbo
    Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Early Hum Dev 89:S44-6. 2013
    ....
  44. doi request reprint Genomic alterations in human umbilical cord-derived mesenchymal stromal cells call for stringent quality control before any possible therapeutic approach
    Alessandro Borghesi
    Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy Laboratory of Neonatal Immunology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy Electronic address
    Cytotherapy 15:1362-73. 2013
    ..However, it is still unclear whether UC-MSCs are prone or not to the acquisition of genomic imbalances during in vitro expansion...
  45. ncbi request reprint Respiratory syncytial virus infection and prophylaxis with palivizumab in immunosuppressed children: the experience of a large Italian neonatal care setting
    Paolo Manzoni
    Pediatr Transplant 11:456-7. 2007
  46. ncbi request reprint Erythropoietin as a retinal angiogenic factor
    Paolo Manzoni
    N Engl J Med 353:2190-1; author reply 2190-1. 2005
  47. ncbi request reprint Optimal timing and dosing intervals of palivizumab in premature neonates: still some work to do
    Paolo Manzoni
    Pediatrics 115:1439-40; author reply 1440-1. 2005
  48. ncbi request reprint Glucose regulation in young adults with very low birth weight
    Paolo Manzoni
    N Engl J Med 357:616; author reply 617. 2007
  49. ncbi request reprint Prevention strategies in patients at high-risk for Candida infections: data from a neonatal intensive care setting
    Paolo Manzoni
    Intensive Care Med 32:936; author reply 935. 2006
  50. ncbi request reprint Risk factors for severe retinopathy of prematurity among very preterm infants: a unit-based or population-based approach?
    Paolo Manzoni
    Pediatrics 116:516; author reply 516-7. 2005