Vandana Malhotra

Summary

Publications

  1. doi request reprint Mycobacterium tuberculosis Response Regulators, DevR and NarL, Interact in Vivo and Co-regulate Gene Expression during Aerobic Nitrate Metabolism
    Vandana Malhotra
    From the Center for Infectious Diseases and Vaccinology, Biodesign Institute, and
    J Biol Chem 290:8294-309. 2015
  2. pmc DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism
    Vandana Malhotra
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Tuberculosis (Edinb) 89:169-74. 2009
  3. pmc Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation
    Vandana Malhotra
    Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287, USA
    Microbiology 156:2829-41. 2010
  4. pmc Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control
    Vandana Malhotra
    Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, Arizona, USA
    J Bacteriol 194:4184-96. 2012
  5. pmc The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions
    Shelley E Haydel
    The Biodesign Institute Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, Arizona, USA
    J Bacteriol 194:354-61. 2012

Detail Information

Publications5

  1. doi request reprint Mycobacterium tuberculosis Response Regulators, DevR and NarL, Interact in Vivo and Co-regulate Gene Expression during Aerobic Nitrate Metabolism
    Vandana Malhotra
    From the Center for Infectious Diseases and Vaccinology, Biodesign Institute, and
    J Biol Chem 290:8294-309. 2015
    ..We propose NarL-DevR binding, possibly as a heterodimer, as a novel mechanism for co-regulation of gene expression by the DevRS/DosT and NarL/NarS regulatory systems. ..
  2. pmc DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism
    Vandana Malhotra
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Tuberculosis (Edinb) 89:169-74. 2009
    ..This is the first report of medium-specific constitutive expression of the DevR regulon in an avirulent strain and suggests a potential role for metabolite(s) in the activation of the DevR-DevS TCS...
  3. pmc Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation
    Vandana Malhotra
    Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287, USA
    Microbiology 156:2829-41. 2010
    ..Finally, we provide evidence for the localization of PknK during infection and discuss its implications in pathogenesis...
  4. pmc Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control
    Vandana Malhotra
    Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, Arizona, USA
    J Bacteriol 194:4184-96. 2012
    ..Significantly, the invariant lysine 55 residue was only essential for activity in the full-length PknK protein, and the truncated mutant proteins were active. A model for PknK autoregulation is proposed and discussed...
  5. pmc The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions
    Shelley E Haydel
    The Biodesign Institute Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, Arizona, USA
    J Bacteriol 194:354-61. 2012
    ..These data provide the first report describing the essentiality of the M. tuberculosis prrAB two-component system and reveal insights into its potential role in mycobacterial growth and metabolism...