Maciej T Malecki

Summary

Publications

  1. ncbi request reprint Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population
    Maciej T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, 15 Kopernika Street, 31 501 Krakow, Poland
    Eur J Endocrinol 146:695-9. 2002
  2. doi request reprint Cystatin C is not a good candidate biomarker for HNF1A-MODY
    Natalia Nowak
    Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, 31 501, Krakow, Poland
    Acta Diabetol 50:815-20. 2013
  3. pmc Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis
    P Wojciechowski
    HTA Consulting, Krakow, Poland
    Diabetologia 55:2636-45. 2012
  4. doi request reprint Altered fibrin-clot properties are associated with retinopathy in type 2 diabetes mellitus
    M Walus-Miarka
    Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, 21 501, Krakow, Poland
    Diabetes Metab 38:462-5. 2012
  5. ncbi request reprint Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 80:139-45. 2008
  6. doi request reprint Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction
    M T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, Krakow, Poland
    Eur J Clin Invest 38:925-30. 2008
  7. ncbi request reprint Plasma asymmetric dimethylarginine (ADMA) is associated with retinopathy in type 2 diabetes
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, 15 Kopernika St, 31 501 Krakow, Poland
    Diabetes Care 30:2899-901. 2007
  8. ncbi request reprint Monogenic diabetes: implications for therapy of rare types of disease
    Maciej T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, Krakow, Poland
    Diabetes Obes Metab 10:607-16. 2008
  9. ncbi request reprint Problems in differential diagnosis of diabetes types
    Maciej Małecki
    Department of Metabolic Diseases, Collegium Medicum Jagiellonian University, Krakow, Poland
    Pol Arch Med Wewn 118:435-40. 2008
  10. ncbi request reprint Renal malformations may be linked to mutations in the hepatocyte nuclear factor-1alpha (MODY3) gene
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, Medical College, Krakow, Poland
    Diabetes Care 28:2774-6. 2005

Detail Information

Publications43

  1. ncbi request reprint Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population
    Maciej T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, 15 Kopernika Street, 31 501 Krakow, Poland
    Eur J Endocrinol 146:695-9. 2002
    ..However, substantial differences were shown between ethnic groups in at risk alleles and haplotypes as well as in their attributable risk. Thus, it is important to determine the role of calpain 10 in various populations...
  2. doi request reprint Cystatin C is not a good candidate biomarker for HNF1A-MODY
    Natalia Nowak
    Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, 31 501, Krakow, Poland
    Acta Diabetol 50:815-20. 2013
    ..In HNF1A-MODY, the cystatin C-based GFR estimate is higher than the creatinine-based one. ..
  3. pmc Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis
    P Wojciechowski
    HTA Consulting, Krakow, Poland
    Diabetologia 55:2636-45. 2012
    ..Several small studies have suggested a greater than expected effect of the FTO rs9939609 SNP on weight in polycystic ovary syndrome (PCOS). We therefore aimed to examine the impact of FTO genotype on BMI and weight in PCOS...
  4. doi request reprint Altered fibrin-clot properties are associated with retinopathy in type 2 diabetes mellitus
    M Walus-Miarka
    Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, 21 501, Krakow, Poland
    Diabetes Metab 38:462-5. 2012
    ..As the formation of dense fibrin clots resistant to lysis has been described in diabetes patients, this study tested the hypothesis that altered clot structure and function are associated with DR in T2DM patients...
  5. ncbi request reprint Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 80:139-45. 2008
    ..Molecular background of diabetic retinopathy (DR) remains unknown. An interesting group of candidate genes encode proteins involved in insulin resistance...
  6. doi request reprint Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction
    M T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, Krakow, Poland
    Eur J Clin Invest 38:925-30. 2008
    ..Here we described the search for the association between DR and intima-media thickness (IMT) in T2DM. We also compared endothelial function in subjects with and without DR...
  7. ncbi request reprint Plasma asymmetric dimethylarginine (ADMA) is associated with retinopathy in type 2 diabetes
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, 15 Kopernika St, 31 501 Krakow, Poland
    Diabetes Care 30:2899-901. 2007
  8. ncbi request reprint Monogenic diabetes: implications for therapy of rare types of disease
    Maciej T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, Krakow, Poland
    Diabetes Obes Metab 10:607-16. 2008
    ..In this paper, the aetiology of some monogenic diabetes forms is reviewed together with the clinical aspects of management of the affected individuals...
  9. ncbi request reprint Problems in differential diagnosis of diabetes types
    Maciej Małecki
    Department of Metabolic Diseases, Collegium Medicum Jagiellonian University, Krakow, Poland
    Pol Arch Med Wewn 118:435-40. 2008
    ..In this article, a review of problems associated with the differential diagnostics of diabetes and its practical clinical application was made...
  10. ncbi request reprint Renal malformations may be linked to mutations in the hepatocyte nuclear factor-1alpha (MODY3) gene
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, Medical College, Krakow, Poland
    Diabetes Care 28:2774-6. 2005
  11. ncbi request reprint Can geneticists help clinicians to understand and treat non-autoimmune diabetes?
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 82:S83-93. 2008
    ..In this review, we present the clinical application of genetic testing in non-autoimmune diabetes, mostly monogenic forms of disease...
  12. ncbi request reprint The Pro12Ala polymorphism of PPARgamma2 gene and susceptibility to type 2 diabetes mellitus in a Polish population
    Maciej T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 62:105-11. 2003
    ..The Pro12Ala amino acid variant of the PPARgamma2 isoform is associated with T2DM in several populations...
  13. ncbi request reprint Vitamin D binding protein gene and genetic susceptibility to type 2 diabetes mellitus in a Polish population
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 57:99-104. 2002
    ..No evidence was found for an association between DBP frequent polymorphisms and T2DM in this population...
  14. doi request reprint Glycemic control and pregnancy outcomes in women with type 2 diabetes from Poland. The impact of pregnancy planning and a comparison with type 1 diabetes subjects
    Katarzyna Cyganek
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 511, Krakow, Poland
    Endocrine 40:243-9. 2011
    ..This could have been the reason for the slightly lower number of macrosomic babies but did not affect other outcomes. In T2DM, pregnancy planning had a beneficial glycemic effect in the first trimester...
  15. doi request reprint Efficacy and safety of sulfonylurea use in permanent neonatal diabetes due to KCNJ11 gene mutations: 34-month median follow-up
    Tomasz Klupa
    Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
    Diabetes Technol Ther 12:387-91. 2010
    ..The long-term efficacy and safety of SU treatment in PNDM patients, however, have not yet been determined...
  16. doi request reprint The first case report of sulfonylurea use in a woman with permanent neonatal diabetes mellitus due to KCNJ11 mutation during a high-risk pregnancy
    Tomasz Klupa
    Department of Metabolic Diseases, Jagiellonian University Medical College, University Hospital, 15 Kopernika Street, 31 501 Krakow, Poland
    J Clin Endocrinol Metab 95:3599-604. 2010
    ..SUs, which seem to constitute an alternative to insulin during pregnancy in Kir6.2-related PNDM, were used during the conception period and most of the second and third trimesters...
  17. doi request reprint Variants of the adiponectin gene and type 2 diabetes in a Polish population
    Magdalena Szopa
    Department of Metabolic Diseases, Medical College, Jagiellonian University, 15 Kopernika Street, 31 501, Krakow, Poland
    Acta Diabetol 46:317-22. 2009
    ..391G>A and +276G>T were independently associated with T2DM. Finally, we conclude that the adiponectin gene polymorphisms are associated with T2DM and prediabetic quantitative traits in Polish Caucasians...
  18. doi request reprint LMNA gene mutation search in Polish patients: new features of the heterozygous Arg482Gln mutation phenotype
    Tomasz Klupa
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Endocrine 36:518-23. 2009
    ..A clinical picture related to the LMNA Arg482Gln mutation may be more diversified than it was previously considered and include low BMI and pulmonary fibrosis...
  19. doi request reprint Dipeptidyl peptidase-IV inhibitors are efficient adjunct therapy in HNF1A maturity-onset diabetes of the young patients--report of two cases
    Barbara Katra
    Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, Krakow, Poland
    Diabetes Technol Ther 12:313-6. 2010
    ..Over time, such therapy fails, and additional treatment is required. Dipeptidyl peptidase IV (DPP-IV) inhibitors are new agents that lower blood glucose by prolonging the activity of circulating incretins...
  20. ncbi request reprint Transfer to sulphonylurea therapy in adult subjects with permanent neonatal diabetes due to KCNJ11-activating [corrected] mutations: evidence for improvement in insulin sensitivity
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika St, 31 501 Krakow, Poland
    Diabetes Care 30:147-9. 2007
  21. pmc Insulin pump therapy is equally effective and safe in elderly and young type 1 diabetes patients
    Bartlomiej Matejko
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Rev Diabet Stud 8:254-8. 2011
    ..We aimed to compare the glycemic control and use of selected pump tools in T1D subjects using CSII over the age of 50 (50+ T1D) with patients younger than 50 years of age...
  22. doi request reprint The dual-wave bolus feature in type 1 diabetes adult users of insulin pumps
    Tomasz Klupa
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, Krakow, Poland
    Acta Diabetol 48:11-4. 2011
    ..In conclusion, DWB might be a tool potentially helping to improve glycemic control in T1DM adult users of insulin pumps. Male patients and those with a shorter duration of diabetes seem to use it more willingly...
  23. doi request reprint Glycemic control and selected pregnancy outcomes in type 1 diabetes women on continuous subcutaneous insulin infusion and multiple daily injections: the significance of pregnancy planning
    Katarzyna Cyganek
    Department of Metabolic Diseases, Jagiellonian University Medical College, 31 511 Krakow, Poland
    Diabetes Technol Ther 12:41-7. 2010
    ..We assessed their efficacy and safety and the effect of pregnancy planning...
  24. pmc Clinical application of 1,5-anhydroglucitol measurements in patients with hepatocyte nuclear factor-1alpha maturity-onset diabetes of the young
    Jan Skupien
    1Department of Metabolic Diseases, Jagiellonian University, Medical College, Krakow, Poland
    Diabetes Care 31:1496-501. 2008
    ..In addition, we aimed to evaluate this particle as a biomarker for HNF-1alpha MODY...
  25. pmc Monogenic models: what have the single gene disorders taught us?
    Tomasz Klupa
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501, Krakow, Poland
    Curr Diab Rep 12:659-66. 2012
    ..In this review paper, we summarize the impact of single gene disease discoveries on diabetes research and clinical practice...
  26. doi request reprint The effect of hematocrit on the results of measurements using glucose meters based on different techniques
    Bogdan Solnica
    Department of Diagnostics, Jagiellonian University Medical College, Krakow, Poland
    Clin Chem Lab Med 50:361-5. 2012
    ..The aim of the study was to evaluate the effect of hematocrit (HCT) on glucose meter assays based on different measurement techniques...
  27. pmc Evaluation of Apolipoprotein M Serum Concentration as a Biomarker of HNF-1alpha MODY
    Jan Skupien
    Department and Chair of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
    Rev Diabet Stud 4:231-5. 2007
    ..In summary, our study showed no association between HNF-1alpha mutations resulting in MODY phenotype and apoM levels. Thus, we cannot confirm the clinical usefulness of apoM as a biomarker of HNF-1alpha MODY...
  28. pmc Postpregnancy glycemic control and weight changes in type 1 diabetic women
    Katarzyna Cyganek
    University Hospital, Krakow, Poland
    Diabetes Care 36:1083-7. 2013
    ..Most pregnant type 1 diabetic women achieve normoglycemia; however, there is scarce data on their postdelivery characteristics. We aimed to examine postpregnancy glycemic control and weight changes in type 1 diabetes...
  29. ncbi request reprint Type 2 diabetes mellitus: from genes to disease
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, Medical College, Kopernika 15, PL 31 501, Krakow, Poland
    Pharmacol Rep 57:20-32. 2005
    ..Although major genes for T2DM still await to be discovered, we have probably established a "road map" that we should follow...
  30. doi request reprint Mutations in the ABCC8 (SUR1 subunit of the K(ATP) channel) gene are associated with a variable clinical phenotype
    Tomasz Klupa
    Department of Metabolic Diseases, Jagiellonian University, Medical College, Krakow, Poland
    Clin Endocrinol (Oxf) 71:358-62. 2009
    ..We aimed to determine the contribution of ABCC8 gene to ND in Poland, to describe the clinical phenotype associated with its mutations and to examine potential modifying factors...
  31. pmc Evaluation of the analytical performance of the coulometry-based Optium Omega blood glucose meter
    Bogdan Solnica
    Department of Diagnostics, Jagiellonian University Medical College, Krakow, Poland
    J Diabetes Sci Technol 5:1612-7. 2011
    ..In this study, an evaluation of the analytical performance of the coulometry-based Optium Omega™ glucose meter designed for SMBG has been carried out...
  32. ncbi request reprint Genetics of type 2 diabetes mellitus
    Maciej T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 68:S10-21. 2005
    ..In addition, some evidence exists that genes, such as adiponectin, IRS-1, and some others may also influence the susceptibility to T2DM. It is expected that in the nearest future more T2DM susceptibility genes will be identified...
  33. pmc Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study
    Ewa Konduracka
    Department of Coronary Disease, Jagiellonian University School of Medicine, John Paul II Hospital, Pradnicka 80, 31 202, Krakow, Poland
    Acta Diabetol 50:597-606. 2013
    ..While the cause of this observation remains uncertain, it could probably be explained, at least partially, by the cardioprotective effect of concomitant treatment...
  34. pmc Connexin 43 and metabolic effect of fatty acids in stressed endothelial cells
    Beata Kiec-Wilk
    Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
    Genes Nutr 7:257-63. 2012
    ....
  35. doi request reprint The CpG island methylation regulated expression of endothelial proangiogenic genes in response to β-carotene and arachidonic acid
    Beata Kiec-Wilk
    Department of Medical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
    Nutr Cancer 63:1053-63. 2011
    ..However more research is necessary to confirm this hypothesis...
  36. ncbi request reprint A2 alelle of GpIIIa gene is a risk factor for stroke caused by large-vessel disease in males
    Agnieszka Slowik
    Department of Neurology, Jagiellonian University, 31 503 Krakow, Botaniczna 3, Poland
    Stroke 35:1589-93. 2004
    ..We studied the significance of the GpIIIa gene A1/A2 polymorphism in stroke patients with different stroke causes...
  37. pmc All we need is GWAS: Genome-Wide Association Studies in Type 2 Diabetes Mellitus presented on the 2008 EASD Meeting in Rome
    Tomasz Klupa
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Rev Diabet Stud 5:175-9. 2008
    ..Also, there are the problems of low sensitivity in identifying the signals from relatively rare variants, and the low effectiveness in identifying epistatic gene-gene interactions...
  38. ncbi request reprint Determinants of the development of diabetes (maturity-onset diabetes of the young-3) in carriers of HNF-1alpha mutations: evidence for parent-of-origin effect
    Tomasz Klupa
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 25:2292-301. 2002
    ..To determine the distribution of the age at onset of diabetes (maturity-onset diabetes of the young-3 [MODY3]) and to identify determinants of the onset of diabetes in carriers of HNF-1alpha mutations...
  39. ncbi request reprint Islet-specific antibody seroconversion in patients with long duration of permanent neonatal diabetes caused by mutations in the KCNJ11 gene
    Agnieszka Gach
    Department of Pediatrics, Medical University of Lodz, 38 50 Sporna St, 91 738 Lodz, Poland
    Diabetes Care 30:2080-2. 2007
  40. ncbi request reprint Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses
    Takafumi Tsuchiya
    Departments of Medicine and Human Genetics, The University of Chicago, 5841 S Maryland Ave, MC1027, Chicago, IL 60637, USA
    Mol Genet Metab 89:174-84. 2006
    ..68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans...
  41. ncbi request reprint Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations
    Ewan R Pearson
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom
    N Engl J Med 355:467-77. 2006
    ..Diabetes results from impaired insulin secretion caused by a failure of the beta-cell K(ATP) channel to close in response to increased intracellular ATP. Sulfonylureas close the K(ATP) channel by an ATP-independent route...
  42. ncbi request reprint Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11
    Wojciech Mlynarski
    Department of Pediatrics, Medical University of Lodz, Lodz, Poland
    Nat Clin Pract Neurol 3:640-5. 2007
    ..The patient underwent genetic evaluation at the age of 6 years, prompted by reports that mutations in the KCNJ11 gene caused neonatal diabetes...