Irwan T Makagiansar

Summary

Publications

  1. pmc NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:3580-90. 2004
  2. ncbi request reprint Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility
    Irwan T Makagiansar
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:55262-70. 2004
  3. pmc Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration
    Irwan T Makagiansar
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Cell Biol 178:155-65. 2007
  4. ncbi request reprint Molecular basis of interaction between NG2 proteoglycan and galectin-3
    Yunfei Wen
    Burnham Institute, Developmental Neurobiology Program, La Jolla, California 92037, USA
    J Cell Biochem 98:115-27. 2006
  5. ncbi request reprint Disulfide bond formation promotes the cis- and trans-dimerization of the E-cadherin-derived first repeat
    Irwan T Makagiansar
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    J Biol Chem 277:16002-10. 2002
  6. ncbi request reprint Localized production of human E-cadherin-derived first repeat in Escherichia coli
    Irwan T Makagiansar
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047 2504, USA
    Protein Expr Purif 26:449-54. 2002
  7. ncbi request reprint Expression, purification, and structural study of the EC4 domain of E-cadherin
    Kai Zheng
    Department of Molecular Biosciences, The University of Kansas, Lawrence, KS 66045, USA
    Protein Expr Purif 33:72-9. 2004

Collaborators

Detail Information

Publications7

  1. pmc NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:3580-90. 2004
    ....
  2. ncbi request reprint Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility
    Irwan T Makagiansar
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:55262-70. 2004
    ..PKC-alpha-mediated NG2 phosphorylation at Thr(2256) is therefore a key step for initiating cell polarization and motility...
  3. pmc Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration
    Irwan T Makagiansar
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Cell Biol 178:155-65. 2007
    ..Thus, phosphorylation and the resulting site of NG2-integrin localization may determine the specific downstream effects of integrin signaling...
  4. ncbi request reprint Molecular basis of interaction between NG2 proteoglycan and galectin-3
    Yunfei Wen
    Burnham Institute, Developmental Neurobiology Program, La Jolla, California 92037, USA
    J Cell Biochem 98:115-27. 2006
    ..These studies establish a foundation for attempts to reduce the aggressive properties of tumor cells by disrupting the NG2/galectin-3 interaction...
  5. ncbi request reprint Disulfide bond formation promotes the cis- and trans-dimerization of the E-cadherin-derived first repeat
    Irwan T Makagiansar
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    J Biol Chem 277:16002-10. 2002
    ..Accordingly, it is plausible that, under oxidative stress, the homophilic interactions of E-cadherin through E-CAD1 may be promoted and stabilized by this disulfide bond...
  6. ncbi request reprint Localized production of human E-cadherin-derived first repeat in Escherichia coli
    Irwan T Makagiansar
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047 2504, USA
    Protein Expr Purif 26:449-54. 2002
    ..The expression and purification protocol for unlabeled and isotopically labeled E-CAD1 permits rapid preparative production of this protein for mechanistic and structural studies...
  7. ncbi request reprint Expression, purification, and structural study of the EC4 domain of E-cadherin
    Kai Zheng
    Department of Molecular Biosciences, The University of Kansas, Lawrence, KS 66045, USA
    Protein Expr Purif 33:72-9. 2004
    ..The CD results showed that this protein has high conformational stability in Tris buffer at pH 6.0 in the presence of 10 mM calcium chloride...