Lai Meng Looi

Summary

Affiliation: University of Malaya
Country: Malaysia

Publications

  1. ncbi request reprint Tissue Microarray Immunohistochemical Profiles of p53 and pRB in Hepatocellular Carcinoma and Hepatoblastoma
    Abdul Hadi Azlin
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia e mail
    Asian Pac J Cancer Prev 15:3959-63. 2014
  2. ncbi request reprint The Pathology Laboratory Act 2007 explained
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University Malaya Medical Centre, Kuala Lumpur
    Malays J Pathol 30:1-10. 2008
  3. ncbi request reprint Historical development of the renal histopathology services in Malaysia
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 31:11-6. 2009
  4. ncbi request reprint p16(INK4a) is a useful marker of human papillomavirus integration allowing risk stratification for cervical malignancies
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
    Asian Pac J Cancer Prev 13:469-72. 2012
  5. ncbi request reprint Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya
    Asian Pac J Cancer Prev 11:713-6. 2010
  6. ncbi request reprint Implications of continued upregulation of p16(INK4a) through the evolution from high-grade squamous intraepithelial lesion to invasive squamous carcinoma of the cervix
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 33:83-7. 2011
  7. ncbi request reprint An analysis of predictive biomarkers in routine histopathological reporting of infiltrating ductal breast carcinoma in a tertiary hospital in Malaysia with a focus on limitations and directions for future development
    Kean Hooi Teoh
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 33:35-42. 2011
  8. ncbi request reprint Proliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri-neoplastic and normal liver
    Kein Seong Mun
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 28:73-7. 2006
  9. ncbi request reprint Telomerase activation in neoplastic cell immortalization and tumour progression
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya, Malaysia
    Malays J Pathol 29:33-5. 2007
  10. ncbi request reprint Aberrant expression of acute-phase reactant proteins in sera and breast lesions of patients with malignant and benign breast tumors
    Saeid R Doustjalali
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Electrophoresis 25:2392-401. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Tissue Microarray Immunohistochemical Profiles of p53 and pRB in Hepatocellular Carcinoma and Hepatoblastoma
    Abdul Hadi Azlin
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia e mail
    Asian Pac J Cancer Prev 15:3959-63. 2014
    ..Hence the use of p53 and pRB protein expression has no contribution in the situation where there is a diagnostic difficulty in deciding between HCC and HB. ..
  2. ncbi request reprint The Pathology Laboratory Act 2007 explained
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University Malaya Medical Centre, Kuala Lumpur
    Malays J Pathol 30:1-10. 2008
    ..Sincere professional input is thus required to embrace its philosophy, ensure rational and transparent enforcement of legislation, and develop National guidelines for good pathology practices upon which enforcement may be based...
  3. ncbi request reprint Historical development of the renal histopathology services in Malaysia
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 31:11-6. 2009
    ..More recently, there has been increasing involvement of renal teams in clinical trials, particularly for lupus nephritis and renal transplant modulation...
  4. ncbi request reprint p16(INK4a) is a useful marker of human papillomavirus integration allowing risk stratification for cervical malignancies
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
    Asian Pac J Cancer Prev 13:469-72. 2012
    ....
  5. ncbi request reprint Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya
    Asian Pac J Cancer Prev 11:713-6. 2010
    ..05) relative to BNL (2.9 kb). The findings imply that telomere attrition and telomerase activation differ between malignant and benign tumours of the breast and may be important for targeted therapy...
  6. ncbi request reprint Implications of continued upregulation of p16(INK4a) through the evolution from high-grade squamous intraepithelial lesion to invasive squamous carcinoma of the cervix
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 33:83-7. 2011
    ..Interestingly, the occurrence of HSIL and LSIL in almost the same age group could mean that alteration from episomal to integrated form of HPV may not incur a prolonged incubation period, unlike from HSIL to SCC...
  7. ncbi request reprint An analysis of predictive biomarkers in routine histopathological reporting of infiltrating ductal breast carcinoma in a tertiary hospital in Malaysia with a focus on limitations and directions for future development
    Kean Hooi Teoh
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 33:35-42. 2011
    ....
  8. ncbi request reprint Proliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri-neoplastic and normal liver
    Kein Seong Mun
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 28:73-7. 2006
    ..This is probably related to the malignant nature of HCC and may reflect the uncontrolled proliferation of the neoplastic hepatocytes...
  9. ncbi request reprint Telomerase activation in neoplastic cell immortalization and tumour progression
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya, Malaysia
    Malays J Pathol 29:33-5. 2007
    ..These findings support a contributory role for telomerase in tumourigenesis with activation occurring from neoplastic transformation and increasing with tumour progression...
  10. ncbi request reprint Aberrant expression of acute-phase reactant proteins in sera and breast lesions of patients with malignant and benign breast tumors
    Saeid R Doustjalali
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Electrophoresis 25:2392-401. 2004
    ..The differential expression of the serum proteins was apparently abrogated when a six-month follow-up study was performed on nine of the BC patients subsequent to treatment...
  11. pmc Unusual finding of endocervical-like mucinous epithelium in continuity with urothelium in endocervicosis of the urinary bladder
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Diagn Pathol 6:56. 2011
    ..The patient has remained well and without evidence of disease 18-months following transurethral resection of the lesion...
  12. ncbi request reprint Colorectal carcinoma in Malaysians: DNA mismatch repair pattern in a multiethnic population
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia e mail
    Asian Pac J Cancer Prev 15:3287-91. 2014
    ..0%) dMMR CRC cases amongst the Chinese and 1 of 9 cases (11.1%) amongst the combined Malay and Indian group were <50-years of age. No significant association of dMMR was noted with patient age and gender, tumour stage or mucinous type...
  13. ncbi request reprint Microwave-stimulated formaldehyde fixation of experimental renal biopsy tissues: computerised morphometric analysis of distortion artefacts
    Lai Meng Looi
    Department of Pathology University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    Malays J Pathol 27:23-7. 2005
    ..These findings have implications on the logistics of tissue preparation of renal biopsies in clinical practice...
  14. doi request reprint Human papillomavirus in cervical cancers of Malaysians
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Obstet Gynaecol Res 37:489-95. 2011
    ..With cervical carcinoma remaining the second leading cancer among Malaysian women, it is imperative to clarify the prevalence of human papillomavirus (HPV) in this respect, considering the dearth of local information...
  15. ncbi request reprint Computer-linked image analysis of nuclear area: is there a use in diagnosis and grading of hepatocellular carcinoma?
    Phaik Leng Cheah
    Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    Malays J Pathol 29:37-40. 2007
    ....
  16. doi request reprint Adjuvant! Online is overoptimistic in predicting survival of Asian breast cancer patients
    Nirmala Bhoo-Pathy
    National Clinical Research Centre, Level 3, Dermatology Block, Kuala Lumpur Hospital, 50586 Jalan Pahang, Kuala Lumpur, Malaysia
    Eur J Cancer 48:982-9. 2012
    ..As its prognostic performance has only been validated in high income Caucasian populations, we validated the model in a middle income Asian setting...
  17. doi request reprint Clinical predictors of non-diabetic renal disease and role of renal biopsy in diabetic patients with renal involvement: a single centre review
    Yip Boon Chong
    Division of Nephrology, Department of Medicine, University Malaya Medical Centre, University of Malaya, Kuala Lumpur, Malaysia
    Ren Fail 34:323-8. 2012
    ..Our study aimed to examine the prevalence of NDRD in T2DM and clinical markers for diabetic nephropathy (DN) and NDRD and to determine the role of renal biopsy in T2DM patients and its impact on clinical practice...
  18. doi request reprint Outcome of biliary atresia in Malaysia: a single-centre study
    Way Seah Lee
    Departments of Paediatrics, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    J Paediatr Child Health 45:279-85. 2009
    ..This study aimed to determine the outcome of the operation of children with biliary atresia (BA) at a tertiary paediatric referral centre in Malaysia...
  19. ncbi request reprint P53 immunohistochemical expression: messages in cervical carcinogenesis
    Phaik Leng Cheah
    Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    Pathology 34:326-31. 2002
    ..The pattern of p53 expression was studied in pre-invasive and invasive cervical carcinoma in an attempt to clarify its role in cervical carcinogenesis...
  20. ncbi request reprint Mammographic breast glandularity in Malaysian women: data derived from radiography
    Noriah Jamal
    Department of Radiology, University of Malaya, Kuala Lumpur 59100, Malaysia
    AJR Am J Roentgenol 182:713-7. 2004
    ..This study was undertaken to estimate mammographic breast glandularity in Malaysian women from radiographic data...
  21. ncbi request reprint Tuberculosis or systemic lupus erythematosus? A diagnostic and therapeutic dilemma
    Asmah Mohd
    Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 34:361-4. 2003
    ..Treatment for the collagen vascular disease with corticosteroids exacerbated the intercurrent infection. The problems in the diagnosis and management of such cases are discussed...
  22. ncbi request reprint Detection of the human papillomavirus in cervical carcinoma: a comparison between non-isotopic in-situ hybridisation and polymerase chain reaction as methods for detection in formalin-fixed, paraffin-embedded tissues
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
    Malays J Pathol 30:37-42. 2008
    ..It thus appears that PCR and NISH can be successfully used to detect HPV in formalin-fixed, paraffin-embedded tissue and in the presence of intact DNA NISH may be as sensitive as PCR...
  23. ncbi request reprint Lessons from the Nipah virus outbreak in Malaysia
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya, Malaysia
    Malays J Pathol 29:63-7. 2007
    ..Environmental mismanagement (such as deforestation and haze) has far-reaching effects, including encroachment of wildlife into human habitats and the introduction of zoonotic infections into domestic animals and humans...
  24. ncbi request reprint CD44 expression and axillary lymph node metastasis in infiltrating ductal carcinoma of the breast
    Lai Meng Looi
    Department of Pathology, Faculty of Medincine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 28:83-6. 2006
    ..Our results suggest that CD44 may have a role in the progression of breast cancer and emphasise the need to investigate its interaction with other mechanisms of cancer advancement...
  25. ncbi request reprint alpha1-Antitrypsin deficiency is not an important cause of childhood liver diseases in a multi-ethnic Southeast Asian population
    Way Seah Lee
    Department of Paediatrics, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    J Paediatr Child Health 43:636-9. 2007
    ..We conducted a prospective study to determine the role of alpha1-antitrypsin (alpha1AT) deficiency in the pathogenesis of neonatal cholestasis and other childhood liver diseases in a multi-ethnic Southeast Asian population...
  26. ncbi request reprint Association of Ki67 with raised transaminases in hepatocellular carcinoma
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 30:103-7. 2008
    ..Thus rising levels of the transaminases could signal a more rapid growth of the tumour and these routinely performed tests can be of prognostic value in management of HCC patients...