Kok Gan Chan

Summary

Affiliation: University of Malaya
Country: Malaysia

Publications

  1. pmc Degradation of bacterial quorum sensing signaling molecules by the microscopic yeast Trichosporon loubieri isolated from tropical wetland waters
    Cheng Siang Wong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:12943-57. 2013
  2. pmc Anti-quorum sensing activity of the traditional Chinese herb, Phyllanthus amarus
    Kumutha Priya
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14558-69. 2013
  3. pmc Pandoraea sp. RB-44, a novel quorum sensing soil bacterium
    Robson Ee Han-Jen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 13:14121-32. 2013
  4. pmc Short chain N-acyl homoserine lactone production by soil isolate Burkholderia sp. strain A9
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13217-27. 2013
  5. pmc N-acyl homoserine lactone-producing Pseudomonas putida strain T2-2 from human tongue surface
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13192-203. 2013
  6. pmc Short chain N-acylhomoserine lactone production by clinical multidrug resistant Klebsiella pneumoniae strain CSG20
    Yun Fong Ngeow
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:15242-51. 2013
  7. pmc Quorum sensing activity of Enterobacter asburiae isolated from lettuce leaves
    Yin Yin Lau
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14189-99. 2013
  8. pmc Comparative genomic analysis of six bacteria belonging to the genus Novosphingobium: insights into marine adaptation, cell-cell signaling and bioremediation
    Han Ming Gan
    Science Vision SB, Shah Alam, Selangor, Malaysia
    BMC Genomics 14:431. 2013
  9. pmc Exochelin production in Mycobacterium neoaurum
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia
    Int J Mol Sci 10:345-53. 2009
  10. pmc Plant-derived natural products as sources of anti-quorum sensing compounds
    Chong Lek Koh
    Natural Sciences and Science Education AG, National Institute of Education, Nanyang Technological University, Singapore
    Sensors (Basel) 13:6217-28. 2013

Collaborators

  • Wai Fong Yin
  • Kok Keng Tee
  • Han Ming Gan
  • Kek Heng Chua
  • Steve Atkinson
  • Yun Fong Ngeow
  • Siti Nur Maisarah Norizan
  • Kalai Mathee
  • Thiba Krishnan
  • Paul Williams
  • Khalijah Awang
  • Chong Lek Koh
  • Jian Woon Chen
  • Kar Wai Hong
  • Choon Kook Sam
  • Cheng Siang Wong
  • Teik Min Chong
  • Li Ying Tan
  • Yee Meng Chong
  • Yeun Mun Choo
  • Wei Zhen Chow
  • Robson Ee
  • Kumutha Priya
  • Yin Yin Lau
  • Robson Ee Han-Jen
  • Xin Yue Chan
  • Shenyang Chin
  • Kathiravan Purmal
  • Haider Abdulrazzaq Abed Al-Darraji
  • Clayton Koh
  • Malarvelli Soorya Prakasa
  • Nur Ezreen Syafina
  • Adeeba Kamarulzaman
  • Yutaka Takebe
  • Yan Lue Lim
  • Yin Wai-Fong
  • Joanita Sulaiman
  • Chan Kok-Gan
  • Dinaiz Al Thinagaran
  • Hun Jiat Tung
  • Catherine Grandcl√©ment
  • Samuel Mondy
  • Siew Moon Low
  • Patrick Kok Yuen Lee
  • Savithri D Puthucheary
  • Yves Dessaux
  • Putri Narrima
  • A Hamid A Hadi
  • Mohamad Rais Mustafa
  • David R Appleton
  • Chia Yong Ho
  • JOHN PINTO

Detail Information

Publications38

  1. pmc Degradation of bacterial quorum sensing signaling molecules by the microscopic yeast Trichosporon loubieri isolated from tropical wetland waters
    Cheng Siang Wong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:12943-57. 2013
    ....
  2. pmc Anti-quorum sensing activity of the traditional Chinese herb, Phyllanthus amarus
    Kumutha Priya
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14558-69. 2013
    ..amarus could be useful for attenuating pathogens and hence, more local traditional herbs should be screened for its anti-quorum sensing properties as their active compounds may serve as promising anti-pathogenic drugs...
  3. pmc Pandoraea sp. RB-44, a novel quorum sensing soil bacterium
    Robson Ee Han-Jen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 13:14121-32. 2013
    ..To the best of our knowledge, this is the first report that showed quorum sensing activity exhibited by Pandoraea sp. Our data add Pandoraea sp. to the growing number of bacteria that possess QS systems. ..
  4. pmc Short chain N-acyl homoserine lactone production by soil isolate Burkholderia sp. strain A9
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13217-27. 2013
    ..We have demonstrated that Burkholderia sp. strain A9 produces AHLs that are known to be produced by other Burkholderia spp. with CepI/CepR homologs. ..
  5. pmc N-acyl homoserine lactone-producing Pseudomonas putida strain T2-2 from human tongue surface
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13192-203. 2013
    ..This is the first report of the finding of quorum sensing of P. putida strain T2-2 isolated from the human tongue surface and their quorum sensing molecules were identified. ..
  6. pmc Short chain N-acylhomoserine lactone production by clinical multidrug resistant Klebsiella pneumoniae strain CSG20
    Yun Fong Ngeow
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:15242-51. 2013
    ..pneumoniae strain CSG20 produced N-hexanoyl-homoserine lactone (C6-HSL). To the best of our knowledge, this is the first report on the production of N-hexanoylhomoserine lactone (C6-HSL) in clinical isolate K. pneumoniae. ..
  7. pmc Quorum sensing activity of Enterobacter asburiae isolated from lettuce leaves
    Yin Yin Lau
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14189-99. 2013
    ..asburiae spent supernatant confirmed the production of N-butanoyl homoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL). To the best of our knowledge, this is the first report of AHL production by E. asburiae. ..
  8. pmc Comparative genomic analysis of six bacteria belonging to the genus Novosphingobium: insights into marine adaptation, cell-cell signaling and bioremediation
    Han Ming Gan
    Science Vision SB, Shah Alam, Selangor, Malaysia
    BMC Genomics 14:431. 2013
    ..Additionally, we show the taxonomic relationship between the sequenced bacteria based on phylogenomic analysis, average amino acid identity (AAI) and genomic signatures...
  9. pmc Exochelin production in Mycobacterium neoaurum
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia
    Int J Mol Sci 10:345-53. 2009
    ..neoaurum by semi-preparative chromatography. When saturated ferric chloride solution was added into the purified exochelin, a ferri-exochelin complex was formed. It is proposed that iron uptake in M. neoaurum is exochelin-mediated...
  10. pmc Plant-derived natural products as sources of anti-quorum sensing compounds
    Chong Lek Koh
    Natural Sciences and Science Education AG, National Institute of Education, Nanyang Technological University, Singapore
    Sensors (Basel) 13:6217-28. 2013
    ..In this review, we have surveyed the various types of plant-based natural products that exhibit anti-quorum sensing properties and their anti-quorum sensing mechanisms...
  11. doi request reprint A novel medium for the isolation of N-acylhomoserine lactone-degrading bacteria
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
    J Ind Microbiol Biotechnol 36:247-51. 2009
    ..To the best of our knowledge, this is the first documentation of the isolation of an AHL-degrading proteobacterium from sewage...
  12. doi request reprint Rapid degradation of N-3-oxo-acylhomoserine lactones by a Bacillus cereus isolate from Malaysian rainforest soil
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Antonie Van Leeuwenhoek 98:299-305. 2010
    ..Sequence analysis indicated the presence of the motif (106)HXDH-59 amino acids-H(169)-21 amino acids-D(191) for N-acylhomoserine lactone lactonases...
  13. doi request reprint Quorum sensing in Aeromonas species isolated from patients in Malaysia
    Kok Gan Chan
    Institute of Biological Sciences Division of Genetics and Molecular Biology, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
    Curr Microbiol 62:167-72. 2011
    ..Our data provides a better understanding of the mechanism(s) of this environmental bacterium emerging as a human pathogen...
  14. pmc Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    BMC Microbiol 11:51. 2011
    ..Here we sought to discover novel N-acylhomoserine lactone (AHL)-dependent QS and QQ strains by investigating a bacterial community associated with the rhizosphere of ginger (Zingiber officinale) growing in the Malaysian rainforest...
  15. pmc Characterization of quorum sensing and quorum quenching soil bacteria isolated from Malaysian tropical montane forest
    Teik Min Chong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:4846-59. 2012
    ..To the best of our knowledge, this is the first documentation of Arthrobacter and Pseudomonas spp. capable of degrading p-coumaroyl-homoserine lactone and the production of C12-HSL by P. frederiksbergensis...
  16. pmc N-acyl homoserine lactone production by Klebsiella pneumoniae isolated from human tongue surface
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:3472-83. 2012
    ..To the best of our knowledge, this is the first report of the isolation of K. pneumoniae from the posterior dorsal surface of the human tongue and the production of these AHLs by this bacterium...
  17. ncbi request reprint Characterization of wetland quorum quenching Pseudomonas aeruginosa strain 2SW8 and its 2-heptyl-3-hydroxy-4-quinolone production
    Cheng Siang Wong
    Division of Genetics and Molecular Biology, University of Malaya, Kuala Lumpur, Malaysia
    New Microbiol 35:43-51. 2012
    ..Strain 2SW8 also showed 2-heptyl-3-hydroxy-4-quinolone production...
  18. doi request reprint Coexistence of quorum-quenching and quorum-sensing in tropical marine Pseudomonas aeruginosa strain MW3A
    Cheng Siang Wong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
    World J Microbiol Biotechnol 28:453-61. 2012
    ..Hence, we report here a novel marine P. aeruginosa strain MW3A possessing both quorum-quenching and quorum-sensing properties...
  19. pmc Long chain N-acyl homoserine lactone production by Enterobacter sp. isolated from human tongue surfaces
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:14307-14. 2012
    ..To the best of our knowledge, this is the first isolation of Enterobacter sp., strain T1-1 from the posterior dorsal surface of the human tongue and N-acyl homoserine lactones production by this bacterium...
  20. pmc Piper nigrum, Piper betle and Gnetum gnemon--natural food sources with anti-quorum sensing properties
    Li Ying Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:3975-85. 2013
    ..Since there is a variety of plants that serve as food sources in Malaysia that have yet to be tested for anti-QS activity, future work should focus on identification of these plants and isolation of the anti-QS compounds...
  21. pmc Complete genome sequence of Burkholderia sp. Strain GG4, a betaproteobacterium that reduces 3-oxo-N-acylhomoserine lactones and produces different N-acylhomoserine lactones
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6317. 2012
    ..To the best of our knowledge, this is the first sequenced genome from a bacterium of the genus Burkholderia that shows both quorum-sensing and signaling confusion activities...
  22. pmc Whole-genome sequence of N-acylhomoserine lactone-synthesizing and -degrading Acinetobacter sp. strain GG2
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6318. 2012
    ..It degrades a broad range of N-acylhomoserine lactone molecules via lactonase. The genome sequence of strain GG2 may provide insights on the regulation of quorum-sensing and quorum-quenching mechanisms in this bacterium...
  23. pmc Insights from the genome sequence of quorum-quenching Staphylococcus sp. strain AL1, isolated from traditional Chinese soy sauce brine fermentation
    Teik Min Chong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6611-2. 2012
    ..To the best of our knowledge, this is the first documentation that reports the whole genome sequence and quorum-quenching activity of Staphylococcus sp. strain AL1...
  24. pmc Genome sequence of Roseomonas sp. strain B5, a quorum-quenching N-acylhomoserine lactone-degrading bacterium isolated from Malaysian tropical soil
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6681-2. 2012
    ..This is the first genome announcement of a member from the genus of Roseomonas and the first report on the quorum-quenching activity of Roseomonas spp...
  25. pmc Draft genome sequence of an Aeromonas sp. strain 159 clinical isolate that shows quorum-sensing activity
    Xin Yue Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6350. 2012
    ..In the draft genome of strain 159, luxI and luxR homologue genes were found to be located at contig 47, and these genes are believed to be important for the quorum-sensing system present in this pathogen...
  26. doi request reprint Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity
    Yee Meng Chong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 74:2261-4. 2011
    ..These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further...
  27. pmc Draft genome sequence of Pantoea sp. strain A4, a Rafflesia-associated bacterium that produces N-acylhomoserine lactones as quorum-sensing molecules
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6610. 2012
    ..Pantoea sp. strain A4 is a Gram-negative bacterium isolated from the Rafflesia flower. We present here, for the first time, the genome sequence of Rafflesia-associated Pantoea sp. strain A4, which exhibited quorum-sensing activity...
  28. pmc Caffeine as a potential quorum sensing inhibitor
    Siti Nur Maisarah Norizan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:5117-29. 2013
    ..To the best of our knowledge, this is the first documentation providing evidence on the presence of anti-quorum sensing activity in caffeine. Our work will allow caffeine to be explored as anti-infective drugs...
  29. pmc Genome sequence of Dyella japonica strain A8, a quorum-quenching bacterium that degrades N-acylhomoserine lactones, isolated from Malaysian tropical soil
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6331. 2012
    ..To the best of our knowledge, this is the first genome announcement of a member from the genus of Dyella, and this is also the first work that reports the quorum-quenching activity of Dyella japonica...
  30. pmc Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium aromaticum) bud extract
    Thiba Krishnan
    Division of Genetics and Molecular Biology, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 12:4016-30. 2012
    ..This study shows that the presence of natural compounds that exhibit anti-quorum sensing activity in the clove extracts may be useful as the lead of anti-infective drugs...
  31. pmc Heavy-metal resistance of a France vineyard soil bacterium, Pseudomonas mendocina strain S5.2, revealed by whole-genome sequencing
    Teik Min Chong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6366. 2012
    ..In addition to being copper resistant, the genome of P. mendocina strain S5.2 contains a number of heavy-metal-resistant genes known to confer resistance to multiple heavy-metal ions...
  32. pmc Quorum quenching revisited--from signal decays to signalling confusion
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 12:4661-96. 2012
    ..While quorum quenching has been explored as a novel anti-infective therapy targeting, quorum sensing evidence begins to show the development of resistance against quorum quenching...
  33. pmc Quorum quenching Bacillus sonorensis isolated from soya sauce fermentation brine
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:4065-73. 2012
    ..To the best of our knowledge, this is the first report of AHL-degrading B. sonorensis from soya sauce liquid state fermentation...
  34. doi request reprint Quorum Sensing Activity of Serratia fonticola Strain RB-25 Isolated From an Ex-landfill Site
    Robson Ee
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:5136-46. 2014
    ..This is the first report of the production of these AHLs in S. fonticola. ..
  35. pmc Silencing quorum sensing through extracts of Melicope lunu-ankenda
    Li Ying Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:4339-51. 2012
    ..Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds...
  36. pmc Whole-genome sequence of Cupriavidus sp. strain BIS7, a heavy-metal-resistant bacterium
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6324. 2012
    ..It is particularly resistant to Fe(II), Fe(III), and Zn(II). Here we present the assembly and annotation of its genome...
  37. doi request reprint A Newly Emerging HIV-1 Recombinant Lineage (CRF58_01B) Disseminating among People Who Inject Drugs in Malaysia
    Wei Zhen Chow
    Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 9:e85250. 2014
    ....
  38. pmc Microbial contamination of orthodontic buccal tubes from manufacturers
    Kathiravan Purmal
    Department of General Dental Practice and Oral and Maxillofacial Imaging, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia e mail
    Int J Mol Sci 11:3349-56. 2010
    ..We also suggest that manufacturers should list the sterility state of orthodontic buccal tubes on their packaging or instructions stating the need for sterilization...