Yoke Fun Chan

Summary

Affiliation: University of Malaya
Country: Malaysia

Publications

  1. doi request reprint Recent developments in antiviral agents against enterovirus 71 infection
    Chee Wah Tan
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Biomed Sci 21:14. 2014
  2. doi request reprint Phylogenetic designation of enterovirus 71 genotypes and subgenotypes using complete genome sequences
    Yoke Fun Chan
    Department of Medical Microbiology, University Malaya, Kuala Lumpur, Malaysia
    Infect Genet Evol 10:404-12. 2010
  3. pmc Recombinant human enterovirus 71 in hand, foot and mouth disease patients
    Yoke Fun Chan
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 10:1468-70. 2004
  4. pmc Genotypic and phenotypic characterization of Chikungunya virus of different genotypes from Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 7:e50476. 2012
  5. doi request reprint Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989 and 2011
    Chee Sieng Khor
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Infect Genet Evol 14:357-60. 2013
  6. pmc Inhibition of enterovirus 71 (EV-71) infections by a novel antiviral peptide derived from EV-71 capsid protein VP1
    Chee Wah Tan
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 7:e34589. 2012
  7. ncbi request reprint Emergence of dengue virus type 4 genotype IIA in Malaysia
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Gen Virol 83:2437-42. 2002
  8. pmc Seroprevalence survey of Chikungunya virus in Bagan Panchor, Malaysia
    Said Mas Ayu
    Department of Social and Preventive Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Am J Trop Med Hyg 83:1245-8. 2010
  9. doi request reprint Real-time polymerase chain reaction for diagnosis and quantitation of negative strand of chikungunya virus
    Chun Wei Chiam
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    Diagn Microbiol Infect Dis 77:133-7. 2013
  10. pmc Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years
    Chee Sieng Khor
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    BMC Pediatr 12:32. 2012

Collaborators

Detail Information

Publications17

  1. doi request reprint Recent developments in antiviral agents against enterovirus 71 infection
    Chee Wah Tan
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Biomed Sci 21:14. 2014
    ..The continued effort to develop antiviral agents for treatment is crucial in the absence of a vaccine. The coupling of antivirals with an effective vaccine will accelerate eradication of the disease. ..
  2. doi request reprint Phylogenetic designation of enterovirus 71 genotypes and subgenotypes using complete genome sequences
    Yoke Fun Chan
    Department of Medical Microbiology, University Malaya, Kuala Lumpur, Malaysia
    Infect Genet Evol 10:404-12. 2010
    ..Hence, in the absence of full genome sequences, it is proposed here that a combination of VP1 and 3D RNA polymerase gene sequences be used for initial genotyping of EV-71 isolates...
  3. pmc Recombinant human enterovirus 71 in hand, foot and mouth disease patients
    Yoke Fun Chan
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 10:1468-70. 2004
    ..When caused by CV-A16 infection, it is usually a mild disease, and patients normally recover without requiring any special medical attention...
  4. pmc Genotypic and phenotypic characterization of Chikungunya virus of different genotypes from Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 7:e50476. 2012
    ..To gain insight into these observed epidemiological differences, we compared genotypic and phenotypic characteristics of CHIKV of Asian and ECSA genotypes isolated in Malaysia...
  5. doi request reprint Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989 and 2011
    Chee Sieng Khor
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Infect Genet Evol 14:357-60. 2013
    ..A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention...
  6. pmc Inhibition of enterovirus 71 (EV-71) infections by a novel antiviral peptide derived from EV-71 capsid protein VP1
    Chee Wah Tan
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 7:e34589. 2012
    ..The data demonstrated the potential and feasibility of SP40 as a broad spectrum antiviral agent against EV-71...
  7. ncbi request reprint Emergence of dengue virus type 4 genotype IIA in Malaysia
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Gen Virol 83:2437-42. 2002
    ..These results suggest that intra-serotypic recombination amongst DENV-4 from independent ancestral lineages may have contributed to the emergence of DENV-4 subgenotype IIA in Malaysia...
  8. pmc Seroprevalence survey of Chikungunya virus in Bagan Panchor, Malaysia
    Said Mas Ayu
    Department of Social and Preventive Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Am J Trop Med Hyg 83:1245-8. 2010
    ..CHIKV had a high attack rate and considerable clinical impact during the Bagan Panchor outbreak...
  9. doi request reprint Real-time polymerase chain reaction for diagnosis and quantitation of negative strand of chikungunya virus
    Chun Wei Chiam
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    Diagn Microbiol Infect Dis 77:133-7. 2013
    ..The positive-strand nsP3 assay is suitable for diagnosis, while the negative-strand nsP3 assay, which uses tagged primers to increase specificity, is useful for study of active viral replication kinetics...
  10. pmc Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years
    Chee Sieng Khor
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    BMC Pediatr 12:32. 2012
    ..A retrospective study was performed from 1982-2008 to investigate the viral etiology of children (≤ 5 years old) admitted with RTI in a tertiary hospital in Kuala Lumpur, Malaysia...
  11. doi request reprint Seroprevalence of seasonal and pandemic influenza a in Kuala Lumpur, Malaysia in 2008-2010
    I Ching Sam
    Department of Medical Microbiology, Tropical Infectious Diseases Research and Education Centre, University Malaya, Kuala Lumpur, Malaysia
    J Med Virol 85:1420-5. 2013
    ..7% for seasonal H1N1 and 21.0% for H3N2, and these rates did not change significantly after the pandemic. Seasonal and pandemic influenza cause a considerable burden in tropical Malaysia, particularly in children and young adults...
  12. pmc Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor
    Chee Wah Tan
    Department of Medical Microbiology, University Malaya, Kuala Lumpur, Malaysia
    J Virol 87:611-20. 2013
    ..Direct binding of EV-71 particles to heparin-Sepharose columns under physiological salt conditions was demonstrated. We conclude that EV-71 infection requires initial binding to heparan sulfate as an attachment receptor...
  13. doi request reprint Chikungunya virus of Asian and Central/East African genotypes in Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    J Clin Virol 46:180-3. 2009
    ..In Malaysia, limited CHIKV outbreaks of the endemic Asian and imported Central/East African genotypes were reported in 1998 and 2006. Since April 2008, an unprecedented nationwide outbreak has affected Malaysia...
  14. doi request reprint Multisensitive community-acquired methicillin-resistant Staphylococcus aureus infections in Malaysia
    I Ching Sam
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia
    Diagn Microbiol Infect Dis 62:437-9. 2008
    ..There was considerable clonal diversity, with both pandemic and novel multilocus sequence types detected. CA-MRSA rates appear to be increasing in our hospital, warranting close surveillance...
  15. doi request reprint Characterisation of mouse monoclonal antibodies targeting linear epitopes on Chikungunya virus E2 glycoprotein
    Chong Long Chua
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol Methods 195:126-33. 2014
    ..These mAbs with their mapped epitopes are useful for the development of diagnostic or research tools, including immunofluorescence, ELISA and Western blot. ..
  16. ncbi request reprint Enterovirus 71 infection induces apoptosis in Vero cells
    Yoke Fun Chan
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 25:29-35. 2003
    ..The induction, however, requires high level of HEV71 infectivity and the presence of live virus particles, suggesting the need for the presence of specific viral proteins for apoptosis to occur...
  17. doi request reprint Clinical features of Malaysian children hospitalized with community-acquired seasonal influenza
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Int J Infect Dis 14:e36-40. 2010
    ..The aim of this study was to describe the clinical features and seasonal pattern of influenza in children hospitalized in Malaysia, and to identify predictors of severe disease...