Suzana Makpol

Summary

Publications

  1. pmc Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats
    Shafina Hanim Mohd Habib
    Department of Biochemistry, Faculty of Medicine, Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 63:807-13. 2008
  2. pmc 5-Azacytidine is insufficient for cardiogenesis in human adipose-derived stem cells
    Wan Kamarul Zaman Wan Safwani
    Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
    J Negat Results Biomed 11:3. 2012
  3. pmc Modulation of Cell Cycle Profile by Chlorella vulgaris Prevents Replicative Senescence of Human Diploid Fibroblasts
    Tayyebeh Saberbaghi
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Evid Based Complement Alternat Med 2013:780504. 2013
  4. pmc Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
    Arch Med Sci 7:889-95. 2011
  5. pmc Gelam honey attenuated radiation-induced cell death in human diploid fibroblasts by promoting cell cycle progression and inhibiting apoptosis
    Tengku Ahbrizal Farizal Tengku Ahmad
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    BMC Complement Altern Med 14:108. 2014
  6. pmc Comparative effect of Piper betle, Chlorella vulgaris and tocotrienol-rich fraction on antioxidant enzymes activity in cellular ageing of human diploid fibroblasts
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    BMC Complement Altern Med 13:210. 2013
  7. pmc Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 2013:454328. 2013
  8. pmc Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts
    Suzana Makpol
    Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Biochemistry, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 67:135-43. 2012
  9. pmc Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 2012:785743. 2012
  10. pmc Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    J Biomed Biotechnol 2011:506171. 2011

Collaborators

  • Zaiton Zakaria
  • Azalina Zainuddin
  • Zakiah Jubri
  • Wan Kamarul Zaman Wan Safwani
  • Musalmah Mazlan
  • Goon Jo Aan
  • Mi Kyoung Kwak
  • Chua Kien Hui
  • Yasmin Anum Mohd Yusof
  • Yasmin Anum Mohd Yusof
  • Wan Zurinah Wan Ngah
  • Saba Zuhair Hussein
  • Tengku Ahbrizal Farizal Tengku Ahmad
  • Wan Kamarul Zaman Wan Safwani
  • Kien Hui Chua
  • Somasundaram Sathapan
  • Wan Safwani Wan Kamarul Zaman
  • Luqman Hakim
  • Nur Fathiah Abdul Sani
  • Wan Nuraini Wan Hasan
  • Khairuddin Abdul Rahim
  • Nor Fadilah Rajab
  • Tayyebeh Saberbaghi
  • Nor Syahida Aliahmat
  • Christinal Teh Pey Wen
  • Kamaruddin Mohd Yusoff
  • Siok Fong Chin
  • Srijit Das
  • Noor Aini Abdul Hamid
  • Shafina Hanim Mohd Habib
  • Siti Nor Amilah Abdul Rahman
  • Chong Pui Sin
  • Ekram Alias
  • Faizul Jaafar
  • Levin Kesu Belani
  • Nor Azian Morad
  • Thent Zar Chi
  • Firouz Abbasian
  • Mohd Razman Mohd Noor
  • Wan Junizam Wan Yusof
  • Shailah Abdullah
  • Norwahidah Abdul Karim
  • Johari Ibahim
  • Azian Abdul Latiff
  • Aminuddin Abdul Karim
  • Suhana Md Saad
  • Nor Aripin Shamaan

Detail Information

Publications30

  1. pmc Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats
    Shafina Hanim Mohd Habib
    Department of Biochemistry, Faculty of Medicine, Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 63:807-13. 2008
    ..To evaluate the effect of ginger extract on the expression of NFkappaB and TNF-alpha in liver cancer-induced rats...
  2. pmc 5-Azacytidine is insufficient for cardiogenesis in human adipose-derived stem cells
    Wan Kamarul Zaman Wan Safwani
    Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
    J Negat Results Biomed 11:3. 2012
    ..Therefore, in this study, we investigated the effect 5-azacytidine on the cardiogenic ability of ASCs...
  3. pmc Modulation of Cell Cycle Profile by Chlorella vulgaris Prevents Replicative Senescence of Human Diploid Fibroblasts
    Tayyebeh Saberbaghi
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Evid Based Complement Alternat Med 2013:780504. 2013
    ..05). In conclusion, hot water extract of Chlorella vulgaris effectively decreased the biomarkers of ageing, indicating its potential as an antiageing compound...
  4. pmc Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
    Arch Med Sci 7:889-95. 2011
    ....
  5. pmc Gelam honey attenuated radiation-induced cell death in human diploid fibroblasts by promoting cell cycle progression and inhibiting apoptosis
    Tengku Ahbrizal Farizal Tengku Ahmad
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    BMC Complement Altern Med 14:108. 2014
    ....
  6. pmc Comparative effect of Piper betle, Chlorella vulgaris and tocotrienol-rich fraction on antioxidant enzymes activity in cellular ageing of human diploid fibroblasts
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    BMC Complement Altern Med 13:210. 2013
    ..betle, C. vulgaris and TRF in preventing cellular ageing of HDFs by determining the activity of antioxidant enzymes viz.; catalase, superoxide dismutase (SOD) and glutathione peroxidase...
  7. pmc Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 2013:454328. 2013
    ..These findings revealed that γ -tocotrienol may prevent cellular aging of human diploid fibroblasts by modulating gene expression...
  8. pmc Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts
    Suzana Makpol
    Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Biochemistry, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 67:135-43. 2012
    ..This study determined the molecular mechanism of γ-tocotrienol, a vitamin E homolog, in the prevention of cellular aging in human diploid fibroblasts using the expression of senescence-associated genes...
  9. pmc Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 2012:785743. 2012
    ..In conclusion, GTT delays cellular senescence of human diploid fibroblasts through the inhibition of intrinsic mitochondria-mediated pathway which involved the regulation of pro- and anti-apoptotic genes and proteins...
  10. pmc Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    J Biomed Biotechnol 2011:506171. 2011
    ..These findings confirmed the ability of tocotrienol-rich fraction in preventing HDFs cellular ageing by restoring telomere length and telomerase activity, reducing damaged DNA, and reversing cell cycle arrest associated with senescence...
  11. pmc Chlorella vulgaris modulates hydrogen peroxide-induced DNA damage and telomere shortening of human fibroblasts derived from different aged individuals
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Afr J Tradit Complement Altern Med 6:560-72. 2009
    ....
  12. doi request reprint Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Planta Med 76:869-75. 2010
    ..In conclusion, alpha-tocopherol protected against H(2)O(2)-induced telomere shortening by restoring the telomerase activity. It also modulated H(2)O(2)-induced DNA damage and this modulation was affected by donor age...
  13. pmc Antioxidant enzyme activity and malondialdehyde levels can be modulated by Piper betle, tocotrienol rich fraction and Chlorella vulgaris in aging C57BL/6 mice
    Nor Syahida Aliahmat
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan, Malaysia, Jalan Raja Muda Abdul Aziz, Malaysia
    Clinics (Sao Paulo) 67:1447-54. 2012
    ....
  14. ncbi request reprint Gelam honey protects against gamma-irradiation damage to antioxidant enzymes in human diploid fibroblasts
    Tengku Ahbrizal Farizal Tengku Ahmad
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    Molecules 18:2200-11. 2013
    ..As a conclusion, Gelam honey modulates the expression of antioxidant enzymes at gene and protein levels in irradiated HDFs indicating its potential as a radioprotectant agent...
  15. pmc Effect of experimental treatment on GAPDH mRNA expression as a housekeeping gene in human diploid fibroblasts
    Azalina Zainuddin
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    BMC Mol Biol 11:59. 2010
    ..Standard curve of GAPDH expression in serial diluted total RNA, melting curve analysis and agarose gel electrophoresis were used to determine the reliability of GAPDH as reference gene...
  16. ncbi request reprint Gelam and Nenas honeys inhibit proliferation of HT 29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation
    Christinal Teh Pey Wen
    Department of Biomedical Science, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Asian Pac J Cancer Prev 13:1605-10. 2012
    ..In conclusion, our study indicated and confirmed that both Gelam and Nenas honeys are capable of suppressing the growth of HT 29 colon cancer cells by inducing apoptosis and suppressing inflammation...
  17. doi request reprint The impact of long-term in vitro expansion on the senescence-associated markers of human adipose-derived stem cells
    Wan Kamarul Zaman Wan Safwani
    Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Appl Biochem Biotechnol 166:2101-13. 2012
    ..Our data showed ASCs cultured beyond P10 favours the senescence pathway and its clinical usage in cell-based therapy may be limited...
  18. pmc gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 3:35-43. 2010
    ..Thus, these data suggest that gamma-tocotrienol protects against oxidative stress-induced cellular ageing by modulating the telomere length possibly via telomerase...
  19. pmc Comparative effects of biodynes, tocotrienol-rich fraction, and tocopherol in enhancing collagen synthesis and inhibiting collagen degradation in stress-induced premature senescence model of human diploid fibroblasts
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 2013:298574. 2013
    ..05). These findings indicated that biodynes, TRF, and tocopherol effectively enhanced collagen synthesis and inhibited collagen degradation and therefore may protect the skin from aging. ..
  20. doi request reprint Alteration of gene expression levels during osteogenic induction of human adipose derived stem cells in long-term culture
    Wan Kamarul Zaman Wan Safwani
    Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
    Cell Tissue Bank 14:289-301. 2013
    ..During long-term culture, ASCs were only able to differentiate into immature osteogenic cells...
  21. doi request reprint Differences in protein changes between stress-induced premature senescence and replicative senescence states
    Goon Jo Aan
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Electrophoresis 34:2209-17. 2013
    ....
  22. pmc Hot water extract of Chlorella vulgaris induced DNA damage and apoptosis
    Yasmin Anum Mohd Yusof
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 65:1371-7. 2010
    ..The aim of this study was to determine the antiproliferative and apoptotic effects of hot water extracts of Chlorella vulgaris on hepatoma cell line HepG2...
  23. pmc Gelam honey attenuates carrageenan-induced rat paw inflammation via NF-κB pathway
    Saba Zuhair Hussein
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    PLoS ONE 8:e72365. 2013
    ....
  24. ncbi request reprint The changes of stemness biomarkers expression in human adipose-derived stem cells during long-term manipulation
    Wan Kamarul Zaman Wan Safwani
    Department of Physiology, Universiti Kebangsaan Malaysia, Kuala Lumpur
    Biotechnol Appl Biochem 58:261-70. 2011
    ..Our findings suggested that P10 (PD = 26) should be the "cutoff point" for clinical usage because ASCs at passage 15 onward showed significant changes in the stemness genes, CD markers expression, and differentiation capability...
  25. pmc Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
    Siok Fong Chin
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Nutr Metab (Lond) 8:42. 2011
    ..abstract:..
  26. ncbi request reprint Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells
    Luqman Hakim
    Department of Biochemistry, Faculty of Medicine Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia e mail
    Asian Pac J Cancer Prev 15:4651-7. 2014
    ..96 < 1). In conclusion, combined treatment of Gelam honey and ginger extract could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer...
  27. pmc Effect of the combination of gelam honey and ginger on oxidative stress and metabolic profile in streptozotocin-induced diabetic Sprague-Dawley rats
    Nur Fathiah Abdul Sani
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 53000 Kuala Lumpur, Malaysia
    Biomed Res Int 2014:160695. 2014
    ..05) SOD and CAT activities as well as MDA level, while GSH level and GSH/GSSG ratio were significantly elevated (P < 0.05) in STZ-induced diabetic rats compared to diabetic control rats...
  28. pmc Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
    Wan Nuraini Wan Hasan
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    BMC Complement Altern Med 14:72. 2014
    ..The aim of this study was to elucidate the effect of Piper betle (PB) leaves extract in Nrf2 signaling pathway by using 2 types of cells; mouse embryonic fibroblasts (MEFs) derived from wild-type (WT) and Nrf2 knockout (N0) mice...
  29. doi request reprint Long-term in vitro expansion of human adipose-derived stem cells showed low risk of tumourigenicity
    Wan Safwani Wan Kamarul Zaman
    Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    J Tissue Eng Regen Med 8:67-76. 2014
    ..The data showed that ASCs have low risk of tumourigenicity up to P20, with a total population doubling of 42 times. This indicates that adipose tissue should be a safe source of stem cells for cell-based therapy...
  30. doi request reprint Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey
    Saba Zuhair Hussein
    Department of Biochemistry, Faculty of Medicine, University Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia
    Molecules 16:6378-95. 2011
    ..In conclusion, irradiation of honey causes enhanced antioxidant activities and flavonoid compounds...