ANNE M MANICONE
Gharib S, McMahan R, Eddy W, Long M, Parks W, Aitken M, et al
. Transcriptional and functional diversity of human macrophage repolarization. J Allergy Clin Immunol. 2018;: pubmed publisher
..Our findings highlight the diversity of macrophage polarization, attribute functional consequences to different M2 stimuli, and provide a framework to phenotype macrophages in disease states. ..
MANICONE A, Gong K, Johnston L, Giannandrea M. Diet-induced obesity alters myeloid cell populations in naÃ¯ve and injured lung. Respir Res. 2016;17:24 pubmed publisher
..Translation of these findings to people with obesity will be critical for determining the basic inflammatory underpinnings of pulmonary disease susceptibility. ..
Long M, Eddy W, Gong K, Lovelace Macon L, McMahan R, Charron J, et al
. MEK1/2 Inhibition Promotes Macrophage Reparative Properties. J Immunol. 2017;198:862-872 pubmed publisher
..These studies suggest that the MEK1/2 pathway may be a therapeutic target to promote the resolution of inflammation via modulation of macrophage functions. ..
MANICONE A, Gharib S, Gong K, Eddy W, Long M, Frevert C, et al
. Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis. Am J Pathol. 2017;187:1288-1300 pubmed publisher
..These results highlight a previously unrecognized role for MMP-28 in promoting chronic lung inflammation and tissue remodeling induced by cigarette smoke and highlight another potential target to modulate COPD. ..
Eddy W, Gong K, Bell B, Parks W, Ziegler S, MANICONE A. Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury. J Immunol. 2017;198:4813-4822 pubmed publisher
..These findings demonstrate the critical importance of Stat5 signaling in maintaining lung homeostasis, and underscore the importance of resident macrophages in moderating tissue damage and excess inflammation. ..