Sazaly AbuBakar

Summary

Affiliation: University of Malaya
Country: Malaysia

Publications

  1. ncbi Emergence of dengue virus type 4 genotype IIA in Malaysia
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Gen Virol 83:2437-42. 2002
  2. pmc Isolation of ancestral sylvatic dengue virus type 1, Malaysia
    Boon Teong Teoh
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 16:1783-5. 2010
  3. pmc Review of Dengue hemorrhagic fever fatal cases seen among adults: a retrospective study
    Sing Sin Sam
    Tropical Infectious Diseases Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS Negl Trop Dis 7:e2194. 2013
  4. pmc Recombinant human enterovirus 71 in hand, foot and mouth disease patients
    Yoke Fun Chan
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 10:1468-70. 2004
  5. pmc Detection of dengue viruses using reverse transcription-loop-mediated isothermal amplification
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Infect Dis 13:387. 2013
  6. pmc Dengue virus type 1 clade replacement in recurring homotypic outbreaks
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Evol Biol 13:213. 2013
  7. pmc Colonized Aedes albopictus and its sexual performance in the wild: implications for SIT technology and containment
    Dieng Hamady
    School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
    Parasit Vectors 6:206. 2013
  8. pmc Human neuronal cell protein responses to Nipah virus infection
    Li Yen Chang
    Center for Proteomics Research, Department of Forest Biotechnology, Forest Research Institute Malaysia, Selangor, Malaysia
    Virol J 4:54. 2007
  9. pmc Quantitative estimation of Nipah virus replication kinetics in vitro
    Li Yen Chang
    Center for Proteomics Research, Department of Forest Biotechnology, Forest Research Institute, 52109, Selangor, Malaysia
    Virol J 3:47. 2006
  10. pmc Human enterovirus 71 subgenotype B3 lacks coxsackievirus A16-like neurovirulence in mice infection
    Yoke Fun Chan
    Sime Darby Technology Centre, 2, Jalan Tandang, 46050 Petaling Jaya, Selangor, Malaysia
    Virol J 2:74. 2005

Collaborators

Detail Information

Publications44

  1. ncbi Emergence of dengue virus type 4 genotype IIA in Malaysia
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Gen Virol 83:2437-42. 2002
    ..These results suggest that intra-serotypic recombination amongst DENV-4 from independent ancestral lineages may have contributed to the emergence of DENV-4 subgenotype IIA in Malaysia...
  2. pmc Isolation of ancestral sylvatic dengue virus type 1, Malaysia
    Boon Teong Teoh
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 16:1783-5. 2010
    ..The virus is neutralized by serum of patients with endemic DENV-1 infection. Rare isolation of this virus suggests a limited spillover infection from an otherwise restricted sylvatic cycle...
  3. pmc Review of Dengue hemorrhagic fever fatal cases seen among adults: a retrospective study
    Sing Sin Sam
    Tropical Infectious Diseases Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS Negl Trop Dis 7:e2194. 2013
    ..The disease affects mainly children, but in recent years it is becoming more of an adult disease. Malaysia experienced a large dengue outbreak in 2006 to 2007, involving mostly adults, with a high number of deaths...
  4. pmc Recombinant human enterovirus 71 in hand, foot and mouth disease patients
    Yoke Fun Chan
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 10:1468-70. 2004
    ..When caused by CV-A16 infection, it is usually a mild disease, and patients normally recover without requiring any special medical attention...
  5. pmc Detection of dengue viruses using reverse transcription-loop-mediated isothermal amplification
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Infect Dis 13:387. 2013
    ..An easy to perform and highly sensitive method is needed for routine implementation especially in the resource-limited rural healthcare settings where dengue is endemic...
  6. pmc Dengue virus type 1 clade replacement in recurring homotypic outbreaks
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Evol Biol 13:213. 2013
    ..Understanding the DENV evolutionary mechanism underlying the recurring dengue outbreaks has important implications for epidemic prediction and disease control...
  7. pmc Colonized Aedes albopictus and its sexual performance in the wild: implications for SIT technology and containment
    Dieng Hamady
    School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
    Parasit Vectors 6:206. 2013
    ..albopictus and wild populations...
  8. pmc Human neuronal cell protein responses to Nipah virus infection
    Li Yen Chang
    Center for Proteomics Research, Department of Forest Biotechnology, Forest Research Institute Malaysia, Selangor, Malaysia
    Virol J 4:54. 2007
    ..In the present study, the SK-N-MC human neuronal cell protein response to NiV infection is examined using proteomic approaches...
  9. pmc Quantitative estimation of Nipah virus replication kinetics in vitro
    Li Yen Chang
    Center for Proteomics Research, Department of Forest Biotechnology, Forest Research Institute, 52109, Selangor, Malaysia
    Virol J 3:47. 2006
    ....
  10. pmc Human enterovirus 71 subgenotype B3 lacks coxsackievirus A16-like neurovirulence in mice infection
    Yoke Fun Chan
    Sime Darby Technology Centre, 2, Jalan Tandang, 46050 Petaling Jaya, Selangor, Malaysia
    Virol J 2:74. 2005
    ....
  11. pmc Enterovirus 71 outbreak, Brunei
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 15:79-82. 2009
    ..Isolated EV71 strains formed a distinct lineage with low diversity within subgenogroup B5, suggesting recent introduction and rapid spread within Brunei...
  12. ncbi Outlook of dengue in Malaysia: a century later
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 24:23-7. 2002
    ....
  13. pmc Isolation and molecular identification of Nipah virus from pigs
    Sazaly AbuBakar
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 10:2228-30. 2004
    ..At least two different Nipah virus strains, including a previously unreported strain, were identified. The findings highlight the possibility that the Malaysia outbreaks had two origins of Nipah virus infections...
  14. pmc Novel antiviral activity of baicalein against dengue virus
    Keivan Zandi
    Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center TIDREC, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    BMC Complement Altern Med 12:214. 2012
    ..Among the natural compounds, bioflavonoids derived mainly from plants are of interest because of their biological and medicinal benefits...
  15. pmc Extract of Scutellaria baicalensis inhibits dengue virus replication
    Keivan Zandi
    Tropical Infectious Disease Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    BMC Complement Altern Med 13:91. 2013
    ..In the present study, we evaluated the in vitro antiviral activity of aqueous extract of the roots of S. baicalensis against all the four dengue virus (DENV) serotypes...
  16. doi Chikungunya virus of Asian and Central/East African genotypes in Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    J Clin Virol 46:180-3. 2009
    ..In Malaysia, limited CHIKV outbreaks of the endemic Asian and imported Central/East African genotypes were reported in 1998 and 2006. Since April 2008, an unprecedented nationwide outbreak has affected Malaysia...
  17. doi Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells
    Keivan Zandi
    Tropical Infectious Diseases Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia
    Molecules 17:2437-45. 2012
    ..The CC₅₀ value of flavone against Vero cells was 446 µg/mL. These results suggest that flavone might enhance dengue virus replication by acting antagonistically towards flavonoids known to inhibit dengue virus replication...
  18. doi Phylogenetic designation of enterovirus 71 genotypes and subgenotypes using complete genome sequences
    Yoke Fun Chan
    Department of Medical Microbiology, University Malaya, Kuala Lumpur, Malaysia
    Infect Genet Evol 10:404-12. 2010
    ..Hence, in the absence of full genome sequences, it is proposed here that a combination of VP1 and 3D RNA polymerase gene sequences be used for initial genotyping of EV-71 isolates...
  19. pmc Antiviral activity of four types of bioflavonoid against dengue virus type-2
    Keivan Zandi
    Tropical Infectious Disease Research and Education Center TIDREC, Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
    Virol J 8:560. 2011
    ..Selectivity Index value (SI) was determined as the ratio of cytotoxic concentration 50 (CC50) to inhibitory concentration 50 (IC50) for each compound...
  20. pmc Genotypic and phenotypic characterization of Chikungunya virus of different genotypes from Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 7:e50476. 2012
    ..To gain insight into these observed epidemiological differences, we compared genotypic and phenotypic characteristics of CHIKV of Asian and ECSA genotypes isolated in Malaysia...
  21. doi Dengue virus type 2 envelope protein displayed as recombinant phage attachment protein reveals potential cell binding sites
    Juraina Abd-Jamil
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia
    Protein Eng Des Sel 21:605-11. 2008
    ..The phage displayed truncated DENV-2 E is a powerful and useful method for the direct determination of DENV-2 E cell binding sites...
  22. pmc Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypes
    Chan Yoke-Fun
    Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
    BMC Microbiol 6:74. 2006
    ..Several new EV-71 subgenotypes were identified from these outbreaks. The mechanisms that contributed to the emergence of these subgenotypes are unknown...
  23. pmc Molecular identification of adenovirus causing respiratory tract infection in pediatric patients at the University of Malaya Medical Center
    Juraina Abd-Jamil
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Tropical Infectious Diseases Research and Education Center 50603 Kuala Lumpur, Malaysia
    BMC Pediatr 10:46. 2010
    ..Presently, there are no reports of the prevalent HAdV types found in Malaysia. The present study was undertaken to identify the HAdV types associated primarily with respiratory tract infections (RTI) of young children in Malaysia...
  24. doi MicroRNA 299-3p modulates replicative senescence in endothelial cells
    Hui Lan Jong
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Physiol Genomics 45:256-67. 2013
    ..Hence, these findings provide an early insight into the role of hsa-miR-299-3p in the modulation of replicative senescence in HUVECs...
  25. ncbi Antigenic cell associated dengue 2 virus proteins detected in vitro using dengue fever patients sera
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 24:29-36. 2002
    ..Detection of dengue 2 virus C antibody in some patients further suggested that C could be antigenic if presented in vivo...
  26. pmc Reemergence of endemic Chikungunya, Malaysia
    Sazaly AbuBakar
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 13:147-9. 2007
    ..The reemergence of the infection is not part of the epidemics in other Indian Ocean countries but raises the possibility that chikungunya virus is endemic in Malaysia...
  27. pmc Virus-specific read-through codon preference affects infectivity of chimeric cucumber green mottle mosaic viruses displaying a dengue virus epitope
    Pak Guan Teoh
    Center for Research in Biotechnology for Agriculture CEBAR and Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    J Biomed Biotechnol 2009:781712. 2009
    ....
  28. ncbi Enterovirus 71 infection induces apoptosis in Vero cells
    Yoke Fun Chan
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 25:29-35. 2003
    ..The induction, however, requires high level of HEV71 infectivity and the presence of live virus particles, suggesting the need for the presence of specific viral proteins for apoptosis to occur...
  29. ncbi Baicalin, a metabolite of baicalein with antiviral activity against dengue virus
    Ehsan Moghaddam
    Tropical Infectious Disease Research and Education Center, Department of Medical Microbiology Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 4:5452. 2014
    ..07 ± 0.2 μg/ml. Our findings showed that baicalin as the main metabolite of baicalein exerting in vitro anti-DENV activity. Further investigations on baicalein and baicalin to deduce its antiviral therapeutic effects are warranted. ..
  30. pmc Anti-inflammatory, gastroprotective and anti-ulcerogenic effects of red algae Gracilaria changii (Gracilariales, Rhodophyta) extract
    Meng Hooi Shu
    Tropical Infectious Diseases Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Complement Altern Med 13:61. 2013
    ..The aim of the study was to investigate anti-inflammatory, gastroprotective and anti-ulcerogenic activities of a mass spectrometry standardized methanolic extract of Gracilaria changii...
  31. ncbi Nipah virus RNA synthesis in cultured pig and human cells
    Li Yen Chang
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia
    J Med Virol 78:1105-12. 2006
    ..However, there are differences between these cells and human neuronal cells and monocytes in the ability to support Nipah virus replication and virus release...
  32. ncbi Comparative transcriptional study of the effects of high intracellular zinc on prostate carcinoma cells
    Pooi Fong Wong
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Oncol Rep 23:1501-16. 2010
    ..This could be the antagonistic mechanism used to overcome the initial cell growth inhibitory effects of high Zn2+. These findings support a potential detrimental role of Zn2+ in prostate cancer...
  33. ncbi Dengue virus type 2 NS3 protease and NS2B-NS3 protease precursor induce apoptosis
    Norazizah Shafee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    J Gen Virol 84:2191-5. 2003
    ..These findings suggest the importance of NS2B as a cofactor to NS3 protease-induced apoptosis...
  34. doi High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells
    Pooi Fong Wong
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Cell Mol Biol Lett 13:375-90. 2008
    ..These results highlight the importance of a high intracellular Zn(2+) content and the VHR/ZAP-70-associated pathways in the modulation of LNCaP prostate cancer cell growth...
  35. ncbi Senescence affects endothelial cells susceptibility to dengue virus infection
    Sazaly AbuBakar
    1 Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Med Sci 11:538-44. 2014
    ..These results suggest that senescing HUVECs do not support DENV infection and DENV infection induces HUVECs senescence. The finding highlights the possible role of induction of senescence in DENV infection of the endothelial cells. ..
  36. doi Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28
    Pooi Fong Wong
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Phytomedicine 19:138-44. 2012
    ..The treatment also resulted in suppression of the lung cancer cell tumor markers and several known cancer cell growth-associated genes...
  37. pmc Antiviral Activity of Baicalein and Quercetin against the Japanese Encephalitis Virus
    Jefree Johari
    Tropical Infectious Disease Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Mol Sci 13:16785-95. 2012
    ....
  38. ncbi Zinc accelerates dengue virus type 2-induced apoptosis in Vero cells
    Norazizah Shafee
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    FEBS Lett 524:20-4. 2002
    ..These results suggest that (i) apoptosis is induced in African green monkey kidney cells infected with live DENV-2 and (ii) the addition of high extracellular Zn(2+) accelerates detection of apoptosis in the DENV-2-infected cells...
  39. ncbi Identification of a 48kDa tubulin or tubulin-like C6/36 mosquito cells protein that binds dengue virus 2 using mass spectrometry
    Hui Yee Chee
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia
    Biochem Biophys Res Commun 320:11-7. 2004
    ..These findings suggest that DENV-2 through DENV-2 E binds directly to a 48 kDa tubulin or tubulin-like protein of C6/36 mosquito cells...
  40. doi LNCaP prostate cancer cells are insensitive to zinc-induced senescence
    Pooi Fong Wong
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia
    J Trace Elem Med Biol 22:242-7. 2008
    ..These findings suggest that prostate cancer cells are insensitive to the senescence-inducing effects of zinc but the cancer cells retain the capacity to undergo senescence through other pathways...
  41. ncbi Community knowledge, health beliefs, practices and experiences related to dengue fever and its association with IgG seropositivity
    Li Ping Wong
    Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Julius Centre University of Malaya JCUM, University of Malaya, Kuala Lumpur, Malaysia
    PLoS Negl Trop Dis 8:e2789. 2014
    ..This study aimed to examine these factors and their association with the seroprevalence of this disease...
  42. pmc Health beliefs and practices related to dengue fever: a focus group study
    Li Ping Wong
    Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS Negl Trop Dis 7:e2310. 2013
    ..The Health Belief Model was used as a framework to explore and understand dengue prevention behaviours...
  43. ncbi Antibody neutralization and viral virulence in recurring dengue virus type 2 outbreaks
    Sook San Wong
    Macfarlane Burnet Institute for Medical Research and Public Health Limited, Melbourne, Australia
    Viral Immunol 20:359-68. 2007
    ..This could be an important contributing factor in the recurring homogenotypic dengue virus outbreaks seen in dengue-endemic regions...