Ogobara K Doumbo

Summary

Affiliation: University of Bamako
Country: Mali

Publications

  1. pmc The implementation of malaria intermittent preventive trialtreatment with sulphadoxine-pyrimethamine in infants reduced all-cause mortality in the district of Kolokani, Mali: results from a cluster randomized control
    Alassane Dicko
    Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805, Bamako, Mali
    Malar J 11:73. 2012
  2. pmc Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali
    Stephane Picot
    Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, Lyon, France
    Malar J 8:169. 2009
  3. pmc Modelling malaria incidence with environmental dependency in a locality of Sudanese savannah area, Mali
    Jean Gaudart
    Biostatistics Research Unit, Laboratory of Education and Research in Medical Information Processing LERTIM, EA 3283 Aix Marseille University, Faculty of Medicine, Marseille Cedex 5, France
    Malar J 8:61. 2009
  4. pmc Differences in Fcgamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in Mali
    Elisabeth Israelsson
    Department of Immunology, Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    Malar J 7:175. 2008
  5. pmc Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa
    Elisabeth Israelsson
    Department of Cardiology, Karolinska University Hospital Solna, 17176 Stockholm, Sweden
    Malar J 8:136. 2009
  6. pmc Use of insecticide-treated nets (ITNs) following a malaria education intervention in Piron, Mali: a control trial with systematic allocation of households
    Michelle Rhee
    Health Research and Policy Department, Stanford Medical School, Stanford University, Stanford, CA 94305, USA
    Malar J 4:35. 2005
  7. pmc Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali
    Mahamadou A Thera
    Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases DEAP Faculty of Medicine, Pharmacy and Odonto Stomatologie, University of Bamako, Bamako, Mali
    Malar J 6:68. 2007
  8. pmc A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 5:31. 2006
  9. pmc Space-time clustering of childhood malaria at the household level: a dynamic cohort in a Mali village
    Jean Gaudart
    Medical Statistics and Informatics Research Team, LIF UMR 6166 CNRS Aix Marseille University, Faculty of Medicine, 27 Bd Jean Moulin 13385 Marseille Cedex 05, France
    BMC Public Health 6:286. 2006
  10. pmc Oblique decision trees for spatial pattern detection: optimal algorithm and application to malaria risk
    Jean Gaudart
    Medical Statistics and Informatics Research Team, LIF UMR 6166, CNRS Aix Marseille University, Faculty of Medicine, 27 Bd Jean Moulin 13385 Marseille Cedex 05, France
    BMC Med Res Methodol 5:22. 2005

Detail Information

Publications93

  1. pmc The implementation of malaria intermittent preventive trialtreatment with sulphadoxine-pyrimethamine in infants reduced all-cause mortality in the district of Kolokani, Mali: results from a cluster randomized control
    Alassane Dicko
    Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805, Bamako, Mali
    Malar J 11:73. 2012
    ..However, there was no published study on the impact of the strategy on mortality. The present study assessed the impact of the implementation of IPTi-SP in health services in Mali on all-cause mortality...
  2. pmc Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali
    Stephane Picot
    Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, Lyon, France
    Malar J 8:169. 2009
    ..In this context, a new adjunctive strategy using a neuroprotective drug: erythropoietin (epoietin-beta, Epo) was proposed...
  3. pmc Modelling malaria incidence with environmental dependency in a locality of Sudanese savannah area, Mali
    Jean Gaudart
    Biostatistics Research Unit, Laboratory of Education and Research in Medical Information Processing LERTIM, EA 3283 Aix Marseille University, Faculty of Medicine, Marseille Cedex 5, France
    Malar J 8:61. 2009
    ..Remote sensing data on environment were incorporated into a temporal model of the transmission, to forecast the evolution of malaria epidemiology, in a locality of Sudanese savannah area...
  4. pmc Differences in Fcgamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in Mali
    Elisabeth Israelsson
    Department of Immunology, Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    Malar J 7:175. 2008
    ....
  5. pmc Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa
    Elisabeth Israelsson
    Department of Cardiology, Karolinska University Hospital Solna, 17176 Stockholm, Sweden
    Malar J 8:136. 2009
    ..The present study was performed to investigate if polymorphisms in the CRP gene could contribute to the lower susceptibility to malaria seen in the Fulani ethnic group...
  6. pmc Use of insecticide-treated nets (ITNs) following a malaria education intervention in Piron, Mali: a control trial with systematic allocation of households
    Michelle Rhee
    Health Research and Policy Department, Stanford Medical School, Stanford University, Stanford, CA 94305, USA
    Malar J 4:35. 2005
    ..A barrier to ITN use may be lack of knowledge regarding malaria transmission and prevention. This study is a controlled trial comparing ITN use and malaria knowledge levels between households in Piron, Mali, undertaken in 2003...
  7. pmc Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali
    Mahamadou A Thera
    Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases DEAP Faculty of Medicine, Pharmacy and Odonto Stomatologie, University of Bamako, Bamako, Mali
    Malar J 6:68. 2007
    ..The acceptability and efficacy of a new kit with a new formulation of quinine alkaloids designed for the intra-rectal administration in the treatment of non-per os malaria was assessed in the peripheral health care system of Mopti, Mali...
  8. pmc A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 5:31. 2006
    ..Methods are needed to monitor genetic diversity in polymorphic vaccine antigens, but determining which genetic variants of such antigens are present in infected individuals is complicated by the frequent occurrence of mixed infections...
  9. pmc Space-time clustering of childhood malaria at the household level: a dynamic cohort in a Mali village
    Jean Gaudart
    Medical Statistics and Informatics Research Team, LIF UMR 6166 CNRS Aix Marseille University, Faculty of Medicine, 27 Bd Jean Moulin 13385 Marseille Cedex 05, France
    BMC Public Health 6:286. 2006
    ..The aim of this study was to identify, spatially and temporally, high-risk zones of malaria, at the household level (resolution of 1 to 3 m)...
  10. pmc Oblique decision trees for spatial pattern detection: optimal algorithm and application to malaria risk
    Jean Gaudart
    Medical Statistics and Informatics Research Team, LIF UMR 6166, CNRS Aix Marseille University, Faculty of Medicine, 27 Bd Jean Moulin 13385 Marseille Cedex 05, France
    BMC Med Res Methodol 5:22. 2005
    ..For this purpose, we have developed an ODT-algorithm to find an oblique partition of the space defined by the geographic coordinates...
  11. pmc High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children
    Ogobara K Doumbo
    Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
    Am J Trop Med Hyg 81:987-93. 2009
    ..28). Thus rosetting may contribute to the pathogenesis of all severe malaria syndromes in African children, and interventions to disrupt rosetting could be potential adjunctive therapies for all forms of severe malaria in Africa...
  12. ncbi request reprint Global voices of science. It takes a village: medical research and ethics in Mali
    Ogobara K Doumbo
    Department of Epidemiology of Parasitic Diseases DEAP, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Mali, BP 1805, Bamako, Mali
    Science 307:679-81. 2005
  13. pmc Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali
    Mamadou Tekete
    Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Malaria Research and Training Center, Bamako, Mali
    Malar J 8:34. 2009
    ..To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria...
  14. pmc Malaria morbidity in children in the year after they had received intermittent preventive treatment of malaria in Mali: a randomized control trial
    Alassane Dicko
    Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali
    PLoS ONE 6:e23390. 2011
    ..Here we report the results of a follow-on study undertaken to establish whether children who had received IPTc would be at increased risk of malaria during the subsequent malaria transmission season...
  15. pmc A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults
    Issaka Sagara
    Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry, BP 1805, Bamako, University of Bamako, Mali
    Vaccine 27:7292-8. 2009
    ..05). This is the first use of the novel adjuvant CPG 7909 in a malaria-exposed population...
  16. pmc Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial
    Mahamadou A Thera
    Malaria Research and Training Center, University of Bamako, Bamako, Mali
    PLoS ONE 5:e9041. 2010
    ..The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A) in children exposed to seasonal falciparum malaria...
  17. pmc A molecular map of chloroquine resistance in Mali
    Abdoulaye A Djimde
    Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Mali, West Africa
    FEMS Immunol Med Microbiol 58:113-8. 2010
    ..We present a comprehensive map of CQR in Mali, which strongly supports recent changes in drug policy away from chloroquine...
  18. ncbi request reprint Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 77:1028-33. 2007
    ..Our results suggest that, although the age distribution of clinical malaria depends on transmission intensity, the total burden of disease may be similar or higher in settings of low transmission...
  19. pmc Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
    Amed Ouattara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, Bamako, Mali
    Malar J 9:175. 2010
    ....
  20. pmc Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805 Bamako, Mali
    Malar J 9:9. 2010
    ..However, there is a fear that IPTi may result in a rapid increase of parasite resistance to SP...
  21. pmc Repeated artemisinin-based combination therapies in a malaria hyperendemic area of Mali: efficacy, safety, and public health impact
    Issaka Sagara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 87:50-6. 2012
    ..002) and RR = 0.80 (P = 0.001), respectively. The treatment efficacy was similar and above 95% in all arms. Although all drugs were highly efficacious and well tolerated, AS+AQ and AS+SP were associated with less episodes of malaria...
  22. ncbi request reprint Season, fever prevalence and pyrogenic threshold for malaria disease definition in an endemic area of Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Trop Med Int Health 10:550-6. 2005
    ..Modelling malaria parasitaemia as function of fever has been proposed as best alternative to estimate the attributable fraction of malaria fever and the sensitivity and specificity of different case definitions of malaria disease...
  23. pmc A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali
    Issaka Sagara
    Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry BP 1805 Bamako, University of Bamako, Mali, Malaysia
    Vaccine 27:3090-8. 2009
    ..5 g/dL, in the direction of lower hemoglobin in the children who received AMA1-C1, although these differences were not significant after correction for multiple tests. These differences were not seen in the second year of transmission...
  24. ncbi request reprint Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in Mali
    Abdoulaye A Djimde
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 78:455-61. 2008
    ..The ACTs were efficacious and safe, but the selection of markers for resistance to the partner drugs raises concerns over their lifespan in areas of intense malaria transmission...
  25. pmc Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali
    Alassane Dicko
    Malaria Research and Training Center, Departments of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, P O Box 1805, Bamako, Mali
    Malar J 7:123. 2008
    ..However in most areas malaria morbidity and mortality remain high in older children...
  26. ncbi request reprint A randomized trial of artesunate-mefloquine versus artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Mali
    Issaka Sagara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 79:655-61. 2008
    ..04% versus 96.93%). Artesunate-mefloquine is well-tolerated and is as effective as artemether-lumefantrine for the treatment of P. falciparum malaria. Artesunate-mefloquine also prevented more new infections...
  27. pmc Artemisinin-based combinations versus amodiaquine plus sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Faladje, Mali
    Kassoum Kayentao
    Malaria Research and Training Centre, Department of Epidemiology of Parasitologic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
    Malar J 8:5. 2009
    ....
  28. pmc Sulfadoxine-pyrimethamine impairs Plasmodium falciparum gametocyte infectivity and Anopheles mosquito survival
    Aminatou Kone
    Malaria Research and Training Center MRTC, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, P O Box 1805, Point G, Bamako, Mali
    Int J Parasitol 40:1221-8. 2010
    ..001). In addition, day 3 concentrations of SP decreased mosquito survival by up to 65% (P<0.001). This study demonstrates that SP is deleterious in vitro for gametocyte infectivity as well as mosquito survival...
  29. ncbi request reprint Assessing malaria burden during pregnancy in Mali
    Kassoum Kayentao
    Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, Malaria Research and Training Center, PO Box 1805, Bamako, Mali
    Acta Trop 102:106-12. 2007
    ..The methodology could be used by other malaria-endemic countries to direct their national malaria program efforts...
  30. pmc Low infectivity of Plasmodium falciparum gametocytes to Anopheles gambiae following treatment with sulfadoxine-pyrimethamine in Mali
    Abdoul H Beavogui
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Bamako, P O Box 1805, Point G, Bamako, Mali
    Int J Parasitol 40:1213-20. 2010
    ..Accurate and robust methods for measuring infectivity are needed to guide malaria control interventions that affect transmission...
  31. pmc Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications
    Amed Ouattara
    Malaria Research and Training Center, University of Sciences, Techniques and Technology, Bamako, Mali
    J Infect Dis 207:511-9. 2013
    ..These results indicate that a multivalent AMA1 vaccine with broad efficacy could include only a limited set of key alleles of this extremely polymorphic antigen...
  32. pmc Efficacy and safety of a fixed dose artesunate-sulphamethoxypyrazine-pyrimethamine compared to artemether-lumefantrine for the treatment of uncomplicated falciparum malaria across Africa: a randomized multi-centre trial
    Issaka Sagara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Malar J 8:63. 2009
    ..Ease of administration of anti-malarial treatments with shorter courses and fewer tablets may be key determinant of compliance...
  33. pmc Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali
    Amed Ouattara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
    Malar J 10:345. 2011
    ..In this context, Rapid Diagnostic Tests (RDTs) may improve case management particularly in remote areas...
  34. pmc Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial
    Mahamadou A Thera
    Malaria Research and Training Center, University of Bamako, Bamako, Mali
    PLoS ONE 3:e1465. 2008
    ..The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria...
  35. doi request reprint High frequency of PfCRT 76T in two Malian villages and its prevalence in severe relative to non-severe malaria
    Mamadou Wele
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
    Acta Trop 119:11-3. 2011
    ..0001). In children 5 years or younger, these proportions were 62.9% (n=294) vs. 73.5% (n=147), respectively (p<0.01). PfCRT 76T was therefore associated with malaria severity in this setting of Mali...
  36. pmc Serum antibody levels to glycosylphosphatidylinositols in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls
    Yacouba Cissoko
    Bandiagara Malaria Project, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, Malaria Research and Training Center, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 75:199-204. 2006
    ..A direct correlation between age and parasitemia and IgG antibodies to GPI was observed. In summary, higher levels of IgM and IgG antibodies to GPI in young children were associated with disease severity and were short-lived...
  37. ncbi request reprint Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones
    Abdoulaye A Djimde
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali
    J Infect Dis 190:853-5. 2004
    ..This example illustrates how molecular markers for drug resistance can provide timely data that inform malaria-control policy during epidemics and other emergency situations...
  38. pmc Quinine treatment selects the pfnhe-1 ms4760-1 polymorphism in Malian patients with Falciparum malaria
    Aminatou Kone
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto Stomatology, University of Science, Techniques and Technology, Bamako, Mali
    J Infect Dis 207:520-7. 2013
    ..The mechanism of Plasmodium falciparum resistance to quinine is not known. In vitro quantitative trait loci mapping suggests involvement of a predicted P. falciparum sodium-hydrogen exchanger (pfnhe-1) on chromosome 13...
  39. pmc Sickle cell trait protects against Plasmodium falciparum infection
    Mounkaila A Billo
    Mali Tulane Tropical Medicine Research Center, Malaria Research and Training Center, Bamako, Mali
    Am J Epidemiol 176:S175-85. 2012
    ..falciparum infection under conditions of natural transmission were demonstrable using a cohort-based approach but not when the same data were examined using a cross-sectional approach...
  40. pmc Increase in EPI vaccines coverage after implementation of intermittent preventive treatment of malaria in infant with Sulfadoxine -pyrimethamine in the district of Kolokani, Mali: results from a cluster randomized control trial
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Bamako, Mali
    BMC Public Health 11:573. 2011
    ..However IPTi may also increase the adherence of the community to EPI services and improve EPI coverage, once the benefice of strategy is perceived...
  41. ncbi request reprint A randomized trial of artesunate-sulfamethoxypyrazine-pyrimethamine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali
    Issaka Sagara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 75:630-6. 2006
    ..0%, respectively (P = 0.08). No serious adverse events occurred. Artesunate-sulfamethoxypyrazine-pyrimethamine is well-tolerated and effective against P. falciparum malaria. It showed an additional benefit of preventing new infections...
  42. ncbi request reprint A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria
    Dapa A Diallo
    faculté de médecine de pharmacie et d odontostomatologie, University of Bamako, Bamako, Mali
    Acta Trop 90:295-9. 2004
    ..By this measure, HbC, a malaria-protective polymorphism with few deleterious consequences, does not appear to be associated with more frequent anemia than normal HbA in episodes of uncomplicated P. falciparum malaria...
  43. pmc Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali
    Mamadou M Tekete
    Molecular Epidemiology and Drug Resistance Unit, Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, P, O, Box 1805, Bamako, Mali
    Malar J 10:275. 2011
    ..Yet, limited data is available on pharmacokinetic interactions between these drugs...
  44. doi request reprint Superiority of 3 over 2 doses of intermittent preventive treatment with sulfadoxine-pyrimethamine for the prevention of malaria during pregnancy in mali: a randomized controlled trial
    Oumou S Maïga Diakite
    Department of Health System Information, National Directorate of Health, University of Bamako, Bamako, Mali
    Clin Infect Dis 53:215-23. 2011
    ..The aim of the study was to compare the efficacy and safety of 3-dose versus 2-dose IPTp-SP for the prevention of placental malaria and associated low birth weight (LBW)...
  45. pmc No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali
    Amelia W Maiga
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto Stomatology, University of Bamako, Mali
    Am J Trop Med Hyg 87:23-8. 2012
    ..Artesunate was highly efficacious, with no evidence of delayed parasite clearance. We provide baseline surveillance data for the emergence or dissemination of P. falciparum resistance in sub-Saharan Africa...
  46. pmc A field trial to assess a blood-stage malaria vaccine
    Mahamadou A Thera
    Malaria Research and Training Center, University of Bamako, Bamako, Mali
    N Engl J Med 365:1004-13. 2011
    ..1/AS02(A), a recombinant protein based on apical membrane antigen 1 (AMA1) from the 3D7 strain of Plasmodium falciparum, has previously been shown to have immunogenicity and acceptable safety in Malian adults and children...
  47. pmc Efficacy of artesunate + sulfamethoxypyrazine/pyrimethamine versus praziquantel in the treatment of Schistosoma haematobium in children
    Mahamadou S Sissoko
    Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, Malaria Research and Training Center, University of Bamako, Bamako, Mali
    PLoS ONE 4:e6732. 2009
    ....
  48. pmc The TLR9 agonist CpG fails to enhance the acquisition of Plasmodium falciparum-specific memory B cells in semi-immune adults in Mali
    Boubacar Traore
    Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odonto Stomatology, Department of Epidemiology of Parasitic Diseases BP 1805 Bamako, Mali
    Vaccine 27:7299-303. 2009
    ..Understanding the molecular basis of this apparent refractoriness to TLR9 agonist will be of significant interest in vaccine design...
  49. pmc Phase 1 study of a combination AMA1 blood stage malaria vaccine in Malian children
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
    PLoS ONE 3:e1563. 2008
    ..The aim of this study was to assess the safety and immunogenicity of this vaccine in young children in a malaria endemic area...
  50. ncbi request reprint Malaria incidence in relation to rice cultivation in the irrigated Sahel of Mali
    Mahamadou Soumana Sissoko
    Département d épidémiologie des affections parasitaires, Faculte de Medecine, de Pharmacie et d Odonto Stomatologie, BP 1805, Bamako, Mali
    Acta Trop 89:161-70. 2004
    ..Rice cultivation in the semi-arid sub-Saharan environment altered the transmission pattern from seasonal to perennial, but reduced annual incidence more than two-fold...
  51. ncbi request reprint Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria
    Abdoulaye A Djimde
    Bandiagara Malaria Project, Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 69:558-63. 2003
    ..Age-adjusted comparison of subjects able to clear resistant parasites and those unable to do so provides a new phenotype for identifying host immune and genetic factors responsible for protective immunity against malaria...
  52. pmc Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease
    Mahamadou A Thera
    Bandiagara Malaria Project, Malaria Research and Training Center, University of Bamako, Mali
    J Infect Dis 192:1823-9. 2005
    ..CONCLUSIONS. In this setting of low antifolate resistance, TS was highly effective in preventing falciparum malaria infection and disease and did not appear to select for SP-resistant parasites...
  53. ncbi request reprint The etiology of severe anemia in a village and a periurban area in Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, PO Box 1805, Bamako, Mali
    Blood 104:1198-200. 2004
    ..2 years of age. Raising the baseline hemoglobin level and lowering peak parasitemia in infants and young children may reduce the incidence of severe anemia resulting from malarial infection...
  54. ncbi request reprint Community permission for medical research in developing countries
    Dapa A Diallo
    Department of Hematology, Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
    Clin Infect Dis 41:255-9. 2005
    ..Far from competing with the individual informed consent process, the process of obtaining community permission both initiated and facilitated the process of disclosure for individual informed consent...
  55. pmc Spatio-temporal analysis of malaria within a transmission season in Bandiagara, Mali
    Drissa Coulibaly
    Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Point G, BP 1805, Bamako, Mali
    Malar J 12:82. 2013
    ..To assess time and space distribution of malaria disease in Bandiagara, Mali, within a transmission season, data were used from an ongoing malaria incidence study that enrolled 300 participants aged under six years old"...
  56. pmc Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial
    Kassoum Kayentao
    Malaria Research and Training Center, Faculté de Médecine de Pharmacie et d Odonto Stomatologie, Bamako, Mali
    Malar J 11:364. 2012
    ..Children are most vulnerable to malaria. A pyronaridine-artesunate pediatric granule formulation is being developed for the treatment of uncomplicated Plasmodium falciparum malaria...
  57. pmc X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria
    Aldiouma Guindo
    Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali
    PLoS Med 4:e66. 2007
    ..These proposals are paradoxical, and they are not consistent with currently hypothesized mechanisms of protection...
  58. pmc False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene
    Ousmane A Koita
    Mali Tulane Tropical Medicine Research Center, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 86:194-8. 2012
    ..These findings suggest that the use of HRP2-based RDTs should be reconsidered...
  59. pmc Evaluation and optimization of membrane feeding compared to direct feeding as an assay for infectivity
    Mouctar Diallo
    Malaria Research and Training Center, University of Bamako, Bamako, Mali
    Malar J 7:248. 2008
    ..Anopheles gambiae s.l is the main vector responsible of Plasmodium falciparum transmission in Bancoumana and represents about 90% of the laboratory findings, whereas Plasmodium malariae and Plasmodium ovale together represent only 10%...
  60. pmc Urinary schistosomiasis among preschool-aged children in Sahelian rural communities in Mali
    Abdoulaye Dabo
    Department of Epidemiology of Infectious Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Box 1805, Bamako, Mali
    Parasit Vectors 4:21. 2011
    ..For Schistosoma haematobium diagnosis, a single urine sample of 10 ml obtained from each child was subjected to the standard urine filtration method...
  61. ncbi request reprint Responses to comments by Ishag Adam and Mustafa Idriss El Bechir on our paper "Risk factors for malaria infection and anemia for pregnant women in the Sahel area of Bandiagara, Mali" published in Acta Tropica 89 (1) 17-23
    Alassane Dicko
    Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odonto Stomatology, Department of Epidemiology of Parasitic Diseases, Bamako, Mali
    Acta Trop 96:62-3. 2005
  62. ncbi request reprint Impact of preseason treatment on incidence of falciparum malaria and parasite density at a site for testing malaria vaccines in Bandiagara, Mali
    Drissa Coulibaly
    Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Mali, Bamako, Mali, West Africa
    Am J Trop Med Hyg 67:604-10. 2002
    ....
  63. pmc Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children
    Kirsten E Lyke
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 73:1124-30. 2005
    ..falciparum malaria was observed in children 9-14 years of age. We conclude that underlying schistosomiasis is associated with protection against clinical falciparum malaria in an age-dependent manner...
  64. pmc Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS Med 4:e93. 2007
    ....
  65. pmc Promoting good clinical laboratory practices and laboratory accreditation to support clinical trials in sub-Saharan Africa
    Merepen A Guindo
    Mali International Center for Excellence in Research, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Mali
    Am J Trop Med Hyg 86:573-9. 2012
    ..Other disease-specific research groups in resource-limited settings may benefit by incorporating similar training initiatives, QMS methods, and continual improvement practices to ensure best practices...
  66. pmc Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Mali: a randomised, double-blind, placebo-controlled trial
    Alassane Dicko
    Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali
    PLoS Med 8:e1000407. 2011
    ..However, these studies were conducted in communities with low coverage with insecticide-treated nets (ITNs). Whether IPTc provides additional protection to children sleeping under an ITN has not been established...
  67. ncbi request reprint A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa
    Oumou Maïga
    Universite Paris Descartes, Paris, France
    J Infect Dis 196:165-72. 2007
    ..A predominant haplotype associated with the N51I+C59R+S108N triple-mutant dhfr allele has been reported recently in 4 African countries. A more comprehensive picture of the evolution of this mutant allele in Africa is lacking...
  68. pmc Short report: rare Plasmodium falciparum merozoite surface protein 1 19-kda (msp-1(19)) haplotypes identified in Mali using high-throughput genotyping methods
    Shannon L Takala
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 76:855-9. 2007
    ....
  69. ncbi request reprint Risk factors for malaria infection and anemia for pregnant women in the Sahel area of Bandiagara, Mali
    Alassane Dicko
    Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, Malaria Research and Training Center, Bamako, Mali
    Acta Trop 89:17-23. 2003
    ..Thus, control measures against malaria infection should target younger rural women in their first trimester of pregnancy...
  70. ncbi request reprint Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa
    Edgard Brice Ngoungou
    Institute of Neuroepidemiology and Tropical Neurology EA 3174, Faculty of Medicine, Limoges, France
    Epilepsia 47:873-9. 2006
    ..Cerebral malaria (CM) is suspected to be a potential cause of epilepsy in tropical areas, but little information is available. The purpose of this study was to evaluate the role of CM in epilepsy among children in Mali...
  71. ncbi request reprint Association of intraleukocytic Plasmodium falciparum malaria pigment with disease severity, clinical manifestations, and prognosis in severe malaria
    Kirsten E Lyke
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 69:253-9. 2003
    ....
  72. doi request reprint Life-threatening malaria in African children: a prospective study in a mesoendemic urban setting
    Stephane Ranque
    Immunology and Genetics of Parasitic Diseases, Faculty of Medicine, Universite de la Mediterrane, Marseilles, France
    Pediatr Infect Dis J 27:130-5. 2008
    ..However, comprehensive data on life-threatening malaria features and risk factors in children from urban areas with seasonal malaria transmission, such as in Bamako (Mali), are lacking...
  73. ncbi request reprint Associations between the IL-4 -590 T allele and Plasmodium falciparum infection prevalence in asymptomatic Fulani of Mali
    Manijeh Vafa
    Department of Immunology, Wenner Gren Institute, Stockholm University, Svante Arrheniusväg 16, S 106 91 Stockholm, Sweden
    Microbes Infect 9:1043-8. 2007
    ..falciparum prevalence within the Fulani but not the Dogon. No associations between IL-10 genotypes and studied malariometric indexes were observed in any of the two communities...
  74. pmc Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children
    Monica Arman
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Trop Med Hyg 77:943-6. 2007
    ..001) but not with disease category (F(2,122) = 1.8, P = 0.17). Therefore platelet-mediated clumping in Malian P. falciparum isolates is primarily associated with high parasitemia and not with severe clinical manifestations of malaria...
  75. doi request reprint Toxoplasma gondii Seroprevalence in Mali
    Dinkorma T Ouologuem
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Mali
    J Parasitol 99:371-4. 2013
    ..gondii antibody titers with age. Modeling the observed age distribution suggests a seroconversion rate of ∼1%/yr, indicating that congenital toxoplasmosis may be an under-appreciated public health concern in Mali...
  76. ncbi request reprint [Neighbourhood rural medicine: an experience of rural doctors in Mali]
    Seydou Coulibaly
    Sante Sud, Bamako, Mali
    Educ Health (Abingdon) 20:47. 2007
    ..It highlights the potential of health care personnel in Africa to provide primary health care well beyond traditional programs on prevalent diseases and to respond to both urgent individual needs and pressing public health requirements...
  77. pmc A randomized trial of doxycycline for Mansonella perstans infection
    Yaya I Coulibaly
    Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali
    N Engl J Med 361:1448-58. 2009
    ..perstans is refractory to standard antifilarial therapies. The recent discovery of bacterial endosymbionts (e.g., wolbachia) in most filarial species, including M. perstans, provides new therapeutic options for reducing microfilaremia...
  78. ncbi request reprint Different antibody- and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in Mali
    Salah E Farouk
    Department of Immunology, Wenner Gren Institute, Stockholm University, Svante Arrheniusväg 16, S 10691 Stockholm, Sweden
    Microbes Infect 7:110-7. 2005
    ....
  79. ncbi request reprint Incidence of severe Plasmodium falciparum malaria as a primary endpoint for vaccine efficacy trials in Bandiagara, Mali
    Kirsten E Lyke
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF 480, Baltimore, MD, USA
    Vaccine 22:3169-74. 2004
    ..This approach may be useful in assessing the suitability of potential sites for malaria vaccine trials...
  80. pmc Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence
    Anne Marie Deans
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Trop Med Hyg 74:554-63. 2006
    ..This raises the possibility of differences in the mechanisms of malaria virulence between sub-Saharan Africa and Asia...
  81. ncbi request reprint Risk factors for severe malaria in Bamako, Mali: a matched case-control study
    Innocent Safeukui-Noubissi
    Laboratoire de Parasitologie Mycologie, Immunology and Genetics of Parasitic Diseases, INSERM U 399, Faculte de Medecine Timone, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Microbes Infect 6:572-8. 2004
    ..Programmes aiming to improve both maternal health and maternal education may reduce the incidence of severe malaria in children and should therefore be advocated in Bamako and in areas with similar epidemiological patterns for malaria...
  82. ncbi request reprint Clinical characteristics of post-treatment reactions to ivermectin/albendazole for Wuchereria bancrofti in a region co-endemic for Mansonella perstans
    Paul B Keiser
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Am J Trop Med Hyg 69:331-5. 2003
    ..bancrofti infection in this community, and that acute post-treatment reactions should not limit patient compliance in community-based programs to eliminate lymphatic filariasis...
  83. pmc Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia
    Helen M Kyriacou
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 150:211-8. 2006
    ..These results suggest that var genes with DBLalpha1-like domains (Group A or B/A) may be implicated in the pathogenesis of cerebral malaria, while var genes with DBLalpha0-like domains promote less virulent malaria infections...
  84. pmc HLA-A2 supertype-restricted cell-mediated immunity by peripheral blood mononuclear cells derived from Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls
    Kirsten E Lyke
    The University of Maryland at Baltimore, Center for Vaccine Development, 685 W Baltimore St, HSF 480, Baltimore, MD 21201, USA
    Infect Immun 73:5799-808. 2005
    ..However, whether these immune responses to TRAP, CSP, and Exp-1 malarial proteins play a substantial role in protection remains a matter of controversy...
  85. pmc Inverse associations of human leukocyte antigen and malaria parasite types in two West African populations
    Karen Young
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Infect Immun 73:953-5. 2005
    ..e., the malaria parasite, and a major biological mechanism are well defined. We show that this surprising result fits well with the predictions of a mathematical model describing the population genetics and dynamics of this interaction...
  86. ncbi request reprint Familial aggregation of cerebral malaria and severe malarial anemia
    Stephane Ranque
    Immunology and Genetics of Parasitic Diseases, Institut National de la Santé et de la Recherche Médicale U 399, Faculty of Medicine, Universite de la Mediterranee, Marseilles, France
    J Infect Dis 191:799-804. 2005
    ..As a first step toward a family-based approach to identify the environmental and genetic pathways that contribute to severe malaria, we tested whether it aggregates within families...
  87. ncbi request reprint Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 435:1117-21. 2005
    ..Haemoglobin C might protect against malaria by reducing PfEMP-1-mediated adherence of parasitized erythrocytes, thereby mitigating the effects of their sequestration in the microvasculature...
  88. ncbi request reprint The pathogenic basis of malaria
    Louis H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:673-9. 2002
    ..The inability of many countries to fund expensive campaigns and antimalarial treatment requires these tools to be highly effective and affordable...
  89. pmc Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
    J Alexandra Rowe
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 104:17471-6. 2007
    ..falciparum rosetting. This work provides insights into malaria pathogenesis and suggests that the selective pressure imposed by malaria may contribute to the variable global distribution of ABO blood groups in the human population...
  90. pmc Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection in Malian children
    Kirsten E Lyke
    Center for Vaccine Development, University of Maryland at Baltimore, 685 W Baltimore St, HSFI 480, Baltimore, MD 21201, USA
    Infect Immun 74:5718-24. 2006
    ..001) and the Sch(-) children (P < 0.001) who were 4 to 8 years old. We postulate that the Th2-enriched environment induced by schistosomiasis protects against malaria and alters the cytokine milieu during an actual infection...
  91. pmc Valid consent for genomic epidemiology in developing countries
    Dave A Chokshi
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Med 4:e95. 2007
  92. pmc Filaria-induced monocyte dysfunction and its reversal following treatment
    Roshanak Tolouei Semnani
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 4 Center Drive, Room 4 126, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 74:4409-17. 2006
    ..These data suggest that the function and gene expression of monocytes in filaria-infected patients are altered but that this dysfunction is partially reversible following antifilarial treatment...
  93. pmc Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin
    Rushina Cholera
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:991-6. 2008
    ..Coinherited hemoglobin polymorphisms and naturally acquired antibodies to PfEMP-1 may influence the degree of malaria protection in AS children by further weakening cytoadherence interactions...