Mantovani A, Allavena P. The interaction of anticancer therapies with tumor-associated macrophages. J Exp Med. 2015;212:435-45 pubmed publisher
..A better understanding of the interaction of anticancer therapies with innate immunity, and TAMs in particular, may pave the way to better patient selection and innovative combinations of conventional approaches with immunotherapy. ..
Mantovani A, Bonecchi R. One Clever Macrophage Checkpoint. Clin Cancer Res. 2019;: pubmed publisher
..Myeloid checkpoints including Clever-1 hold promise as alternative or complementary immunotherapy strategies.See related article by Viitala et al. ..
Rappuoli R, Santoni A, Mantovani A. Vaccines: An achievement of civilization, a human right, our health insurance for the future. J Exp Med. 2019;216:7-9 pubmed publisher
..We argue that vaccines represent a safety belt and life insurance for humankind. ..
Bottazzi B, Riboli E, Mantovani A. Aging, inflammation and cancer. Semin Immunol. 2018;40:74-82 pubmed publisher
..We argue that uncontrolled smoldering inflammation drives carcinogenesis in aging and acts as a common denominator linking aging and cancer. ..
Bonavita E, Galdiero M, Jaillon S, Mantovani A. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation. Adv Cancer Res. 2015;128:141-71 pubmed publisher
..Targeting phagocytes (TAMs and TANs) as corrupted policemen in cancer may pave the way to innovative therapeutic strategies complementing cytoreductive therapies and immunotherapy. ..
Bottazzi B, Inforzato A, Messa M, Barbagallo M, Magrini E, Garlanda C, et al
. The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling. J Hepatol. 2016;64:1416-27 pubmed publisher
..Thus acidification during tissue repair sets PTX3 in a tissue remodelling and repair mode, suggesting that matrix and microbial recognition are common, ancestral features of the humoral arm of innate immunity. ..
Mantovani A, Locati M. Macrophage Metabolism Shapes Angiogenesis in Tumors. Cell Metab. 2016;24:653-654 pubmed publisher
..Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis. ..
Doni A, D Amico G, Morone D, Mantovani A, Garlanda C. Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage. Semin Cell Dev Biol. 2017;61:31-40 pubmed publisher
..Thus, recognition of extracellular matrix and microbial components is a recurrent theme in the humoral arm of the innate immune system. ..
Jaillon S, Ponzetta A, Magrini E, Barajon I, Barbagallo M, Garlanda C, et al
. Fluid phase recognition molecules in neutrophil-dependent immune responses. Semin Immunol. 2016;28:109-18 pubmed publisher
..Here, we will review the expression and general function of soluble PRMs, focusing our attention on molecules involved in neutrophil effector functions. ..