A Mantovani

Summary

Publications

  1. ncbi request reprint IL-10 and macrophages orchestrate gut homeostasis
    Alberto Mantovani
    Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy Electronic address
    Immunity 40:637-9. 2014
  2. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012"
    Paolo A Ascierto
    Istituto Nazionale Tumori, Fondazione G, Pascale, Naples, Italy
    J Transl Med 11:137. 2013
  3. doi request reprint Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions
    Alberto Mantovani
    Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Arterioscler Thromb Vasc Biol 33:1478-83. 2013
  4. doi request reprint The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules
    Alberto Mantovani
    Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Ann N Y Acad Sci 1285:1-14. 2013
  5. doi request reprint Macrophage plasticity and polarization in tissue repair and remodelling
    Alberto Mantovani
    Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    J Pathol 229:176-85. 2013
  6. doi request reprint MSCs, macrophages, and cancer: a dangerous ménage-à-trois
    Alberto Mantovani
    Humanitas Clinical and Research Center, University of Milan, Via Manzoni 56, 20089 Rozzano, Milano, Italy
    Cell Stem Cell 11:730-2. 2012
  7. pmc Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner
    Nele S Pauwels
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Respir Res 11:134. 2010
  8. ncbi request reprint Molecular pathways linking inflammation and cancer
    A Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Mol Med 10:369-73. 2010
  9. doi request reprint The growing diversity and spectrum of action of myeloid-derived suppressor cells
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, University of Milan, Rozzano, Milan, Italy
    Eur J Immunol 40:3317-20. 2010
  10. doi request reprint Cancer-promoting tumor-associated macrophages: new vistas and open questions
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS and Dept Translational Medicine, University of Milan, Rozzano, Italy
    Eur J Immunol 41:2522-5. 2011

Collaborators

Detail Information

Publications71

  1. ncbi request reprint IL-10 and macrophages orchestrate gut homeostasis
    Alberto Mantovani
    Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy Electronic address
    Immunity 40:637-9. 2014
    ..In this issue of Immunity,Zigmond et al. (2014) and Shouval et al. (2014) report that interleukin-10 drives macrophages to express homeostatic tolerogenic functions, preventing colitis...
  2. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012"
    Paolo A Ascierto
    Istituto Nazionale Tumori, Fondazione G, Pascale, Naples, Italy
    J Transl Med 11:137. 2013
    ....
  3. doi request reprint Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions
    Alberto Mantovani
    Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Arterioscler Thromb Vasc Biol 33:1478-83. 2013
    ..Preclinical and early clinical data suggest that macrophages may serve as tools for the development of innovative diagnostic and therapeutic strategies in cancer and chronic nonresolving inflammatory diseases...
  4. doi request reprint The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules
    Alberto Mantovani
    Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Ann N Y Acad Sci 1285:1-14. 2013
    ..Here we will briefly review the general properties of CRP and PTX3 as prototypes of short and long pentraxins, respectively, emphasizing in particular the functional role of PTX3 as a prototypic PRM with antibody-like properties...
  5. doi request reprint Macrophage plasticity and polarization in tissue repair and remodelling
    Alberto Mantovani
    Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    J Pathol 229:176-85. 2013
    ..These properties of cells of the monocyte-macrophage lineage may represent a tool and a target for therapeutic exploitation...
  6. doi request reprint MSCs, macrophages, and cancer: a dangerous ménage-à-trois
    Alberto Mantovani
    Humanitas Clinical and Research Center, University of Milan, Via Manzoni 56, 20089 Rozzano, Milano, Italy
    Cell Stem Cell 11:730-2. 2012
    ..Lee et al. (2012) show that preactivated MSCs have antitumor effects upon adoptive transfer in vivo, and Ren et al. (2012) show that tumor-resident MSCs can promote tumor growth by influencing macrophages...
  7. pmc Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner
    Nele S Pauwels
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Respir Res 11:134. 2010
    ..Since Pentraxin-3 (PTX3) is a tuner of inflammatory responses and is produced by endothelial and inflammatory cells upon stimuli such as interleukin-1β (IL-1β), we hypothesized that PTX3 is involved in COPD pathogenesis...
  8. ncbi request reprint Molecular pathways linking inflammation and cancer
    A Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Mol Med 10:369-73. 2010
    ..Cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
  9. doi request reprint The growing diversity and spectrum of action of myeloid-derived suppressor cells
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, University of Milan, Rozzano, Milan, Italy
    Eur J Immunol 40:3317-20. 2010
    ..These recent results provide a basis to better define the relationship of MDSC with the adaptive immune responses of mononuclear phagocytes and neutrophils and to exploit their function in a therapeutic setting...
  10. doi request reprint Cancer-promoting tumor-associated macrophages: new vistas and open questions
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS and Dept Translational Medicine, University of Milan, Rozzano, Italy
    Eur J Immunol 41:2522-5. 2011
    ....
  11. doi request reprint Neutrophils in the activation and regulation of innate and adaptive immunity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    Nat Rev Immunol 11:519-31. 2011
    ..Accordingly, neutrophils have a crucial role in the pathogenesis of a broad range of diseases, including infections caused by intracellular pathogens, autoimmunity, chronic inflammation and cancer...
  12. ncbi request reprint Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells
    A Vecchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 66:489-94. 1999
    ..This study shows that selective responsiveness of mature and immature DC to inducible vs. constitutively produced chemokines can contribute to the regulated trafficking of DC...
  13. ncbi request reprint IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
    P Allavena
    Department of Immunology and Cell Biology Mario Negri Institute, Milano, Italy
    Eur J Immunol 28:359-69. 1998
    ..Intriguingly, IL-10 inhibits antigen presentation while it stimulates endocytic activity...
  14. pmc Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium
    P Allavena
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Exp Med 173:439-48. 1991
    ....
  15. ncbi request reprint Molecules involved in the adhesion and cytotoxicity of activated monocytes on endothelial cells
    N Jonjic
    Instituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 148:2080-3. 1992
    ..Thus, in the ensemble of adhesion molecules available for interaction between endothelium and activated monocytes, the hierarchy of their importance may vary for different functions...
  16. ncbi request reprint Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 161:1083-6. 1998
    ..Conversely, the slower acquisition of responsiveness to ELC/MIP-3beta may guide subsequent localization of DC in lymphoid organs...
  17. ncbi request reprint MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression
    S Sozzani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 62:30-3. 1997
    ..High levels of MCP-1 may underlie monocyte recruitment and tissue damage in CMV encephalitis and may represent a rapid and useful tool in the diagnostic armamentarium for neurological disorders associated with HIV...
  18. ncbi request reprint IL-4 inhibits binding and cytotoxicity of NK cells to vascular endothelium
    C Paganin
    Department of Immunology, Mario Negri Institute, Milano, Italy
    Cytokine 6:135-40. 1994
    ..The inhibition by IL-4 of NK cell binding to EC and subsequent recruitment and activation may thus contribute to development of TH2 responses...
  19. ncbi request reprint Migration of natural killer cells across endothelial cell monolayers
    G Bianchi
    Istituto di Ricerche Farmacologiche Mario Negri Via Eritrea, Milano, Italy
    J Immunol 151:5135-44. 1993
    ..The capacity to bind and migrate across endothelial monolayers underlies the recruitment of NK cells in tissues under certain physiologic and pathologic conditions...
  20. ncbi request reprint Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 28:496-501. 1998
    ..PTX3 protein secretion by activated monocytes is also suppressed by exposure to IFN-gamma. Altogether, these data identify a negative pathway of regulation mediated by IFN-gamma, which may occur under inflammatory conditions...
  21. ncbi request reprint Heterogeneous susceptibility of human melanoma clones to monocyte cytotoxicity: role of ICAM-1 defined by antibody blocking and gene transfer
    N Jonjic
    Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Eur J Immunol 22:2255-60. 1992
    ....
  22. pmc Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses
    P Fraticelli
    Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Clin Invest 107:1173-81. 2001
    ..These results indicate that regulated expression of FKN in ECs participates in an amplification circuit of polarized type I responses...
  23. ncbi request reprint Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma
    A Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:733-8. 2000
    ....
  24. ncbi request reprint Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:3862-9. 2000
    ..Therefore, IL-8 and related chemokines may contribute to the accumulation and positioning of mononuclear phagocytes in Th2-dominated responses...
  25. ncbi request reprint Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites
    M Introna
    Istituto di Recerche Farmacologiche Mario Negri, Milano, Italy
    Blood 87:1862-72. 1996
    ..Thus, mptx3 shows a distinct pattern of in vivo expression indicative of a significant role in cardiovascular and inflammatory pathology...
  26. ncbi request reprint Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4
    F Colotta
    Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Science 261:472-5. 1993
    ..The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action...
  27. ncbi request reprint Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur Cytokine Netw 8:271-4. 1997
    ..In contrast, IL-4, IL-13 and IL-10 either did not affect or they amplified MCP-3 induction in EC. EC-produced MCP-3 may be important in the regulation of extravasation of receptor-expressing cells, including NK cells and eosinophils...
  28. ncbi request reprint Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression
    I Martin-Padura
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Res 51:2239-41. 1991
    ..These data demonstrate intratumor heterogeneity in the expression of VLA-4 and that this can represent a crucial determinant of tumor cell interaction with EC during secondary spread...
  29. ncbi request reprint Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo
    M Vulcano
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:812-22. 2001
    ..Processing of MDC to MDC(3-69) and shorter forms which do not recognize CCR4 is likely to represent a feedback mechanism of negative regulation...
  30. ncbi request reprint Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    J Immunol 164:5998-6004. 2000
    ..These data suggest that TLR can be classified based on expression pattern as ubiquitous (TLR1), restricted (TLR2, TLR4, and TLR5 in myelomonocytic cells), and specific (TLR3 in DC) molecules...
  31. pmc Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages
    P Allavena
    Deptartment Immunology and Inflammation, IRCCS Clinical Institute Humanitas, Rozzano, 20089 Milan, Italy
    Clin Dev Immunol 2010:547179. 2010
    ..This study highlights that tumoral mucin-mediated ligation of the MR on infiltrating TAM may contribute to their immune suppressive phenotype...
  32. ncbi request reprint Monocytes from Wiskott-Aldrich patients differentiate in functional mature dendritic cells with a defect in CD83 expression
    P Allavena
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:3413-21. 2001
    ....
  33. ncbi request reprint Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milan, Italy
    Trends Immunol 22:328-36. 2001
    ..Moreover, silent nonsignaling receptors could act as decoys for chemokines. Therefore, the use of decoy receptors is a general strategy to regulate the action of primary pro-inflammatory cytokines and chemokines...
  34. ncbi request reprint The role of chemokines in the regulation of dendritic cell trafficking
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 66:1-9. 1999
    ..A better understanding of the molecular basis of DC trafficking may provide molecular and conceptual tools to direct and modulate DC traffic as a strategy to up-regulate and orient specific immunity...
  35. ncbi request reprint Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells
    D D'Ambrosio
    Roche Milano Ricerche, Milan, Italy
    J Immunol 161:5111-5. 1998
    ....
  36. ncbi request reprint Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 159:1993-2000. 1997
    ..Chemokines may play a role in the trafficking of DC under resting or stimulated conditions. Chemokine receptors expressed in DC are likely to underlie HIV infection of this cell type...
  37. ncbi request reprint Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    FEBS Lett 418:98-100. 1997
    ..Since DC are highly motile cells, protein chemoattractants as well as bioactive phospholipids are likely to contribute to tissue localization of DC, in vivo...
  38. pmc Expression of a long pentraxin, PTX3, by monocytes exposed to the mycobacterial cell wall component lipoarabinomannan
    V Vouret-Craviari
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Infect Immun 65:1345-50. 1997
    ..The significance of PTX3 in the immunobiology of mycobacterial infection and its relevance in relation to clinical involvement remain to be determined...
  39. ncbi request reprint Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes
    M Muzio
    Department of Immunology, Mario Negri Institute, Milano, Italy
    J Leukoc Biol 67:450-6. 2000
    ..Alternately, the expression of a TLR in a single cell type may indicate a specific role for this molecule in a restricted setting...
  40. ncbi request reprint Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages
    A Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:762-7. 2000
    ..Blocking IL-10, as well as other immunosuppressive cytokines present in the tumor microenvironment, such as TGF-beta, may complement therapeutic strategies aimed at activating type I antitumor immune responses...
  41. ncbi request reprint Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells
    P Sambo
    Istituto de Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 87:1682-6. 1996
    ..Release of the IL-1 type II decoy R might represent one mechanism by which ROI antagonize and limit the proinflammatory effects of IL-1...
  42. ncbi request reprint Role of leukocyte function-associated antigen-1 and very late antigen-4 in the adhesion and transmigration of c-myc-transfected B-lymphoblastoid cell lines across vascular endothelium
    C Paganin
    Immunology Laboratory, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Clin Lab Res 24:29-32. 1994
    ..This may be relevant in the localization and malignant behavior of B-cell lymphomas carrying an activated c-myc oncogene...
  43. ncbi request reprint Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of incompletely spliced transcripts
    G Penton-Rol
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 162:2931-8. 1999
    ..This early event, followed by prolonged inhibition of IL-1RII expression and up-regulation of IL-1RI, may render monocytes more responsive to IL-1 at sites of inflammation...
  44. pmc Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment
    P Allavena
    Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute Department of Translational Medicine, University of Milan, Milan, Rozzano, Italy
    Clin Exp Immunol 167:195-205. 2012
    ....
  45. ncbi request reprint Regulation of the chemokine system at the level of chemokine receptor expression and signaling activity
    M Locati
    Istituto di Patologia Generale, University of Milan, Milano, Italy
    Immunobiology 204:536-42. 2001
    ..Receptor signaling activity represents a further potential level of regulation of the system. Finally, chemokines can also influence the microenvironment by modulating gene expression in target cells...
  46. ncbi request reprint The chemokine system: tuning and shaping by regulation of receptor expression and coupling in polarized responses
    M Locati
    Centro di Eccellenza IDET, Institute of General Pathology, University of Milan, Milan, Italy
    Allergy 57:972-82. 2002
  47. ncbi request reprint Chemokine receptors: interaction with HIV-1 and viral-encoded chemokines
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Pharm Acta Helv 74:305-12. 2000
    ..This biological activity could represent a strategy developed by the virus to subvert immunity impairing the generation of an effective anti-viral immune response...
  48. ncbi request reprint The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses
    E M Borroni
    Istituto Clinico Humanitas, Via Manzoni 56, I 20089 Rozzano, Milan, Italy
    Biochem Soc Trans 34:1014-7. 2006
    ....
  49. ncbi request reprint Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients
    B Muller
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Crit Care Med 29:1404-7. 2001
    ..Compared with the short pentraxin C-reactive protein, PTX3 may be a more direct indicator of tissue involvement by inflammatory and infectious processes...
  50. pmc Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors
    C Garlanda
    Istituto Mario Negri, Milan, Italy
    Proc Natl Acad Sci U S A 91:7291-5. 1994
    ....
  51. ncbi request reprint A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants
    Q G Dong
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    Arterioscler Thromb Vasc Biol 17:1599-604. 1997
    ..The general strategy outlined here is simple, effective, and flexible, allowing the inclusion of further positive or negative selection steps...
  52. ncbi request reprint A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells
    G Peri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol Methods 174:249-57. 1994
    ..The 5D3-F7 mAb provides a novel, highly specific reagent with which to investigate the in vitro and in vivo production and role of MCP-1...
  53. doi request reprint Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    G Solinas
    Department of Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    J Leukoc Biol 86:1065-73. 2009
    ..Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors...
  54. ncbi request reprint IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences
    N Polentarutti
    Institute of Pharmacologic Research, Mario Negri, Milano, Italy
    J Immunol 158:2689-94. 1997
    ..The predominant long transcript is polyadenylated and present in the cytoplasm. The augmented migratory capacity of IL-2 activated vs resting NK cells was associated with increased CCR2 transcript levels...
  55. ncbi request reprint Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration
    T Ravizza
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Neuroscience 105:43-53. 2001
    ..Our results provide evidence that pentraxin 3 is synthesized in brain after seizures and may exert a protective role in seizure-induced neurodegeneration...
  56. ncbi request reprint IL-1 inducible genes in human umbilical vein endothelial cells
    M Introna
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur Heart J 14:78-81. 1993
    ..PTX3 may represent a novel marker of inflammatory reactions, particularly those involving the vessel wall...
  57. ncbi request reprint Toll-like receptor family and signalling pathway
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Via Eritrea 62, Milano, I 20157, Italy
    Biochem Soc Trans 28:563-6. 2000
    ..Alternatively, the expression of a TLR in a single cell type may indicate a specific role for this molecule in a restricted setting...
  58. doi request reprint The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling
    A Inforzato
    Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Italy
    Tissue Antigens 77:271-82. 2011
    ..Here we review the studies on PTX3, with emphasis on pathogen recognition, tissue remodelling and crosstalk with other components of the innate immune system...
  59. ncbi request reprint Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    M Romano
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    Immunity 6:315-25. 1997
    ..Hence, in vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment...
  60. ncbi request reprint Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells
    M Mengozzi
    AIDS Immunopathogenesis Unit, DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Blood 93:1851-7. 1999
    ..HIV replication-dependent expression of MCP-1 in MP may be of particular relevance for the pathogenesis of HIV infection in nonlymphoid organs such as the brain...
  61. ncbi request reprint Toll-like receptors (TLRs) signalling and expression pattern
    M Muzio
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Endotoxin Res 7:297-300. 2001
    ..Differential expression and regulation as well as distinct, though overlapping, ligand recognition patterns may underlie the existence of a such a large, seemingly redundant, TLR family...
  62. ncbi request reprint A novel mechanism of colon carcinoma cell adhesion to the endothelium triggered by beta 1 integrin chain
    I Martin-Padura
    Laboratory of Vascular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 269:6124-32. 1994
    ....
  63. ncbi request reprint Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer
    S Danese
    Inflammatory Bowel Disease Unit, Division of Gastroenterology, Milan, Italy
    Oncogene 29:3313-23. 2010
    ..Dissection of molecular pathways involved in colitis-associated cancer may offer opportunities for innovative therapeutic strategies...
  64. ncbi request reprint Early activation signals in endothelial cells. Stimulation by cytokines
    M Introna
    Dipartimento di Immunologia e Biologia Cellulare, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Arterioscler Thromb Vasc Biol 17:423-8. 1997
    ..Only a few molecular pathways have been characterized so far, and key issues in endothelial biology, such as endothelial specificity of gene expression and heterogeneity of different endothelial populations, remain largely unexplored...
  65. ncbi request reprint Macrophage infiltration and growth of sarcoma clones expressing different amounts of monocyte chemotactic protein/JE
    S Walter
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Cancer 49:431-5. 1991
    ..These results are consistent with the hypothesis that TDCF, identified as MCP/JE, is one important determinant of macrophage infiltration in tumors...
  66. ncbi request reprint PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans
    G Peri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 102:636-41. 2000
    ..The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested...
  67. ncbi request reprint PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation
    F Fazzini
    Istituto Scientifico H San Raffaele and Università, Milan, Italy
    Arthritis Rheum 44:2841-50. 2001
    ..To verify whether the prototypical long pentraxin PTX3 represents an indicator of the activity of small-vessel vasculitis...
  68. ncbi request reprint Regulation of inhibitory pathways of the interleukin-1 system
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Ann N Y Acad Sci 840:338-51. 1998
    ..The structural and functional features of this molecule as well as initial evidence of involvement in human pathology will be discussed...
  69. ncbi request reprint Killing of tumor cells with pleiotropic drug resistance by OK432-activated effector cells
    P Allavena
    Laboratory of Immunology, Istituto di Richerche Farmacologiche Mario Negri, Milan, Italy
    Immunopharmacol Immunotoxicol 11:257-68. 1989
    ..Activation of effector cells has the potential to complement conventional cytoreductive therapy by eliminating residual-tumor cells surviving and resistant to chemotherapy...
  70. ncbi request reprint Pentraxins and atherosclerosis: the role of PTX3
    Cecilia Garlanda
    Istituto Clinico Humanitas, Via Manzoni 113, 20089 Rozzano, Milan, Italy
    Curr Pharm Des 17:38-46. 2011
    ..PTX3 may represent a new marker in vascular pathology which correlates with the risk of developing vascular events...