R J Mandel

Summary

Publications

  1. pmc Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
    R J Mandel
    Department of Gene Therapy Applications, Cell Genesys Inc, 342 Lakeside Drive, Foster City, CA 94404, USA
    Proc Natl Acad Sci U S A 94:14083-8. 1997
  2. ncbi request reprint In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase
    S E Leff
    Department of Gene Therapy Applications, Cell Genesys Inc, 342 Lakeside Drive, Foster City, California, 94404, USA
    Exp Neurol 151:249-64. 1998
  3. pmc A third-generation lentivirus vector with a conditional packaging system
    T Dull
    Cell Genesys, Foster City, California 94404, USA
    J Virol 72:8463-71. 1998

Collaborators

Detail Information

Publications3

  1. pmc Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
    R J Mandel
    Department of Gene Therapy Applications, Cell Genesys Inc, 342 Lakeside Drive, Foster City, CA 94404, USA
    Proc Natl Acad Sci U S A 94:14083-8. 1997
    ..These data indicate that the use of rAAV, a noncytopathic viral vector, can promote delivery of functional levels of GDNF in a degenerative model of Parkinson's disease...
  2. ncbi request reprint In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase
    S E Leff
    Department of Gene Therapy Applications, Cell Genesys Inc, 342 Lakeside Drive, Foster City, California, 94404, USA
    Exp Neurol 151:249-64. 1998
    ....
  3. pmc A third-generation lentivirus vector with a conditional packaging system
    T Dull
    Cell Genesys, Foster City, California 94404, USA
    J Virol 72:8463-71. 1998
    ..While the actual biosafety of the vector will ultimately be proven in vivo, the improved design presented here should facilitate testing of lentivirus vectors...