Phaik Leng Cheah

Summary

Affiliation: University of Malaya
Country: Malaysia

Publications

  1. ncbi request reprint p16(INK4a) is a useful marker of human papillomavirus integration allowing risk stratification for cervical malignancies
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
    Asian Pac J Cancer Prev 13:469-72. 2012
  2. ncbi request reprint Implications of continued upregulation of p16(INK4a) through the evolution from high-grade squamous intraepithelial lesion to invasive squamous carcinoma of the cervix
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 33:83-7. 2011
  3. pmc Telomerase activation and human papillomavirus infection in invasive uterine cervical carcinoma in a set of Malaysian patients
    P L Cheah
    Department of Pathology, University of Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia
    J Clin Pathol 55:22-6. 2002
  4. pmc Unusual finding of endocervical-like mucinous epithelium in continuity with urothelium in endocervicosis of the urinary bladder
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Diagn Pathol 6:56. 2011
  5. doi request reprint Human papillomavirus in cervical cancers of Malaysians
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Obstet Gynaecol Res 37:489-95. 2011
  6. ncbi request reprint Association of Ki67 with raised transaminases in hepatocellular carcinoma
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 30:103-7. 2008
  7. ncbi request reprint Detection of the human papillomavirus in cervical carcinoma: a comparison between non-isotopic in-situ hybridisation and polymerase chain reaction as methods for detection in formalin-fixed, paraffin-embedded tissues
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
    Malays J Pathol 30:37-42. 2008
  8. ncbi request reprint P53 immunohistochemical expression: messages in cervical carcinogenesis
    Phaik Leng Cheah
    Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    Pathology 34:326-31. 2002
  9. pmc Susceptibility and gene interaction study of the angiotensin II type 1 receptor (AGTR1) gene polymorphisms with non-alcoholic fatty liver disease in a multi-ethnic population
    Shamsul Mohd Zain
    The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 8:e58538. 2013
  10. doi request reprint Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene
    Shamsul Mohd Zain
    The Pharmacogenomics Laboratory, Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia
    J Gastroenterol Hepatol 28:873-9. 2013

Collaborators

Detail Information

Publications27

  1. ncbi request reprint p16(INK4a) is a useful marker of human papillomavirus integration allowing risk stratification for cervical malignancies
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
    Asian Pac J Cancer Prev 13:469-72. 2012
    ....
  2. ncbi request reprint Implications of continued upregulation of p16(INK4a) through the evolution from high-grade squamous intraepithelial lesion to invasive squamous carcinoma of the cervix
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 33:83-7. 2011
    ..Interestingly, the occurrence of HSIL and LSIL in almost the same age group could mean that alteration from episomal to integrated form of HPV may not incur a prolonged incubation period, unlike from HSIL to SCC...
  3. pmc Telomerase activation and human papillomavirus infection in invasive uterine cervical carcinoma in a set of Malaysian patients
    P L Cheah
    Department of Pathology, University of Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia
    J Clin Pathol 55:22-6. 2002
    ....
  4. pmc Unusual finding of endocervical-like mucinous epithelium in continuity with urothelium in endocervicosis of the urinary bladder
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Diagn Pathol 6:56. 2011
    ..The patient has remained well and without evidence of disease 18-months following transurethral resection of the lesion...
  5. doi request reprint Human papillomavirus in cervical cancers of Malaysians
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Obstet Gynaecol Res 37:489-95. 2011
    ..With cervical carcinoma remaining the second leading cancer among Malaysian women, it is imperative to clarify the prevalence of human papillomavirus (HPV) in this respect, considering the dearth of local information...
  6. ncbi request reprint Association of Ki67 with raised transaminases in hepatocellular carcinoma
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 30:103-7. 2008
    ..Thus rising levels of the transaminases could signal a more rapid growth of the tumour and these routinely performed tests can be of prognostic value in management of HCC patients...
  7. ncbi request reprint Detection of the human papillomavirus in cervical carcinoma: a comparison between non-isotopic in-situ hybridisation and polymerase chain reaction as methods for detection in formalin-fixed, paraffin-embedded tissues
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
    Malays J Pathol 30:37-42. 2008
    ..It thus appears that PCR and NISH can be successfully used to detect HPV in formalin-fixed, paraffin-embedded tissue and in the presence of intact DNA NISH may be as sensitive as PCR...
  8. ncbi request reprint P53 immunohistochemical expression: messages in cervical carcinogenesis
    Phaik Leng Cheah
    Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    Pathology 34:326-31. 2002
    ..The pattern of p53 expression was studied in pre-invasive and invasive cervical carcinoma in an attempt to clarify its role in cervical carcinogenesis...
  9. pmc Susceptibility and gene interaction study of the angiotensin II type 1 receptor (AGTR1) gene polymorphisms with non-alcoholic fatty liver disease in a multi-ethnic population
    Shamsul Mohd Zain
    The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 8:e58538. 2013
    ..We report novel findings of an association between the G allele of the rs3772622 with occurrence of fibrosis and of the gene-gene interaction between AGTR1gene and the much-studied PNPLA3 gene...
  10. doi request reprint Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene
    Shamsul Mohd Zain
    The Pharmacogenomics Laboratory, Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia
    J Gastroenterol Hepatol 28:873-9. 2013
    ..This study attempted to assess whether polymorphisms in the leptin receptor (LEPR) gene and its combined effect with patatin-like phospholipase domain-containing protein 3 (PNPLA3/adiponutrin) are associated with risk of NAFLD...
  11. ncbi request reprint Evaluation of a new biopsy urease test: Pronto Dry, for the diagnosis of Helicobacter pylori infection
    Rosaida Mohd Said
    Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Eur J Gastroenterol Hepatol 16:195-9. 2004
    ..Large endoscopy units use their own 'homemade' unbuffered ultra rapid urease test for diagnosis of H. pylori infection...
  12. ncbi request reprint Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya
    Asian Pac J Cancer Prev 11:713-6. 2010
    ..05) relative to BNL (2.9 kb). The findings imply that telomere attrition and telomerase activation differ between malignant and benign tumours of the breast and may be important for targeted therapy...
  13. ncbi request reprint Ethnicity and H. pylori as risk factors for gastric cancer in Malaysia: A prospective case control study
    Khean Lee Goh
    Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Am J Gastroenterol 102:40-5. 2007
    ..To determine the risk factors for gastric cancer (GCA), with particular emphasis on ethnicity in our multiracial population...
  14. ncbi request reprint Proliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri-neoplastic and normal liver
    Kein Seong Mun
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 28:73-7. 2006
    ..This is probably related to the malignant nature of HCC and may reflect the uncontrolled proliferation of the neoplastic hepatocytes...
  15. ncbi request reprint Telomerase activation in neoplastic cell immortalization and tumour progression
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya, Malaysia
    Malays J Pathol 29:33-5. 2007
    ..These findings support a contributory role for telomerase in tumourigenesis with activation occurring from neoplastic transformation and increasing with tumour progression...
  16. ncbi request reprint An analysis of predictive biomarkers in routine histopathological reporting of infiltrating ductal breast carcinoma in a tertiary hospital in Malaysia with a focus on limitations and directions for future development
    Kean Hooi Teoh
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 33:35-42. 2011
    ....
  17. ncbi request reprint HUITAI rapid urease test: a new ultra-rapid biopsy urease test for the diagnosis of Helicobacter pylori infection
    Khean Lee Goh
    Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Dig Dis 8:139-42. 2007
    ..Large endoscopy units use their own homemade unbuffered ultra-rapid urease test for diagnosis of H. pylori infection but several commercial rapid urease tests are available...
  18. ncbi request reprint CD44 expression and axillary lymph node metastasis in infiltrating ductal carcinoma of the breast
    Lai Meng Looi
    Department of Pathology, Faculty of Medincine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 28:83-6. 2006
    ..Our results suggest that CD44 may have a role in the progression of breast cancer and emphasise the need to investigate its interaction with other mechanisms of cancer advancement...
  19. doi request reprint Clinical predictors of non-diabetic renal disease and role of renal biopsy in diabetic patients with renal involvement: a single centre review
    Yip Boon Chong
    Division of Nephrology, Department of Medicine, University Malaya Medical Centre, University of Malaya, Kuala Lumpur, Malaysia
    Ren Fail 34:323-8. 2012
    ..Our study aimed to examine the prevalence of NDRD in T2DM and clinical markers for diabetic nephropathy (DN) and NDRD and to determine the role of renal biopsy in T2DM patients and its impact on clinical practice...
  20. doi request reprint Performance of transient elastography (TE) and factors associated with discordance in non-alcoholic fatty liver disease
    Sanjiv Mahadeva
    Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Dig Dis 14:604-10. 2013
    ..To determine the accuracy of transient elastography (TE) and factors associated with discordance between TE and liver histology in patients with non-alcoholic fatty liver disease (NAFLD)...
  21. pmc A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease
    Shamsul Mohd Zain
    The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Hum Genet 131:1145-52. 2012
    ..029) in the NAFLD patients. Overall, the rs738409 G allele is associated with severity of NASH and occurrence of fibrosis in patients with NAFLD...
  22. ncbi request reprint Computer-linked image analysis of nuclear area: is there a use in diagnosis and grading of hepatocellular carcinoma?
    Phaik Leng Cheah
    Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    Malays J Pathol 29:37-40. 2007
    ....
  23. ncbi request reprint Non-alcoholic fatty liver disease in Malaysia: a demographic, anthropometric, metabolic and histological study
    Abdul Malik
    Division of Gastroenterology, Faculty of Medicine, University of Malaya Medical Center, Kuala Lumpur, Malaysia
    J Dig Dis 8:58-64. 2007
    ..The aims of this study were to define the demographic, anthropometric, metabolic and histological characteristics of patients with NAFLD in our local population and to determine independent predictors of severe liver fibrosis...
  24. ncbi request reprint Significance of Bcl-2 and Bax proteins in cervical carcinogenesis: an immunohistochemical study in squamous cell carcinoma and squamous intraepithelial lesions
    Phaik Leng Cheah
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 28:1-5. 2006
    ..Intensification of staining of Bcl-2 at the basement membrane in some HSIL and SCC is interesting and may augur for increased aggressiveness...
  25. ncbi request reprint Evaluation of the monoclonal stool antigen test for Helicobacter pylori in an Asian population with dyspepsia
    Yusuf Bhewa
    Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Dig Dis 8:207-10. 2007
    ..The aim of this study is to validate the diagnostic accuracy of a stool antigen test, Hp STAR, for the detection of Helicobacter pylori...
  26. ncbi request reprint CD133 marks for colorectal adenocarcinoma
    Man Fong Chew
    Department of Pathology, Faculty of Medicine, University of Malaya
    Malays J Pathol 34:25-8. 2012
    ..9%) of colorectal adenocarcinoma had scores >4. This study shows that CD133 is able to mark colorectal adenocarcinoma but it is still unclear at this juncture whether CD133 is indeed a marker for colorectal adenocarcinoma "stem cells"...
  27. ncbi request reprint Historical development of the renal histopathology services in Malaysia
    Lai Meng Looi
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Malays J Pathol 31:11-6. 2009
    ..More recently, there has been increasing involvement of renal teams in clinical trials, particularly for lupus nephritis and renal transplant modulation...