Genomes and Genes


Chung Yeng Looi


Affiliation: University of Malaya
Country: Malaysia


  1. Jamali H, Paydar M, Ismail S, Looi C, Wong W, Radmehr B, et al. Prevalence, antimicrobial susceptibility and virulotyping of Listeria species and Listeria monocytogenes isolated from open-air fish markets. BMC Microbiol. 2015;15:144 pubmed publisher
    ..monocytogenes isolates. Recovery of potentially pathogenic L. monocytogenes from raw fish and environment of open-air fish market samples in this study is a convincing evidence for the zoonotic potential of listeriosis. ..
  2. Ananda Sadagopan S, Mohebali N, Looi C, Hasanpourghadi M, Pandurangan A, Arya A, et al. Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo. J Exp Clin Cancer Res. 2015;34:147 pubmed publisher
    ..Our results suggest that PI3K-Akt/FOXOa pathway is a critical mediator of vernodalin-induced cytotoxicity and this compound could be further developed as a potential chemopreventive or chemotherapeutic agent for breast cancer therapy. ..
  3. Looi C, Arya A, Cheah F, Muharram B, Leong K, Mohamad K, et al. Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PLoS ONE. 2013;8:e56643 pubmed publisher
    ..seeds (CACF) by inhibiting tumor necrosis factor-? (TNF-?)-induced growth of human breast cancer cells. However, the active compounds in CACF have not been investigated previously...
  4. Rouhollahi E, Zorofchian Moghadamtousi S, Paydar M, Fadaeinasab M, Zahedifard M, Hajrezaie M, et al. Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. BMC Complement Altern Med. 2015;15:15 pubmed publisher
    ..The findings presented in the current study showed that DECP suppressed the proliferation of HT-29 colon cancer cells and triggered the induction of apoptosis through mitochondrial-dependent pathway. ..
  5. Looi C, Moharram B, Paydar M, Wong Y, Leong K, Mohamad K, et al. Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways. BMC Complement Altern Med. 2013;13:166 pubmed publisher
    ..Moreover, CACF prevented TNF-?-induced NF-?B nuclear translocation, which further committed A375 cells toward apoptosis. Together, our findings suggest CACF as a potential therapeutic agent against human melanoma malignancy. ..