A Mantovani



  1. Mantovani A, Allavena P. The interaction of anticancer therapies with tumor-associated macrophages. J Exp Med. 2015;212:435-45 pubmed publisher
    ..A better understanding of the interaction of anticancer therapies with innate immunity, and TAMs in particular, may pave the way to better patient selection and innovative combinations of conventional approaches with immunotherapy. ..
  2. Mantovani A, Bonecchi R. One Clever Macrophage Checkpoint. Clin Cancer Res. 2019;: pubmed publisher
    ..Myeloid checkpoints including Clever-1 hold promise as alternative or complementary immunotherapy strategies.See related article by Viitala et al. ..
  3. Rappuoli R, Santoni A, Mantovani A. Vaccines: An achievement of civilization, a human right, our health insurance for the future. J Exp Med. 2019;216:7-9 pubmed publisher
    ..We argue that vaccines represent a safety belt and life insurance for humankind. ..
  4. Bottazzi B, Riboli E, Mantovani A. Aging, inflammation and cancer. Semin Immunol. 2018;40:74-82 pubmed publisher
    ..We argue that uncontrolled smoldering inflammation drives carcinogenesis in aging and acts as a common denominator linking aging and cancer. ..
  5. Bonavita E, Galdiero M, Jaillon S, Mantovani A. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation. Adv Cancer Res. 2015;128:141-71 pubmed publisher
    ..Targeting phagocytes (TAMs and TANs) as corrupted policemen in cancer may pave the way to innovative therapeutic strategies complementing cytoreductive therapies and immunotherapy. ..
  6. Bottazzi B, Inforzato A, Messa M, Barbagallo M, Magrini E, Garlanda C, et al. The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling. J Hepatol. 2016;64:1416-27 pubmed publisher
    ..Thus acidification during tissue repair sets PTX3 in a tissue remodelling and repair mode, suggesting that matrix and microbial recognition are common, ancestral features of the humoral arm of innate immunity. ..
  7. Mantovani A, Locati M. Macrophage Metabolism Shapes Angiogenesis in Tumors. Cell Metab. 2016;24:653-654 pubmed publisher
    ..Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis. ..
  8. Doni A, D Amico G, Morone D, Mantovani A, Garlanda C. Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage. Semin Cell Dev Biol. 2017;61:31-40 pubmed publisher
    ..Thus, recognition of extracellular matrix and microbial components is a recurrent theme in the humoral arm of the innate immune system. ..
  9. Jaillon S, Ponzetta A, Magrini E, Barajon I, Barbagallo M, Garlanda C, et al. Fluid phase recognition molecules in neutrophil-dependent immune responses. Semin Immunol. 2016;28:109-18 pubmed publisher
    ..Here, we will review the expression and general function of soluble PRMs, focusing our attention on molecules involved in neutrophil effector functions. ..

More Information


  1. De Paoli P, Ciliberto G, Ferrarini M, Pelicci P, Dellabona P, De Lorenzo F, et al. Alliance Against Cancer, the network of Italian cancer centers bridging research and care. J Transl Med. 2015;13:360 pubmed publisher
    ..In conclusion, ACC is a growing organization, trying to respond to the need of networking in Italy and may contribute significantly to improve the way we face cancer in Europe. ..
  2. Magrini E, Mantovani A, Garlanda C. The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?. Trends Mol Med. 2016;22:497-510 pubmed publisher
    ..Dissection of such a yin-and-yang role of pentraxins in immunity and inflammation is timely and significant as it may pave the way for better clinical exploitation against various diseases. ..
  3. Jaillon S, Moalli F, Ragnarsdottir B, Bonavita E, Puthia M, Riva F, et al. The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Immunity. 2014;40:621-32 pubmed publisher
    ..These results suggest that PTX3 is an essential component of innate resistance against UTIs. Thus, the cellular and humoral arms of innate immunity exert complementary functions in mediating resistance against UTIs. ..
  4. Mantovani A, Cassatella M, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 2011;11:519-31 pubmed publisher
    ..Accordingly, neutrophils have a crucial role in the pathogenesis of a broad range of diseases, including infections caused by intracellular pathogens, autoimmunity, chronic inflammation and cancer. ..
  5. Mantovani A, Germano G, Marchesi F, Locatelli M, Biswas S. Cancer-promoting tumor-associated macrophages: new vistas and open questions. Eur J Immunol. 2011;41:2522-5 pubmed publisher
  6. Mantovani A, Biswas S, Galdiero M, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. 2013;229:176-85 pubmed publisher
    ..These properties of cells of the monocyte-macrophage lineage may represent a tool and a target for therapeutic exploitation. ..
  7. Mantovani A. Wandering pathways in the regulation of innate immunity and inflammation. J Autoimmun. 2017;85:1-5 pubmed publisher
  8. request reprint
    Mantovani A. Molecular pathways linking inflammation and cancer. Curr Mol Med. 2010;10:369-73 pubmed
    ..Cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies. ..
  9. Cardoso A, Pinto M, Pinto A, Pinto M, Monteiro C, Oliveira M, et al. Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour. BMC Cancer. 2015;15:456 pubmed publisher
    ..We propose that IL-10- and LPS-stimulated macrophages distinctly modulate gastric and colorectal cancer cell behaviour, as result of distinct proteolytic profiles that impact cell invasion and angiogenesis. ..
  10. Daigo K, Mantovani A, Bottazzi B. The yin-yang of long pentraxin PTX3 in inflammation and immunity. Immunol Lett. 2014;161:38-43 pubmed publisher
    ..Here we will review the general properties of CRP and PTX3, emphasizing the differences between the two molecules and the regulatory functions exerted by PTX3 in innate immunity and inflammation. ..
  11. Garlanda C, Dinarello C, Mantovani A. The interleukin-1 family: back to the future. Immunity. 2013;39:1003-18 pubmed publisher
    ..Here we will review the key properties of IL-1 family members, with emphasis on pathways of negative regulation and orchestration of innate and adaptive immunity. ..
  12. Garlanda C, Jaillon S, Doni A, Bottazzi B, Mantovani A. PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition. Curr Opin Immunol. 2016;38:39-44 pubmed publisher
    ..Based on these data and scattered information on humoral PRM and matrix components, we surmise that matrix and microbial recognition are related functions in evolution. ..
  13. Isailovic N, Daigo K, Mantovani A, Selmi C. Interleukin-17 and innate immunity in infections and chronic inflammation. J Autoimmun. 2015;60:1-11 pubmed publisher
    ..New drugs targeting the IL17 pathway include brodalumab, ixekizumab, and secukinumab and their use in psoriatic disease is expected to dramatically impact our approach to this systemic condition. ..
  14. Bonecchi R, Garlanda C, Mantovani A, Riva F. Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation. Cytokine. 2016;87:37-45 pubmed publisher
    ..Decoy and scavenger receptors with no or atypical signaling have emerged as a general strategy conserved in evolution to tune the action of cytokines, chemokines and growth factors. ..
  15. Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, et al. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 2015;212:905-25 pubmed publisher
  16. Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B, Garlanda C. The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules. Ann N Y Acad Sci. 2013;1285:1-14 pubmed publisher
    ..Here we will briefly review the general properties of CRP and PTX3 as prototypes of short and long pentraxins, respectively, emphasizing in particular the functional role of PTX3 as a prototypic PRM with antibody-like properties. ..
  17. Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, et al. PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell. 2015;160:700-714 pubmed publisher
    ..Thus, PTX3, an effector molecule belonging to the humoral arm of innate immunity, acts as an extrinsic oncosuppressor gene in mouse and man by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation. ..