Maria Makuwa

Summary

Publications

  1. ncbi request reprint Reliability of rapid diagnostic tests for HIV variant infection
    Maria Makuwa
    Centre International de Recherches Medicales, Franceville, Gabon
    J Virol Methods 103:183-90. 2002
  2. ncbi request reprint Analysis of partial pol and env sequences indicates a high prevalence of HIV type 1 recombinant strains circulating in Gabon
    Ivona Pandrea
    Laboratoire de Retroviologie, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 18:1103-16. 2002
  3. ncbi request reprint Two distinct STLV-1 subtypes infecting Mandrillus sphinx follow the geographic distribution of their hosts
    M Makuwa
    Laboratoire de Virologie, UGENET, CDP, SEGC Lopé, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 20:1137-43. 2004
  4. ncbi request reprint Hepatitis viruses in non-human primates
    M Makuwa
    Unité de Rétro Virologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    J Med Primatol 35:384-7. 2006
  5. doi request reprint Human immunodeficiency virus type 1 seroprevalence and antiretroviral drug resistance-associated mutations in miners in Gabon, central Africa
    Melanie Caron
    Unité de Rétrovirologie, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 24:1225-8. 2008
  6. ncbi request reprint Identification of hepatitis B virus subgenotype A3 in rural Gabon
    Maria Makuwa
    Laboratoire de Retrovirologie, Centre International de Recherches Medicales, CIRMF, Franceville, Gabon
    J Med Virol 78:1175-84. 2006
  7. ncbi request reprint Identification of hepatitis B virus genome in faecal sample from wild living chimpanzee (Pan troglodytes troglodytes) in Gabon
    M Makuwa
    Laboratoire de Retrovirologie, Centre International de Recherches Medicales, Franceville, Gabon
    J Clin Virol 34:S83-8. 2005
  8. ncbi request reprint Complete-genome analysis of hepatitis B virus from wild-born chimpanzees in central Africa demonstrates a strain-specific geographical cluster
    Maria Makuwa
    Centre International de Recherches Medicales de Franceville, Unité de Rétrovirologie et Centre de Primatologie, Franceville, Gabon
    J Gen Virol 88:2679-85. 2007
  9. ncbi request reprint A New STLV-1 in a household pet Cercopithecus nictitans from Gabon
    Maria Makuwa
    Laboratoire de Virologie, UGENET, CDP, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 20:679-83. 2004
  10. ncbi request reprint Occurrence of hepatitis viruses in wild-born non-human primates: a 3 year (1998-2001) epidemiological survey in Gabon
    M Makuwa
    Centre International de Recherches Medicales, Franceville, Gabon
    J Med Primatol 32:307-14. 2003

Detail Information

Publications33

  1. ncbi request reprint Reliability of rapid diagnostic tests for HIV variant infection
    Maria Makuwa
    Centre International de Recherches Medicales, Franceville, Gabon
    J Virol Methods 103:183-90. 2002
    ..These results stress the need for better screening tools and specific local evaluations...
  2. ncbi request reprint Analysis of partial pol and env sequences indicates a high prevalence of HIV type 1 recombinant strains circulating in Gabon
    Ivona Pandrea
    Laboratoire de Retroviologie, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 18:1103-16. 2002
    ..The main advantage of this approach is that it also allows for evaluation of genotypic susceptibility to antiretroviral drugs without the need for supplementary analyses...
  3. ncbi request reprint Two distinct STLV-1 subtypes infecting Mandrillus sphinx follow the geographic distribution of their hosts
    M Makuwa
    Laboratoire de Virologie, UGENET, CDP, SEGC Lopé, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 20:1137-43. 2004
    ..The clustering of these new STLV-1mnd sequences with HTLV-1 subtype D and F suggests first, past simian-to-human transmissions in Central Africa and second, that species barriers are easier to cross over than geographic barriers...
  4. ncbi request reprint Hepatitis viruses in non-human primates
    M Makuwa
    Unité de Rétro Virologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    J Med Primatol 35:384-7. 2006
    ..In order to investigate the prevalence of the blood-born hepatitis viruses in apes and monkeys living in the same area, we performed an epidemiological survey of HBV, HCV and HDV in wild-born non-human primates...
  5. doi request reprint Human immunodeficiency virus type 1 seroprevalence and antiretroviral drug resistance-associated mutations in miners in Gabon, central Africa
    Melanie Caron
    Unité de Rétrovirologie, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 24:1225-8. 2008
    ..To avoid the rapid emergence of resistant viruses in this part of central Africa, continuous surveillance of the circulation of drug-resistant viruses must be maintained to guide treatment strategies...
  6. ncbi request reprint Identification of hepatitis B virus subgenotype A3 in rural Gabon
    Maria Makuwa
    Laboratoire de Retrovirologie, Centre International de Recherches Medicales, CIRMF, Franceville, Gabon
    J Med Virol 78:1175-84. 2006
    ..Two full genome sequences of two new Gabonese HBV isolates are also presented and confirm the distinctive HBV-Gab-A3 cluster...
  7. ncbi request reprint Identification of hepatitis B virus genome in faecal sample from wild living chimpanzee (Pan troglodytes troglodytes) in Gabon
    M Makuwa
    Laboratoire de Retrovirologie, Centre International de Recherches Medicales, Franceville, Gabon
    J Clin Virol 34:S83-8. 2005
    ..This is the first evidence of HBV infection in wild apes and confirms that the HBV-like strains thus far characterized in captive apes are directly related to those circulating in the wild...
  8. ncbi request reprint Complete-genome analysis of hepatitis B virus from wild-born chimpanzees in central Africa demonstrates a strain-specific geographical cluster
    Maria Makuwa
    Centre International de Recherches Medicales de Franceville, Unité de Rétrovirologie et Centre de Primatologie, Franceville, Gabon
    J Gen Virol 88:2679-85. 2007
    ..The strong phylogenetic associations of ChHBV sequences with both chimpanzee subspecies and their geographical origin were therefore confirmed...
  9. ncbi request reprint A New STLV-1 in a household pet Cercopithecus nictitans from Gabon
    Maria Makuwa
    Laboratoire de Virologie, UGENET, CDP, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 20:679-83. 2004
    ..These data show that C. nictitans may be the natural carrier of two different molecular types of STLV, one related to STLV-3 and the other possibly one of the simian STLV type 1 counterparts of HTLV-1 subtype D...
  10. ncbi request reprint Occurrence of hepatitis viruses in wild-born non-human primates: a 3 year (1998-2001) epidemiological survey in Gabon
    M Makuwa
    Centre International de Recherches Medicales, Franceville, Gabon
    J Med Primatol 32:307-14. 2003
    ..9% wild-born and 8.3% at CIRMF harboured HBV-DNA despite the presence of neutralizing HbsAb. Together with previous findings, we confirm the high HBV prevalence not only in humans but also in chimpanzees and gorillas in Gabon and Congo...
  11. pmc Prevalence and molecular diversity of hepatitis B virus and hepatitis delta virus in urban and rural populations in northern Gabon in central Africa
    Maria Makuwa
    Unité de virologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    J Clin Microbiol 47:2265-8. 2009
    ..Phylogenetic analysis showed the circulation of HBV-A3 and -E genotypes and the presence of HDV-1, HDV-7, and HDV-8 clades...
  12. doi request reprint Simian immunodeficiency virus types 1 and 2 (SIV mnd 1 and 2) have different pathogenic potentials in rhesus macaques upon experimental cross-species transmission
    Sandrine Souquiere
    Laboratoire de Retrovirologie, Centre International de Recherches Médicales CIRMF, Franceville, Gabon
    J Gen Virol 90:488-99. 2009
    ..The demonstration of the ability of both SIVmnd types to induce persistent infections in rhesus macaques calls for a careful assessment of the potential of these two viruses to emerge as new human pathogens...
  13. pmc New insights into prevalence, genetic diversity, and proviral load of human T-cell leukemia virus types 1 and 2 in pregnant women in Gabon in equatorial central Africa
    Sonia Lekana Douki Etenna
    Département de Rétrovirologie, Centre International de Recherches Medicales, BP 769 Franceville, Gabon
    J Clin Microbiol 46:3607-14. 2008
    ..The sole HTLV-2 strain belonged to subtype B. In this study we showed that the prevalence of HTLV-1 in the southeast is one of the highest in the world for pregnant women...
  14. doi request reprint High HIV Type 1 prevalence and wide genetic diversity with dominance of recombinant strains but low level of antiretroviral drug-resistance mutations in untreated patients in northeast Gabon, Central Africa
    Armel Mintsa-Ndong
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    AIDS Res Hum Retroviruses 25:411-8. 2009
    ..The wide diversity and the emergence of recombinant strains are in accordance with the rapid spread of new HIV strains in the population and, thus, the dynamic evolution of the epidemic...
  15. doi request reprint Absence of intrafamilial transmission of hepatitis C virus and low risk for sexual transmission in rural central Africa indicate a cohort effect
    Guy Roger Ndong-Atome
    Departement de Virologie, Centre International de Recherches Medicales de Franceville CIRMF, BP 769, Franceville, Gabon
    J Clin Virol 45:349-53. 2009
    ..Intrafamilial and sexual transmission of hepatitis C virus (HCV) are still being debated, and little is known about such transmission in central Africa...
  16. pmc Phylogeography, risk factors and genetic history of hepatitis C virus in Gabon, central Africa
    Richard Njouom
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS ONE 7:e42002. 2012
    ..The aim of this study was to determine the prevalence, genotype distribution and epidemic history of HCV in the Gabonese general population...
  17. pmc New strain of simian immunodeficiency virus identified in wild-born chimpanzees from central Africa
    Sandrine Souquiere
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    PLoS ONE 7:e44298. 2012
    ..Further field studies with non-invasive methods are needed to determine the prevalence, geographic distribution, species association, and natural history of SIVcpz strains in the chimpanzee habitat in Gabon...
  18. pmc Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa
    Guy Roger Ndong-Atome
    Laboratoire de Virologie, Centre International de Recherches Médicales CIRMF, BP 769, Franceville, Gabon
    BMC Infect Dis 8:82. 2008
    ..The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women...
  19. pmc Prevalence, genetic diversity and antiretroviral drugs resistance-associated mutations among untreated HIV-1-infected pregnant women in Gabon, central Africa
    Melanie Caron
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville BP 769, Gabon
    BMC Infect Dis 12:64. 2012
    ..In Africa, the wide genetic diversity of HIV has resulted in emergence of new strains, rapid spread of this virus in sub-Saharan populations and therefore spread of the HIV epidemic throughout the continent...
  20. pmc Prevalence and genetic diversity of hepatitis B and delta viruses in pregnant women in Gabon: molecular evidence that hepatitis delta virus clade 8 originates from and is endemic in central Africa
    Maria Makuwa
    Laboratoire de Virologie, Centre International de Recherches Medicales, BP 769, Franceville, Gabon
    J Clin Microbiol 46:754-6. 2008
    ..6% of the HBsAg-positive women. The HBV strains were of the A3 and E genotypes. The HDV strains belonged to HDV clades 1 and 8. These results provide clear evidence that HDV clade 8 is indigenous to Africa...
  21. pmc Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Retrovirology 7:105. 2010
    ..We evaluated the natural history of the virus in a free-ranging colony of mandrills and investigated possible transmission of mandrill SFV to humans...
  22. doi request reprint Prevention of vaginal simian immunodeficiency virus transmission in macaques by postexposure prophylaxis with zidovudine, lamivudine and indinavir
    Olivier Bourry
    Centre de Primatologie, Centre International de Recherches Medicales de Franceville, Franceville, France
    AIDS 23:447-54. 2009
    ..To evaluate the efficacy of postexposure prophylaxis with a combination of zidovudine (ZDV), lamivudine (3TC) and indinavir (IDV), after vaginal exposure to HIV...
  23. pmc Dynamic interaction between STLV-1 proviral load and T-cell response during chronic infection and after immunosuppression in non-human primates
    Sandrine Souquiere
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    PLoS ONE 4:e6050. 2009
    ..Such studies would provide important information for the development of immune-based therapeutic strategies...
  24. doi request reprint T-cell tropism of simian T-cell leukaemia virus type 1 and cytokine profiles in relation to proviral load and immunological changes during chronic infection of naturally infected mandrills (Mandrillus sphinx)
    Sandrine Souquiere
    Département de Rétrovirologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    J Med Primatol 38:279-89. 2009
    ..Although a wide variety of non-human primates are susceptible to simian T-cell leukaemia virus type 1 (STLV-1), little is known about the virological or molecular determinants of natural STLV-1 infection...
  25. pmc Hepatitis C virus infection may lead to slower emergence of P. falciparum in blood
    Odile Ouwe-Missi-Oukem-Boyer
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS ONE 6:e16034. 2011
    ..Understanding the molecular mechanisms of these interactions could provide new pathophysiological insights for treatment strategies in Malaria...
  26. doi request reprint High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon
    G R Ndong-Atome
    Departement de Virologie, Centre International de Recherches Medicales, Franceville CIRMF, Gabon
    J Med Virol 80:1581-7. 2008
    ..7%), 4c (13.6%), 4p (4.5%), 4r (4.5%) and one unclassified genotype 4 strain. Evolutionary analysis of the subtype 4e sequences indicates a period of raised transmission during the early twentieth century...
  27. pmc Primary simian immunodeficiency virus SIVmnd-2 infection in mandrills (Mandrillus sphinx)
    Richard Onanga
    Departement de Virologie, Centre International de Recherche Médicales, Gabon
    J Virol 80:3301-9. 2006
    ..The dynamics of SIVmnd-2 infection in mandrills showed a pattern similar to that of SIVmnd-1 infection. This might be a general feature of nonpathogenic SIV natural African NHP models...
  28. pmc Natural simian immunodeficiency virus transmission in mandrills: a family affair?
    David Fouchet
    Laboratoire de Biométrie et Biologie Evolutive UMR5558 CNRS, Universite Claude Bernard Lyon 1, Villeurbanne, France
    Proc Biol Sci 279:3426-35. 2012
    ..Outcomes of this study also provide novel insights into the role of host social structure in the evolution of pathogens...
  29. pmc Wild Mandrillus sphinx are carriers of two types of lentivirus
    S Souquiere
    Laboratoire de Virologie, UGENET, SEGC, Réserve de la Lopé, Centre International de Recherches Medicales, Franceville, Gabon
    J Virol 75:7086-96. 2001
    ....
  30. ncbi request reprint Synthetic peptide strategy for the detection of and discrimination among highly divergent primate lentiviruses
    F Simon
    Laboratoire de Virologie and Centre de Primatologie, , Franceville, Gabon
    AIDS Res Hum Retroviruses 17:937-52. 2001
    ..This method should prove useful for studies of lentivirus prevalence and diversity in human and nonhuman primates, and may also have the potential to detect previously undescribed SIVs...
  31. ncbi request reprint Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children
    Francine Ntoumi
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    Immunol Lett 84:9-16. 2002
    ..The role of the high multiclonal carriage associated with high family-specific antibodies reactive to MSP2 in HbAS children with asymptomatic P. falciparum parasitism is discussed...
  32. ncbi request reprint [Intrathecal synthesis of anti-Toxoplasma gondii antibodies during cerebral toxoplasmosis associated with African AIDS]
    M Makuwa
    Laboratoire de Retrovirologie, Centre International de Recherches Medicales de Franceville, Gabon
    Bull Soc Pathol Exot 92:95-8. 1999
    ..Demonstration of intrathecal synthesis of antitoxoplasmic IgG antibodies could be used to confirm clinical diagnosis of cerebral toxoplamosis, especially in an African context, where sophisticated laboratory facilities are often lacking...
  33. pmc Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feeding
    Ivona Pandrea
    Departement de Virologie, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, Louisiana 70433, USA
    J Virol 82:5501-9. 2008
    ....