Vandana Malhotra

Summary

Publications

  1. pmc Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism
    Vandana Malhotra
    From the Center for Infectious Diseases and Vaccinology, Biodesign Institute, and
    J Biol Chem 290:8294-309. 2015
  2. pmc DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism
    Vandana Malhotra
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Tuberculosis (Edinb) 89:169-74. 2009
  3. pmc Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation
    Vandana Malhotra
    Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287, USA
    Microbiology 156:2829-41. 2010
  4. pmc Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control
    Vandana Malhotra
    Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, Arizona, USA
    J Bacteriol 194:4184-96. 2012
  5. pmc The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions
    Shelley E Haydel
    The Biodesign Institute Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, Arizona, USA
    J Bacteriol 194:354-61. 2012
  6. doi request reprint The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition
    Shaleen B Korch
    Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, Arizona, 85287, USA
    J Microbiol 53:783-95. 2015

Detail Information

Publications6

  1. pmc Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism
    Vandana Malhotra
    From the Center for Infectious Diseases and Vaccinology, Biodesign Institute, and
    J Biol Chem 290:8294-309. 2015
    ..We propose NarL-DevR binding, possibly as a heterodimer, as a novel mechanism for co-regulation of gene expression by the DevRS/DosT and NarL/NarS regulatory systems. ..
  2. pmc DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism
    Vandana Malhotra
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Tuberculosis (Edinb) 89:169-74. 2009
    ..This is the first report of medium-specific constitutive expression of the DevR regulon in an avirulent strain and suggests a potential role for metabolite(s) in the activation of the DevR-DevS TCS...
  3. pmc Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation
    Vandana Malhotra
    Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287, USA
    Microbiology 156:2829-41. 2010
    ..Finally, we provide evidence for the localization of PknK during infection and discuss its implications in pathogenesis...
  4. pmc Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control
    Vandana Malhotra
    Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, Arizona, USA
    J Bacteriol 194:4184-96. 2012
    ..Significantly, the invariant lysine 55 residue was only essential for activity in the full-length PknK protein, and the truncated mutant proteins were active. A model for PknK autoregulation is proposed and discussed...
  5. pmc The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions
    Shelley E Haydel
    The Biodesign Institute Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, Arizona, USA
    J Bacteriol 194:354-61. 2012
    ..These data provide the first report describing the essentiality of the M. tuberculosis prrAB two-component system and reveal insights into its potential role in mycobacterial growth and metabolism...
  6. doi request reprint The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition
    Shaleen B Korch
    Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, Arizona, 85287, USA
    J Microbiol 53:783-95. 2015
    ..Here we present evidence that the rel Mtb toxin:antitoxin family is stress-responsive and, through the degradation of mRNA, the RelE Mtb toxin influences the growth, proteome and morphology of mycobacterial cells. ..