S M Graham

Summary

Affiliation: University of Malawi
Country: Malawi

Publications

  1. ncbi Invasive group B streptococcal infection in infants, Malawi
    Katherine J Gray
    Malawi Liverpool Wellcome Trust Programme of Clinical Tropical Research, Blantyre, Malawi
    Emerg Infect Dis 13:223-9. 2007
  2. ncbi Low levels of pyrazinamide and ethambutol in children with tuberculosis and impact of age, nutritional status, and human immunodeficiency virus infection
    S M Graham
    Malawi Liverpool Wellcome Trust Clinical Research Programme, P O Box 30096, Blantyre 3, Malawi
    Antimicrob Agents Chemother 50:407-13. 2006
  3. ncbi Salmonellosis in children in developing and developed countries and populations
    Stephen M Graham
    Wellcome Trust Research Laboratories, Blantyre, Malawi, UK
    Curr Opin Infect Dis 15:507-12. 2002
  4. ncbi Impact of HIV on childhood respiratory illness: differences between developing and developed countries
    S M Graham
    Malawi Liverpool Wellcome Trust Clinical Research Programme and Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi
    Pediatr Pulmonol 36:462-8. 2003
  5. ncbi Childhood tuberculosis: clinical research needs
    S M Graham
    Malawi Liverpool Wellcome Trust Research Programme and Department of Paediatrics, College of Medicine, Blantyre, Malawi
    Int J Tuberc Lung Dis 8:648-57. 2004
  6. ncbi HIV and respiratory infections in children
    Stephen M Graham
    Wellcome Trust Research Laboratories, College of Medicine, Blantyre, Malawi
    Curr Opin Pulm Med 9:215-20. 2003
  7. ncbi Non-tuberculosis opportunistic infections and other lung diseases in HIV-infected infants and children
    S M Graham
    College of Medicine, Malawi Liverpool Wellcome Trust Clinical Research Programme, Department of Paediatrics, Blantyre, Malawi
    Int J Tuberc Lung Dis 9:592-602. 2005
  8. ncbi Bacteremia in febrile Malawian children: clinical and microbiologic features
    A L Walsh
    Wellcome Trust Research Laboratories, University of Malawi, Blantyre
    Pediatr Infect Dis J 19:312-8. 2000
  9. ncbi Effect of concomitant HIV infection on presentation and outcome of rotavirus gastroenteritis in Malawian children
    N A Cunliffe
    Wellcome Trust Research Laboratories, Universities of Malawi and Liverpool, College of Medicine, Blantyre, Malawi
    Lancet 358:550-5. 2001
  10. ncbi Clinical presentation and outcome of Pneumocystis carinii pneumonia in Malawian children
    S M Graham
    Department of Paediatrics, College of Medicine, University of Malawi, Blantyre
    Lancet 355:369-73. 2000

Collaborators

Detail Information

Publications36

  1. ncbi Invasive group B streptococcal infection in infants, Malawi
    Katherine J Gray
    Malawi Liverpool Wellcome Trust Programme of Clinical Tropical Research, Blantyre, Malawi
    Emerg Infect Dis 13:223-9. 2007
    ..Effective locally relevant prevention strategies are needed...
  2. ncbi Low levels of pyrazinamide and ethambutol in children with tuberculosis and impact of age, nutritional status, and human immunodeficiency virus infection
    S M Graham
    Malawi Liverpool Wellcome Trust Clinical Research Programme, P O Box 30096, Blantyre 3, Malawi
    Antimicrob Agents Chemother 50:407-13. 2006
    ..Studies of pharmacokinetic parameters and clinical outcomes obtained by using higher dosages of drugs for treatment of childhood tuberculosis are needed, and recommended dosages may need to be increased...
  3. ncbi Salmonellosis in children in developing and developed countries and populations
    Stephen M Graham
    Wellcome Trust Research Laboratories, Blantyre, Malawi, UK
    Curr Opin Infect Dis 15:507-12. 2002
    ..The present review addresses recent developments that relate to the clinical management and prevention of childhood salmonellosis in developed and developing countries...
  4. ncbi Impact of HIV on childhood respiratory illness: differences between developing and developed countries
    S M Graham
    Malawi Liverpool Wellcome Trust Clinical Research Programme and Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi
    Pediatr Pulmonol 36:462-8. 2003
    ..Autopsy studies have provided a lot of useful data, but more prospective clinical and intervention studies from different parts of the region are needed in order to improve clinical diagnosis and management...
  5. ncbi Childhood tuberculosis: clinical research needs
    S M Graham
    Malawi Liverpool Wellcome Trust Research Programme and Department of Paediatrics, College of Medicine, Blantyre, Malawi
    Int J Tuberc Lung Dis 8:648-57. 2004
    ..Also important are a better understanding of risk factors for infection and disease, including the impact of HIV, and operational research to improve treatment outcomes and management of well childhood contacts...
  6. ncbi HIV and respiratory infections in children
    Stephen M Graham
    Wellcome Trust Research Laboratories, College of Medicine, Blantyre, Malawi
    Curr Opin Pulm Med 9:215-20. 2003
    ..Prospective clinical descriptive and intervention studies are needed from different regions to guide clinical management and prevention of respiratory infections in HIV-infected children living in resource-poor countries...
  7. ncbi Non-tuberculosis opportunistic infections and other lung diseases in HIV-infected infants and children
    S M Graham
    College of Medicine, Malawi Liverpool Wellcome Trust Clinical Research Programme, Department of Paediatrics, Blantyre, Malawi
    Int J Tuberc Lung Dis 9:592-602. 2005
    ....
  8. ncbi Bacteremia in febrile Malawian children: clinical and microbiologic features
    A L Walsh
    Wellcome Trust Research Laboratories, University of Malawi, Blantyre
    Pediatr Infect Dis J 19:312-8. 2000
    ..There are no published data for the incidence or etiology of childhood bacteremia in Malawi. We describe the clinical and microbiologic features of children admitted to hospital from whom blood cultures yielded bacterial pathogens...
  9. ncbi Effect of concomitant HIV infection on presentation and outcome of rotavirus gastroenteritis in Malawian children
    N A Cunliffe
    Wellcome Trust Research Laboratories, Universities of Malawi and Liverpool, College of Medicine, Blantyre, Malawi
    Lancet 358:550-5. 2001
    ..Rotaviruses represent important causes of severe diarrhoea in early childhood. We examined the effect of HIV infection on the presentation and outcome of rotavirus gastroenteritis in Malawian children...
  10. ncbi Clinical presentation and outcome of Pneumocystis carinii pneumonia in Malawian children
    S M Graham
    Department of Paediatrics, College of Medicine, University of Malawi, Blantyre
    Lancet 355:369-73. 2000
    ..We aimed to describe the rate, clinical presentation, and outcome of PCP in young Malawian children with acute severe pneumonia...
  11. ncbi The outcome of non-typhoidal salmonella meningitis in Malawian children, 1997-2006
    E M Molyneux
    Department of Paediatrics, College of Medicine, Blantyre, Malawi
    Ann Trop Paediatr 29:13-22. 2009
    ..The clinical course and outcome of non-typhoidal salmonella (NTS) meningitis in Malawian children over a 10-year period (1997-2006) is described...
  12. ncbi Aetiology of neonatal sepsis in Blantyre, Malawi: 1996-2001
    J Milledge
    Department of Paediatrics, College of Medicine, Blantyre, Malawi
    Ann Trop Paediatr 25:101-10. 2005
    ..The causes of neonatal sepsis in this population show a different pattern from other studies in developing countries...
  13. ncbi Risk factors for TB infection and disease in young childhood contacts in Malawi
    R Sinfield
    Department of Paediatrics, College of Medicine University of Malawi, Malawi
    Ann Trop Paediatr 26:205-13. 2006
    ..It has huge potential to reduce the burden of TB disease in children, particularly if streamlined to focus on those at greatest risk...
  14. ncbi HIV disease and respiratory infection in children
    Stephen M Graham
    Wellcome Trust Research Laboratory and Department of Paediatrics, College of Medicine, University of Malawi, Malawi
    Br Med Bull 61:133-50. 2002
    ....
  15. ncbi Cotrimoxazole prophylaxis for infants exposed to HIV infection
    Stephen M Graham
    Department of Paediatrics, College of Medicine University of Malawi
    Bull World Health Organ 82:297-8. 2004
  16. ncbi Poor attendance at a child TB contact clinic in Malawi
    M Nyirenda
    Department of Paediatrics, College of Medicine, Blantyre, Malawi
    Int J Tuberc Lung Dis 10:585-7. 2006
    ..36, 95% CI 0.23-0.55, P < 0.001). DISCUSSION: Improved uptake and implementation of child contact management in Malawi is a challenge...
  17. ncbi Urban/rural differences in prevalence and risk factors for intestinal helminth infection in southern Malawi
    K Phiri
    Department of Community Health, College of Medicine, University of Malawi, Chichiri, Blantyre
    Ann Trop Med Parasitol 94:381-7. 2000
    ..2; CI = 2.0-14.0), and having mothers below 35 years of age (OR = 4.09; CI = 1.39-16.28). In this part of Africa, efforts to reduce helminth infections may best be focused on reducing geohelminth burden in urban areas...
  18. ncbi A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV
    Joep J G van Oosterhout
    Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi
    J Acquir Immune Defic Syndr 39:626-31. 2005
    ..These should also assess benefit in patients receiving antiretroviral therapy...
  19. ncbi Prophylaxis against Pneumocystis carinii pneumonia for HIV-exposed infants in Africa
    Stephen M Graham
    Wellcome Trust Research Laboratories and Department of Paediatrics, College of Medicine, University of Malawi, Malawi
    Lancet 360:1966-8. 2002
  20. ncbi Pulmonary disease in HIV-infected African children
    S M Graham
    Department of Paediatrics, College of Medicine, University of Malawi
    Int J Tuberc Lung Dis 5:12-23. 2001
    ..This article reviews the literature and highlights the urgent need for further research in order to improve clinical management and appropriate interventions...
  21. ncbi Rotavirus strain diversity in Blantyre, Malawi, from 1997 to 1999
    N A Cunliffe
    Wellcome Trust Research Laboratories, College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Microbiol 39:836-43. 2001
    ..As is the case for some other countries, the diversity of rotaviruses in Malawi implies that rotavirus vaccines in development will need to protect against a wider panel of serotypes than originally envisioned...
  22. ncbi Lobar pneumonia caused by nontyphoidal Salmonella in a Malawian child
    Limangeni A Mankhambo
    Malawi-Liverpool-Wellcome Trust Programme of Clinical Tropical Research and Department of Paediatrics, College of Medicine, Blantyre, Malawi
    Pediatr Infect Dis J 25:1190-2. 2006
    ..She did not respond to first-line antibiotic therapy for benzylpenicillin and gentamicin but improved with ceftriaxone therapy...
  23. ncbi Bacteraemia following blood transfusion in Malawian children: predominance of Salmonella
    A L Walsh
    Wellcome Trust Research Laboratories, P.O. Box 30096, Blantyre 3, Malawi
    Trans R Soc Trop Med Hyg 96:276-7. 2002
  24. ncbi Brain abscesses in Malawian children: value of CT scan
    L Mankhambo
    Malawi Liverpool Wellcome Trust Programme of Clinical Tropical Research and Department of Paediatrics, College of Medicine, Blantyre, Malawi
    Ann Trop Paediatr 28:79-85. 2008
    ....
  25. ncbi Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome
    Rachel N Bronzan
    Blantyre Malaria Project, Blantyre, Malawi
    J Infect Dis 195:895-904. 2007
    ..We examined the prevalence and etiology of bacteremia and the impact of HIV infection on bacteremia in Malawian children with severe malaria, as well as the impact of bacteremia and HIV infection on outcome...
  26. ncbi Pneumocystis pneumonia in HIV-positive adults, Malawi
    Joep J G van Oosterhout
    University of Malawi College of Medicine, Blantyre, Malawi
    Emerg Infect Dis 13:325-8. 2007
    ..PcP incidence was highest in patients with the lowest CD4 counts, but PcP is uncommon compared with incidences of pulmonary tuberculosis and bacterial pneumonia...
  27. ncbi Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica Serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Clin Infect Dis 46:963-9. 2008
    ..Nontyphoidal salmonellae (NTS) have become the most common cause of bacteremia in tropical Africa, particularly among susceptible children and HIV-infected adults...
  28. ncbi Importance of antibody and complement for oxidative burst and killing of invasive nontyphoidal Salmonella by blood cells in Africans
    Esther N Gondwe
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre 3, Malawi
    Proc Natl Acad Sci U S A 107:3070-5. 2010
    ..These findings increase the likelihood that an antibody-inducing vaccine will protect against invasive nontyphoidal Salmonella disease in African children...
  29. ncbi The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Invest 118:1553-62. 2008
    ..This finding and the age-incidence of NTS bacteremia suggest that antibody protects against NTS bacteremia and support the development of vaccines against NTS that induce protective antibody...
  30. ncbi Challenges to improving case management of childhood pneumonia at health facilities in resource-limited settings
    Stephen M Graham
    Centre for International Child Health, University Department of Paediatrics, Royal Children s Hospital, Melbourne, Australia
    Bull World Health Organ 86:349-55. 2008
    ..Improvements in the quality of case management of pneumonia can be a vehicle for overall improvements in child health-care practices...
  31. ncbi Observational cohort study of HIV-infected African children
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Pediatr Infect Dis J 25:623-7. 2006
    ..Children identified through voluntary counseling and testing (VCT) represent a unique cohort that has not been previously described in the literature...
  32. ncbi Scaling-up co-trimoxazole prophylaxis in HIV-exposed and HIV-infected children in high HIV-prevalence countries
    Rony Zachariah
    Medecins Sans Frontieres, Medical Department Operational Research, Brussels Operational Center, Brussels, Belgium
    Lancet Infect Dis 7:686-93. 2007
    ..We discuss some of the major barriers preventing the scale-up of co-trimoxazole prophylaxis for children in countries with a high prevalence of HIV and propose specific actions required to tackle these challenges...
  33. ncbi Severe anemia in Malawian children
    Stephen M Graham
    N Engl J Med 358:2290; author reply 2291. 2008
  34. ncbi Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial
    Pierre N Tariot
    Department of Psychiatry, University of Rochester Medical Center, Monroe Community Hospital, Rochester, NY 14620, USA
    JAMA 291:317-24. 2004
    ....
  35. ncbi Impact of HIV-associated immunosuppression on malaria infection and disease in Malawi
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    J Infect Dis 193:872-8. 2006
    ..Where malaria is common, the high incidence of fever found among immunosuppressed adults may lead to misclassification of illness episodes as malaria...
  36. ncbi Malaria treatment efficacy among people living with HIV: the role of host and parasite factors
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 77:627-32. 2007
    ....