Nhareet Somchit

Summary

Affiliation: Universiti Putra Malaysia
Country: Malaysia

Publications

  1. pmc Effects of cytochrome p450 inhibitors on itraconazole and fluconazole induced cytotoxicity in hepatocytes
    Nhareet Somchit
    Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Putra Malaysia UPM, Serdang, 43400 Selangor, Malaysia
    J Toxicol 2009:912320. 2009
  2. ncbi request reprint Itraconazole- and fluconazole-induced toxicity in rat hepatocytes: a comparative in vitro study
    N Somchit
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor
    Hum Exp Toxicol 21:43-8. 2002
  3. ncbi request reprint In vitro antimicrobial activity of ethanol and water extracts of Cassia alata
    M N Somchit
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    J Ethnopharmacol 84:1-4. 2003
  4. ncbi request reprint Liver injury induced by the non-steroidal anti-inflammatory drug mefenamic acid
    N Somchit
    Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
    Singapore Med J 45:530-2. 2004
  5. ncbi request reprint Hepatotoxicity induced by antifungal drugs itraconazole and fluconazole in rats: a comparative in vivo study
    N Somchit
    Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Hum Exp Toxicol 23:519-25. 2004
  6. ncbi request reprint Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats
    N Somchit
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
    Drug Chem Toxicol 29:237-53. 2006
  7. doi request reprint Lack of hepato- and nephrotoxicity induced by antifungal drug voriconazole in laboratory rats
    Nhareet Somchit
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Serdang, Malaysia
    Drug Chem Toxicol 35:304-9. 2012

Collaborators

Detail Information

Publications7

  1. pmc Effects of cytochrome p450 inhibitors on itraconazole and fluconazole induced cytotoxicity in hepatocytes
    Nhareet Somchit
    Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Putra Malaysia UPM, Serdang, 43400 Selangor, Malaysia
    J Toxicol 2009:912320. 2009
    ..Differences of the effects of SKF 525A on the cytotoxicity induced by itraconazole and fluconazole may be due to the differences on the metabolism of each antifungal drug in vivo...
  2. ncbi request reprint Itraconazole- and fluconazole-induced toxicity in rat hepatocytes: a comparative in vitro study
    N Somchit
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor
    Hum Exp Toxicol 21:43-8. 2002
    ..Phenobarbital plays a role in the cytoprotection of hepatocytes to itraconazole-induced but not fluconazole-induced cytotoxicity in vitro...
  3. ncbi request reprint In vitro antimicrobial activity of ethanol and water extracts of Cassia alata
    M N Somchit
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    J Ethnopharmacol 84:1-4. 2003
    ..E. coli showed resistance to all types of extracts. Based on the current findings, it can be concluded that this plant has antimicrobial activity, which is as potent as standard antimicrobial drugs against certain microorganisms...
  4. ncbi request reprint Liver injury induced by the non-steroidal anti-inflammatory drug mefenamic acid
    N Somchit
    Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
    Singapore Med J 45:530-2. 2004
    ..Virtually all NSAIDs are capable of producing liver injury ranging from mild reversible elevation of liver enzymes to severe hepatic necrosis...
  5. ncbi request reprint Hepatotoxicity induced by antifungal drugs itraconazole and fluconazole in rats: a comparative in vivo study
    N Somchit
    Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Hum Exp Toxicol 23:519-25. 2004
    ..In the subchronic fluconazole treated rats, only mild degenerative changes of centrilobular hepatocytes were observed. These results demonstrated that itraconazole was a more potent hepatotoxicant than fluconazole in vivo in rats...
  6. ncbi request reprint Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats
    N Somchit
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
    Drug Chem Toxicol 29:237-53. 2006
    ..SKF 525A enhanced the hepatotoxicity of both antifungal drugs in vivo. Therefore, it can be concluded that inhibition of CYP may play a key role in the mechanism of hepatotoxicity induced by itraconazole and fluconazole...
  7. doi request reprint Lack of hepato- and nephrotoxicity induced by antifungal drug voriconazole in laboratory rats
    Nhareet Somchit
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Serdang, Malaysia
    Drug Chem Toxicol 35:304-9. 2012
    ..Under TEM, only small changes in the 100 mg/kg/day group were revealed. These results collectively demonstrated that voriconazole did not induce significant hepatotoxicity and nephrotoxicity, even at very high doses...