Pravat K Mandal

Summary

Publications

  1. doi request reprint Brain oxidative stress: detection and mapping of anti-oxidant marker 'Glutathione' in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Gurgaon, India
    Biochem Biophys Res Commun 417:43-8. 2012
  2. ncbi request reprint Visuospatial perception: an emerging biomarker for Alzheimer's disease
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Gurgaon, India
    J Alzheimers Dis 31:S117-35. 2012
  3. ncbi request reprint Structural brain atlases: design, rationale, and applications in normal and pathological cohorts
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Gurgaon, India
    J Alzheimers Dis 31:S169-88. 2012
  4. ncbi request reprint Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male/female, mild cognitive impairment, and Alzheimer's disease
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Gurgaon, India
    J Alzheimers Dis 31:S75-86. 2012
  5. doi request reprint In vivo proton magnetic resonance spectroscopic signal processing for the absolute quantitation of brain metabolites
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Gurgaon, India
    Eur J Radiol 81:e653-64. 2012
  6. doi request reprint A new experimental approach and signal processing scheme for the detection and quantitation of ³¹P brain neurochemicals from in vivo MRS studies using dual tuned (¹H/³¹P) head coil
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Gurgaon, India
    Biochem Biophys Res Commun 412:302-6. 2011
  7. ncbi request reprint NMR investigations of amyloid-β peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Manesar, Gurgaon, India
    J Alzheimers Dis 21:1303-9. 2010
  8. doi request reprint Comprehensive nuclear magnetic resonance studies on interactions of amyloid-β with different molecular sized anesthetics
    Pravat K Mandal
    National Brain Research Centre, Manesar, Gurgaon, India
    J Alzheimers Dis 22:27-34. 2010
  9. doi request reprint Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Manesar, Gurgaon, India
    J Alzheimers Dis 20:127-34. 2010
  10. doi request reprint Inhaled anesthesia and cognitive performance
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Manesar, Gurgaon, India
    Drugs Today (Barc) 45:47-54. 2009

Detail Information

Publications22

  1. doi request reprint Brain oxidative stress: detection and mapping of anti-oxidant marker 'Glutathione' in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Gurgaon, India
    Biochem Biophys Res Commun 417:43-8. 2012
    ..It is the first scientific report correlating alteration (in selective brain regions) of GSH level with clinical status of male and female subjects using non-invasive imaging technique...
  2. ncbi request reprint Visuospatial perception: an emerging biomarker for Alzheimer's disease
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Gurgaon, India
    J Alzheimers Dis 31:S117-35. 2012
    ..The diagnostic scope of monitoring the brain activation correlates of VSP processing in AD is discussed in terms of the key advantages of utilizing VSP-related deficits in AD for early detection and longitudinal tracking of AD...
  3. ncbi request reprint Structural brain atlases: design, rationale, and applications in normal and pathological cohorts
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Gurgaon, India
    J Alzheimers Dis 31:S169-88. 2012
    ..We conclude by discussing the scope of brain templates as a research tool and their application in various neuroimaging modalities...
  4. ncbi request reprint Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male/female, mild cognitive impairment, and Alzheimer's disease
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Gurgaon, India
    J Alzheimers Dis 31:S75-86. 2012
    ....
  5. doi request reprint In vivo proton magnetic resonance spectroscopic signal processing for the absolute quantitation of brain metabolites
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Gurgaon, India
    Eur J Radiol 81:e653-64. 2012
    ..Special emphasis has been provided for the handling of macromolecules and lipid in LCModel and jMRUI methods. The author also suggests certain points to be noted while opting for above software packages...
  6. doi request reprint A new experimental approach and signal processing scheme for the detection and quantitation of ³¹P brain neurochemicals from in vivo MRS studies using dual tuned (¹H/³¹P) head coil
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Gurgaon, India
    Biochem Biophys Res Commun 412:302-6. 2011
    ..Our novel signal processing scheme allows generating metabolite maps of different phospholipids include PC/PE and GPC/GPE using the 'time-domain-frequency-domain' method as referred to in the MATLAB programming language...
  7. ncbi request reprint NMR investigations of amyloid-β peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Manesar, Gurgaon, India
    J Alzheimers Dis 21:1303-9. 2010
    ..These experimental findings reaffirm that smaller molecular sized anesthetics (e.g., halothane) do play a leading role in Aβ oligomerization...
  8. doi request reprint Comprehensive nuclear magnetic resonance studies on interactions of amyloid-β with different molecular sized anesthetics
    Pravat K Mandal
    National Brain Research Centre, Manesar, Gurgaon, India
    J Alzheimers Dis 22:27-34. 2010
    ..In this review, a molecular pathway for the A$\beta $-anesthetic interaction at the atomic level is presented...
  9. doi request reprint Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Manesar, Gurgaon, India
    J Alzheimers Dis 20:127-34. 2010
    ..These results strengthen the hypothesis that the presence of smaller molecular sized anesthetic is instrumental in promoting Abeta oligomerization even when co-administered with a larger sized anesthetic, namely diazepam...
  10. doi request reprint Inhaled anesthesia and cognitive performance
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Manesar, Gurgaon, India
    Drugs Today (Barc) 45:47-54. 2009
    ..However, such information is crucial to improve anesthesia performance and patient safety, as well as outcomes...
  11. doi request reprint Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: an NMR study
    Pravat K Mandal
    Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Centre, Manesar, Gurgaon, India
    Biochem Biophys Res Commun 379:716-20. 2009
    ..These findings support the emerging hypothesis that several commonly used inhaled anesthetics could be involved in neurodegeneration, as well as risk factor for accelerating the onset of AD...
  12. doi request reprint Clinically relevant concentration determination of inhaled anesthetics (halothane, isoflurane, sevoflurane, and desflurane) by 19F NMR
    Pravat K Mandal
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical School, Pittsburgh, PA 15213, USA
    Cell Biochem Biophys 52:31-5. 2008
    ..The standard curve for each of these anesthetics is helpful in determining the prerequisite amount of aqueous anesthetic solution required to prepare clinically relevant concentrations for protein-anesthetic interaction studies...
  13. doi request reprint Abeta peptide interactions with isoflurane, propofol, thiopental and combined thiopental with halothane: a NMR study
    Pravat K Mandal
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, PA 15213, USA
    Biochim Biophys Acta 1778:2633-9. 2008
    ..Perturbation of these specific Abeta residues (G29, A30 and I31) by different anesthetics could play an important role to induce Abeta oligomerization...
  14. ncbi request reprint Molecular understanding of Abeta peptide interaction with isoflurane, propofol, and thiopental: NMR spectroscopic study
    Pravat K Mandal
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213, USA
    Biochemistry 46:762-71. 2007
    ..Thiopental does not interact with specific residues (G29, A30, and I31) of Abeta40; hence, the peptide remains in the monomeric form. On the basis of our NMR study, thiopental does not oligomerize Abeta40 even at higher concentrations...
  15. ncbi request reprint Alzheimer's disease: soluble oligomeric Abeta(1-40) peptide in membrane mimic environment from solution NMR and circular dichroism studies
    Pravat K Mandal
    Neurophysics Laboratory, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neurochem Res 29:2267-72. 2004
    ....
  16. ncbi request reprint NMR structure and backbone dynamics of the extended second transmembrane domain of the human neuronal glycine receptor alpha1 subunit
    Victor E Yushmanov
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Biochemistry 42:3989-95. 2003
    ..The results suggest a relatively high degree of motional freedom of TM2e in micelles and different propensities of the N- and C-terminal moieties of the transmembrane domain to assume stable helical structures...
  17. ncbi request reprint Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease
    Pravat K Mandal
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Neurochem Res 31:1153-62. 2006
    ..To the best of our knowledge, it is the first report using multidimensional NMR spectroscopy that elucidates molecular interactions between Abeta and alpha-Syn which may lead to onset of DLB...
  18. ncbi request reprint Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment
    Pravat K Mandal
    Laboratory of Neurophysics, Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15261, USA
    Neurochem Res 29:447-53. 2004
    ..but that ganglioside GT1b does not bind Abeta. Plausible pathways for the involvement of gangliosides in amyloidogenesis are discussed...
  19. ncbi request reprint Interactions of Abeta(1-40) with glycerophosphocholine and intact erythrocyte membranes: fluorescence and circular dichroism studies
    Pravat K Mandal
    Neurophysics Laboratory, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Neurochem Res 29:2273-9. 2004
    ..In summary, both soluble Abeta and GPC insert into the phospholipid head-group region of the membrane where they interact leading to beta-sheet formation in soluble Abeta which enhances Abeta aggregation...
  20. ncbi request reprint Alzheimer's disease: halothane induces Abeta peptide to oligomeric form--solution NMR studies
    Pravat K Mandal
    Western Psychiatric Institute and Clinic Department of Psychiatry, University of Pittsburgh Medical School, 3811 O Hara Street, PA 15213, USA
    Neurochem Res 31:883-90. 2006
    ..Abeta42 is more prone to oligomerization compared to Abeta40 in the presence of halothane. The molecular mechanism of halothane induced structural alternation of Abeta peptide is discussed...
  21. pmc NMR structures of the second transmembrane domain of the human glycine receptor alpha(1) subunit: model of pore architecture and channel gating
    Pei Tang
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Biophys J 83:252-62. 2002
    ..A similar pore architecture and gating mechanism may apply to other channels in the same superfamily, including GABA(A), nACh, and 5-HT(3) receptors...