Research Topics
| Phaik Leng CheahSummaryAffiliation: University of Malaya Country: Malaysia Publications
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Detail Information
Publications
p16(INK4a) is a useful marker of human papillomavirus integration allowing risk stratification for cervical malignanciesPhaik Leng Cheah
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
Asian Pac J Cancer Prev 13:469-72. 2012....- Implications of continued upregulation of p16(INK4a) through the evolution from high-grade squamous intraepithelial lesion to invasive squamous carcinoma of the cervixPhaik Leng Cheah
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Malays J Pathol 33:83-7. 2011..Interestingly, the occurrence of HSIL and LSIL in almost the same age group could mean that alteration from episomal to integrated form of HPV may not incur a prolonged incubation period, unlike from HSIL to SCC... 
Telomerase activation and human papillomavirus infection in invasive uterine cervical carcinoma in a set of Malaysian patientsP L Cheah
Department of Pathology, University of Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia
J Clin Pathol 55:22-6. 2002....- Unusual finding of endocervical-like mucinous epithelium in continuity with urothelium in endocervicosis of the urinary bladderPhaik Leng Cheah
Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Diagn Pathol 6:56. 2011..The patient has remained well and without evidence of disease 18-months following transurethral resection of the lesion... 
Human papillomavirus in cervical cancers of MalaysiansPhaik Leng Cheah
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
J Obstet Gynaecol Res 37:489-95. 2011..With cervical carcinoma remaining the second leading cancer among Malaysian women, it is imperative to clarify the prevalence of human papillomavirus (HPV) in this respect, considering the dearth of local information...- Association of Ki67 with raised transaminases in hepatocellular carcinomaPhaik Leng Cheah
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Malays J Pathol 30:103-7. 2008..Thus rising levels of the transaminases could signal a more rapid growth of the tumour and these routinely performed tests can be of prognostic value in management of HCC patients... - Detection of the human papillomavirus in cervical carcinoma: a comparison between non-isotopic in-situ hybridisation and polymerase chain reaction as methods for detection in formalin-fixed, paraffin-embedded tissuesPhaik Leng Cheah
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
Malays J Pathol 30:37-42. 2008..It thus appears that PCR and NISH can be successfully used to detect HPV in formalin-fixed, paraffin-embedded tissue and in the presence of intact DNA NISH may be as sensitive as PCR... - P53 immunohistochemical expression: messages in cervical carcinogenesisPhaik Leng Cheah
Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
Pathology 34:326-31. 2002..The pattern of p53 expression was studied in pre-invasive and invasive cervical carcinoma in an attempt to clarify its role in cervical carcinogenesis... - Proliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri-neoplastic and normal liverKein Seong Mun
Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Malays J Pathol 28:73-7. 2006..This is probably related to the malignant nature of HCC and may reflect the uncontrolled proliferation of the neoplastic hepatocytes... - Ethnicity and H. pylori as risk factors for gastric cancer in Malaysia: A prospective case control studyKhean Lee Goh
Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Am J Gastroenterol 102:40-5. 2007..To determine the risk factors for gastric cancer (GCA), with particular emphasis on ethnicity in our multiracial population... - Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian womenLai Meng Looi
Department of Pathology, Faculty of Medicine, University of Malaya
Asian Pac J Cancer Prev 11:713-6. 2010..05) relative to BNL (2.9 kb). The findings imply that telomere attrition and telomerase activation differ between malignant and benign tumours of the breast and may be important for targeted therapy... - Susceptibility and gene interaction study of the angiotensin II type 1 receptor (AGTR1) gene polymorphisms with non-alcoholic fatty liver disease in a multi-ethnic populationShamsul Mohd Zain
The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
PLoS ONE 8:e58538. 2013..We report novel findings of an association between the G allele of the rs3772622 with occurrence of fibrosis and of the gene-gene interaction between AGTR1gene and the much-studied PNPLA3 gene... - HUITAI rapid urease test: a new ultra-rapid biopsy urease test for the diagnosis of Helicobacter pylori infectionKhean Lee Goh
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
J Dig Dis 8:139-42. 2007..Large endoscopy units use their own homemade unbuffered ultra-rapid urease test for diagnosis of H. pylori infection but several commercial rapid urease tests are available... - An analysis of predictive biomarkers in routine histopathological reporting of infiltrating ductal breast carcinoma in a tertiary hospital in Malaysia with a focus on limitations and directions for future developmentKean Hooi Teoh
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Malays J Pathol 33:35-42. 2011.... - Telomerase activation in neoplastic cell immortalization and tumour progressionLai Meng Looi
Department of Pathology, Faculty of Medicine, University of Malaya, Malaysia
Malays J Pathol 29:33-5. 2007..These findings support a contributory role for telomerase in tumourigenesis with activation occurring from neoplastic transformation and increasing with tumour progression... - CD44 expression and axillary lymph node metastasis in infiltrating ductal carcinoma of the breastLai Meng Looi
Department of Pathology, Faculty of Medincine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Malays J Pathol 28:83-6. 2006..Our results suggest that CD44 may have a role in the progression of breast cancer and emphasise the need to investigate its interaction with other mechanisms of cancer advancement... - Clinical predictors of non-diabetic renal disease and role of renal biopsy in diabetic patients with renal involvement: a single centre reviewYip Boon Chong
Division of Nephrology, Department of Medicine, University Malaya Medical Centre, University of Malaya, Kuala Lumpur, Malaysia
Ren Fail 34:323-8. 2012..Our study aimed to examine the prevalence of NDRD in T2DM and clinical markers for diabetic nephropathy (DN) and NDRD and to determine the role of renal biopsy in T2DM patients and its impact on clinical practice... - Non-alcoholic fatty liver disease in Malaysia: a demographic, anthropometric, metabolic and histological studyAbdul Malik
Division of Gastroenterology, Faculty of Medicine, University of Malaya Medical Center, Kuala Lumpur, Malaysia
J Dig Dis 8:58-64. 2007..The aims of this study were to define the demographic, anthropometric, metabolic and histological characteristics of patients with NAFLD in our local population and to determine independent predictors of severe liver fibrosis... - A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver diseaseShamsul Mohd Zain
The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Hum Genet 131:1145-52. 2012..029) in the NAFLD patients. Overall, the rs738409 G allele is associated with severity of NASH and occurrence of fibrosis in patients with NAFLD... - Computer-linked image analysis of nuclear area: is there a use in diagnosis and grading of hepatocellular carcinoma?Phaik Leng Cheah
Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
Malays J Pathol 29:37-40. 2007.... - Significance of Bcl-2 and Bax proteins in cervical carcinogenesis: an immunohistochemical study in squamous cell carcinoma and squamous intraepithelial lesionsPhaik Leng Cheah
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Malays J Pathol 28:1-5. 2006..Intensification of staining of Bcl-2 at the basement membrane in some HSIL and SCC is interesting and may augur for increased aggressiveness... - Evaluation of the monoclonal stool antigen test for Helicobacter pylori in an Asian population with dyspepsiaYusuf Bhewa
Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
J Dig Dis 8:207-10. 2007..The aim of this study is to validate the diagnostic accuracy of a stool antigen test, Hp STAR, for the detection of Helicobacter pylori... - CD133 marks for colorectal adenocarcinomaMan Fong Chew
Department of Pathology, Faculty of Medicine, University of Malaya
Malays J Pathol 34:25-8. 2012..This study shows that CD133 is able to mark colorectal adenocarcinoma but it is still unclear at this juncture whether CD133 is indeed a marker for colorectal adenocarcinoma "stem cells"... - Historical development of the renal histopathology services in MalaysiaLai Meng Looi
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Malays J Pathol 31:11-6. 2009..More recently, there has been increasing involvement of renal teams in clinical trials, particularly for lupus nephritis and renal transplant modulation...